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The map label for this gene is tetA [H]

Identifier: 146340247

GI number: 146340247

Start: 3467867

End: 3469144

Strand: Direct

Name: tetA [H]

Synonym: BRADO3268

Alternate gene names: 146340247

Gene position: 3467867-3469144 (Clockwise)

Preceding gene: 146340239

Following gene: 146340252

Centisome position: 46.51

GC content: 69.64

Gene sequence:

>1278_bases
ATGCTCCGTCCCGACGACACGACATCCGACGACACGATCTTGAATAACACGGCACCGCCGCAGGCGCCGCGCCGTGGCGC
GGTCGCCTTCATCTTCGTCACCATCCTGCTCGACATGCTCGCGCTCGGGCTGATCATGCCGATCCTGCCGAAGCTGATCG
AGGGCTTCGTCGGCAACGACACGGCGCAGGCCGCGCGGATCTTCGGGCTGTTCGGGACGGCCTGGGCGTTGATGCAGTTG
GTGTTCTCGCCGGTGCTCGGCAGCCTGTCCGACCGGTTCGGGCGGCGGCCCGTCATCCTGCTGTCGAATTTCGGCCTCGC
CGCCGACTACGTGCTGATGGCGCTGGCGCCGTCGCTCGCCTGGCTGTTCCTCGGGCGGCTGATTTCCGGCGTCACCTCAG
CCAGCATCTCCACGGCGTTTGCCTACATCTCCGATCTCACGCCGCCGGACCGCCGGGCCGCCGTGTTCGGCCGCATCGGG
GCGGCGTTCGGCGCCGGCTTCGTGCTCGGTCCCGCGACTGGCGGTCTGCTCGGCGACATCGATCCGCGGCTGCCGTTCTG
GGCGGCGGCCGGGCTGAGCTTCGCCAATGCGCTCTATGGCCTGCTGGTGCTGCCGGAATCGCTGCCGGCCGAACGTCGCA
GCGCGTTCCGCTGGCGCGCGGCGAACCCGCTGGGGGCGCTGCGCTTGCTGCGCTCGGAGCGGACATTGGCGGGCTTGTCG
CTGGTCAACTTCATCACCCAGCTCGCCCATGTGGTGCTGCCGTCGACCTTCGTGCTGTACGCGACCTATCGCTATGGGTG
GGACACGCGCACGGTCGGCCTGACGCTCGCGATCGTCGGCGTCTGCGCAATGGTGGTGCAGGGCGGCGCCGTCGGCTTCA
TCGTGCGCAGGCTCGGCGAGCGCGGCGCGCTGATGCTCGGATTGTCCGCGGGCACGGTCGGGTTCCTGATCTTCGGCCTG
GCGCCAACGGGGATGCTGAGCTGGACGGGCATTCCCGCGATGGCGCTGTGGGGCGTGTCGGGTGCGGCGATCCAGGCGTT
GATGACGCGGCTGGTTCCGCCGGACCGGCAAGGCCAGCTGCAGGGCGCGACGTCGAGCGTGCAGAGCATGGCGCAACTCG
CGGGGCCGTTCCTGTTCACGCTGACGTTTGCGTATTTCATCGGCGCCGGCGCGCCGCTGCATCTGCCGGGCGCGCCGTTC
CTGCTGGCCTCGGCGCTGCTGATCGTGGCGCTCGTCATCGCGGTGCGGGCGCTGCGCGCGGAGGAAAGAAAGTCATGA

Upstream 100 bases:

>100_bases
GGGCCGTGGCCGCTGAGCTGCGTGGATTGCCGGTCCGGTCGCCACGTGTATAAGTCGGCTCCGTCCTGCGTCGCCGCGGA
CGCACATCCGATGGCAGGCC

Downstream 100 bases:

>100_bases
TGACGGCAGCGCGCGCAAACCGTGCTGCACAGTCGACTGTGAGCACGCGTGGACGAAGAGCGCACCTTCGTTTCCGCCTG
CCGCATCTTCACGATCCAAG

Product: putative tetracycline-efflux transporter

Products: NA

Alternate protein names: TetA(A) [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MLRPDDTTSDDTILNNTAPPQAPRRGAVAFIFVTILLDMLALGLIMPILPKLIEGFVGNDTAQAARIFGLFGTAWALMQL
VFSPVLGSLSDRFGRRPVILLSNFGLAADYVLMALAPSLAWLFLGRLISGVTSASISTAFAYISDLTPPDRRAAVFGRIG
AAFGAGFVLGPATGGLLGDIDPRLPFWAAAGLSFANALYGLLVLPESLPAERRSAFRWRAANPLGALRLLRSERTLAGLS
LVNFITQLAHVVLPSTFVLYATYRYGWDTRTVGLTLAIVGVCAMVVQGGAVGFIVRRLGERGALMLGLSAGTVGFLIFGL
APTGMLSWTGIPAMALWGVSGAAIQALMTRLVPPDRQGQLQGATSSVQSMAQLAGPFLFTLTFAYFIGAGAPLHLPGAPF
LLASALLIVALVIAVRALRAEERKS

Sequences:

>Translated_425_residues
MLRPDDTTSDDTILNNTAPPQAPRRGAVAFIFVTILLDMLALGLIMPILPKLIEGFVGNDTAQAARIFGLFGTAWALMQL
VFSPVLGSLSDRFGRRPVILLSNFGLAADYVLMALAPSLAWLFLGRLISGVTSASISTAFAYISDLTPPDRRAAVFGRIG
AAFGAGFVLGPATGGLLGDIDPRLPFWAAAGLSFANALYGLLVLPESLPAERRSAFRWRAANPLGALRLLRSERTLAGLS
LVNFITQLAHVVLPSTFVLYATYRYGWDTRTVGLTLAIVGVCAMVVQGGAVGFIVRRLGERGALMLGLSAGTVGFLIFGL
APTGMLSWTGIPAMALWGVSGAAIQALMTRLVPPDRQGQLQGATSSVQSMAQLAGPFLFTLTFAYFIGAGAPLHLPGAPF
LLASALLIVALVIAVRALRAEERKS
>Mature_425_residues
MLRPDDTTSDDTILNNTAPPQAPRRGAVAFIFVTILLDMLALGLIMPILPKLIEGFVGNDTAQAARIFGLFGTAWALMQL
VFSPVLGSLSDRFGRRPVILLSNFGLAADYVLMALAPSLAWLFLGRLISGVTSASISTAFAYISDLTPPDRRAAVFGRIG
AAFGAGFVLGPATGGLLGDIDPRLPFWAAAGLSFANALYGLLVLPESLPAERRSAFRWRAANPLGALRLLRSERTLAGLS
LVNFITQLAHVVLPSTFVLYATYRYGWDTRTVGLTLAIVGVCAMVVQGGAVGFIVRRLGERGALMLGLSAGTVGFLIFGL
APTGMLSWTGIPAMALWGVSGAAIQALMTRLVPPDRQGQLQGATSSVQSMAQLAGPFLFTLTFAYFIGAGAPLHLPGAPF
LLASALLIVALVIAVRALRAEERKS

Specific function: Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Homo sapiens, GI39753965, Length=385, Percent_Identity=25.974025974026, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI94721311, Length=412, Percent_Identity=26.4563106796117, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI225703104, Length=240, Percent_Identity=31.25, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI225703102, Length=240, Percent_Identity=31.25, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI217416366, Length=151, Percent_Identity=27.8145695364238, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI87081738, Length=233, Percent_Identity=31.3304721030043, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71996331, Length=374, Percent_Identity=25.9358288770053, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17551570, Length=415, Percent_Identity=20.7228915662651, Blast_Score=81, Evalue=8e-16,
Organism=Drosophila melanogaster, GI21357569, Length=415, Percent_Identity=25.3012048192771, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24656463, Length=450, Percent_Identity=24.4444444444444, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24656468, Length=450, Percent_Identity=24.4444444444444, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI161080926, Length=450, Percent_Identity=24.4444444444444, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI161080924, Length=450, Percent_Identity=24.4444444444444, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI221513297, Length=362, Percent_Identity=26.7955801104972, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI17738085, Length=438, Percent_Identity=25.5707762557078, Blast_Score=108, Evalue=6e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR004734
- InterPro:   IPR005829
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 44812; Mature: 44812

Theoretical pI: Translated: 10.93; Mature: 10.93

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRPDDTTSDDTILNNTAPPQAPRRGAVAFIFVTILLDMLALGLIMPILPKLIEGFVGND
CCCCCCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TAQAARIFGLFGTAWALMQLVFSPVLGSLSDRFGRRPVILLSNFGLAADYVLMALAPSLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHH
WLFLGRLISGVTSASISTAFAYISDLTPPDRRAAVFGRIGAAFGAGFVLGPATGGLLGDI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEECCCCCCCCCCC
DPRLPFWAAAGLSFANALYGLLVLPESLPAERRSAFRWRAANPLGALRLLRSERTLAGLS
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
LVNFITQLAHVVLPSTFVLYATYRYGWDTRTVGLTLAIVGVCAMVVQGGAVGFIVRRLGE
HHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCC
RGALMLGLSAGTVGFLIFGLAPTGMLSWTGIPAMALWGVSGAAIQALMTRLVPPDRQGQL
CCCEEEEECCCHHHHHHHHCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHCCCCCCCCCC
QGATSSVQSMAQLAGPFLFTLTFAYFIGAGAPLHLPGAPFLLASALLIVALVIAVRALRA
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
EERKS
HHCCC
>Mature Secondary Structure
MLRPDDTTSDDTILNNTAPPQAPRRGAVAFIFVTILLDMLALGLIMPILPKLIEGFVGND
CCCCCCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TAQAARIFGLFGTAWALMQLVFSPVLGSLSDRFGRRPVILLSNFGLAADYVLMALAPSLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHH
WLFLGRLISGVTSASISTAFAYISDLTPPDRRAAVFGRIGAAFGAGFVLGPATGGLLGDI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEECCCCCCCCCCC
DPRLPFWAAAGLSFANALYGLLVLPESLPAERRSAFRWRAANPLGALRLLRSERTLAGLS
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
LVNFITQLAHVVLPSTFVLYATYRYGWDTRTVGLTLAIVGVCAMVVQGGAVGFIVRRLGE
HHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCC
RGALMLGLSAGTVGFLIFGLAPTGMLSWTGIPAMALWGVSGAAIQALMTRLVPPDRQGQL
CCCEEEEECCCHHHHHHHHCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHCCCCCCCCCC
QGATSSVQSMAQLAGPFLFTLTFAYFIGAGAPLHLPGAPFLLASALLIVALVIAVRALRA
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
EERKS
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312499; 6310527 [H]