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The map label for this gene is ywrD [H]

Identifier: 146339517

GI number: 146339517

Start: 2679628

End: 2681430

Strand: Reverse

Name: ywrD [H]

Synonym: BRADO2507

Alternate gene names: 146339517

Gene position: 2681430-2679628 (Counterclockwise)

Preceding gene: 146339518

Following gene: 146339516

Centisome position: 35.96

GC content: 69.44

Gene sequence:

>1803_bases
ATGAGCTTCATCAATCCCGATCCCTTCACCACCCGCCCCGAGATCGACGGCACCTTCGGCGTCGTCACCTCGACGCACTG
GCTCGCGACCGCCGTCGGCATGGCCATGCTGGAACGCGGCGGCAATGCGTTCGATGCCGGCGTCGCGGCCGCCTTCACCC
TGCAGGTGGTCGAGCCGCATCTCAACGGCCCCGGCGGCGACGTGCCGATCATCCTGCACGACGTCAAGCGCGGACGCACC
GAGGTGATCTGCGGCCAGGGCCCCGCTCCAGCCGGCGCCACCATCGCGCACTACAAGCGCGAGGGCCTGGACATGGTGCC
CGGCACCGGCCTTCTGGCCGCCTGCGTCCCCGGCACCTTCGAGTCGTGGATGCTGCTGTTGCGCGACTACGGCACGATGC
GGCTGCGCGATGTGCTGGAGCCGGCGATCTCCTACGCCCGCGACGGCTATCCGCTGGTCGAGCGTGTCTCGGCGACCATC
CAGACCGTCGAGCAGCTGTTCAAGACGCATTGGCCGACCTCGGCCGCGCTCTATCTGACGAACGGCGCCGTGCCGAAACC
TGGCGCGCTGTTCACCAATCCCAAGCTCGCCGAGACCTACGCGCGGATCCTAAGCGAGGCCGAGAGCGCCGGGGGGAATC
GCGACGCGCAGATCGAGCGCGCCCGCAAGGCGTGGTCGCAGGGCTTCGTTGCCGAGGCGATCGACCGTTTCTGCCGGACG
CAGGAGGTGATGGACGTCTCGGGTTCGCGCCACAAGGGCGTGCTCACGGCCGACGACATGGCGCGCTGGCAGCCGACCAT
CGAGGCGCCGCTGACCTATCAGTATGGCCGCTACACCGTGTGCAAGGCCGGCGTCTGGAGCCAGGGCCCGGTGCTGCTGC
AACAGCTCGCGCTGCTCAAGGGCTTTGCGCTCGACGGCCTTGATCCGACCGGCCCCGATTTTATCCATTGGCAGATCGAA
GCCGCCAAGCTGGCGTTCGCCGATCGCGAGGCGTTCTACGGCGATCCGAACTTTGCTGACATCCCGATCGAGACCCTGCT
GTCTGACGCCTATAACGACCAGCGGCGCAAGCTGATCACCGAGAAGGCCTCGCTGGAGCTGCGGCCCGGCAGGCTCGACG
GCTACGGCGCCGAGGTGAAGCTGCGCGAGGCGGCAGGTCACCGCGAGGCCGTCGGCGCGATGGGCTCGGGCGAGCCGACC
GTCGGCCGCTTCGGCGAGGTGCGCGGCGACACCGTGCATTTCGACATCATCGATTCCCAAGGCAACATGATCTCGGCGAC
GCCCTCCGGCGGCTGGCTGCAGTCCTCGCCCGTCATTCCCGAGCTCGGCTTCTGCCTCGGCACCCGCGCGCAGATGTTCT
GGCTCGAAGAGAATCATCCGGCAGCACTCGTGCCGGGCAAGCGGCCGCGCACGACCTTGTCGCCGACCATGGCGCTGCGC
GACGGCGAGCCCTACGTCGCCTGGGGCTCGCCCGGCGGCGACCAGCAGGACCAGTGGAACACGCAGTTCTTCCTGCGCCA
CGTCCATGCCGGCATGAACCTGCAGGAATCGATCGACGCGCCCGCTTGGCACTCCGAGCACTTTCCGATCTCGTTCTGGC
CGCGCACCGCGCGTCCCGGCGTGCTCGTCGTCGAGGGCCGTGTGCCGAAGACGACCGTCGAGGAGCTGCGCCGCCGCGGC
CATGTCGTCGAGATCGGCCCCGACTGGTCGGAGGGGCGCCTCACGGCCGCCTCGCGCGTCGGCCGCCGCCGCCGCGCCGC
CGCCAATCCGCGGGGCATGCAGGGCTACGCCGCGGGCCGATAA

Upstream 100 bases:

>100_bases
GCGAAGCGACGAAGCAATCCAGGGGCGGCATCCTGGGCCCCGGGATTGCTTCGCTATCGCTCGCAATGACGACGACTAGC
TACACAGATCAAAGGGCGCC

Downstream 100 bases:

>100_bases
GAGAGCCACACGCCGATGACCTGGTCGATCATAGCGAAGGACGATACAACCGGCCGGATCGGCATCGCCGTTGCCACGCG
CTTCTTCGCCGTCGGCGCGC

Product: putative gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 600; Mature: 599

Protein sequence:

>600_residues
MSFINPDPFTTRPEIDGTFGVVTSTHWLATAVGMAMLERGGNAFDAGVAAAFTLQVVEPHLNGPGGDVPIILHDVKRGRT
EVICGQGPAPAGATIAHYKREGLDMVPGTGLLAACVPGTFESWMLLLRDYGTMRLRDVLEPAISYARDGYPLVERVSATI
QTVEQLFKTHWPTSAALYLTNGAVPKPGALFTNPKLAETYARILSEAESAGGNRDAQIERARKAWSQGFVAEAIDRFCRT
QEVMDVSGSRHKGVLTADDMARWQPTIEAPLTYQYGRYTVCKAGVWSQGPVLLQQLALLKGFALDGLDPTGPDFIHWQIE
AAKLAFADREAFYGDPNFADIPIETLLSDAYNDQRRKLITEKASLELRPGRLDGYGAEVKLREAAGHREAVGAMGSGEPT
VGRFGEVRGDTVHFDIIDSQGNMISATPSGGWLQSSPVIPELGFCLGTRAQMFWLEENHPAALVPGKRPRTTLSPTMALR
DGEPYVAWGSPGGDQQDQWNTQFFLRHVHAGMNLQESIDAPAWHSEHFPISFWPRTARPGVLVVEGRVPKTTVEELRRRG
HVVEIGPDWSEGRLTAASRVGRRRRAAANPRGMQGYAAGR

Sequences:

>Translated_600_residues
MSFINPDPFTTRPEIDGTFGVVTSTHWLATAVGMAMLERGGNAFDAGVAAAFTLQVVEPHLNGPGGDVPIILHDVKRGRT
EVICGQGPAPAGATIAHYKREGLDMVPGTGLLAACVPGTFESWMLLLRDYGTMRLRDVLEPAISYARDGYPLVERVSATI
QTVEQLFKTHWPTSAALYLTNGAVPKPGALFTNPKLAETYARILSEAESAGGNRDAQIERARKAWSQGFVAEAIDRFCRT
QEVMDVSGSRHKGVLTADDMARWQPTIEAPLTYQYGRYTVCKAGVWSQGPVLLQQLALLKGFALDGLDPTGPDFIHWQIE
AAKLAFADREAFYGDPNFADIPIETLLSDAYNDQRRKLITEKASLELRPGRLDGYGAEVKLREAAGHREAVGAMGSGEPT
VGRFGEVRGDTVHFDIIDSQGNMISATPSGGWLQSSPVIPELGFCLGTRAQMFWLEENHPAALVPGKRPRTTLSPTMALR
DGEPYVAWGSPGGDQQDQWNTQFFLRHVHAGMNLQESIDAPAWHSEHFPISFWPRTARPGVLVVEGRVPKTTVEELRRRG
HVVEIGPDWSEGRLTAASRVGRRRRAAANPRGMQGYAAGR
>Mature_599_residues
SFINPDPFTTRPEIDGTFGVVTSTHWLATAVGMAMLERGGNAFDAGVAAAFTLQVVEPHLNGPGGDVPIILHDVKRGRTE
VICGQGPAPAGATIAHYKREGLDMVPGTGLLAACVPGTFESWMLLLRDYGTMRLRDVLEPAISYARDGYPLVERVSATIQ
TVEQLFKTHWPTSAALYLTNGAVPKPGALFTNPKLAETYARILSEAESAGGNRDAQIERARKAWSQGFVAEAIDRFCRTQ
EVMDVSGSRHKGVLTADDMARWQPTIEAPLTYQYGRYTVCKAGVWSQGPVLLQQLALLKGFALDGLDPTGPDFIHWQIEA
AKLAFADREAFYGDPNFADIPIETLLSDAYNDQRRKLITEKASLELRPGRLDGYGAEVKLREAAGHREAVGAMGSGEPTV
GRFGEVRGDTVHFDIIDSQGNMISATPSGGWLQSSPVIPELGFCLGTRAQMFWLEENHPAALVPGKRPRTTLSPTMALRD
GEPYVAWGSPGGDQQDQWNTQFFLRHVHAGMNLQESIDAPAWHSEHFPISFWPRTARPGVLVVEGRVPKTTVEELRRRGH
VVEIGPDWSEGRLTAASRVGRRRRAAANPRGMQGYAAGR

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=561, Percent_Identity=21.74688057041, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI73915090, Length=561, Percent_Identity=21.74688057041, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI73915096, Length=561, Percent_Identity=21.74688057041, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI73915094, Length=561, Percent_Identity=21.74688057041, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI113429324, Length=556, Percent_Identity=21.7625899280576, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI113429326, Length=561, Percent_Identity=21.5686274509804, Blast_Score=96, Evalue=9e-20,
Organism=Homo sapiens, GI109148539, Length=560, Percent_Identity=25.3571428571429, Blast_Score=88, Evalue=3e-17,
Organism=Escherichia coli, GI1789856, Length=588, Percent_Identity=26.0204081632653, Blast_Score=170, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI193208245, Length=542, Percent_Identity=24.9077490774908, Blast_Score=116, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI193208247, Length=595, Percent_Identity=25.0420168067227, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI212646519, Length=540, Percent_Identity=23.3333333333333, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI72000294, Length=540, Percent_Identity=23.3333333333333, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI18859893, Length=567, Percent_Identity=23.1040564373898, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI161077496, Length=577, Percent_Identity=22.3570190641248, Blast_Score=90, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24642670, Length=594, Percent_Identity=21.2121212121212, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24642666, Length=594, Percent_Identity=21.2121212121212, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI45551474, Length=594, Percent_Identity=21.2121212121212, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI161077880, Length=594, Percent_Identity=21.2121212121212, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI161077878, Length=594, Percent_Identity=21.2121212121212, Blast_Score=78, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 65531; Mature: 65400

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFINPDPFTTRPEIDGTFGVVTSTHWLATAVGMAMLERGGNAFDAGVAAAFTLQVVEPH
CCCCCCCCCCCCCCCCCCEEEHCCHHHHHHHHHHHHHHCCCCCHHHHHHHEEEEEEECCC
LNGPGGDVPIILHDVKRGRTEVICGQGPAPAGATIAHYKREGLDMVPGTGLLAACVPGTF
CCCCCCCCCEEEEECCCCCEEEEECCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHCCCCH
ESWMLLLRDYGTMRLRDVLEPAISYARDGYPLVERVSATIQTVEQLFKTHWPTSAALYLT
HHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
NGAVPKPGALFTNPKLAETYARILSEAESAGGNRDAQIERARKAWSQGFVAEAIDRFCRT
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHH
QEVMDVSGSRHKGVLTADDMARWQPTIEAPLTYQYGRYTVCKAGVWSQGPVLLQQLALLK
HHHHHCCCCCCCCCEEHHHHHHCCCCCCCCEEEECCCEEEEECCCCCCCHHHHHHHHHHH
GFALDGLDPTGPDFIHWQIEAAKLAFADREAFYGDPNFADIPIETLLSDAYNDQRRKLIT
CCCCCCCCCCCCCEEEEEEEEEEEEECCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
EKASLELRPGRLDGYGAEVKLREAAGHREAVGAMGSGEPTVGRFGEVRGDTVHFDIIDSQ
HHCCCEECCCCCCCCCCCEEEHHHCCCHHHHCCCCCCCCCCCCCCCCCCCEEEEEEEECC
GNMISATPSGGWLQSSPVIPELGFCLGTRAQMFWLEENHPAALVPGKRPRTTLSPTMALR
CCEEEECCCCCCCCCCCCCCHHHHHHCCCEEEEEEECCCCEEECCCCCCCCCCCCEEEEE
DGEPYVAWGSPGGDQQDQWNTQFFLRHVHAGMNLQESIDAPAWHSEHFPISFWPRTARPG
CCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCEEECCCCCCCC
VLVVEGRVPKTTVEELRRRGHVVEIGPDWSEGRLTAASRVGRRRRAAANPRGMQGYAAGR
EEEEECCCCHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
SFINPDPFTTRPEIDGTFGVVTSTHWLATAVGMAMLERGGNAFDAGVAAAFTLQVVEPH
CCCCCCCCCCCCCCCCCEEEHCCHHHHHHHHHHHHHHCCCCCHHHHHHHEEEEEEECCC
LNGPGGDVPIILHDVKRGRTEVICGQGPAPAGATIAHYKREGLDMVPGTGLLAACVPGTF
CCCCCCCCCEEEEECCCCCEEEEECCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHCCCCH
ESWMLLLRDYGTMRLRDVLEPAISYARDGYPLVERVSATIQTVEQLFKTHWPTSAALYLT
HHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
NGAVPKPGALFTNPKLAETYARILSEAESAGGNRDAQIERARKAWSQGFVAEAIDRFCRT
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHH
QEVMDVSGSRHKGVLTADDMARWQPTIEAPLTYQYGRYTVCKAGVWSQGPVLLQQLALLK
HHHHHCCCCCCCCCEEHHHHHHCCCCCCCCEEEECCCEEEEECCCCCCCHHHHHHHHHHH
GFALDGLDPTGPDFIHWQIEAAKLAFADREAFYGDPNFADIPIETLLSDAYNDQRRKLIT
CCCCCCCCCCCCCEEEEEEEEEEEEECCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
EKASLELRPGRLDGYGAEVKLREAAGHREAVGAMGSGEPTVGRFGEVRGDTVHFDIIDSQ
HHCCCEECCCCCCCCCCCEEEHHHCCCHHHHCCCCCCCCCCCCCCCCCCCEEEEEEEECC
GNMISATPSGGWLQSSPVIPELGFCLGTRAQMFWLEENHPAALVPGKRPRTTLSPTMALR
CCEEEECCCCCCCCCCCCCCHHHHHHCCCEEEEEEECCCCEEECCCCCCCCCCCCEEEEE
DGEPYVAWGSPGGDQQDQWNTQFFLRHVHAGMNLQESIDAPAWHSEHFPISFWPRTARPG
CCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCEEECCCCCCCC
VLVVEGRVPKTTVEELRRRGHVVEIGPDWSEGRLTAASRVGRRRRAAANPRGMQGYAAGR
EEEEECCCCHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]