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The map label for this gene is kefC [H]

Identifier: 146340478

GI number: 146340478

Start: 3706220

End: 3707950

Strand: Reverse

Name: kefC [H]

Synonym: BRADO3519

Alternate gene names: 146340478

Gene position: 3707950-3706220 (Counterclockwise)

Preceding gene: 146340481

Following gene: 146340477

Centisome position: 49.73

GC content: 65.74

Gene sequence:

>1731_bases
ATGCATGAACTGATCGGCGACATCACGCTCTGCATCCTGTTTGCGTGGGTGCTTGGACTGGCGGCACACAAATGGCGCCA
GCCCTCGATTCTCGCATATCTGGTCGCGGGCTTCGCCATTGGCCCCTTTGGCACCGGCTGGGTCAAGTCCCAGGAATCGA
TCTCGGTGATCTCCGAGCTCGGCCTGATCTTCATGCTGTTCATGATCGGGCTGGAGATCGACCTGAAAAAAATCATCCGC
GCCGGCCCGGTGATCCTGATCGCCGGCGGCGTCCAACTGCTCGGCGGCGCGGCGCTGGGCATCCTGTTCTTCGTCGCGAT
CGGCATGCGGATGGGCGCGGAGAGCTACGACGCGCTGTATCTCTGCGTCGCCTGCGCGCTGTCCTCGACGGTCATCATCG
TGAAGGTGCTGTACGAGAAACGCGAGCTCGACACCCTGCCCGGCCGTATCACTCTGGGCGTGCTGGTGCTGCAGGACGTG
TTCGCGATCCTGTTCCTGGCGGTGCAGCCGAGCCTCGACGATCTGCATTTCGGGGTGATCCTGCTGTCGTTCGCGCGCGC
CGGCGCGCTGGTCGCGATCGCGCTGCTGCTCAGCCGCTACGTGCTGCCGCCGGTGTTCCACCGCATCGCCCGCACCCCGG
AGCTGATCCTGCTCGGCGCGCTCGCCTGGTGCTTTCTGATCGGCGAGATCGCCGAGCGGCTGCATCTGTCGCGCGAGATG
GGATCATTGATCGCCGGCGTGTCGCTGTCGACCTTCCCCTACGCGCTCGACGTCACCGCCAAGGTCACCACTTTGCGCGA
TTTCTTCATCACGCTGTTCTTCGTCGCGCTCGGCATGACCATCCCGATCCCGACGATGTCGGTGGTGGGTCTGGCGCTGG
TGATCGCGCTTTTCACGGTGGCGAGCCGGCTCGTCACCGCCTTCACGCCGCTCTACATAATGCGGCAGGGCCTGCGCGCG
AGCCTGCTGCCGGCGCTCAACCTCGCCCAGATCAGCGAGTTCTCGCTGGTGGTGATCCAGACCGGCGCCGCCGCGGGACA
TCTGAAGGCCGGCACGTCGAGCGCGGCCTCCTTCGCCTTCGTGCTGCTGGCGGTCGCCTCGACCTTCGTCATCGTGCGCT
CCGATCCGATCGTGCGCCGGACGATCCCGCTTCTGAAGCGCGTGGGCCTGCACGACCTCGATGACGCCAAGGAGGGCGAG
GCCGGCCATGAGGGCGGTGGTCATGGCGCCGGGCGGCCGATCGTGCTGCTCGGTTTCTTTCGCACGGCGAGCGCCCTGCT
CAGCGAAATCGAGCGCACCCAGCCGGCGCTGCTGGACCAGATCGGCGTGGTCGATTTCAATCCGGTCGTGTTCCGCACCT
TGTCGGACCGCGGCCTCCAGGTGACCTACGGGGACATCAGCAATGTCGATACGCTGGTACATGCCGGGGTCGGCCAGGCC
GAGCTGATCATCCTCAGCATTCCGGATTCACTGCTCAAGGGCGCCAACAACGAAAAGCTGGTGCGACACGTCCGCAGCAT
CAACGCGTCAGCCAAGATCGTCGCCACCGCCGATCTGCTCGCCGACGTCAACGACCTCTACGATGCCGGCGCGGACTACG
TGACGGTGCCCAGGCTCAGCGACGCGCAGGTGCTGCTCAATCTGATCCAGGACGCCAGCGCCGGCCTGTTGTCGGAGCGC
CGCAGACAGGCCGAAGCGCTGCTCGCGGACCGTCGCGAGGTGCTGCCATGA

