Click here to switch to the map view.

The map label for this gene is aidB [H]

Identifier: 146341411

GI number: 146341411

Start: 4699396

End: 4701039

Strand: Reverse

Name: aidB [H]

Synonym: BRADO4501

Alternate gene names: 146341411

Gene position: 4701039-4699396 (Counterclockwise)

Preceding gene: 146341417

Following gene: 146341410

Centisome position: 63.05

GC content: 68.67

Gene sequence:

>1644_bases
ATGACCCAGCCATCGCTCGAGACCCACGAGGTCTTCAACCAGTCGCCGCCCTTCGCGGACGTGAACCTCTTCACGGCCGA
CCGGCCGCTGATGGACGCGGTCGCGGCGAACGGCGGGAGCGGCGCCGAGCAGGAGCTGATTGCGTTCGGCAAGCTGTGGG
GCTCGGCCGAGATGGCCGAGCAGGGCCGGCTGGCCAACGAGAACACGCCGAAGCTGCGCAGCTTCGACGCCAAGGGTTTT
CGCCGCGACGCCGTCGAGTTTCATCCGGCCTATCATCACATGATGGCGCAGGCCGTCGCGGCCGGGCTGCACAATTCGAC
CTGGACGGCGCAGGGCAAGCCCGTCGGCGGCAGCGCCGAAGTCGTGCGCGCGGCAAAGTTCTACGTCGCCTCGCAGGTCG
AGAGCGGACACCTCTGTCCGATCACGATGACGCGTGCCTCGGTCGCCGCGCTCGCACCGCAGCCGGATCTGCTGGCGCAA
ACGATGCGTGTCATCGCGACACGCGACTACGATCCGGCGTTTGCGCCGTGGTGGCAGAAGCGCGGCATGACGCTGGGCAT
GGGCATGACCGAGAAGCAGGGCGGCACCGACGTGCGCGCCAACATGACGTCGGCCACGCGCTCCACGGACGGTTACCGCA
TCACCGGGCACAAATGGTTCATGTCGGCGCCGATGTGCGACGCGTTCCTGGTGCTGGCGCAGGCCGAGGGCGGGCTGACC
TGCTTCTTCATGCCGCGCTTCACGCCCGATGGCGCCGTCAATGCGCTGCGCTTCCAGCGGCTGAAGGACAAGCTCGGCAA
TCGCTCCAACGCCTCCTCGGAGGTCGAGTTCGCGGGCGCCTATGCCGAGCGGGTCGGCGAGGAGGGCCGGGGCATCAGCA
CCATCATCCAGATGGTGCAGCTGACGCGGCAGGATTGCGCGATCTCGTCCGCCGGCCTGATGCGCTCGGGGCTGGCCCAC
GCGCTCCACCACGCCCGCCATCGCAGCGTGTTCCAGAAGCATCTCGCCGATCAGCCCTTGATGCAGGCGGTGCTGGCCGA
CATGGCGCTGCATGTCGAGGCGACGGTTGCGCTGGTGATGCGGCTGTGCCGCGCTTTCGATCGCATGACGGATGATGCGG
ACGAAGCCGCCTACATGCGGCTGCTGACACCCGCGATCAAGTACTGGGTCTGCAAGAGCGCGCCGCCGTTCCTGTACGAG
GCGATGGAGTGCCTCGGCGGCAATGGCTATGTCGAGGACGGCATCCTCGCGCGCCACTATCGCGAGTCGCCGGTCAATGC
GATCTGGGAGGGCTCGGGCAACGTGATGTGCCTCGACGTGCTGCGCGCGCTGTCGCGCGAGCCGGAGGCGGCGGCTGCCG
TCCTGAACACCTTGTCGGACGCGACGCGTGGCCTGCCTGGCGCAGCGGACGCGGTCGCCATGATCGGCCAGGCCTTCCGG
CGTGGCGACAGCGAGCGTGTTGCACGGCTCGCCGTGGAGAAATTGGCGCTGCTGTCGGCCGCGGCCGCGCTCAACGCGGT
GACGCCCGCCCATGCCGAGCTGTTCGCCGCCACGCGGCTCGCCACCGTTCATCCGAGCATGTATGGCGCGGTCGATCTCG
CTCCCGCCGCCAGCCGTGCCTTGCTGGAGCGCACCCTGCCTTGA

Upstream 100 bases:

>100_bases
GCGACGGAGCGGAGGCATTTTTCGCTGCCGGGCGCGGCCGCGACCCCCTATGATTTTTCAATTCGGCCGCGCCGATGATC
TGTTTGCAAAGGCCACGGCC

Downstream 100 bases:

