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The map label for this gene is fabG [C]

Identifier: 146339591

GI number: 146339591

Start: 2768137

End: 2769051

Strand: Reverse

Name: fabG [C]

Synonym: BRADO2583

Alternate gene names: 146339591

Gene position: 2769051-2768137 (Counterclockwise)

Preceding gene: 146339592

Following gene: 146339590

Centisome position: 37.14

GC content: 65.25

Gene sequence:

>915_bases
ATGACCAAATCGCTTCAGGACAAAGTCGTCATCGTCACCGGCGCCGGCCGCGGCATCGGGCGCGAGATCGCGCTGCTGTG
TGCCGCCGAAGGCGCCAAGGTCGTCGTCAACGATCCCGGCGTCGCTTCCGACGGCTCGGGCACCAGCGCCGCGCCCGCGG
AGGAAGTGGTCGAGGAGATCCGGAAGGCCGGCGGCACCGCGGTTGCGAATTTCGAAAGCGTGTCCGAGGCCATCCCCGCC
AGCAGAATCGTGAAGGCCGCGACCGATCATTTCGGCAAGCTCGACGGCGTGGTGAACAATGCCGGCATCCTGCGCGACAT
GATCTTCCACAAGATGAGCATCGAGGCGTTCGAGGCCGTCATCAAGGTGCACCTGATGGGCTCGTTCTATGTGTCGCACT
CCGCGGCGCGGCTGTTCCGCGAGCAGGAGAGCGGCTCGTTCGTGCACTTCACCTCGACCTCGGGCCTGATCGGCAATTAT
GGCCAGGCGAACTACGCCGCCGCCAAGCTCGGCATCGTCGGCCTGTCGAAGTCGATCGCGCTCGACATGGGCCGCTTCAA
CGTGCGCTCGAACTGCGTCTCGCCGTTCGCCTGGAGCCGCATGATCGGGACCATCCCGGCGGAGACCGAGGCCGAGAAGG
AGCGCGTCGAGCGCATGAAGCGGATGGGGCCGGAGAAGATCGCACCGGTCGTCGCCTATCTGCTGGGCGATGCCTCGAAG
GACGTCACCGGCCAGATCTTTGCCGTGCGCATGAACGAGATCTTCCTGATGGGTCAGTCGCGTCCGCTGCGCTCGGTGCA
TCGCGGCGAAGGCTGGACGCCGCAGACCATCGCCGAACACGGCATGCCCGCGCTGAAGCCGTCGTTCTACAAGCTCGATC
GCTCCGCGGATATTTTCGGCTGGGATCCGATCTGA

Upstream 100 bases:

>100_bases
ATTTGAGTCGGGCTTTCTCGCGAACCACTCAGATCCTCAGATGCGGTTGCCAGCGGCCCATGGCCGGAGCAGATTCTCAC
ATCAAGCCAAGGAAACCACC

Downstream 100 bases:

>100_bases
GCGCTGCATCGCGCAAAATCATCTTCGCAGCGCAAACTATCTCAAGTTGTTTTTTATCCGAACAACCCGCTGAAAGCCAC
GATTTCGTCGTATGGTCGCC

Product: putative short-chain dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MTKSLQDKVVIVTGAGRGIGREIALLCAAEGAKVVVNDPGVASDGSGTSAAPAEEVVEEIRKAGGTAVANFESVSEAIPA
SRIVKAATDHFGKLDGVVNNAGILRDMIFHKMSIEAFEAVIKVHLMGSFYVSHSAARLFREQESGSFVHFTSTSGLIGNY
GQANYAAAKLGIVGLSKSIALDMGRFNVRSNCVSPFAWSRMIGTIPAETEAEKERVERMKRMGPEKIAPVVAYLLGDASK
DVTGQIFAVRMNEIFLMGQSRPLRSVHRGEGWTPQTIAEHGMPALKPSFYKLDRSADIFGWDPI

Sequences:

>Translated_304_residues
MTKSLQDKVVIVTGAGRGIGREIALLCAAEGAKVVVNDPGVASDGSGTSAAPAEEVVEEIRKAGGTAVANFESVSEAIPA
SRIVKAATDHFGKLDGVVNNAGILRDMIFHKMSIEAFEAVIKVHLMGSFYVSHSAARLFREQESGSFVHFTSTSGLIGNY
GQANYAAAKLGIVGLSKSIALDMGRFNVRSNCVSPFAWSRMIGTIPAETEAEKERVERMKRMGPEKIAPVVAYLLGDASK
DVTGQIFAVRMNEIFLMGQSRPLRSVHRGEGWTPQTIAEHGMPALKPSFYKLDRSADIFGWDPI
>Mature_303_residues
TKSLQDKVVIVTGAGRGIGREIALLCAAEGAKVVVNDPGVASDGSGTSAAPAEEVVEEIRKAGGTAVANFESVSEAIPAS
RIVKAATDHFGKLDGVVNNAGILRDMIFHKMSIEAFEAVIKVHLMGSFYVSHSAARLFREQESGSFVHFTSTSGLIGNYG
QANYAAAKLGIVGLSKSIALDMGRFNVRSNCVSPFAWSRMIGTIPAETEAEKERVERMKRMGPEKIAPVVAYLLGDASKD
VTGQIFAVRMNEIFLMGQSRPLRSVHRGEGWTPQTIAEHGMPALKPSFYKLDRSADIFGWDPI

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4504505, Length=272, Percent_Identity=42.2794117647059, Blast_Score=191, Evalue=9e-49,
Organism=Homo sapiens, GI15277342, Length=255, Percent_Identity=33.3333333333333, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI40254992, Length=245, Percent_Identity=31.4285714285714, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI19923817, Length=267, Percent_Identity=27.3408239700375, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI4503817, Length=226, Percent_Identity=26.1061946902655, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI32483357, Length=253, Percent_Identity=25.296442687747, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI10190704, Length=253, Percent_Identity=26.8774703557312, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI31542939, Length=204, Percent_Identity=30.8823529411765, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI59889578, Length=166, Percent_Identity=26.5060240963855, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787335, Length=254, Percent_Identity=33.8582677165354, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI1787905, Length=248, Percent_Identity=31.0483870967742, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI2367175, Length=249, Percent_Identity=30.1204819277108, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1787526, Length=252, Percent_Identity=28.5714285714286, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI87082160, Length=254, Percent_Identity=26.3779527559055, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790717, Length=250, Percent_Identity=26, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87082100, Length=251, Percent_Identity=26.2948207171315, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1788459, Length=246, Percent_Identity=26.8292682926829, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1789208, Length=254, Percent_Identity=25.5905511811024, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786812, Length=254, Percent_Identity=27.9527559055118, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1789057, Length=191, Percent_Identity=30.8900523560209, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17568967, Length=247, Percent_Identity=41.7004048582996, Blast_Score=183, Evalue=8e-47,
Organism=Caenorhabditis elegans, GI25147288, Length=256, Percent_Identity=34.375, Blast_Score=111, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17555706, Length=254, Percent_Identity=33.8582677165354, Blast_Score=95, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17564282, Length=197, Percent_Identity=31.9796954314721, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17562910, Length=286, Percent_Identity=28.3216783216783, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17560676, Length=255, Percent_Identity=25.8823529411765, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17561402, Length=257, Percent_Identity=25.6809338521401, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17559104, Length=248, Percent_Identity=29.8387096774194, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI115534694, Length=248, Percent_Identity=25.8064516129032, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17531453, Length=201, Percent_Identity=29.8507462686567, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71997099, Length=199, Percent_Identity=32.6633165829146, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71994604, Length=263, Percent_Identity=27.7566539923954, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17560332, Length=273, Percent_Identity=27.1062271062271, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562906, Length=251, Percent_Identity=27.4900398406374, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17538486, Length=279, Percent_Identity=26.8817204301075, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17560150, Length=279, Percent_Identity=28.3154121863799, Blast_Score=65, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17562908, Length=254, Percent_Identity=25.9842519685039, Blast_Score=65, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17562990, Length=194, Percent_Identity=29.3814432989691, Blast_Score=64, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI193203115, Length=197, Percent_Identity=26.3959390862944, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=263, Percent_Identity=42.9657794676806, Blast_Score=203, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6324126, Length=186, Percent_Identity=30.1075268817204, Blast_Score=75, Evalue=9e-15,
Organism=Drosophila melanogaster, GI18859837, Length=235, Percent_Identity=44.6808510638298, Blast_Score=181, Evalue=5e-46,
Organism=Drosophila melanogaster, GI24639444, Length=246, Percent_Identity=34.9593495934959, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI23397609, Length=258, Percent_Identity=30.2325581395349, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24644339, Length=252, Percent_Identity=27.7777777777778, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17737361, Length=215, Percent_Identity=27.906976744186, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI21355319, Length=255, Percent_Identity=25.8823529411765, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21357041, Length=197, Percent_Identity=28.9340101522843, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI28571526, Length=251, Percent_Identity=27.0916334661355, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24643142, Length=249, Percent_Identity=24.4979919678715, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24640492, Length=197, Percent_Identity=23.8578680203046, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 32616; Mature: 32485

Theoretical pI: Translated: 8.24; Mature: 8.24

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKSLQDKVVIVTGAGRGIGREIALLCAAEGAKVVVNDPGVASDGSGTSAAPAEEVVEEI
CCCCCCCCEEEEEECCCCCCHHEEEEEECCCCEEEEECCCCCCCCCCCCCCCHHHHHHHH
RKAGGTAVANFESVSEAIPASRIVKAATDHFGKLDGVVNNAGILRDMIFHKMSIEAFEAV
HHCCCCEEECHHHHHHHCCHHHHHHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHHHHHHH
IKVHLMGSFYVSHSAARLFREQESGSFVHFTSTSGLIGNYGQANYAAAKLGIVGLSKSIA
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHEECCHHHH
LDMGRFNVRSNCVSPFAWSRMIGTIPAETEAEKERVERMKRMGPEKIAPVVAYLLGDASK
HCCCCCCHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCC
DVTGQIFAVRMNEIFLMGQSRPLRSVHRGEGWTPQTIAEHGMPALKPSFYKLDRSADIFG
CCCCEEEEEEEEEEEEECCCCCHHHHHCCCCCCHHHHHHCCCCCCCCHHHEECCCCCCCC
WDPI
CCCC
>Mature Secondary Structure 
TKSLQDKVVIVTGAGRGIGREIALLCAAEGAKVVVNDPGVASDGSGTSAAPAEEVVEEI
CCCCCCCEEEEEECCCCCCHHEEEEEECCCCEEEEECCCCCCCCCCCCCCCHHHHHHHH
RKAGGTAVANFESVSEAIPASRIVKAATDHFGKLDGVVNNAGILRDMIFHKMSIEAFEAV
HHCCCCEEECHHHHHHHCCHHHHHHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHHHHHHH
IKVHLMGSFYVSHSAARLFREQESGSFVHFTSTSGLIGNYGQANYAAAKLGIVGLSKSIA
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHEECCHHHH
LDMGRFNVRSNCVSPFAWSRMIGTIPAETEAEKERVERMKRMGPEKIAPVVAYLLGDASK
HCCCCCCHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCC
DVTGQIFAVRMNEIFLMGQSRPLRSVHRGEGWTPQTIAEHGMPALKPSFYKLDRSADIFG
CCCCEEEEEEEEEEEEECCCCCHHHHHCCCCCCHHHHHHCCCCCCCCHHHEECCCCCCCC
WDPI
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]