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The map label for this gene is apxIIID [H]

Identifier: 146339765

GI number: 146339765

Start: 2974513

End: 2975931

Strand: Direct

Name: apxIIID [H]

Synonym: BRADO2765

Alternate gene names: 146339765

Gene position: 2974513-2975931 (Clockwise)

Preceding gene: 146339764

Following gene: 146339766

Centisome position: 39.89

GC content: 70.19

Gene sequence:

>1419_bases
ATGAGCACATCTGCAAATCACTTGCGTGGCTTCTCGTTCGGCGGCAACACGTCGGAGCGCGAGTTCCTGCCGGCGGCGTT
GGAGATCACGGAGACGCCGCCCAACCCGCTCGGACGCATCACCGCGCTGGCACTATGCACGGTGACATTTGCGGCGCTCG
GCTGGGCGGTGTTCGGCAAGGTCGACATCGTCGCGGTCGCCAGCGGCAAGGTGATTTCGCATACCCGCACCCAGGTGGTG
CAGCCGTTCGAGACGGCGAGCGTCAAGGCCGTGCTGGTACAGCCCGGTCAGCGCGTGCGCGCCGGCGACGCGCTGATCGA
GCTCGACAGGACCGCCGTGACGGCGGAGGCCGACCGGGCCCGCAGCGATCTGATCGCGAGCCTGCTCGACGAAGTCCGGC
TGGCGGCCTTCCTGGATGGCGTGAAGAACGGACCGTTCGATCTGGTGGCCGGCGCCGAGCCGCTCGATCGCGCCCGTGCC
CAGGCGCAGCTCACGGCGCAGCTGGCGATGCGCGCCAGCCAGCTGGCGGCGCTGGCGCAGGAGCGCGCCCAACATGTTGC
CGAGCGCGAGGCGCTGCAACAGACGGTCGCGAAATACGAGCAGACCCTGCCGATGGTGACGCAGCGCGCCGATATCCGCA
CCAAGGCGAGCGAGATCGGCAACGCCTCGATCATCGCGCTGCTTGAGAGCCAGCAGCTGCTGGTCGAGACCCGCTCGGAG
CTCGAGATCAACAAGGCGAAAATCGTTGCGCTCGATGCCACCATCGCCGGGCTCGATCAGAAGATCGCGGCGACGGAGGC
CGAGATCCGCGACAAGGCGATGCGCGATCTCGCCACCGCGCGCGAGCGCGCCCGCGCCGCCGGCGAAGCGCTGACCAAGG
CGGCGCGGCGCGCCGAGCTGCAGACCTTGCGCGCGCCGATCGACGGCACGGTGCAGCAGATGCACATCGCGGCCGCCGGC
GCCGTGGTAACGCCGGCGCAGCAGCTGCTGTCCGTCGTGCCCGATGACGACAGGATCGAGGTCGAGGCCGTGGTCGAGAA
CCGCGACGTCGGCTTCGTCGAGGCCGGCCAGCGCGTCGAGCTCAAGGTCGATGCCTTCCCGTTCACGCGCTACGGCCTGC
TGGGCGGCAAGGTGACCTCGGTTGACCGCGACGCGGAGGCCGCGCCGGTCAATCCCCAGGGCGTGCAGGGCGCCGAGCGG
CAGGCGGACCAGACCGACCGCGTCGAGGCCAGCGAGCGGCTGCGCTACATGGTGCACATCGCGCTCGACCGCGCGACGCT
GGACGTCGACGGCCGTGCCGCGGCGCTGGTGCCGGGCATGTCGGTGAAGGCCGAGATCCTGACCGGCAAGCGCCGCATCA
TCGACTTCCTGCTAGCGCCGCTCAGCGAGCACGTCCACGACGCCATGCGCGAGCGCTGA

Upstream 100 bases:

>100_bases
GTCATAGTCGAGGACGGGACCCACGAGCAGCTGGTCGCCGGGGGCGGCCGTTATGCGACCCTGCACCGGATCCAGTCCGC
GGGCCGCTGAGGAGAGGGCG

Downstream 100 bases:

>100_bases
GGCACGCGCGGCATCGTTAACAGGCTTTTGCGCATTTGAGCAAAAACGCACCGTCAAATCCGCGCGCGCACGCTTACGGA
ACGCTGGCGTTCGGAAGGTA

Product: HlyD family secretion protein

Products: NA

Alternate protein names: APX-IIID; Cytolysin IIID; CLY-IIID; Toxin RTX-III secretion protein D [H]

Number of amino acids: Translated: 472; Mature: 471

Protein sequence:

>472_residues
MSTSANHLRGFSFGGNTSEREFLPAALEITETPPNPLGRITALALCTVTFAALGWAVFGKVDIVAVASGKVISHTRTQVV
QPFETASVKAVLVQPGQRVRAGDALIELDRTAVTAEADRARSDLIASLLDEVRLAAFLDGVKNGPFDLVAGAEPLDRARA
QAQLTAQLAMRASQLAALAQERAQHVAEREALQQTVAKYEQTLPMVTQRADIRTKASEIGNASIIALLESQQLLVETRSE
LEINKAKIVALDATIAGLDQKIAATEAEIRDKAMRDLATARERARAAGEALTKAARRAELQTLRAPIDGTVQQMHIAAAG
AVVTPAQQLLSVVPDDDRIEVEAVVENRDVGFVEAGQRVELKVDAFPFTRYGLLGGKVTSVDRDAEAAPVNPQGVQGAER
QADQTDRVEASERLRYMVHIALDRATLDVDGRAAALVPGMSVKAEILTGKRRIIDFLLAPLSEHVHDAMRER

Sequences:

>Translated_472_residues
MSTSANHLRGFSFGGNTSEREFLPAALEITETPPNPLGRITALALCTVTFAALGWAVFGKVDIVAVASGKVISHTRTQVV
QPFETASVKAVLVQPGQRVRAGDALIELDRTAVTAEADRARSDLIASLLDEVRLAAFLDGVKNGPFDLVAGAEPLDRARA
QAQLTAQLAMRASQLAALAQERAQHVAEREALQQTVAKYEQTLPMVTQRADIRTKASEIGNASIIALLESQQLLVETRSE
LEINKAKIVALDATIAGLDQKIAATEAEIRDKAMRDLATARERARAAGEALTKAARRAELQTLRAPIDGTVQQMHIAAAG
AVVTPAQQLLSVVPDDDRIEVEAVVENRDVGFVEAGQRVELKVDAFPFTRYGLLGGKVTSVDRDAEAAPVNPQGVQGAER
QADQTDRVEASERLRYMVHIALDRATLDVDGRAAALVPGMSVKAEILTGKRRIIDFLLAPLSEHVHDAMRER
>Mature_471_residues
STSANHLRGFSFGGNTSEREFLPAALEITETPPNPLGRITALALCTVTFAALGWAVFGKVDIVAVASGKVISHTRTQVVQ
PFETASVKAVLVQPGQRVRAGDALIELDRTAVTAEADRARSDLIASLLDEVRLAAFLDGVKNGPFDLVAGAEPLDRARAQ
AQLTAQLAMRASQLAALAQERAQHVAEREALQQTVAKYEQTLPMVTQRADIRTKASEIGNASIIALLESQQLLVETRSEL
EINKAKIVALDATIAGLDQKIAATEAEIRDKAMRDLATARERARAAGEALTKAARRAELQTLRAPIDGTVQQMHIAAAGA
VVTPAQQLLSVVPDDDRIEVEAVVENRDVGFVEAGQRVELKVDAFPFTRYGLLGGKVTSVDRDAEAAPVNPQGVQGAERQ
ADQTDRVEASERLRYMVHIALDRATLDVDGRAAALVPGMSVKAEILTGKRRIIDFLLAPLSEHVHDAMRER

Specific function: Involved in the transport of the toxin RTX-III [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003997
- InterPro:   IPR006143
- InterPro:   IPR006144
- InterPro:   IPR010129 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 50764; Mature: 50633

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS00543 HLYD_FAMILY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTSANHLRGFSFGGNTSEREFLPAALEITETPPNPLGRITALALCTVTFAALGWAVFGK
CCCCCCCCCCCCCCCCCCCCHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
VDIVAVASGKVISHTRTQVVQPFETASVKAVLVQPGQRVRAGDALIELDRTAVTAEADRA
EEEEEEECCCEEHHHHHHHHCCCCCCCEEEEEECCCCCEECCCHHEEECCHHEECHHHHH
RSDLIASLLDEVRLAAFLDGVKNGPFDLVAGAEPLDRARAQAQLTAQLAMRASQLAALAQ
HHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ERAQHVAEREALQQTVAKYEQTLPMVTQRADIRTKASEIGNASIIALLESQQLLVETRSE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHH
LEINKAKIVALDATIAGLDQKIAATEAEIRDKAMRDLATARERARAAGEALTKAARRAEL
CEECCEEEEEEECHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QTLRAPIDGTVQQMHIAAAGAVVTPAQQLLSVVPDDDRIEVEAVVENRDVGFVEAGQRVE
HHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCEEECCCEEE
LKVDAFPFTRYGLLGGKVTSVDRDAEAAPVNPQGVQGAERQADQTDRVEASERLRYMVHI
EEEECCCCHHHHCCCCEEECCCCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHEE
ALDRATLDVDGRAAALVPGMSVKAEILTGKRRIIDFLLAPLSEHVHDAMRER
EEECEEECCCCCEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
STSANHLRGFSFGGNTSEREFLPAALEITETPPNPLGRITALALCTVTFAALGWAVFGK
CCCCCCCCCCCCCCCCCCCHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
VDIVAVASGKVISHTRTQVVQPFETASVKAVLVQPGQRVRAGDALIELDRTAVTAEADRA
EEEEEEECCCEEHHHHHHHHCCCCCCCEEEEEECCCCCEECCCHHEEECCHHEECHHHHH
RSDLIASLLDEVRLAAFLDGVKNGPFDLVAGAEPLDRARAQAQLTAQLAMRASQLAALAQ
HHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ERAQHVAEREALQQTVAKYEQTLPMVTQRADIRTKASEIGNASIIALLESQQLLVETRSE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHH
LEINKAKIVALDATIAGLDQKIAATEAEIRDKAMRDLATARERARAAGEALTKAARRAEL
CEECCEEEEEEECHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QTLRAPIDGTVQQMHIAAAGAVVTPAQQLLSVVPDDDRIEVEAVVENRDVGFVEAGQRVE
HHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCEEECCCEEE
LKVDAFPFTRYGLLGGKVTSVDRDAEAAPVNPQGVQGAERQADQTDRVEASERLRYMVHI
EEEECCCCHHHHCCCCEEECCCCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHEE
ALDRATLDVDGRAAALVPGMSVKAEILTGKRRIIDFLLAPLSEHVHDAMRER
EEECEEECCCCCEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8494611; 7927703 [H]