>100_bases
CCGACACGCCCGACGCCGCCGTCATCGATTCCCTCGATCCCGCTCATCCGCCGCAGCGGATCGCGCCCGCGCCGCATCAG
CCGCGCACGCTCGGCTTCTG

Product: isovaleryl CoA dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 547; Mature: 546

Protein sequence:

>547_residues
MTQPSLETHEVFNQSPPFADVNLFTADRPLMDAVAANGGSGAEQELIAFGKLWGSAEMAEQGRLANENTPKLRSFDAKGF
RRDAVEFHPAYHHMMAQAVAAGLHNSTWTAQGKPVGGSAEVVRAAKFYVASQVESGHLCPITMTRASVAALAPQPDLLAQ
TMRVIATRDYDPAFAPWWQKRGMTLGMGMTEKQGGTDVRANMTSATRSTDGYRITGHKWFMSAPMCDAFLVLAQAEGGLT
CFFMPRFTPDGAVNALRFQRLKDKLGNRSNASSEVEFAGAYAERVGEEGRGISTIIQMVQLTRQDCAISSAGLMRSGLAH
ALHHARHRSVFQKHLADQPLMQAVLADMALHVEATVALVMRLCRAFDRMTDDADEAAYMRLLTPAIKYWVCKSAPPFLYE
AMECLGGNGYVEDGILARHYRESPVNAIWEGSGNVMCLDVLRALSREPEAAAAVLNTLSDATRGLPGAADAVAMIGQAFR
RGDSERVARLAVEKLALLSAAAALNAVTPAHAELFAATRLATVHPSMYGAVDLAPAASRALLERTLP

Sequences:

>Translated_547_residues
MTQPSLETHEVFNQSPPFADVNLFTADRPLMDAVAANGGSGAEQELIAFGKLWGSAEMAEQGRLANENTPKLRSFDAKGF
RRDAVEFHPAYHHMMAQAVAAGLHNSTWTAQGKPVGGSAEVVRAAKFYVASQVESGHLCPITMTRASVAALAPQPDLLAQ
TMRVIATRDYDPAFAPWWQKRGMTLGMGMTEKQGGTDVRANMTSATRSTDGYRITGHKWFMSAPMCDAFLVLAQAEGGLT
CFFMPRFTPDGAVNALRFQRLKDKLGNRSNASSEVEFAGAYAERVGEEGRGISTIIQMVQLTRQDCAISSAGLMRSGLAH
ALHHARHRSVFQKHLADQPLMQAVLADMALHVEATVALVMRLCRAFDRMTDDADEAAYMRLLTPAIKYWVCKSAPPFLYE
AMECLGGNGYVEDGILARHYRESPVNAIWEGSGNVMCLDVLRALSREPEAAAAVLNTLSDATRGLPGAADAVAMIGQAFR
RGDSERVARLAVEKLALLSAAAALNAVTPAHAELFAATRLATVHPSMYGAVDLAPAASRALLERTLP
>Mature_546_residues
TQPSLETHEVFNQSPPFADVNLFTADRPLMDAVAANGGSGAEQELIAFGKLWGSAEMAEQGRLANENTPKLRSFDAKGFR
RDAVEFHPAYHHMMAQAVAAGLHNSTWTAQGKPVGGSAEVVRAAKFYVASQVESGHLCPITMTRASVAALAPQPDLLAQT
MRVIATRDYDPAFAPWWQKRGMTLGMGMTEKQGGTDVRANMTSATRSTDGYRITGHKWFMSAPMCDAFLVLAQAEGGLTC
FFMPRFTPDGAVNALRFQRLKDKLGNRSNASSEVEFAGAYAERVGEEGRGISTIIQMVQLTRQDCAISSAGLMRSGLAHA
LHHARHRSVFQKHLADQPLMQAVLADMALHVEATVALVMRLCRAFDRMTDDADEAAYMRLLTPAIKYWVCKSAPPFLYEA
MECLGGNGYVEDGILARHYRESPVNAIWEGSGNVMCLDVLRALSREPEAAAAVLNTLSDATRGLPGAADAVAMIGQAFRR
GDSERVARLAVEKLALLSAAAALNAVTPAHAELFAATRLATVHPSMYGAVDLAPAASRALLERTLP