Upstream 100 bases:

>100_bases
GGCCGTGGCGCACAGCGCCAGGGCCACAGCGGCGATGTGACACATTGCGGGTTTCCATGTGCGGCGGCGCGACATAAGTT
GCCCCCTCGGGGGTTGCTTC

Downstream 100 bases:

>100_bases
TGCGCAGCTGCCCGATCCATCACCCCGAAACATCCCGACAGACCGCAACACCATGACAAACAACCACGTCCACGTCGTCG
ATCATCCGCTGGTGCAGCAC

Product: putative glutathione-regulated potassium-efflux system protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 576; Mature: 576

Protein sequence:

>576_residues
MHELIGDITLCILFAWVLGLAAHKWRQPSILAYLVAGFAIGPFGTGWVKSQESISVISELGLIFMLFMIGLEIDLKKIIR
AGPVILIAGGVQLLGGAALGILFFVAIGMRMGAESYDALYLCVACALSSTVIIVKVLYEKRELDTLPGRITLGVLVLQDV
FAILFLAVQPSLDDLHFGVILLSFARAGALVAIALLLSRYVLPPVFHRIARTPELILLGALAWCFLIGEIAERLHLSREM
GSLIAGVSLSTFPYALDVTAKVTTLRDFFITLFFVALGMTIPIPTMSVVGLALVIALFTVASRLVTAFTPLYIMRQGLRA
SLLPALNLAQISEFSLVVIQTGAAAGHLKAGTSSAASFAFVLLAVASTFVIVRSDPIVRRTIPLLKRVGLHDLDDAKEGE
AGHEGGGHGAGRPIVLLGFFRTASALLSEIERTQPALLDQIGVVDFNPVVFRTLSDRGLQVTYGDISNVDTLVHAGVGQA
ELIILSIPDSLLKGANNEKLVRHVRSINASAKIVATADLLADVNDLYDAGADYVTVPRLSDAQVLLNLIQDASAGLLSER
RRQAEALLADRREVLP

Sequences:

>Translated_576_residues
MHELIGDITLCILFAWVLGLAAHKWRQPSILAYLVAGFAIGPFGTGWVKSQESISVISELGLIFMLFMIGLEIDLKKIIR
AGPVILIAGGVQLLGGAALGILFFVAIGMRMGAESYDALYLCVACALSSTVIIVKVLYEKRELDTLPGRITLGVLVLQDV
FAILFLAVQPSLDDLHFGVILLSFARAGALVAIALLLSRYVLPPVFHRIARTPELILLGALAWCFLIGEIAERLHLSREM
GSLIAGVSLSTFPYALDVTAKVTTLRDFFITLFFVALGMTIPIPTMSVVGLALVIALFTVASRLVTAFTPLYIMRQGLRA
SLLPALNLAQISEFSLVVIQTGAAAGHLKAGTSSAASFAFVLLAVASTFVIVRSDPIVRRTIPLLKRVGLHDLDDAKEGE
AGHEGGGHGAGRPIVLLGFFRTASALLSEIERTQPALLDQIGVVDFNPVVFRTLSDRGLQVTYGDISNVDTLVHAGVGQA
ELIILSIPDSLLKGANNEKLVRHVRSINASAKIVATADLLADVNDLYDAGADYVTVPRLSDAQVLLNLIQDASAGLLSER
RRQAEALLADRREVLP
>Mature_576_residues
MHELIGDITLCILFAWVLGLAAHKWRQPSILAYLVAGFAIGPFGTGWVKSQESISVISELGLIFMLFMIGLEIDLKKIIR
AGPVILIAGGVQLLGGAALGILFFVAIGMRMGAESYDALYLCVACALSSTVIIVKVLYEKRELDTLPGRITLGVLVLQDV
FAILFLAVQPSLDDLHFGVILLSFARAGALVAIALLLSRYVLPPVFHRIARTPELILLGALAWCFLIGEIAERLHLSREM
GSLIAGVSLSTFPYALDVTAKVTTLRDFFITLFFVALGMTIPIPTMSVVGLALVIALFTVASRLVTAFTPLYIMRQGLRA
SLLPALNLAQISEFSLVVIQTGAAAGHLKAGTSSAASFAFVLLAVASTFVIVRSDPIVRRTIPLLKRVGLHDLDDAKEGE
AGHEGGGHGAGRPIVLLGFFRTASALLSEIERTQPALLDQIGVVDFNPVVFRTLSDRGLQVTYGDISNVDTLVHAGVGQA
ELIILSIPDSLLKGANNEKLVRHVRSINASAKIVATADLLADVNDLYDAGADYVTVPRLSDAQVLLNLIQDASAGLLSER
RRQAEALLADRREVLP

