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The map label for this gene is copR [H]

Identifier: 146341626

GI number: 146341626

Start: 4915622

End: 4916296

Strand: Reverse

Name: copR [H]

Synonym: BRADO4729

Alternate gene names: 146341626

Gene position: 4916296-4915622 (Counterclockwise)

Preceding gene: 146341630

Following gene: 146341625

Centisome position: 65.93

GC content: 68.15

Gene sequence:

>675_bases
ATGCGTCTGCTGGTCGTCGAAGACAACAACGAGCTGTCCAAGCTGCTGTCGCAGGGGCTCGCCAGCGCCTTCTATCAGGT
CGACACCGTGAGCTCGGCCGCCGACGCGCGCGATGCGCTCAACGACATCAGCTATGCCGCGATGATTCTCGATCTCGGCC
TCCCCGATGAGGACGGCTTGTCGGTGCTGACCGAGCTGCGTCGCCGCGGCGATCCGCTGCCTGTCATCGTTCTCACCGCG
CGCGGCGGACTGCAGGACCGGGTGGGCGGCCTGCGCAGCGGCGCCGATGACTACCTCGTCAAGCCGTTCGCGCTGGAAGA
GCTGGTGGCGCGGCTGCAGGCGATCCTGCGCCGTCCCGGACAGCTGCTCGGCCGCTCGCTCGAGCTCGGCAATCTCGTCT
ACGACACCGAGAGCCGGCAGACCTTCGTGGGCGGTGCGCCGCGCACGCTGTCGGCCCGCGAGCTCTCGGTGCTGGAGATC
CTGCTGCGGCGGCAGGGGCGGGTGGTGCCGAAGAAGGCCGTCGAGGATCACATCTTCGGCCTCACCGGCGAGGTCGGCTC
CAACGCCGTCGAGGTCTACGTGTCGCGGCTGCGCAAGCAGCTTGCAGAGTATGGCGCGACCGTCGTGATCCATACGATCC
GCGGCGTCGGTTACATGATGGCCGCGGAGACCTGA

Upstream 100 bases:

>100_bases
GCTGTCCTCCTTCGGCCGGGCTTGCCACGCGCGGGTGCGGTCGGGCATCGTGGCGCGCACGGGCGCACGATCGCGCCTCC
ATCATCTGAACGTGAGCTGC

Downstream 100 bases:

>100_bases
GCGTGCACGTCAAGTCGCTGCTCTCGCGCATCGTGCTGTTGCATATCGTGGCGGTCGCGATCGCCGCGGTGTTCCTGCCG
CTGGTGCTGTTCTGGCTACT

Product: putative two-component response regulator (QseB/CopT-like)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MRLLVVEDNNELSKLLSQGLASAFYQVDTVSSAADARDALNDISYAAMILDLGLPDEDGLSVLTELRRRGDPLPVIVLTA
RGGLQDRVGGLRSGADDYLVKPFALEELVARLQAILRRPGQLLGRSLELGNLVYDTESRQTFVGGAPRTLSARELSVLEI
LLRRQGRVVPKKAVEDHIFGLTGEVGSNAVEVYVSRLRKQLAEYGATVVIHTIRGVGYMMAAET

Sequences:

>Translated_224_residues
MRLLVVEDNNELSKLLSQGLASAFYQVDTVSSAADARDALNDISYAAMILDLGLPDEDGLSVLTELRRRGDPLPVIVLTA
RGGLQDRVGGLRSGADDYLVKPFALEELVARLQAILRRPGQLLGRSLELGNLVYDTESRQTFVGGAPRTLSARELSVLEI
LLRRQGRVVPKKAVEDHIFGLTGEVGSNAVEVYVSRLRKQLAEYGATVVIHTIRGVGYMMAAET
>Mature_224_residues
MRLLVVEDNNELSKLLSQGLASAFYQVDTVSSAADARDALNDISYAAMILDLGLPDEDGLSVLTELRRRGDPLPVIVLTA
RGGLQDRVGGLRSGADDYLVKPFALEELVARLQAILRRPGQLLGRSLELGNLVYDTESRQTFVGGAPRTLSARELSVLEI
LLRRQGRVVPKKAVEDHIFGLTGEVGSNAVEVYVSRLRKQLAEYGATVVIHTIRGVGYMMAAET

Specific function: Member of the two-component regulatory system CopS/CopR. Involved in the activation of copper resistance gene operon CopABCD. Phosphorylation of CopR by CopS would convert it into an active state to induce expression of the cop operon by binding to a spec

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789402, Length=220, Percent_Identity=41.3636363636364, Blast_Score=167, Evalue=4e-43,
Organism=Escherichia coli, GI1790552, Length=226, Percent_Identity=40.7079646017699, Blast_Score=158, Evalue=2e-40,
Organism=Escherichia coli, GI1786784, Length=221, Percent_Identity=36.6515837104072, Blast_Score=150, Evalue=7e-38,
Organism=Escherichia coli, GI87082012, Length=226, Percent_Identity=39.8230088495575, Blast_Score=148, Evalue=4e-37,
Organism=Escherichia coli, GI1787375, Length=220, Percent_Identity=38.6363636363636, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1786599, Length=224, Percent_Identity=32.1428571428571, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1789809, Length=230, Percent_Identity=33.0434782608696, Blast_Score=119, Evalue=1e-28,
Organism=Escherichia coli, GI1788394, Length=225, Percent_Identity=31.1111111111111, Blast_Score=100, Evalue=7e-23,
Organism=Escherichia coli, GI2367329, Length=230, Percent_Identity=33.0434782608696, Blast_Score=94, Evalue=8e-21,
Organism=Escherichia coli, GI1790860, Length=221, Percent_Identity=29.4117647058824, Blast_Score=91, Evalue=4e-20,
Organism=Escherichia coli, GI1786911, Length=174, Percent_Identity=33.9080459770115, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1788550, Length=144, Percent_Identity=29.1666666666667, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI1787229, Length=232, Percent_Identity=28.8793103448276, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1790299, Length=146, Percent_Identity=31.5068493150685, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790863, Length=233, Percent_Identity=26.6094420600858, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=25.4310344827586, Blast_Score=65, Evalue=3e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 24359; Mature: 24359

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLVVEDNNELSKLLSQGLASAFYQVDTVSSAADARDALNDISYAAMILDLGLPDEDGL
CEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
SVLTELRRRGDPLPVIVLTARGGLQDRVGGLRSGADDYLVKPFALEELVARLQAILRRPG
HHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCCCHHCCHHHHHHHHHHHHHHHHCCH
QLLGRSLELGNLVYDTESRQTFVGGAPRTLSARELSVLEILLRRQGRVVPKKAVEDHIFG
HHHCCCCCCCCEEEECCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHC
LTGEVGSNAVEVYVSRLRKQLAEYGATVVIHTIRGVGYMMAAET
CCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEHHHCCHHEEECCC
>Mature Secondary Structure
MRLLVVEDNNELSKLLSQGLASAFYQVDTVSSAADARDALNDISYAAMILDLGLPDEDGL
CEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
SVLTELRRRGDPLPVIVLTARGGLQDRVGGLRSGADDYLVKPFALEELVARLQAILRRPG
HHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCCCHHCCHHHHHHHHHHHHHHHHCCH
QLLGRSLELGNLVYDTESRQTFVGGAPRTLSARELSVLEILLRRQGRVVPKKAVEDHIFG
HHHCCCCCCCCEEEECCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHC
LTGEVGSNAVEVYVSRLRKQLAEYGATVVIHTIRGVGYMMAAET
CCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEHHHCCHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8449873; 8078459 [H]