Specific function: May help to prevent alkylation damage by protecting DNA and destroying alkylating agents [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=267, Percent_Identity=27.3408239700375, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI226958414, Length=270, Percent_Identity=25.1851851851852, Blast_Score=87, Evalue=6e-17,
Organism=Homo sapiens, GI226958412, Length=270, Percent_Identity=25.1851851851852, Blast_Score=87, Evalue=6e-17,
Organism=Homo sapiens, GI7656849, Length=268, Percent_Identity=28.3582089552239, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI4501859, Length=314, Percent_Identity=24.8407643312102, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI4557235, Length=390, Percent_Identity=24.3589743589744, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI76496475, Length=390, Percent_Identity=24.3589743589744, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI87082384, Length=549, Percent_Identity=46.448087431694, Blast_Score=432, Evalue=1e-122,
Organism=Escherichia coli, GI87081958, Length=276, Percent_Identity=23.5507246376812, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI86563383, Length=410, Percent_Identity=32.1951219512195, Blast_Score=182, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI86563381, Length=410, Percent_Identity=32.1951219512195, Blast_Score=182, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI17538396, Length=270, Percent_Identity=25.9259259259259, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17508101, Length=273, Percent_Identity=24.9084249084249, Blast_Score=83, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17506239, Length=268, Percent_Identity=24.6268656716418, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17533517, Length=266, Percent_Identity=24.812030075188, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71985184, Length=261, Percent_Identity=25.6704980842912, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17505929, Length=274, Percent_Identity=28.1021897810219, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24646207, Length=268, Percent_Identity=26.865671641791, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21356377, Length=268, Percent_Identity=26.1194029850746, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21355753, Length=273, Percent_Identity=24.5421245421245, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI281363737, Length=267, Percent_Identity=25.0936329588015, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24666513, Length=271, Percent_Identity=23.9852398523985, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M [H]

EC number: NA

Molecular weight: Translated: 59052; Mature: 58921

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQPSLETHEVFNQSPPFADVNLFTADRPLMDAVAANGGSGAEQELIAFGKLWGSAEMAE
CCCCCCCHHHHHCCCCCCCCEEEEECCCHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHH
QGRLANENTPKLRSFDAKGFRRDAVEFHPAYHHMMAQAVAAGLHNSTWTAQGKPVGGSAE
CCCCCCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHH
VVRAAKFYVASQVESGHLCPITMTRASVAALAPQPDLLAQTMRVIATRDYDPAFAPWWQK
HHHHHHHHHHHHCCCCCCCEEEEHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCHHHH
RGMTLGMGMTEKQGGTDVRANMTSATRSTDGYRITGHKWFMSAPMCDAFLVLAQAEGGLT
CCCEECCCCCCCCCCCCEEECCHHHHCCCCCEEEECCEEEECCCHHHHHHHHEECCCCEE
CFFMPRFTPDGAVNALRFQRLKDKLGNRSNASSEVEFAGAYAERVGEEGRGISTIIQMVQ
EEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHH
LTRQDCAISSAGLMRSGLAHALHHARHRSVFQKHLADQPLMQAVLADMALHVEATVALVM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
RLCRAFDRMTDDADEAAYMRLLTPAIKYWVCKSAPPFLYEAMECLGGNGYVEDGILARHY
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHH
RESPVNAIWEGSGNVMCLDVLRALSREPEAAAAVLNTLSDATRGLPGAADAVAMIGQAFR
HCCCCCEEEECCCCEEHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
RGDSERVARLAVEKLALLSAAAALNAVTPAHAELFAATRLATVHPSMYGAVDLAPAASRA
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHCCEECCHHHHHH
LLERTLP
HHHHCCC
>Mature Secondary Structure 
TQPSLETHEVFNQSPPFADVNLFTADRPLMDAVAANGGSGAEQELIAFGKLWGSAEMAE
CCCCCCHHHHHCCCCCCCCEEEEECCCHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHH
QGRLANENTPKLRSFDAKGFRRDAVEFHPAYHHMMAQAVAAGLHNSTWTAQGKPVGGSAE
CCCCCCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHH
VVRAAKFYVASQVESGHLCPITMTRASVAALAPQPDLLAQTMRVIATRDYDPAFAPWWQK
HHHHHHHHHHHHCCCCCCCEEEEHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCHHHH
RGMTLGMGMTEKQGGTDVRANMTSATRSTDGYRITGHKWFMSAPMCDAFLVLAQAEGGLT
CCCEECCCCCCCCCCCCEEECCHHHHCCCCCEEEECCEEEECCCHHHHHHHHEECCCCEE
CFFMPRFTPDGAVNALRFQRLKDKLGNRSNASSEVEFAGAYAERVGEEGRGISTIIQMVQ
EEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHH
LTRQDCAISSAGLMRSGLAHALHHARHRSVFQKHLADQPLMQAVLADMALHVEATVALVM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
RLCRAFDRMTDDADEAAYMRLLTPAIKYWVCKSAPPFLYEAMECLGGNGYVEDGILARHY
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHH
RESPVNAIWEGSGNVMCLDVLRALSREPEAAAAVLNTLSDATRGLPGAADAVAMIGQAFR
HCCCCCEEEECCCCEEHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
RGDSERVARLAVEKLALLSAAAALNAVTPAHAELFAATRLATVHPSMYGAVDLAPAASRA
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHCCEECCHHHHHH
LLERTLP
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961409; 7610040; 9278503 [H]