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The map label for this gene is yngE [H]

Identifier: 146340631

GI number: 146340631

Start: 3845398

End: 3847005

Strand: Direct

Name: yngE [H]

Synonym: BRADO3679

Alternate gene names: 146340631

Gene position: 3845398-3847005 (Clockwise)

Preceding gene: 146340628

Following gene: 146340632

Centisome position: 51.57

GC content: 65.86

Gene sequence:

>1608_bases
ATGACGCTTCATTCGACGATCGATCCTTCATCCGCGGATTTCGCGCGCAACGCCGAGTCCATGCGCGCACTCGTCGCGGA
CCTCAAGACCAAGCTGGCGCAGGTCGCCGAAGGCGGCGGCGAGGCGTCGCGCAAACGGCATCTGTCGCGCGGCAAGATGC
TGGCACGGCAGCGGGTCGACCTGCTGCTCGATCCCGGCACCGCGTTTCTGGAGCTGTCGCCGCTGGCGGCGCACGGACTG
TATGGCGGCGATGTTCACTCGGCGAGCATTGTCACCGGCATCGGCCGTATCGCGGGCCGTGAGTGCGTCATCGTCGCCAA
TGACGCGACCATCAAGGGCGGCACCTACTACCCGATGACGGTGAAGAAGCATCTGCGCGCCCAGGACATCGCGCGGCAGA
ACAATCTGCCCTGCGTCTACATGGTCGATTCTGGCGGCGCCTTCCTGCCGCTGCAGGACGAGATCTTTCCCGACGAGCGG
CATTTCGGCCGCATCTTCTACAACCAGGCGCAGATGTCGGCCATTGGAATCCCGCAGATCGCGGTCGTGATGGGCTCGTG
CACGGCCGGCGGCGCCTATGTGCCGGCGATGTCGGACGAGAGCATCATCGTGCGCAATCAGGGCACGATCTTCCTCGGGG
GGCCGCCGCTGGTGAAGGCGGCGACCGGCGAGGTCGTCAGCGCCGAGGAGCTCGGCGGCGCCGATGTGCATTCGCGACAG
TCGGGCGTCACCGATCACTACGCGCAGAACGACGCACATGCGATCGGCATCGCGCGCCGCGTCGTCGGCACGTTGAAGCC
GCCGGGCGCGCGCACCGTGCTGAACATGCGCGCCGTCCGCGAGCCGCGTTATGCCGCGGAGGAGATCTATGGGGTGGTGC
CAGCAGACGGCCGCAAGCCGTTCGACGTCCGCGACATCATTGCGCGTGTGGTCGACGGCTCGGAGTTCGACGAATTCAAG
AAGCTCTACGGCCAGACGCTGGTGTGCGGCTTCGCCCACATCTTCGGCTACCCCGTCGGCATCATCGCTAATAATGGCAT
CCTGTTCAGCGAGAGCTCGTTGAAGGGCGCGCACTTCATCGAGCTGTGCTGCCAGCGCAACATTCCGCTGGTGTTCCTGC
AGAACATCACCGGCTTCATGGTCGGCAAGAAATATGAGGCCGGCGGCATCGCGCGCGACGGCGCCAAGCTGGTGACCGCG
GTGGCGACCGCCTCTGTGCCGAAATTCACCGTCGTGATCGGCGGCTCCTATGGCGCCGGCAATTACGGCATGTGCGGCCG
CGCCTACGCGCCGCGCTTCCTCTGGATGTGGCCAAATGCGCGCATCTCGGTCATGGGCGGCGAGCAGGCCGCGATGGTGC
TGAGCCAGGTCCGCCGCGACGGCATCGAGGCCAAGGGTGAGAGCTGGCCGGCGGAAGAGGAAGAGAAATTCCGCGCGCCC
ATCCGCGAGCAATACGAGGCGCAGGGCAATCCATACTATGCGACCGCGCGGCTTTGGGATGACGGCGTGATCGATCCCGC
CGACACCCGCCTCGTGCTCGGGCTCGGATTATCTGCCGCCGCCAATGCCCCGGTCGAGCCGACCAAGTTCGGCCTGTTCA
GGATGTGA

Upstream 100 bases:

>100_bases
AGATGGTACACCCGCCCGTGACGCGGCCTCCCGGGCCGCGGCCGGTCTGAAGCTTGCTCTCACGGCTTTTCCTCGGGCCC
AAGCAACGAAGACGCCGATC

Downstream 100 bases:

>100_bases
TCATGGCTCGTCCCGGATTGTATCGCCGTTTCCGCAAGCTCCTGATCGCCAACCGTGGAGAGATCGCCGTGCGCGTCATC
CGTACCGCGCGCGCGATGGG

Product: putative acyl-CoA carboxylase subunit beta

Products: ADP; phosphate; 3-methylglutaconyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 535; Mature: 534

Protein sequence:

>535_residues
MTLHSTIDPSSADFARNAESMRALVADLKTKLAQVAEGGGEASRKRHLSRGKMLARQRVDLLLDPGTAFLELSPLAAHGL
YGGDVHSASIVTGIGRIAGRECVIVANDATIKGGTYYPMTVKKHLRAQDIARQNNLPCVYMVDSGGAFLPLQDEIFPDER
HFGRIFYNQAQMSAIGIPQIAVVMGSCTAGGAYVPAMSDESIIVRNQGTIFLGGPPLVKAATGEVVSAEELGGADVHSRQ
SGVTDHYAQNDAHAIGIARRVVGTLKPPGARTVLNMRAVREPRYAAEEIYGVVPADGRKPFDVRDIIARVVDGSEFDEFK
KLYGQTLVCGFAHIFGYPVGIIANNGILFSESSLKGAHFIELCCQRNIPLVFLQNITGFMVGKKYEAGGIARDGAKLVTA
VATASVPKFTVVIGGSYGAGNYGMCGRAYAPRFLWMWPNARISVMGGEQAAMVLSQVRRDGIEAKGESWPAEEEEKFRAP
IREQYEAQGNPYYATARLWDDGVIDPADTRLVLGLGLSAAANAPVEPTKFGLFRM

Sequences:

>Translated_535_residues
MTLHSTIDPSSADFARNAESMRALVADLKTKLAQVAEGGGEASRKRHLSRGKMLARQRVDLLLDPGTAFLELSPLAAHGL
YGGDVHSASIVTGIGRIAGRECVIVANDATIKGGTYYPMTVKKHLRAQDIARQNNLPCVYMVDSGGAFLPLQDEIFPDER
HFGRIFYNQAQMSAIGIPQIAVVMGSCTAGGAYVPAMSDESIIVRNQGTIFLGGPPLVKAATGEVVSAEELGGADVHSRQ
SGVTDHYAQNDAHAIGIARRVVGTLKPPGARTVLNMRAVREPRYAAEEIYGVVPADGRKPFDVRDIIARVVDGSEFDEFK
KLYGQTLVCGFAHIFGYPVGIIANNGILFSESSLKGAHFIELCCQRNIPLVFLQNITGFMVGKKYEAGGIARDGAKLVTA
VATASVPKFTVVIGGSYGAGNYGMCGRAYAPRFLWMWPNARISVMGGEQAAMVLSQVRRDGIEAKGESWPAEEEEKFRAP
IREQYEAQGNPYYATARLWDDGVIDPADTRLVLGLGLSAAANAPVEPTKFGLFRM
>Mature_534_residues
TLHSTIDPSSADFARNAESMRALVADLKTKLAQVAEGGGEASRKRHLSRGKMLARQRVDLLLDPGTAFLELSPLAAHGLY
GGDVHSASIVTGIGRIAGRECVIVANDATIKGGTYYPMTVKKHLRAQDIARQNNLPCVYMVDSGGAFLPLQDEIFPDERH
FGRIFYNQAQMSAIGIPQIAVVMGSCTAGGAYVPAMSDESIIVRNQGTIFLGGPPLVKAATGEVVSAEELGGADVHSRQS
GVTDHYAQNDAHAIGIARRVVGTLKPPGARTVLNMRAVREPRYAAEEIYGVVPADGRKPFDVRDIIARVVDGSEFDEFKK
LYGQTLVCGFAHIFGYPVGIIANNGILFSESSLKGAHFIELCCQRNIPLVFLQNITGFMVGKKYEAGGIARDGAKLVTAV
ATASVPKFTVVIGGSYGAGNYGMCGRAYAPRFLWMWPNARISVMGGEQAAMVLSQVRRDGIEAKGESWPAEEEEKFRAPI
REQYEAQGNPYYATARLWDDGVIDPADTRLVLGLGLSAAANAPVEPTKFGLFRM

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=535, Percent_Identity=62.6168224299065, Blast_Score=696, Evalue=0.0,
Organism=Homo sapiens, GI119943100, Length=537, Percent_Identity=32.7746741154562, Blast_Score=243, Evalue=5e-64,
Organism=Homo sapiens, GI295821216, Length=557, Percent_Identity=31.9569120287253, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI310133460, Length=144, Percent_Identity=52.0833333333333, Blast_Score=142, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI17552936, Length=534, Percent_Identity=63.1086142322097, Blast_Score=716, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147359, Length=484, Percent_Identity=33.8842975206612, Blast_Score=240, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI25147362, Length=484, Percent_Identity=33.8842975206612, Blast_Score=240, Evalue=1e-63,
Organism=Drosophila melanogaster, GI24586065, Length=549, Percent_Identity=64.8451730418944, Blast_Score=750, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.4

Molecular weight: Translated: 57526; Mature: 57394

Theoretical pI: Translated: 7.83; Mature: 7.83

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLHSTIDPSSADFARNAESMRALVADLKTKLAQVAEGGGEASRKRHLSRGKMLARQRVD
CCCCCCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC
LLLDPGTAFLELSPLAAHGLYGGDVHSASIVTGIGRIAGRECVIVANDATIKGGTYYPMT
EEECCCCCEEEECCHHHCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCEECCCEECCHH
VKKHLRAQDIARQNNLPCVYMVDSGGAFLPLQDEIFPDERHFGRIFYNQAQMSAIGIPQI
HHHHHHHHHHHHHCCCCEEEEECCCCEEECCCCCCCCCCHHHHHEEECCHHHHHCCCCEE
AVVMGSCTAGGAYVPAMSDESIIVRNQGTIFLGGPPLVKAATGEVVSAEELGGADVHSRQ
EEEEECCCCCCEEECCCCCCEEEEEECCEEEECCCCEEEECCCCEEEHHHCCCCCCHHCC
SGVTDHYAQNDAHAIGIARRVVGTLKPPGARTVLNMRAVREPRYAAEEIYGVVPADGRKP
CCCCHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHEEECCCCCCCC
FDVRDIIARVVDGSEFDEFKKLYGQTLVCGFAHIFGYPVGIIANNGILFSESSLKGAHFI
CCHHHHHHHHHCCCCHHHHHHHHCHHHHHHHHHHHCCCEEEEECCCEEEECCCCCCHHHH
ELCCQRNIPLVFLQNITGFMVGKKYEAGGIARDGAKLVTAVATASVPKFTVVIGGSYGAG
HHHHCCCCCEEEECCCCHHEECCEECCCCCCCCCHHHHHHHHHCCCCEEEEEEECCCCCC
NYGMCGRAYAPRFLWMWPNARISVMGGEQAAMVLSQVRRDGIEAKGESWPAEEEEKFRAP
CCCCCCCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCC
IREQYEAQGNPYYATARLWDDGVIDPADTRLVLGLGLSAAANAPVEPTKFGLFRM
HHHHHHCCCCCEEEEEEEECCCCCCCCCCEEEEEECCHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TLHSTIDPSSADFARNAESMRALVADLKTKLAQVAEGGGEASRKRHLSRGKMLARQRVD
CCCCCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC
LLLDPGTAFLELSPLAAHGLYGGDVHSASIVTGIGRIAGRECVIVANDATIKGGTYYPMT
EEECCCCCEEEECCHHHCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCEECCCEECCHH
VKKHLRAQDIARQNNLPCVYMVDSGGAFLPLQDEIFPDERHFGRIFYNQAQMSAIGIPQI
HHHHHHHHHHHHHCCCCEEEEECCCCEEECCCCCCCCCCHHHHHEEECCHHHHHCCCCEE
AVVMGSCTAGGAYVPAMSDESIIVRNQGTIFLGGPPLVKAATGEVVSAEELGGADVHSRQ
EEEEECCCCCCEEECCCCCCEEEEEECCEEEECCCCEEEECCCCEEEHHHCCCCCCHHCC
SGVTDHYAQNDAHAIGIARRVVGTLKPPGARTVLNMRAVREPRYAAEEIYGVVPADGRKP
CCCCHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHEEECCCCCCCC
FDVRDIIARVVDGSEFDEFKKLYGQTLVCGFAHIFGYPVGIIANNGILFSESSLKGAHFI
CCHHHHHHHHHCCCCHHHHHHHHCHHHHHHHHHHHCCCEEEEECCCEEEECCCCCCHHHH
ELCCQRNIPLVFLQNITGFMVGKKYEAGGIARDGAKLVTAVATASVPKFTVVIGGSYGAG
HHHHCCCCCEEEECCCCHHEECCEECCCCCCCCCHHHHHHHHHCCCCEEEEEEECCCCCC
NYGMCGRAYAPRFLWMWPNARISVMGGEQAAMVLSQVRRDGIEAKGESWPAEEEEKFRAP
CCCCCCCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCC
IREQYEAQGNPYYATARLWDDGVIDPADTRLVLGLGLSAAANAPVEPTKFGLFRM
HHHHHHCCCCCEEEEEEEECCCCCCCCCCEEEEEECCHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; 3-methylcrotonoyl-CoA; HCO3-

Specific reaction: ATP + 3-methylcrotonoyl-CoA + HCO3- = ADP + phosphate + 3-methylglutaconyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]