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The map label for this gene is moaA [H]

Identifier: 146341616

GI number: 146341616

Start: 4905117

End: 4906148

Strand: Direct

Name: moaA [H]

Synonym: BRADO4718

Alternate gene names: 146341616

Gene position: 4905117-4906148 (Clockwise)

Preceding gene: 146341615

Following gene: 146341617

Centisome position: 65.78

GC content: 66.57

Gene sequence:

>1032_bases
ATGACTGTTGAGACGTCTGAAGACACCGCCCTGACGCGCCCGATGACCGACCCGTTCGGCCGTCGCATCAGCTATCTGCG
CGTCTCCGTGACCGACCGCTGCGACCTCCGCTGCTTCTACTGCATGTCCGAGGACATGACGTTCCTGCCGAAAGCGGACC
TGCTGACGCTGGAGGAGCTCGACCGGCTGTGCTCGGCCTTCATCCACAAGGGCGTGAAGAAGCTCAGGCTCACCGGCGGC
GAGCCGCTGGTCCGGCGCAACGTCATGGGCCTGGTGCGCTCGCTGTCGCGGCATCTGAAGAGCGGCGCGCTCAACGAGCT
GACGATGACGACCAACGCGACGCAGCTCGCGAAATATGCCGCCGAGCTCGCCGATTGCGGCGTTCGCCGCATCAACGTCT
CGCTCGACACGCTCGATCCCGACAAGTTCCGCGCCATCACCCGCTGGGGCGATCTCGACCGCGTGCTCGCGGGCATCGAG
GCCGCGCGCGACGCTGGCCTGAAGGTGAAGATCAACGCGGTGGCGCTGAAGAACATGAACGAGGACGAGATCCCGCAGCT
GATCGACTGGGCGCATGGCAAGGGCATGGCGCTGACCTTGATCGAGGTGATGCCGATGGGCGAGATCGGCGAAGGCCGCA
TCGACCAGTATCTGCCGCTGTCGCTGCTGCGCGCGCGGCTGTCGCAGCAGTACACGATGACCGATCTCGACGAGACCACA
GGCGGCCCCGCCCGCTACGTCCGCGTCGCCGAGACCGGCGGCACGATCGGCTTCATCACGCCGATGACGCATAATTTCTG
CGAGAGCTGCAACCGCGTGCGCGTCACCTGCACCGGCACCCTGCACACCTGCCTCGGCCACGAGGACGCCTCCGATCTGC
GCAAACCCTTACGCGCCTCGGCCAGCGACGAGCAACTGAGCGACGCGATCGACCGCGCCATCGGCCTGAAGCCGAAGGGC
CACGACTTCATCATCGACCGCCGCCACAACCGCCCGAGCGTCAGCCGGCACATGAGCGTGACCGGCGGCTGA

Upstream 100 bases:

>100_bases
CCGATCATGATTAGATTGCCTGGATAGACATCCGGCCGCGCGCCTCGCGCGGCCGCCGCGTGGCATCGCTGCTACGTGCC
GCCAGCCGCCAAGGCCATCC

Downstream 100 bases:

>100_bases
TCCGTGCTCCCCTGGACGCTGATCGACACCGCTGATGTGCCCGGCGGCGGCGAGCCGCTGCGGCTGATGCAGCGCGGCCG
CGACTTCTCGATCAAGCTCG

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 342

Protein sequence:

>343_residues
MTVETSEDTALTRPMTDPFGRRISYLRVSVTDRCDLRCFYCMSEDMTFLPKADLLTLEELDRLCSAFIHKGVKKLRLTGG
EPLVRRNVMGLVRSLSRHLKSGALNELTMTTNATQLAKYAAELADCGVRRINVSLDTLDPDKFRAITRWGDLDRVLAGIE
AARDAGLKVKINAVALKNMNEDEIPQLIDWAHGKGMALTLIEVMPMGEIGEGRIDQYLPLSLLRARLSQQYTMTDLDETT
GGPARYVRVAETGGTIGFITPMTHNFCESCNRVRVTCTGTLHTCLGHEDASDLRKPLRASASDEQLSDAIDRAIGLKPKG
HDFIIDRRHNRPSVSRHMSVTGG

Sequences:

>Translated_343_residues
MTVETSEDTALTRPMTDPFGRRISYLRVSVTDRCDLRCFYCMSEDMTFLPKADLLTLEELDRLCSAFIHKGVKKLRLTGG
EPLVRRNVMGLVRSLSRHLKSGALNELTMTTNATQLAKYAAELADCGVRRINVSLDTLDPDKFRAITRWGDLDRVLAGIE
AARDAGLKVKINAVALKNMNEDEIPQLIDWAHGKGMALTLIEVMPMGEIGEGRIDQYLPLSLLRARLSQQYTMTDLDETT
GGPARYVRVAETGGTIGFITPMTHNFCESCNRVRVTCTGTLHTCLGHEDASDLRKPLRASASDEQLSDAIDRAIGLKPKG
HDFIIDRRHNRPSVSRHMSVTGG
>Mature_342_residues
TVETSEDTALTRPMTDPFGRRISYLRVSVTDRCDLRCFYCMSEDMTFLPKADLLTLEELDRLCSAFIHKGVKKLRLTGGE
PLVRRNVMGLVRSLSRHLKSGALNELTMTTNATQLAKYAAELADCGVRRINVSLDTLDPDKFRAITRWGDLDRVLAGIEA
ARDAGLKVKINAVALKNMNEDEIPQLIDWAHGKGMALTLIEVMPMGEIGEGRIDQYLPLSLLRARLSQQYTMTDLDETTG
GPARYVRVAETGGTIGFITPMTHNFCESCNRVRVTCTGTLHTCLGHEDASDLRKPLRASASDEQLSDAIDRAIGLKPKGH
DFIIDRRHNRPSVSRHMSVTGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=325, Percent_Identity=37.2307692307692, Blast_Score=208, Evalue=5e-54,
Organism=Homo sapiens, GI22027536, Length=325, Percent_Identity=37.2307692307692, Blast_Score=208, Evalue=6e-54,
Organism=Escherichia coli, GI1786999, Length=336, Percent_Identity=33.0357142857143, Blast_Score=197, Evalue=8e-52,
Organism=Caenorhabditis elegans, GI32566331, Length=345, Percent_Identity=33.6231884057971, Blast_Score=210, Evalue=9e-55,
Organism=Caenorhabditis elegans, GI32566329, Length=346, Percent_Identity=34.1040462427746, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17561210, Length=333, Percent_Identity=34.8348348348348, Blast_Score=201, Evalue=6e-52,
Organism=Drosophila melanogaster, GI28574488, Length=331, Percent_Identity=37.4622356495468, Blast_Score=204, Evalue=8e-53,
Organism=Drosophila melanogaster, GI28574490, Length=325, Percent_Identity=37.8461538461538, Blast_Score=203, Evalue=1e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 38077; Mature: 37946

Theoretical pI: Translated: 7.74; Mature: 7.74

Prosite motif: PS00144 ASN_GLN_ASE_1 ; PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVETSEDTALTRPMTDPFGRRISYLRVSVTDRCDLRCFYCMSEDMTFLPKADLLTLEEL
CCCCCCCCCEECCCCCCHHHCCEEEEEEEECCCCCCEEEEEECCCCCCCCCCCCCCHHHH
DRLCSAFIHKGVKKLRLTGGEPLVRRNVMGLVRSLSRHLKSGALNELTMTTNATQLAKYA
HHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHH
AELADCGVRRINVSLDTLDPDKFRAITRWGDLDRVLAGIEAARDAGLKVKINAVALKNMN
HHHHHCCEEEEEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEEEEECCCC
EDEIPQLIDWAHGKGMALTLIEVMPMGEIGEGRIDQYLPLSLLRARLSQQYTMTDLDETT
HHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCHHCCHHHHHHHHHCCCEECCCCCCC
GGPARYVRVAETGGTIGFITPMTHNFCESCNRVRVTCTGTLHTCLGHEDASDLRKPLRAS
CCCEEEEEEEECCCEEEEECCCHHHHHHCCCCEEEEEECHHHHHHCCCCHHHHHHHHHCC
ASDEQLSDAIDRAIGLKPKGHDFIIDRRHNRPSVSRHMSVTGG
CCHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHEEECCCC
>Mature Secondary Structure 
TVETSEDTALTRPMTDPFGRRISYLRVSVTDRCDLRCFYCMSEDMTFLPKADLLTLEEL
CCCCCCCCEECCCCCCHHHCCEEEEEEEECCCCCCEEEEEECCCCCCCCCCCCCCHHHH
DRLCSAFIHKGVKKLRLTGGEPLVRRNVMGLVRSLSRHLKSGALNELTMTTNATQLAKYA
HHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHH
AELADCGVRRINVSLDTLDPDKFRAITRWGDLDRVLAGIEAARDAGLKVKINAVALKNMN
HHHHHCCEEEEEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEEEEECCCC
EDEIPQLIDWAHGKGMALTLIEVMPMGEIGEGRIDQYLPLSLLRARLSQQYTMTDLDETT
HHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCHHCCHHHHHHHHHCCCEECCCCCCC
GGPARYVRVAETGGTIGFITPMTHNFCESCNRVRVTCTGTLHTCLGHEDASDLRKPLRAS
CCCEEEEEEEECCCEEEEECCCHHHHHHCCCCEEEEEECHHHHHHCCCCHHHHHHHHHCC
ASDEQLSDAIDRAIGLKPKGHDFIIDRRHNRPSVSRHMSVTGG
CCHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]