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=378, Percent_Identity=25.6613756613757, Blast_Score=99, Evalue=1e-20,
Organism=Escherichia coli, GI1786232, Length=520, Percent_Identity=28.8461538461538, Blast_Score=142, Evalue=6e-35,
Organism=Escherichia coli, GI1786685, Length=575, Percent_Identity=25.0434782608696, Blast_Score=113, Evalue=4e-26,
Organism=Escherichia coli, GI1789749, Length=537, Percent_Identity=26.4432029795158, Blast_Score=99, Evalue=8e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 61694; Mature: 61694

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHELIGDITLCILFAWVLGLAAHKWRQPSILAYLVAGFAIGPFGTGWVKSQESISVISEL
CCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
GLIFMLFMIGLEIDLKKIIRAGPVILIAGGVQLLGGAALGILFFVAIGMRMGAESYDALY
HHHHHHHHHCCCHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LCVACALSSTVIIVKVLYEKRELDTLPGRITLGVLVLQDVFAILFLAVQPSLDDLHFGVI
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
LLSFARAGALVAIALLLSRYVLPPVFHRIARTPELILLGALAWCFLIGEIAERLHLSREM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GSLIAGVSLSTFPYALDVTAKVTTLRDFFITLFFVALGMTIPIPTMSVVGLALVIALFTV
HHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
ASRLVTAFTPLYIMRQGLRASLLPALNLAQISEFSLVVIQTGAAAGHLKAGTSSAASFAF
HHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHHH
VLLAVASTFVIVRSDPIVRRTIPLLKRVGLHDLDDAKEGEAGHEGGGHGAGRPIVLLGFF
HHHHHHHHEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHH
RTASALLSEIERTQPALLDQIGVVDFNPVVFRTLSDRGLQVTYGDISNVDTLVHAGVGQA
HHHHHHHHHHHHHCHHHHHHCCCCCCCHHHHEECCCCCCEEEECCCCCHHHHHHCCCCCE
ELIILSIPDSLLKGANNEKLVRHVRSINASAKIVATADLLADVNDLYDAGADYVTVPRLS
EEEEEECCHHHHCCCCHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHCCCCEEECCCCC
DAQVLLNLIQDASAGLLSERRRQAEALLADRREVLP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MHELIGDITLCILFAWVLGLAAHKWRQPSILAYLVAGFAIGPFGTGWVKSQESISVISEL
CCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
GLIFMLFMIGLEIDLKKIIRAGPVILIAGGVQLLGGAALGILFFVAIGMRMGAESYDALY
HHHHHHHHHCCCHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LCVACALSSTVIIVKVLYEKRELDTLPGRITLGVLVLQDVFAILFLAVQPSLDDLHFGVI
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
LLSFARAGALVAIALLLSRYVLPPVFHRIARTPELILLGALAWCFLIGEIAERLHLSREM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GSLIAGVSLSTFPYALDVTAKVTTLRDFFITLFFVALGMTIPIPTMSVVGLALVIALFTV
HHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
ASRLVTAFTPLYIMRQGLRASLLPALNLAQISEFSLVVIQTGAAAGHLKAGTSSAASFAF
HHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHHH
VLLAVASTFVIVRSDPIVRRTIPLLKRVGLHDLDDAKEGEAGHEGGGHGAGRPIVLLGFF
HHHHHHHHEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHH
RTASALLSEIERTQPALLDQIGVVDFNPVVFRTLSDRGLQVTYGDISNVDTLVHAGVGQA
HHHHHHHHHHHHHCHHHHHHCCCCCCCHHHHEECCCCCCEEEECCCCCHHHHHHCCCCCE
ELIILSIPDSLLKGANNEKLVRHVRSINASAKIVATADLLADVNDLYDAGADYVTVPRLS
EEEEEECCHHHHCCCCHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHCCCCEEECCCCC
DAQVLLNLIQDASAGLLSERRRQAEALLADRREVLP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA