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The map label for this gene is livH [H]

Identifier: 146340682

GI number: 146340682

Start: 3896061

End: 3896924

Strand: Direct

Name: livH [H]

Synonym: BRADO3733

Alternate gene names: 146340682

Gene position: 3896061-3896924 (Clockwise)

Preceding gene: 146340681

Following gene: 146340683

Centisome position: 52.25

GC content: 63.43

Gene sequence:

>864_bases
ATGCAGGCCCTCTACGCACAGCTCCTTGTCGGACTGATCAACGGCTCGTTCTACGCGCTGCTCAGTCTGGGGCTTGCCGT
CATCTTCGGCATGCTCAACATCATCAACTTCGCCCATGGCGCGCTCTACATGATGGGCGCGTTCTGCGCCTATTTCCTGC
TGAACCTCGGCGGCATCAATTATTGGTGGGCGCTGCTGCTGGCGCCGATCATCGTCGGCGCATTCGGCATGGTCCTGGAG
CGCACGCTGCTGCAATGGTTGACCGGGCTTGACCATCTCTACGGCCTGCTCTTGACCTTCGGCATCGCGCTGATCGTGCA
GGGCATCTTCCAGAACTATTTCGGCTCCTCGGGCCTGCCTTACGCGATCCCGGATCAGCTGCGCGGCGGCATGAATCTCG
GCTTTATGTTCCTGCCGGTCTATCGCGGCTGGGTCGTGGTGTTCTCGCTGGTGGTGTGTCTCGCCACCTGGTTCCTGATC
GAGCGCACCCGGCTCGGCGCCTATCTGCGCGCCGCCACCGAGAATCCCACCCTGGTTCGCGCCTTCGGCATCAACGTGCC
GCGCATGATCACGCTCACCTACGGGCTCGGCGTCGGCCTTGCCGCGCTCGCCGGCGTGCTGTCGGCCCCGATCAACCAGG
TGCGGCCGCTGATGGGCGCCGACCTGATCATCGTCGTGTTCGCGGTCGTCGTGATCGGCGGCATGGGCTCGATCATGGGC
TCGATCATCACCGGCTTCGCGCTCGGCGTCGTCGAGGGACTGACCAAATATTTCTATCCCGAGGCTTCCAACACCGTGGT
CTTCGTTCTGATGGTCCTGGTGCTCCTGGTGAAGCCGACGGGTCTGACCGGACGGGCGGCCTGA

Upstream 100 bases:

>100_bases
GCCTGCGCTCTGTTGAAGAAATAAGCCGCCGCGGCCCCCGGCGGTCCGCCGCCGGGCTGTTGTTGACGTCAGGAAACGCC
GAGAGAAACAGAACAAGACG

Downstream 100 bases:

>100_bases
CATGACATCGATCACCGACGAGACATTGCCGATCACCCCGCGCGCGATGCGCGACGAGATGATCGCGTTCGTCATCATGG
CGGCGCTGCTCGCCATCGTG

Product: putative branched-chain amino acid transport permease

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MQALYAQLLVGLINGSFYALLSLGLAVIFGMLNIINFAHGALYMMGAFCAYFLLNLGGINYWWALLLAPIIVGAFGMVLE
RTLLQWLTGLDHLYGLLLTFGIALIVQGIFQNYFGSSGLPYAIPDQLRGGMNLGFMFLPVYRGWVVVFSLVVCLATWFLI
ERTRLGAYLRAATENPTLVRAFGINVPRMITLTYGLGVGLAALAGVLSAPINQVRPLMGADLIIVVFAVVVIGGMGSIMG
SIITGFALGVVEGLTKYFYPEASNTVVFVLMVLVLLVKPTGLTGRAA

Sequences:

>Translated_287_residues
MQALYAQLLVGLINGSFYALLSLGLAVIFGMLNIINFAHGALYMMGAFCAYFLLNLGGINYWWALLLAPIIVGAFGMVLE
RTLLQWLTGLDHLYGLLLTFGIALIVQGIFQNYFGSSGLPYAIPDQLRGGMNLGFMFLPVYRGWVVVFSLVVCLATWFLI
ERTRLGAYLRAATENPTLVRAFGINVPRMITLTYGLGVGLAALAGVLSAPINQVRPLMGADLIIVVFAVVVIGGMGSIMG
SIITGFALGVVEGLTKYFYPEASNTVVFVLMVLVLLVKPTGLTGRAA
>Mature_287_residues
MQALYAQLLVGLINGSFYALLSLGLAVIFGMLNIINFAHGALYMMGAFCAYFLLNLGGINYWWALLLAPIIVGAFGMVLE
RTLLQWLTGLDHLYGLLLTFGIALIVQGIFQNYFGSSGLPYAIPDQLRGGMNLGFMFLPVYRGWVVVFSLVVCLATWFLI
ERTRLGAYLRAATENPTLVRAFGINVPRMITLTYGLGVGLAALAGVLSAPINQVRPLMGADLIIVVFAVVVIGGMGSIMG
SIITGFALGVVEGLTKYFYPEASNTVVFVLMVLVLLVKPTGLTGRAA

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=292, Percent_Identity=31.8493150684932, Blast_Score=109, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 30860; Mature: 30860

Theoretical pI: Translated: 9.21; Mature: 9.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQALYAQLLVGLINGSFYALLSLGLAVIFGMLNIINFAHGALYMMGAFCAYFLLNLGGIN
CHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
YWWALLLAPIIVGAFGMVLERTLLQWLTGLDHLYGLLLTFGIALIVQGIFQNYFGSSGLP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
YAIPDQLRGGMNLGFMFLPVYRGWVVVFSLVVCLATWFLIERTRLGAYLRAATENPTLVR
CCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
AFGINVPRMITLTYGLGVGLAALAGVLSAPINQVRPLMGADLIIVVFAVVVIGGMGSIMG
EECCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHCCHHHHHH
SIITGFALGVVEGLTKYFYPEASNTVVFVLMVLVLLVKPTGLTGRAA
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MQALYAQLLVGLINGSFYALLSLGLAVIFGMLNIINFAHGALYMMGAFCAYFLLNLGGIN
CHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
YWWALLLAPIIVGAFGMVLERTLLQWLTGLDHLYGLLLTFGIALIVQGIFQNYFGSSGLP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
YAIPDQLRGGMNLGFMFLPVYRGWVVVFSLVVCLATWFLIERTRLGAYLRAATENPTLVR
CCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
AFGINVPRMITLTYGLGVGLAALAGVLSAPINQVRPLMGADLIIVVFAVVVIGGMGSIMG
EECCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHCCHHHHHH
SIITGFALGVVEGLTKYFYPEASNTVVFVLMVLVLLVKPTGLTGRAA
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]