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The map label for this gene is hmgL [H]

Identifier: 146340633

GI number: 146340633

Start: 3849038

End: 3849952

Strand: Direct

Name: hmgL [H]

Synonym: BRADO3681

Alternate gene names: 146340633

Gene position: 3849038-3849952 (Clockwise)

Preceding gene: 146340632

Following gene: 146340637

Centisome position: 51.62

GC content: 67.21

Gene sequence:

>915_bases
ATGAGCGAGAGCGTGCGCATCATCGAAATGGGCCCGCGCGACGGCCTGCAGAACGAGAAGACGTCCGTCAGTGTCGCCGA
CCGCATCGCCTTCGTCCGCGCGCTGGTCGACGCCGGCCTGACCACCGTCGAGGTCGGCGCCTTCGTCTCGCCCAAGGCGA
TCCCGCAGATGGTGGGGTCCGACGAGGTGATGCGCAGCGTCGCCGCGCTGCCCGGCGAGTTCCACGTCCTCGTGCCCAAC
GTGAAGGGCTACGAGGCCGCGCATGCCGCGGGTGCCAAGGTGATCTCGGTGTTCACTGCCGCCTCCGAGAGCTTTTCCCG
CGCCAACATCAACTGTTCGATCGAAGAGTCGCTGGAGCGGTTCAAGCCGGTGGTGGCGCACGCGAAGACCGACGGCATCA
AGGTGCGCGGCTACGTCTCCTGCGTGCTCGGCTGTCCCTATGAGGGCGAGATCAAGCCGCAAGCGGTGGCCGATGTCGCC
AAGGCGCTGTGGAACCTCGGCTGCTACGAGGTGTCGCTGGGCGACACGATCGGCGTCGGCACGCCCGTGAAGGCCAAGCA
GATGCTGCGCGCGGTCTGCGACGACGTGCCGGTGTCGCATCTGGCGATGCACTTTCACGACACCTATGGCCAGGCGCTCG
CCAACCTCTATGCCGGGATGGAGGAGGGCGTTCGCGTCATCGATGCCGCCGCCGGTGGCCTTGGCGGCTGTCCGTTTGCA
CCGGGCGCGACCGGCAATGTCGCGACCGAGGATGTCGTCTACATGCTCGAGGGCATGGGCATCCGGACCGGCGTCGACAT
GACCGGACTCCTGGCAGCCACCAATGAGATCAGCCGGCTGATCGGGCGTCCGCCGGTCAGCCGCGTCGCCGCGGCGCTGA
ATGCGAAGAACAGGCGAGTAGCGAATGGCGAGTAG

Upstream 100 bases:

>100_bases
TCAAGGCGATCAAGTGCAAGGTCGGCGACATCGTGCAGGAAGGCGTCGAACTGGCGGAAGTCGAACCCTCCGCCTGATCC
TCCAACTCATAGAGGTCAGC

Downstream 100 bases:

>100_bases
CGAATAGGGGCCTGCCCCCTCGCCAATCTATTCGCTACTCCCTATTCGCCATTCGCCAGCCGTGTCAGCGGCTCAGATCC
GGTCCCATCACGAGGTTCGG

Product: hydroxymethylglutaryl-CoA lyase

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MSESVRIIEMGPRDGLQNEKTSVSVADRIAFVRALVDAGLTTVEVGAFVSPKAIPQMVGSDEVMRSVAALPGEFHVLVPN
VKGYEAAHAAGAKVISVFTAASESFSRANINCSIEESLERFKPVVAHAKTDGIKVRGYVSCVLGCPYEGEIKPQAVADVA
KALWNLGCYEVSLGDTIGVGTPVKAKQMLRAVCDDVPVSHLAMHFHDTYGQALANLYAGMEEGVRVIDAAAGGLGGCPFA
PGATGNVATEDVVYMLEGMGIRTGVDMTGLLAATNEISRLIGRPPVSRVAAALNAKNRRVANGE

Sequences:

>Translated_304_residues
MSESVRIIEMGPRDGLQNEKTSVSVADRIAFVRALVDAGLTTVEVGAFVSPKAIPQMVGSDEVMRSVAALPGEFHVLVPN
VKGYEAAHAAGAKVISVFTAASESFSRANINCSIEESLERFKPVVAHAKTDGIKVRGYVSCVLGCPYEGEIKPQAVADVA
KALWNLGCYEVSLGDTIGVGTPVKAKQMLRAVCDDVPVSHLAMHFHDTYGQALANLYAGMEEGVRVIDAAAGGLGGCPFA
PGATGNVATEDVVYMLEGMGIRTGVDMTGLLAATNEISRLIGRPPVSRVAAALNAKNRRVANGE
>Mature_303_residues
SESVRIIEMGPRDGLQNEKTSVSVADRIAFVRALVDAGLTTVEVGAFVSPKAIPQMVGSDEVMRSVAALPGEFHVLVPNV
KGYEAAHAAGAKVISVFTAASESFSRANINCSIEESLERFKPVVAHAKTDGIKVRGYVSCVLGCPYEGEIKPQAVADVAK
ALWNLGCYEVSLGDTIGVGTPVKAKQMLRAVCDDVPVSHLAMHFHDTYGQALANLYAGMEEGVRVIDAAAGGLGGCPFAP
GATGNVATEDVVYMLEGMGIRTGVDMTGLLAATNEISRLIGRPPVSRVAAALNAKNRRVANGE

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI62198232, Length=293, Percent_Identity=54.9488054607508, Blast_Score=336, Evalue=1e-92,
Organism=Homo sapiens, GI109150427, Length=297, Percent_Identity=52.8619528619529, Blast_Score=323, Evalue=2e-88,
Organism=Homo sapiens, GI109150422, Length=297, Percent_Identity=52.8619528619529, Blast_Score=323, Evalue=2e-88,
Organism=Homo sapiens, GI260654708, Length=136, Percent_Identity=57.3529411764706, Blast_Score=162, Evalue=3e-40,
Organism=Escherichia coli, GI1786261, Length=292, Percent_Identity=25.6849315068493, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17510563, Length=296, Percent_Identity=46.2837837837838, Blast_Score=270, Evalue=1e-72,
Organism=Drosophila melanogaster, GI24582381, Length=300, Percent_Identity=49.6666666666667, Blast_Score=309, Evalue=2e-84,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000138
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 31828; Mature: 31697

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSESVRIIEMGPRDGLQNEKTSVSVADRIAFVRALVDAGLTTVEVGAFVSPKAIPQMVGS
CCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHCCC
DEVMRSVAALPGEFHVLVPNVKGYEAAHAAGAKVISVFTAASESFSRANINCSIEESLER
HHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
FKPVVAHAKTDGIKVRGYVSCVLGCPYEGEIKPQAVADVAKALWNLGCYEVSLGDTIGVG
HHHHHHHCCCCCEEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCC
TPVKAKQMLRAVCDDVPVSHLAMHFHDTYGQALANLYAGMEEGVRVIDAAAGGLGGCPFA
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
PGATGNVATEDVVYMLEGMGIRTGVDMTGLLAATNEISRLIGRPPVSRVAAALNAKNRRV
CCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCC
ANGE
CCCC
>Mature Secondary Structure 
SESVRIIEMGPRDGLQNEKTSVSVADRIAFVRALVDAGLTTVEVGAFVSPKAIPQMVGS
CCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHCCC
DEVMRSVAALPGEFHVLVPNVKGYEAAHAAGAKVISVFTAASESFSRANINCSIEESLER
HHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
FKPVVAHAKTDGIKVRGYVSCVLGCPYEGEIKPQAVADVAKALWNLGCYEVSLGDTIGVG
HHHHHHHCCCCCEEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCC
TPVKAKQMLRAVCDDVPVSHLAMHFHDTYGQALANLYAGMEEGVRVIDAAAGGLGGCPFA
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
PGATGNVATEDVVYMLEGMGIRTGVDMTGLLAATNEISRLIGRPPVSRVAAALNAKNRRV
CCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCC
ANGE
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2687236; 2656635; 1637819 [H]