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The map label for this gene is accC [H]

Identifier: 146340460

GI number: 146340460

Start: 3683147

End: 3684496

Strand: Reverse

Name: accC [H]

Synonym: BRADO3500

Alternate gene names: 146340460

Gene position: 3684496-3683147 (Counterclockwise)

Preceding gene: 146340461

Following gene: 146340459

Centisome position: 49.41

GC content: 66.15

Gene sequence:

>1350_bases
ATGTTCGACAAGATCCTGATCGCCAACCGCGGCGAAATCGCCCTCCGCATCCTCCGAGCCTGCAAGGAGCTCGGCATCTC
CACGGTCGCGGTGCATTCGACCGCGGACGCCGATGCCATGCATGTGCGCCTTGCCGATGAGAGCGTCTGCATCGGTCCGC
CGCCGTCGAAGGACAGCTATCTCAATATCCCCGCGCTGCTCGCGGCGTGCGAGATCACCGGCGCCGACGCGGTGCATCCG
GGCTACGGCTTCCTGTCCGAGAACGCGCGCTTCGCAGAGATCCTCTCCGATCACAATCTGCATTTCATCGGGCCGAAGGC
GGAGCACATCCGCCTGATGGGCGACAAGATCGAGGCCAAGAAGACCGCCAAGCGTCTGGGCATCCCGGTCGTGCCCGGCT
CCGACGGCGCGGTGACGCCGGACCAGGATGCGATGGCGATCGCCAAGGCGATCGGCTTCCCGGTGCTGGTGAAGGCGGCC
GCCGGCGGCGGCGGCCGCGGCATGAAGGTCGCGCACACCGAGGCGGACCTGCAGCTGGCGCTGACCACCGCGGCCAACGA
GGCCAAGTCGGCGTTCGGCGATGCGTCGGTCTATCTGGAGAAATATCTGCAGAAGCCGCGACACATCGAGATCCAGGTGC
TCGGCGACGGCCGCGGCGGCGCGATCCATCTCGGCGAGCGCGACTGCTCGCTGCAGCGCCGCCACCAGAAGGTCTGGGAG
GAAGGCCCCTCGCCGGTGCTCGATGTCGCCTCGCGGGCCAAGATCGGCAACACTGTCGCCAAGGCGATGCAGGAGCTGAA
ATATATCGGCGTCGGCACGATCGAATTCCTCTACGAGGACGGCGAGTTCTATTTCATCGAAATGAACACCCGCATCCAGG
TCGAGCATCCCGTCACCGAGATGATCACCGGCATCGACCTCGTGCTGGAGCAGATCCGCATCGCCGCCGGCGGCGACCTG
CCGATGACCCAGGACCAGGTGACCATCAACGGCCACTCGATCGAGTGCCGCGTCAACGCCGAGAACCCGGTCAGCTTCCG
GCCCTCTCCCGGCAAGATCCAGCAATACCACCCGCCCGGCGGCCTCGGCGTCCGCATCGACTCCGCCGTGTATCAGGGCT
ACGTGATCCCGCCTTATTACGACTCGCTGGTCGGCAAGCTGATCGTGCACGGCAAGAGCCGGGTCGAGTGCCTGATGCGG
CTGCGCCGCGCGCTGGACGAGATGGTGGTCGACGGCATCGAGACCACGCTGCCGCTGTTCCGCGCGTTGGTGCGCGAGCC
CGCGATCATCGACGGCGACTATCACATCCACTGGCTCGAGCAGTATCTGGCCGGCCAGAAGGCGGACTGA

Upstream 100 bases:

>100_bases
GGTGATCATCGAGTAGGGGCGAGTGGCGAATGGCGAGTAGCGAATGGTCGCTGCTTCCCTACTCGCCATTCGCCATTCGC
CATTCGCTTCGTAGGACGCC

Downstream 100 bases:

>100_bases
CACGGGCCCGTTCATAAAACCCTCATCTGACGTGGAACCTTCCTGGGCCGGCCGCGTTTTGCTCGGTCGGATGAGTTCCG
CCAGGGGGCAGTGATTTCCA

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MFDKILIANRGEIALRILRACKELGISTVAVHSTADADAMHVRLADESVCIGPPPSKDSYLNIPALLAACEITGADAVHP
GYGFLSENARFAEILSDHNLHFIGPKAEHIRLMGDKIEAKKTAKRLGIPVVPGSDGAVTPDQDAMAIAKAIGFPVLVKAA
AGGGGRGMKVAHTEADLQLALTTAANEAKSAFGDASVYLEKYLQKPRHIEIQVLGDGRGGAIHLGERDCSLQRRHQKVWE
EGPSPVLDVASRAKIGNTVAKAMQELKYIGVGTIEFLYEDGEFYFIEMNTRIQVEHPVTEMITGIDLVLEQIRIAAGGDL
PMTQDQVTINGHSIECRVNAENPVSFRPSPGKIQQYHPPGGLGVRIDSAVYQGYVIPPYYDSLVGKLIVHGKSRVECLMR
LRRALDEMVVDGIETTLPLFRALVREPAIIDGDYHIHWLEQYLAGQKAD

Sequences:

>Translated_449_residues
MFDKILIANRGEIALRILRACKELGISTVAVHSTADADAMHVRLADESVCIGPPPSKDSYLNIPALLAACEITGADAVHP
GYGFLSENARFAEILSDHNLHFIGPKAEHIRLMGDKIEAKKTAKRLGIPVVPGSDGAVTPDQDAMAIAKAIGFPVLVKAA
AGGGGRGMKVAHTEADLQLALTTAANEAKSAFGDASVYLEKYLQKPRHIEIQVLGDGRGGAIHLGERDCSLQRRHQKVWE
EGPSPVLDVASRAKIGNTVAKAMQELKYIGVGTIEFLYEDGEFYFIEMNTRIQVEHPVTEMITGIDLVLEQIRIAAGGDL
PMTQDQVTINGHSIECRVNAENPVSFRPSPGKIQQYHPPGGLGVRIDSAVYQGYVIPPYYDSLVGKLIVHGKSRVECLMR
LRRALDEMVVDGIETTLPLFRALVREPAIIDGDYHIHWLEQYLAGQKAD
>Mature_449_residues
MFDKILIANRGEIALRILRACKELGISTVAVHSTADADAMHVRLADESVCIGPPPSKDSYLNIPALLAACEITGADAVHP
GYGFLSENARFAEILSDHNLHFIGPKAEHIRLMGDKIEAKKTAKRLGIPVVPGSDGAVTPDQDAMAIAKAIGFPVLVKAA
AGGGGRGMKVAHTEADLQLALTTAANEAKSAFGDASVYLEKYLQKPRHIEIQVLGDGRGGAIHLGERDCSLQRRHQKVWE
EGPSPVLDVASRAKIGNTVAKAMQELKYIGVGTIEFLYEDGEFYFIEMNTRIQVEHPVTEMITGIDLVLEQIRIAAGGDL
PMTQDQVTINGHSIECRVNAENPVSFRPSPGKIQQYHPPGGLGVRIDSAVYQGYVIPPYYDSLVGKLIVHGKSRVECLMR
LRRALDEMVVDGIETTLPLFRALVREPAIIDGDYHIHWLEQYLAGQKAD

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI189095269, Length=442, Percent_Identity=49.0950226244344, Blast_Score=423, Evalue=1e-118,
Organism=Homo sapiens, GI65506442, Length=442, Percent_Identity=49.0950226244344, Blast_Score=423, Evalue=1e-118,
Organism=Homo sapiens, GI295821183, Length=442, Percent_Identity=49.0950226244344, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI116805327, Length=442, Percent_Identity=43.4389140271493, Blast_Score=388, Evalue=1e-108,
Organism=Homo sapiens, GI106049528, Length=445, Percent_Identity=44.7191011235955, Blast_Score=377, Evalue=1e-104,
Organism=Homo sapiens, GI106049295, Length=445, Percent_Identity=44.7191011235955, Blast_Score=377, Evalue=1e-104,
Organism=Homo sapiens, GI106049292, Length=445, Percent_Identity=44.7191011235955, Blast_Score=377, Evalue=1e-104,
Organism=Homo sapiens, GI134142062, Length=517, Percent_Identity=29.0135396518375, Blast_Score=221, Evalue=9e-58,
Organism=Homo sapiens, GI38679960, Length=513, Percent_Identity=28.6549707602339, Blast_Score=215, Evalue=5e-56,
Organism=Homo sapiens, GI38679977, Length=513, Percent_Identity=28.6549707602339, Blast_Score=215, Evalue=6e-56,
Organism=Homo sapiens, GI38679967, Length=513, Percent_Identity=28.6549707602339, Blast_Score=215, Evalue=6e-56,
Organism=Homo sapiens, GI38679974, Length=513, Percent_Identity=28.6549707602339, Blast_Score=215, Evalue=6e-56,
Organism=Homo sapiens, GI38679971, Length=513, Percent_Identity=28.6549707602339, Blast_Score=215, Evalue=7e-56,
Organism=Escherichia coli, GI1789654, Length=448, Percent_Identity=59.375, Blast_Score=531, Evalue=1e-152,
Organism=Escherichia coli, GI1786216, Length=243, Percent_Identity=26.3374485596708, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17567343, Length=442, Percent_Identity=46.1538461538462, Blast_Score=395, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI71987519, Length=439, Percent_Identity=42.8246013667426, Blast_Score=370, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17562816, Length=450, Percent_Identity=40.8888888888889, Blast_Score=348, Evalue=3e-96,
Organism=Caenorhabditis elegans, GI71997168, Length=507, Percent_Identity=28.5996055226824, Blast_Score=204, Evalue=8e-53,
Organism=Caenorhabditis elegans, GI71997163, Length=507, Percent_Identity=28.5996055226824, Blast_Score=204, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI133931226, Length=494, Percent_Identity=27.5303643724696, Blast_Score=182, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6319685, Length=445, Percent_Identity=42.0224719101124, Blast_Score=354, Evalue=2e-98,
Organism=Saccharomyces cerevisiae, GI6319695, Length=450, Percent_Identity=42, Blast_Score=328, Evalue=9e-91,
Organism=Saccharomyces cerevisiae, GI6321376, Length=447, Percent_Identity=41.6107382550336, Blast_Score=320, Evalue=3e-88,
Organism=Saccharomyces cerevisiae, GI6324343, Length=523, Percent_Identity=29.8279158699809, Blast_Score=218, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6323863, Length=433, Percent_Identity=32.1016166281755, Blast_Score=214, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24652212, Length=445, Percent_Identity=45.6179775280899, Blast_Score=388, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652210, Length=445, Percent_Identity=45.6179775280899, Blast_Score=388, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652214, Length=445, Percent_Identity=45.6179775280899, Blast_Score=388, Evalue=1e-108,
Organism=Drosophila melanogaster, GI19921944, Length=445, Percent_Identity=45.6179775280899, Blast_Score=388, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652216, Length=445, Percent_Identity=45.6179775280899, Blast_Score=388, Evalue=1e-108,
Organism=Drosophila melanogaster, GI281363050, Length=445, Percent_Identity=45.6179775280899, Blast_Score=387, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652224, Length=445, Percent_Identity=45.6179775280899, Blast_Score=387, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652222, Length=445, Percent_Identity=45.6179775280899, Blast_Score=387, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652220, Length=445, Percent_Identity=45.6179775280899, Blast_Score=387, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652218, Length=445, Percent_Identity=45.6179775280899, Blast_Score=387, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24651757, Length=444, Percent_Identity=42.7927927927928, Blast_Score=370, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24651759, Length=408, Percent_Identity=41.6666666666667, Blast_Score=330, Evalue=1e-90,
Organism=Drosophila melanogaster, GI161076407, Length=501, Percent_Identity=28.3433133732535, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24586460, Length=501, Percent_Identity=28.3433133732535, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI161076409, Length=501, Percent_Identity=28.3433133732535, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI24586458, Length=501, Percent_Identity=28.3433133732535, Blast_Score=202, Evalue=3e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 48831; Mature: 48831

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDKILIANRGEIALRILRACKELGISTVAVHSTADADAMHVRLADESVCIGPPPSKDSY
CCCCEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCCEECCCCCCCCCE
LNIPALLAACEITGADAVHPGYGFLSENARFAEILSDHNLHFIGPKAEHIRLMGDKIEAK
ECHHHHHHHHEECCCCCCCCCCCCCCCCCHHHHHHCCCCEEEECCCHHEEEEECCHHHHH
KTAKRLGIPVVPGSDGAVTPDQDAMAIAKAIGFPVLVKAAAGGGGRGMKVAHTEADLQLA
HHHHHCCCEECCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCEEEEECCCCEEEE
LTTAANEAKSAFGDASVYLEKYLQKPRHIEIQVLGDGRGGAIHLGERDCSLQRRHQKVWE
EEEHHHHHHHHCCHHHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHHH
EGPSPVLDVASRAKIGNTVAKAMQELKYIGVGTIEFLYEDGEFYFIEMNTRIQVEHPVTE
CCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCCEEEEEECCEEEECCCHHH
MITGIDLVLEQIRIAAGGDLPMTQDQVTINGHSIECRVNAENPVSFRPSPGKIQQYHPPG
HHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCEEEEEECCCCCCCCCCCCCCCEEECCCC
GLGVRIDSAVYQGYVIPPYYDSLVGKLIVHGKSRVECLMRLRRALDEMVVDGIETTLPLF
CCEEEEEHHHHCCEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHH
RALVREPAIIDGDYHIHWLEQYLAGQKAD
HHHHCCCCEECCCCCHHHHHHHHCCCCCC
>Mature Secondary Structure
MFDKILIANRGEIALRILRACKELGISTVAVHSTADADAMHVRLADESVCIGPPPSKDSY
CCCCEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCCEECCCCCCCCCE
LNIPALLAACEITGADAVHPGYGFLSENARFAEILSDHNLHFIGPKAEHIRLMGDKIEAK
ECHHHHHHHHEECCCCCCCCCCCCCCCCCHHHHHHCCCCEEEECCCHHEEEEECCHHHHH
KTAKRLGIPVVPGSDGAVTPDQDAMAIAKAIGFPVLVKAAAGGGGRGMKVAHTEADLQLA
HHHHHCCCEECCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCEEEEECCCCEEEE
LTTAANEAKSAFGDASVYLEKYLQKPRHIEIQVLGDGRGGAIHLGERDCSLQRRHQKVWE
EEEHHHHHHHHCCHHHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHHH
EGPSPVLDVASRAKIGNTVAKAMQELKYIGVGTIEFLYEDGEFYFIEMNTRIQVEHPVTE
CCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCCEEEEEECCEEEECCCHHH
MITGIDLVLEQIRIAAGGDLPMTQDQVTINGHSIECRVNAENPVSFRPSPGKIQQYHPPG
HHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCEEEEEECCCCCCCCCCCCCCCEEECCCC
GLGVRIDSAVYQGYVIPPYYDSLVGKLIVHGKSRVECLMRLRRALDEMVVDGIETTLPLF
CCEEEEEHHHHCCEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHH
RALVREPAIIDGDYHIHWLEQYLAGQKAD
HHHHCCCCEECCCCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7693652; 10984043 [H]