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The map label for this gene is cobB1 [H]

Identifier: 146340624

GI number: 146340624

Start: 3839170

End: 3839937

Strand: Direct

Name: cobB1 [H]

Synonym: BRADO3672

Alternate gene names: 146340624

Gene position: 3839170-3839937 (Clockwise)

Preceding gene: 146340622

Following gene: 146340625

Centisome position: 51.49

GC content: 63.93

Gene sequence:

>768_bases
GTGCTGTCGATGATCGCTTCCAACTTGCAGGATGGCGTCAACCGCCTGGGCGACATGATCGCAGCCGCGCGCGTCATTGT
GCCGTTTACCGGCGCCGGCATCTCGACGGAAGCCGGCATTCCCGATTTCCGCTCGCCGGGAGGACTATGGACGCGCAACC
GGCCGATCGACTTCGAGGAGTTCGTCGCCAGTCAGGATGCGCGCGACGAGGCGTGGCGGCGGCGCTTCGCAATGCAGGAG
ACGTTTGCCGCGGCGCGTCCCAGCCGCGGTCATCACGCGCTGGTCTCGCTCTATCGCGCCGGGAAGATACCGGCCGTCAT
CACCCAGAACATCGACAATCTGCATCAGGACTCCGGCTTTGCCGCCGAGCACGTCATCGAGCTGCACGGTAACACCACCT
ATGCACGCTGCATCGGATGTGGGCAGCGCTATGAGCTCGCCTGGGTGCGCGAGCGCTTCGCGCGTAACGGTGCGCCGGAT
TGTCCGGAGTGCGCCGAGCCGGTGAAGACGGCGACGGTTTCGTTCGGTCAGGCCATGCCGGAGAACGAAATGCAACGCGC
GGCCGAGCTCGCGCAGCATTGCGACCTTTTCATCGCGATCGGCTCATCGCTGGTTGTATGGCCGGCGGCGGGCTTTCCGT
TGATGGCAAAGCAGGCGGGTGCGCGACTCGTGATCATCAACCGGGAACCGACCGATCAGGACGACGTTGCCGACCTCGTT
ATTCACGACGAGATCGGCGAAGTACTCGGATCGTTCGTCCGTAATTGA

Upstream 100 bases:

>100_bases
CCGGTTCCTGCTGATGCTCAATAGACGCACCTACGAGCCGCGGCGATGCCGTTACCGGTATGATAGAGAGCGGCTGTTAC
GCCGCGCGTGAAACTTTGGG

Downstream 100 bases:

>100_bases
ACGGAAATTGATGCATTTTTGTCGGTAAGTCTGTTCATATGCCTCACTGAATCCGATTTTTGTCTATGCGCGGCACGAGG
GAATGTTATCTTCGATTCGA

Product: putative transciptional regulatory Sir2-family protein NAD-dependent protein deacetylase

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog 1 [H]

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
MLSMIASNLQDGVNRLGDMIAAARVIVPFTGAGISTEAGIPDFRSPGGLWTRNRPIDFEEFVASQDARDEAWRRRFAMQE
TFAAARPSRGHHALVSLYRAGKIPAVITQNIDNLHQDSGFAAEHVIELHGNTTYARCIGCGQRYELAWVRERFARNGAPD
CPECAEPVKTATVSFGQAMPENEMQRAAELAQHCDLFIAIGSSLVVWPAAGFPLMAKQAGARLVIINREPTDQDDVADLV
IHDEIGEVLGSFVRN

Sequences:

>Translated_255_residues
MLSMIASNLQDGVNRLGDMIAAARVIVPFTGAGISTEAGIPDFRSPGGLWTRNRPIDFEEFVASQDARDEAWRRRFAMQE
TFAAARPSRGHHALVSLYRAGKIPAVITQNIDNLHQDSGFAAEHVIELHGNTTYARCIGCGQRYELAWVRERFARNGAPD
CPECAEPVKTATVSFGQAMPENEMQRAAELAQHCDLFIAIGSSLVVWPAAGFPLMAKQAGARLVIINREPTDQDDVADLV
IHDEIGEVLGSFVRN
>Mature_255_residues
MLSMIASNLQDGVNRLGDMIAAARVIVPFTGAGISTEAGIPDFRSPGGLWTRNRPIDFEEFVASQDARDEAWRRRFAMQE
TFAAARPSRGHHALVSLYRAGKIPAVITQNIDNLHQDSGFAAEHVIELHGNTTYARCIGCGQRYELAWVRERFARNGAPD
CPECAEPVKTATVSFGQAMPENEMQRAAELAQHCDLFIAIGSSLVVWPAAGFPLMAKQAGARLVIINREPTDQDDVADLV
IHDEIGEVLGSFVRN

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI300797577, Length=256, Percent_Identity=32.421875, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI300797597, Length=247, Percent_Identity=33.1983805668016, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI6912662, Length=269, Percent_Identity=31.2267657992565, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI13775602, Length=232, Percent_Identity=31.0344827586207, Blast_Score=101, Evalue=6e-22,
Organism=Homo sapiens, GI13775600, Length=232, Percent_Identity=31.0344827586207, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI7657575, Length=225, Percent_Identity=33.3333333333333, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI300795542, Length=228, Percent_Identity=29.8245614035088, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI13787215, Length=249, Percent_Identity=28.9156626506024, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI6912664, Length=238, Percent_Identity=28.9915966386555, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI7706712, Length=257, Percent_Identity=29.9610894941634, Blast_Score=95, Evalue=5e-20,
Organism=Homo sapiens, GI6912660, Length=227, Percent_Identity=32.15859030837, Blast_Score=95, Evalue=8e-20,
Organism=Homo sapiens, GI63054862, Length=205, Percent_Identity=31.219512195122, Blast_Score=94, Evalue=9e-20,
Organism=Homo sapiens, GI300797705, Length=201, Percent_Identity=30.3482587064677, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI215982798, Length=162, Percent_Identity=33.3333333333333, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI308199517, Length=217, Percent_Identity=37.7880184331797, Blast_Score=96, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17567771, Length=273, Percent_Identity=28.2051282051282, Blast_Score=119, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71990482, Length=273, Percent_Identity=27.8388278388278, Blast_Score=115, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI71990487, Length=275, Percent_Identity=27.6363636363636, Blast_Score=110, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17505510, Length=261, Percent_Identity=26.8199233716475, Blast_Score=103, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17541892, Length=227, Percent_Identity=31.7180616740088, Blast_Score=100, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6325242, Length=260, Percent_Identity=31.1538461538462, Blast_Score=97, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24645650, Length=250, Percent_Identity=30, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI28571445, Length=271, Percent_Identity=31.3653136531365, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24648389, Length=217, Percent_Identity=33.1797235023041, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24650933, Length=258, Percent_Identity=26.7441860465116, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI17137536, Length=252, Percent_Identity=30.5555555555556, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI28571443, Length=217, Percent_Identity=28.110599078341, Blast_Score=81, Evalue=8e-16,
Organism=Drosophila melanogaster, GI28571441, Length=217, Percent_Identity=28.110599078341, Blast_Score=81, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 27916; Mature: 27916

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSMIASNLQDGVNRLGDMIAAARVIVPFTGAGISTEAGIPDFRSPGGLWTRNRPIDFEE
CHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHH
FVASQDARDEAWRRRFAMQETFAAARPSRGHHALVSLYRAGKIPAVITQNIDNLHQDSGF
HHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCC
AAEHVIELHGNTTYARCIGCGQRYELAWVRERFARNGAPDCPECAEPVKTATVSFGQAMP
HHHHEEEECCCCHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCC
ENEMQRAAELAQHCDLFIAIGSSLVVWPAAGFPLMAKQAGARLVIINREPTDQDDVADLV
HHHHHHHHHHHHHCCEEEEECCCEEEECCCCCCHHHHCCCCEEEEEECCCCCHHHHHHHH
IHDEIGEVLGSFVRN
HHHHHHHHHHHHHCC
>Mature Secondary Structure
MLSMIASNLQDGVNRLGDMIAAARVIVPFTGAGISTEAGIPDFRSPGGLWTRNRPIDFEE
CHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHH
FVASQDARDEAWRRRFAMQETFAAARPSRGHHALVSLYRAGKIPAVITQNIDNLHQDSGF
HHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCC
AAEHVIELHGNTTYARCIGCGQRYELAWVRERFARNGAPDCPECAEPVKTATVSFGQAMP
HHHHEEEECCCCHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCC
ENEMQRAAELAQHCDLFIAIGSSLVVWPAAGFPLMAKQAGARLVIINREPTDQDDVADLV
HHHHHHHHHHHHHCCEEEEECCCEEEECCCCCCHHHHCCCCEEEEEECCCCCHHHHHHHH
IHDEIGEVLGSFVRN
HHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]