Click here to switch to the map view.

The map label for this gene is upp [H]

Identifier: 146340477

GI number: 146340477

Start: 3705532

End: 3706167

Strand: Reverse

Name: upp [H]

Synonym: BRADO3518

Alternate gene names: 146340477

Gene position: 3706167-3705532 (Counterclockwise)

Preceding gene: 146340478

Following gene: 146340474

Centisome position: 49.7

GC content: 64.47

Gene sequence:

>636_bases
ATGACAAACAACCACGTCCACGTCGTCGATCATCCGCTGGTGCAGCACAAGCTCACCTTGATGCGCGAGCGCGACCGCTC
CACCAAGGGCTTCCGCGAGTTGCTCAACGAGATCGGCATGCTGCTGGCCTACGAGGTCACGCGCGACCTGCCGATCGAGC
TCGTCGACATCCAAACGCCGATCGCGGCGATGAAGGCGCCAAAGATCGCCGGCAAGAAGCTCACGCTCGCGCCGATCCTG
CGCGCCGGAGTGGGATTCTTGGACGGGATGCTGGCGCTGATGCCGTCGGCGCGCATCGCCCATATCGGCCTGTACCGTGA
CCCCAACACGCTGCAGGCCGTGGAGTATTATTTCAAGGCGCCCCAGGATCTGACCGATCGCACCGTGATTTTGATGGACC
CGATGCTGGCGACCGGCAATTCCGCCTGTGCCGCAGCCGAACTTCTCAAGGCACGCGGCGCCCGCGACATCCGCTTCGTC
TGCCTGCTGGCCGCGCCAGAGGGCATCGCGAGCTTCAGCGCCGAGCATCCGGACATCCCGATCTGGACCGCCGCGATCGA
CGAGAAGCTGAACGACCACGCCTATATCGTCCCTGGCCTCGGCGACGCGGGAGACCGGATGTTCGGCACGAAGTGA

Upstream 100 bases:

>100_bases
AGACAGGCCGAAGCGCTGCTCGCGGACCGTCGCGAGGTGCTGCCATGATGCGCAGCTGCCCGATCCATCACCCCGAAACA
TCCCGACAGACCGCAACACC

Downstream 100 bases:

>100_bases
TTCAGCCGGCATACGCCGAGTTGGACGCATGGCAGCAACGGTCGAGACGGAGAATAGGACCTCAGGCCTTCGGCCGCGAG
ACCAGTTCGATCATGCGGCC

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 211; Mature: 210

Protein sequence:

>211_residues
MTNNHVHVVDHPLVQHKLTLMRERDRSTKGFRELLNEIGMLLAYEVTRDLPIELVDIQTPIAAMKAPKIAGKKLTLAPIL
RAGVGFLDGMLALMPSARIAHIGLYRDPNTLQAVEYYFKAPQDLTDRTVILMDPMLATGNSACAAAELLKARGARDIRFV
CLLAAPEGIASFSAEHPDIPIWTAAIDEKLNDHAYIVPGLGDAGDRMFGTK

Sequences:

>Translated_211_residues
MTNNHVHVVDHPLVQHKLTLMRERDRSTKGFRELLNEIGMLLAYEVTRDLPIELVDIQTPIAAMKAPKIAGKKLTLAPIL
RAGVGFLDGMLALMPSARIAHIGLYRDPNTLQAVEYYFKAPQDLTDRTVILMDPMLATGNSACAAAELLKARGARDIRFV
CLLAAPEGIASFSAEHPDIPIWTAAIDEKLNDHAYIVPGLGDAGDRMFGTK
>Mature_210_residues
TNNHVHVVDHPLVQHKLTLMRERDRSTKGFRELLNEIGMLLAYEVTRDLPIELVDIQTPIAAMKAPKIAGKKLTLAPILR
AGVGFLDGMLALMPSARIAHIGLYRDPNTLQAVEYYFKAPQDLTDRTVILMDPMLATGNSACAAAELLKARGARDIRFVC
LLAAPEGIASFSAEHPDIPIWTAAIDEKLNDHAYIVPGLGDAGDRMFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=32.6732673267327, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=32.6732673267327, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI21450816, Length=194, Percent_Identity=27.8350515463918, Blast_Score=65, Evalue=3e-11,
Organism=Escherichia coli, GI87082118, Length=203, Percent_Identity=52.7093596059113, Blast_Score=225, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17539892, Length=201, Percent_Identity=24.8756218905473, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17539894, Length=201, Percent_Identity=24.8756218905473, Blast_Score=78, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6321920, Length=193, Percent_Identity=35.2331606217617, Blast_Score=109, Evalue=4e-25,
Organism=Drosophila melanogaster, GI28573516, Length=206, Percent_Identity=29.6116504854369, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI28573514, Length=206, Percent_Identity=29.6116504854369, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI28573512, Length=206, Percent_Identity=29.6116504854369, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI45550449, Length=206, Percent_Identity=29.6116504854369, Blast_Score=86, Evalue=1e-17,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 23136; Mature: 23005

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNNHVHVVDHPLVQHKLTLMRERDRSTKGFRELLNEIGMLLAYEVTRDLPIELVDIQTP
CCCCEEEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
IAAMKAPKIAGKKLTLAPILRAGVGFLDGMLALMPSARIAHIGLYRDPNTLQAVEYYFKA
HHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHCC
PQDLTDRTVILMDPMLATGNSACAAAELLKARGARDIRFVCLLAAPEGIASFSAEHPDIP
CCCCCCCEEEEECCCHHCCCCHHHHHHHHHHCCCCCEEEEEEEECCCCHHHCCCCCCCCC
IWTAAIDEKLNDHAYIVPGLGDAGDRMFGTK
EEHHHHHHCCCCCEEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
TNNHVHVVDHPLVQHKLTLMRERDRSTKGFRELLNEIGMLLAYEVTRDLPIELVDIQTP
CCCEEEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
IAAMKAPKIAGKKLTLAPILRAGVGFLDGMLALMPSARIAHIGLYRDPNTLQAVEYYFKA
HHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHCC
PQDLTDRTVILMDPMLATGNSACAAAELLKARGARDIRFVCLLAAPEGIASFSAEHPDIP
CCCCCCCEEEEECCCHHCCCCHHHHHHHHHHCCCCCEEEEEEEECCCCHHHCCCCCCCCC
IWTAAIDEKLNDHAYIVPGLGDAGDRMFGTK
EEHHHHHHCCCCCEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA