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The map label for this gene is pepA [H]

Identifier: 146340305

GI number: 146340305

Start: 3525813

End: 3527312

Strand: Direct

Name: pepA [H]

Synonym: BRADO3328

Alternate gene names: 146340305

Gene position: 3525813-3527312 (Clockwise)

Preceding gene: 146340296

Following gene: 146340306

Centisome position: 47.28

GC content: 65.87

Gene sequence:

>1500_bases
ATGTCCGACACCGTCAAGGTCGGCTTCGTCCCGCTGTCGGCCGCTCCCCGCGGCATCGTGGCGGCGTTTTGTGACGACTC
GCTGCGGCTAGGAGCCGCGACCGACAAGGCGCTCGGGGGAGCGGCGGAGCTGATCAAGCGCGCGGCCGGCGCAGCGCGGT
TCAAGGGCAAGGACGGCGCGGTGCTCGATCTGCTGGCGCCCGAGGGAATTAAGATTCAGCGCTTGATCGTGATCGGAACG
GGCAAGGGCGGCGATCACAAGGAACGGGATTTTCTCAAATATGGCGGGACTTTAACGGGAAAGCTCAATCCCGGAACTGA
AGCCGTGACGGTGCTGGCCGAGCTGCCGGCGGGGCACATGACGCCCGACCAGGTCAGCTCCCTGGCTGCCGGCATGAGGC
TTCGGGCCTATCGATTCGACCGCTACAAGACCAAGAAGAAGGATGACGACGGCAGCGTCAGCGCGACCGTCTCGATCGCC
GTCGCCGACGTCGCCGCGGCCAAGAAGGCCTTCGCGCCCCGCGCCCATGTGACCGACGGCGTGATCCTTGCCCGTGACCT
CGTCAACGAGCCGCCGAACGTCCTCTACCCGGAGGAGTTCGCCAAGCGCGCTGCCGAGCTGCGCAAGCTCGGCGTCACCG
TCGAGATTCTCGACGTGCCCGCGATGAAGAAGCTCGGCATGGGCGCGCTGCTCGGCGTCGGCCAGGGTTCGGCGCGGCCG
AGCCGCACGGTGGTGATGCGATACAATGGCGGCAAGAAGGGCGACCAGCCGGTGGCGTTCATCGGCAAGGGCGTCTGCTT
CGACACCGGCGGCATCTCGATCAAGCCGGCTGGCTCGATGGAGGACATGAAGGGCGACATGGGCGGCGCCGCCTGCGTCG
TCGGTCTGATGCACGCGCTGGCGGCGCGCAAAGCCAAAGCCAATGTGATCGGCGCGATCGGCCTGGTCGAGAACATGCCG
GACGGCAACGCCCAGCGCCCGGGCGACATCGTCACCTCGATGTCCGGGCAGACCATCGAGATCATCAACACCGACGCGGA
AGGGCGGCTCGTGCTCGCCGATGTGCTCTGGTACGTCGCGACCAAGTACAAGCCGAAATTCATGATCGATCTGGCGACGC
TGACCGGTGCGATCATGGTCGCGCTCGGCACCGAGCATGCCGGCCTGTTCGCCAACAATGACGATCTGGCCGAGAAGCTG
CTGAAGGCGGGGAAGGAGACCGGCGAGAAGGTCTGGCGCATGCCGCTCGGCTCCGAATACGACAAGCTGATCGATTCGCA
ATTCGCCGACATGAAGAACACCGGCGGCCGCCACGGCGGCTCGATCACGGCCGCGCAATTCCTGCAGCGCTTCGTCAACG
ACACGCCCTGGGCGCATCTCGACATCGCCGGCACCGCGATGGGTGCGCCGAAGTCGGAGATCAACCAGAGCTGGGGCTCC
GGCTACGGCGTGCGCCTGCTCGACCGTCTCGTCTGGGATTCCTACGAAGCAAAATCGTAA

Upstream 100 bases:

>100_bases
CTGCCAAGTTGGGTTCCGAACTGCCGCCATCCCCGTCTGTCCGCTCGGATTTCGGCCCGGTCGCGGCGGCTCTCATGTCG
AAAATTTGGAGGTTTGCTTG

Downstream 100 bases:

>100_bases
GGGTCGACGGCACGCATGACCGAAGTCCTGTTCTATCATCTGCAGAGCATGACGCTGGAAGGCGTGCTGCCGCCGCTGCT
CGAGAAGTCGCTCGAGCGCG

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 499; Mature: 498

Protein sequence:

>499_residues
MSDTVKVGFVPLSAAPRGIVAAFCDDSLRLGAATDKALGGAAELIKRAAGAARFKGKDGAVLDLLAPEGIKIQRLIVIGT
GKGGDHKERDFLKYGGTLTGKLNPGTEAVTVLAELPAGHMTPDQVSSLAAGMRLRAYRFDRYKTKKKDDDGSVSATVSIA
VADVAAAKKAFAPRAHVTDGVILARDLVNEPPNVLYPEEFAKRAAELRKLGVTVEILDVPAMKKLGMGALLGVGQGSARP
SRTVVMRYNGGKKGDQPVAFIGKGVCFDTGGISIKPAGSMEDMKGDMGGAACVVGLMHALAARKAKANVIGAIGLVENMP
DGNAQRPGDIVTSMSGQTIEIINTDAEGRLVLADVLWYVATKYKPKFMIDLATLTGAIMVALGTEHAGLFANNDDLAEKL
LKAGKETGEKVWRMPLGSEYDKLIDSQFADMKNTGGRHGGSITAAQFLQRFVNDTPWAHLDIAGTAMGAPKSEINQSWGS
GYGVRLLDRLVWDSYEAKS

Sequences:

>Translated_499_residues
MSDTVKVGFVPLSAAPRGIVAAFCDDSLRLGAATDKALGGAAELIKRAAGAARFKGKDGAVLDLLAPEGIKIQRLIVIGT
GKGGDHKERDFLKYGGTLTGKLNPGTEAVTVLAELPAGHMTPDQVSSLAAGMRLRAYRFDRYKTKKKDDDGSVSATVSIA
VADVAAAKKAFAPRAHVTDGVILARDLVNEPPNVLYPEEFAKRAAELRKLGVTVEILDVPAMKKLGMGALLGVGQGSARP
SRTVVMRYNGGKKGDQPVAFIGKGVCFDTGGISIKPAGSMEDMKGDMGGAACVVGLMHALAARKAKANVIGAIGLVENMP
DGNAQRPGDIVTSMSGQTIEIINTDAEGRLVLADVLWYVATKYKPKFMIDLATLTGAIMVALGTEHAGLFANNDDLAEKL
LKAGKETGEKVWRMPLGSEYDKLIDSQFADMKNTGGRHGGSITAAQFLQRFVNDTPWAHLDIAGTAMGAPKSEINQSWGS
GYGVRLLDRLVWDSYEAKS
>Mature_498_residues
SDTVKVGFVPLSAAPRGIVAAFCDDSLRLGAATDKALGGAAELIKRAAGAARFKGKDGAVLDLLAPEGIKIQRLIVIGTG
KGGDHKERDFLKYGGTLTGKLNPGTEAVTVLAELPAGHMTPDQVSSLAAGMRLRAYRFDRYKTKKKDDDGSVSATVSIAV
ADVAAAKKAFAPRAHVTDGVILARDLVNEPPNVLYPEEFAKRAAELRKLGVTVEILDVPAMKKLGMGALLGVGQGSARPS
RTVVMRYNGGKKGDQPVAFIGKGVCFDTGGISIKPAGSMEDMKGDMGGAACVVGLMHALAARKAKANVIGAIGLVENMPD
GNAQRPGDIVTSMSGQTIEIINTDAEGRLVLADVLWYVATKYKPKFMIDLATLTGAIMVALGTEHAGLFANNDDLAEKLL
KAGKETGEKVWRMPLGSEYDKLIDSQFADMKNTGGRHGGSITAAQFLQRFVNDTPWAHLDIAGTAMGAPKSEINQSWGSG
YGVRLLDRLVWDSYEAKS

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=342, Percent_Identity=41.5204678362573, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI47155554, Length=320, Percent_Identity=35.625, Blast_Score=162, Evalue=9e-40,
Organism=Escherichia coli, GI1790710, Length=422, Percent_Identity=41.4691943127962, Blast_Score=297, Evalue=1e-81,
Organism=Escherichia coli, GI87082123, Length=336, Percent_Identity=37.202380952381, Blast_Score=190, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17556903, Length=313, Percent_Identity=33.5463258785943, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17565172, Length=255, Percent_Identity=27.843137254902, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI20129969, Length=287, Percent_Identity=34.4947735191638, Blast_Score=194, Evalue=2e-49,
Organism=Drosophila melanogaster, GI21355725, Length=282, Percent_Identity=38.2978723404255, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24662227, Length=287, Percent_Identity=35.191637630662, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24661038, Length=282, Percent_Identity=38.6524822695035, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI161077148, Length=287, Percent_Identity=35.5400696864112, Blast_Score=186, Evalue=5e-47,
Organism=Drosophila melanogaster, GI20130057, Length=287, Percent_Identity=35.5400696864112, Blast_Score=186, Evalue=5e-47,
Organism=Drosophila melanogaster, GI21355645, Length=287, Percent_Identity=31.3588850174216, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24662223, Length=287, Percent_Identity=31.3588850174216, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI20129963, Length=348, Percent_Identity=32.4712643678161, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI19922386, Length=287, Percent_Identity=34.8432055749129, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI21357381, Length=317, Percent_Identity=34.0694006309148, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI221379063, Length=317, Percent_Identity=34.0694006309148, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI221379062, Length=317, Percent_Identity=34.0694006309148, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24646701, Length=178, Percent_Identity=30.8988764044944, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24646703, Length=178, Percent_Identity=30.8988764044944, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21358201, Length=178, Percent_Identity=30.8988764044944, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 52597; Mature: 52466

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTVKVGFVPLSAAPRGIVAAFCDDSLRLGAATDKALGGAAELIKRAAGAARFKGKDGA
CCCCEEEEEEECCCCCCCEEEEECCCCCEECCCCCHHCCHHHHHHHHHHCCCEECCCCCC
VLDLLAPEGIKIQRLIVIGTGKGGDHKERDFLKYGGTLTGKLNPGTEAVTVLAELPAGHM
EEEEECCCCCEEEEEEEEECCCCCCCCHHHHHHHCCEEEECCCCCHHHHHHEECCCCCCC
TPDQVSSLAAGMRLRAYRFDRYKTKKKDDDGSVSATVSIAVADVAAAKKAFAPRAHVTDG
CHHHHHHHHHHHHHEEEHHHHHHCCCCCCCCCEEEEEEEEEHHHHHHHHHCCCCCCCCCC
VILARDLVNEPPNVLYPEEFAKRAAELRKLGVTVEILDVPAMKKLGMGALLGVGQGSARP
HHEEHHHHCCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCHHHCCCCCEEECCCCCCCC
SRTVVMRYNGGKKGDQPVAFIGKGVCFDTGGISIKPAGSMEDMKGDMGGAACVVGLMHAL
CEEEEEEECCCCCCCCCEEEEECCEEEECCCEEECCCCCHHHHCCCCCHHHHHHHHHHHH
AARKAKANVIGAIGLVENMPDGNAQRPGDIVTSMSGQTIEIINTDAEGRLVLADVLWYVA
HHHHHHHHHEEEHHHHHCCCCCCCCCCCHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHH
TKYKPKFMIDLATLTGAIMVALGTEHAGLFANNDDLAEKLLKAGKETGEKVWRMPLGSEY
HCCCCEEEEEHHHHHCEEEEEECCCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCCCCHH
DKLIDSQFADMKNTGGRHGGSITAAQFLQRFVNDTPWAHLDIAGTAMGAPKSEINQSWGS
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHCC
GYGVRLLDRLVWDSYEAKS
CCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SDTVKVGFVPLSAAPRGIVAAFCDDSLRLGAATDKALGGAAELIKRAAGAARFKGKDGA
CCCEEEEEEECCCCCCCEEEEECCCCCEECCCCCHHCCHHHHHHHHHHCCCEECCCCCC
VLDLLAPEGIKIQRLIVIGTGKGGDHKERDFLKYGGTLTGKLNPGTEAVTVLAELPAGHM
EEEEECCCCCEEEEEEEEECCCCCCCCHHHHHHHCCEEEECCCCCHHHHHHEECCCCCCC
TPDQVSSLAAGMRLRAYRFDRYKTKKKDDDGSVSATVSIAVADVAAAKKAFAPRAHVTDG
CHHHHHHHHHHHHHEEEHHHHHHCCCCCCCCCEEEEEEEEEHHHHHHHHHCCCCCCCCCC
VILARDLVNEPPNVLYPEEFAKRAAELRKLGVTVEILDVPAMKKLGMGALLGVGQGSARP
HHEEHHHHCCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCHHHCCCCCEEECCCCCCCC
SRTVVMRYNGGKKGDQPVAFIGKGVCFDTGGISIKPAGSMEDMKGDMGGAACVVGLMHAL
CEEEEEEECCCCCCCCCEEEEECCEEEECCCEEECCCCCHHHHCCCCCHHHHHHHHHHHH
AARKAKANVIGAIGLVENMPDGNAQRPGDIVTSMSGQTIEIINTDAEGRLVLADVLWYVA
HHHHHHHHHEEEHHHHHCCCCCCCCCCCHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHH
TKYKPKFMIDLATLTGAIMVALGTEHAGLFANNDDLAEKLLKAGKETGEKVWRMPLGSEY
HCCCCEEEEEHHHHHCEEEEEECCCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCCCCHH
DKLIDSQFADMKNTGGRHGGSITAAQFLQRFVNDTPWAHLDIAGTAMGAPKSEINQSWGS
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHCC
GYGVRLLDRLVWDSYEAKS
CCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA