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The map label for this gene is mutA [H]

Identifier: 146339687

GI number: 146339687

Start: 2882724

End: 2884583

Strand: Reverse

Name: mutA [H]

Synonym: BRADO2682

Alternate gene names: 146339687

Gene position: 2884583-2882724 (Counterclockwise)

Preceding gene: 146339688

Following gene: 146339686

Centisome position: 38.69

GC content: 70.32

Gene sequence:

>1860_bases
ATGACCACCGACACCGAACAGCTGCGATTGGCCGCCGATTTCGCGCCGGCTAGCGAGGCGGACTGGCGCAAGCTGGTCGA
CGGCGTGTTGAAGGGCGCGGCGTTCGAGAAGCTGGTCGGCAAGACCTATGACGGCCTGAAGATCCAGCCGATCTATTCGC
GCGCCCAGGGCGCCGCGCCGGTCGCCGGCCGCGCGCCGGCGGCGGCGTGGCAGATCATGCAGCGCGTCGACCATCGCGAT
GCCGGCAAGGCCAATGCGCAGGCGCTGCTCGACCTCGAAAACGGCGCGACCGGGCTGACGCTGGTATTCGCCGGCGCCAA
CGCCGCGCATGGCTTCGGCCTCGCCGCCACCGCGGACGCGCTGGCCCGCGCGCTGGATGGCGTGCATCTCGACGCTGCGA
TTGCCATCGAATTGCAGGCAACTGACGCATCTGCCGCCGCACTGCTCGCGGACTACGTCAAGCAGCGCGGGTTCAAGCCG
GGCGCTTGCGACATCCGCTTCGGCCTCGATCCGATCGGCGATGCAGCCAGTAGCGGCGCGAGCGCCCATGATGCGGGCGC
GCTTGCCGGCAGCGCCGTCGACTTGGTGAAGCAATTGCACGGCGCCGGCTTCCAGGGTCCCTTCCTGGCCGCGGATGGCC
GCGTGGTGCACGACGCCGGTGGTTCGGAGGCGCAGGAGCTCGCCTTCGTGCTGGCCTCCGGCGTCGCCTATCTGCGGGCG
CTCGAAGCGGGCGGCATCGCGTTGGAGACCGCGCGTGGCCTGATCTTCGCGCGGCTCGCGGCCGATACTGATCAGTTCCT
GACGCTGGCGAAATTCCGTAGCCTGCGCCGGCTTTGGGCGCGCATCGAAGAGGCCTGCGGCCTGCAACCGAAGCCGCTCG
TCGTCTCCGGCGAGACGGCGTGGCGCATGCTCACCCGGCGCGATCCCTATGTGAACATGCTGCGCGCCACCATCGCGACG
CTCGCCGCGGGCCTCGGCGGCGCCAATGCGATCACCGTGCTGCCGCACACCGCAGCGCTCGGACTGCCCGATGCGTTTGC
TCGCCGCGTCGCGCGCAACACGCAGCTGGTGCTGCTTGAGGAGAGCAATCTCGCCCGCGTCGCCGATCCCGCGGCCGGCG
CCGGCGGCATCGAGGCGCTGACGAGCGAGTTGAGCACCACCGCCTGGGCGCTGTTCCAGGAGATCGAGAAGGCCGGCGGG
ATCGTCGCCGCGCTGCAGGCCGGCCTGATCCAGAGCAAGGTCGCCGCCGTGAAGCAGGCGCGCGACGTCAACATCGCCAG
ACGCCGCGACGTGCTGACCGGCGCCAGCGAGTTTCCGAACTTGAACGAGGCTGATGTGAGCGTTGAGGCGGTCGCGCCGC
TGCCCTCGCCGCCTCCGGTCAAAGCTGCGCTCAGCTTCGCGCCGCTCGCCCCGATCCGTCTTGCAGACGCGTTCGAGAAG
TTGCGCGACCGCTCGGACGCCCTGCTGAAGAGCAAGGGCGGACGGCCGCACGTGTTCCTCGCCAATCTCGGCTCCGCCGC
CGACTACACCGCGCGCGCGACCTTTGCCCGCAGCTTCTTCGAGGCCGGCGGCATCGCCGCGGTCGATGGCGAGGGCGGCT
CCGACCCAGCCGCGCTCGCGGCGGCGTACCGCGCCTCGGGAGCGGCGATCGCCTGCCTCTGCTCATCCGACAAGGTCTAC
GCCGATGCCGCGGTTCCCGCAGCCAAGGCCCTGCAAGCGGCCGGCGCGCGACATATCTATCTGGCAGGCCGCGGCGGCGA
GCAGGAAGAAGCCTTGCGCGAGGCCGGGATCGGCAGCTTCGTATTCGCAGGCGGTGACGCGCTGGCAACGCTCGAAGACG
CCTATACGCATCTGGAGTGA

Upstream 100 bases:

>100_bases
GACATCTCCGGCGAAACAACCGTTTGGCTTGGCGGTCGCGACGTGGCATTTTGCGCCACAATAATCGCCATAACAGACGC
TTCCGGGAGATACGGGCCGC

Downstream 100 bases:

>100_bases
GCATGACCGAGGCCAGCAAACCCGTCCTCACCGGCGGCTGCCAATGCGGCACGATCCGCTATGCGCTGATGGCGGCGCCG
ACGCGCGTGAGCATCTGCCA

Product: methylmalonyl-CoA mutase small subunit

Products: NA

Alternate protein names: MCM-beta [H]

Number of amino acids: Translated: 619; Mature: 618

Protein sequence:

>619_residues
MTTDTEQLRLAADFAPASEADWRKLVDGVLKGAAFEKLVGKTYDGLKIQPIYSRAQGAAPVAGRAPAAAWQIMQRVDHRD
AGKANAQALLDLENGATGLTLVFAGANAAHGFGLAATADALARALDGVHLDAAIAIELQATDASAAALLADYVKQRGFKP
GACDIRFGLDPIGDAASSGASAHDAGALAGSAVDLVKQLHGAGFQGPFLAADGRVVHDAGGSEAQELAFVLASGVAYLRA
LEAGGIALETARGLIFARLAADTDQFLTLAKFRSLRRLWARIEEACGLQPKPLVVSGETAWRMLTRRDPYVNMLRATIAT
LAAGLGGANAITVLPHTAALGLPDAFARRVARNTQLVLLEESNLARVADPAAGAGGIEALTSELSTTAWALFQEIEKAGG
IVAALQAGLIQSKVAAVKQARDVNIARRRDVLTGASEFPNLNEADVSVEAVAPLPSPPPVKAALSFAPLAPIRLADAFEK
LRDRSDALLKSKGGRPHVFLANLGSAADYTARATFARSFFEAGGIAAVDGEGGSDPAALAAAYRASGAAIACLCSSDKVY
ADAAVPAAKALQAAGARHIYLAGRGGEQEEALREAGIGSFVFAGGDALATLEDAYTHLE

Sequences:

>Translated_619_residues
MTTDTEQLRLAADFAPASEADWRKLVDGVLKGAAFEKLVGKTYDGLKIQPIYSRAQGAAPVAGRAPAAAWQIMQRVDHRD
AGKANAQALLDLENGATGLTLVFAGANAAHGFGLAATADALARALDGVHLDAAIAIELQATDASAAALLADYVKQRGFKP
GACDIRFGLDPIGDAASSGASAHDAGALAGSAVDLVKQLHGAGFQGPFLAADGRVVHDAGGSEAQELAFVLASGVAYLRA
LEAGGIALETARGLIFARLAADTDQFLTLAKFRSLRRLWARIEEACGLQPKPLVVSGETAWRMLTRRDPYVNMLRATIAT
LAAGLGGANAITVLPHTAALGLPDAFARRVARNTQLVLLEESNLARVADPAAGAGGIEALTSELSTTAWALFQEIEKAGG
IVAALQAGLIQSKVAAVKQARDVNIARRRDVLTGASEFPNLNEADVSVEAVAPLPSPPPVKAALSFAPLAPIRLADAFEK
LRDRSDALLKSKGGRPHVFLANLGSAADYTARATFARSFFEAGGIAAVDGEGGSDPAALAAAYRASGAAIACLCSSDKVY
ADAAVPAAKALQAAGARHIYLAGRGGEQEEALREAGIGSFVFAGGDALATLEDAYTHLE
>Mature_618_residues
TTDTEQLRLAADFAPASEADWRKLVDGVLKGAAFEKLVGKTYDGLKIQPIYSRAQGAAPVAGRAPAAAWQIMQRVDHRDA
GKANAQALLDLENGATGLTLVFAGANAAHGFGLAATADALARALDGVHLDAAIAIELQATDASAAALLADYVKQRGFKPG
ACDIRFGLDPIGDAASSGASAHDAGALAGSAVDLVKQLHGAGFQGPFLAADGRVVHDAGGSEAQELAFVLASGVAYLRAL
EAGGIALETARGLIFARLAADTDQFLTLAKFRSLRRLWARIEEACGLQPKPLVVSGETAWRMLTRRDPYVNMLRATIATL
AAGLGGANAITVLPHTAALGLPDAFARRVARNTQLVLLEESNLARVADPAAGAGGIEALTSELSTTAWALFQEIEKAGGI
VAALQAGLIQSKVAAVKQARDVNIARRRDVLTGASEFPNLNEADVSVEAVAPLPSPPPVKAALSFAPLAPIRLADAFEKL
RDRSDALLKSKGGRPHVFLANLGSAADYTARATFARSFFEAGGIAAVDGEGGSDPAALAAAYRASGAAIACLCSSDKVYA
DAAVPAAKALQAAGARHIYLAGRGGEQEEALREAGIGSFVFAGGDALATLEDAYTHLE

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates. This conversion most likely represents an important source of building blocks for polyketide antibiotic biosynthes

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methylmalonyl-CoA mutase family [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=486, Percent_Identity=26.1316872427983, Blast_Score=125, Evalue=1e-28,
Organism=Escherichia coli, GI1789284, Length=468, Percent_Identity=26.2820512820513, Blast_Score=144, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI25144500, Length=249, Percent_Identity=32.9317269076305, Blast_Score=128, Evalue=7e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR004608 [H]

Pfam domain/function: PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 63689; Mature: 63557

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTDTEQLRLAADFAPASEADWRKLVDGVLKGAAFEKLVGKTYDGLKIQPIYSRAQGAAP
CCCCHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHCCCCCC
VAGRAPAAAWQIMQRVDHRDAGKANAQALLDLENGATGLTLVFAGANAAHGFGLAATADA
CCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCCCHHHHHHH
LARALDGVHLDAAIAIELQATDASAAALLADYVKQRGFKPGACDIRFGLDPIGDAASSGA
HHHHHCCCEECEEEEEEEEECCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHCCCC
SAHDAGALAGSAVDLVKQLHGAGFQGPFLAADGRVVHDAGGSEAQELAFVLASGVAYLRA
CCCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCEEEECCCCCHHHHHHHHHHHHHHHHHH
LEAGGIALETARGLIFARLAADTDQFLTLAKFRSLRRLWARIEEACGLQPKPLVVSGETA
HHCCCEEEEHHCCCEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHH
WRMLTRRDPYVNMLRATIATLAAGLGGANAITVLPHTAALGLPDAFARRVARNTQLVLLE
HHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHCCCCHHHHHHHHCCCEEEEEE
ESNLARVADPAAGAGGIEALTSELSTTAWALFQEIEKAGGIVAALQAGLIQSKVAAVKQA
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
RDVNIARRRDVLTGASEFPNLNEADVSVEAVAPLPSPPPVKAALSFAPLAPIRLADAFEK
HCCCHHHHHHHHCCHHHCCCCCCCCEEEEEECCCCCCCCHHHHHCCCCCCHHHHHHHHHH
LRDRSDALLKSKGGRPHVFLANLGSAADYTARATFARSFFEAGGIAAVDGEGGSDPAALA
HHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHH
AAYRASGAAIACLCSSDKVYADAAVPAAKALQAAGARHIYLAGRGGEQEEALREAGIGSF
HHHHCCCCEEEEEECCCCEEEHHHCCHHHHHHHCCCCEEEEECCCCCHHHHHHHCCCCCE
VFAGGDALATLEDAYTHLE
EEECCCHHHHHHHHHHCCC
>Mature Secondary Structure 
TTDTEQLRLAADFAPASEADWRKLVDGVLKGAAFEKLVGKTYDGLKIQPIYSRAQGAAP
CCCHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHCCCCCC
VAGRAPAAAWQIMQRVDHRDAGKANAQALLDLENGATGLTLVFAGANAAHGFGLAATADA
CCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCCCHHHHHHH
LARALDGVHLDAAIAIELQATDASAAALLADYVKQRGFKPGACDIRFGLDPIGDAASSGA
HHHHHCCCEECEEEEEEEEECCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHCCCC
SAHDAGALAGSAVDLVKQLHGAGFQGPFLAADGRVVHDAGGSEAQELAFVLASGVAYLRA
CCCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCEEEECCCCCHHHHHHHHHHHHHHHHHH
LEAGGIALETARGLIFARLAADTDQFLTLAKFRSLRRLWARIEEACGLQPKPLVVSGETA
HHCCCEEEEHHCCCEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHH
WRMLTRRDPYVNMLRATIATLAAGLGGANAITVLPHTAALGLPDAFARRVARNTQLVLLE
HHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHCCCCHHHHHHHHCCCEEEEEE
ESNLARVADPAAGAGGIEALTSELSTTAWALFQEIEKAGGIVAALQAGLIQSKVAAVKQA
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
RDVNIARRRDVLTGASEFPNLNEADVSVEAVAPLPSPPPVKAALSFAPLAPIRLADAFEK
HCCCHHHHHHHHCCHHHCCCCCCCCEEEEEECCCCCCCCHHHHHCCCCCCHHHHHHHHHH
LRDRSDALLKSKGGRPHVFLANLGSAADYTARATFARSFFEAGGIAAVDGEGGSDPAALA
HHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHH
AAYRASGAAIACLCSSDKVYADAAVPAAKALQAAGARHIYLAGRGGEQEEALREAGIGSF
HHHHCCCCEEEEEECCCCEEEHHHCCHHHHHHHCCCCEEEEECCCCCHHHHHHHCCCCCE
VFAGGDALATLEDAYTHLE
EEECCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8099072 [H]