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The map label for this gene is hemF [H]

Identifier: 146339023

GI number: 146339023

Start: 2098989

End: 2099876

Strand: Reverse

Name: hemF [H]

Synonym: BRADO1972

Alternate gene names: 146339023

Gene position: 2099876-2098989 (Counterclockwise)

Preceding gene: 146339024

Following gene: 146339022

Centisome position: 28.16

GC content: 66.55

Gene sequence:

>888_bases
ATGACCACTGCCGCCATCGAGGATCGCAAGGCTCGCGCCCGTGCCTGGTTCGAGAGCCTGCGCGATCAGATCTGCGCGGC
GTTCGAGCGGCTCGAGGAGGAGGCGCCGGCCGACCTGTATCCCCGGGCGTCCGCCCACTTCGTGCGCACGCCGTGGGAGC
GCACCGACCATGGCGGCGGCCACGGCGGCGGCGGCGTCATGAGCATGATGCATGGCCGGCTGTTCGAAAAGGTCGGCGTG
CACTGCTCGACCGTGCACGGCGAGTTCGCGCCCGAATTCCGCAGCCAGATCCCCGGCGCGTCGGAGGACCCGCGGTTCTG
GGCTTCGGGCATCTCGCTGATCGCGCATCTGTGGTCGCCCCACGTGCCGGCGGTGCACATGAACACCCGCTTCGTCGTCA
CCACCAAGTCCTGGTTCGGCGGCGGCGCCGATCTCACCCCGGTGCTGGACCGACGGCGCAACCAGGAGGACCCGGATACG
GTCGCCTTCCATGCCGCGATGAAGGGCGCCTGCGACGCGCATGCGGCTGTGGCGTCCTACGACAAGTACAAGCGCTGGTG
CGACGAGTACTTCTACCTGCCGCATCGCAAGGAGCCGCGCGGCATCGGCGGCATCTTTTATGATCATCATGATTCCGGCA
ACTGGGACGCCGACCTCGCCTTCACCCAGGACGTCGGACGCGCCTTCCTGAAAGTCTATCCCGATCTGGTCCGGCGCAAT
TTCAGTGCGCCGTGGACGGAGGCCGATCGCGAGGAGCAGCTGATCCGCCGCGGCCGCTACGTCGAATTCAACCTGCTTTA
TGACCGCGGCACCACATTTGGGCTCAAAACCGGCGGCAATGTCGACAGCATTCTGTCCTCGATGCCCCCCGAGGTGAAAT
GGCCGTGA

Upstream 100 bases:

>100_bases
GAGTGTGGTAGGACGTCACCGGTAGAGACAACGACGCTGTCACCCATCGCCGTCATGGCGTCTTGACAAGGGGGGCGGCC
AATTTGCCCCGGGGGACGCT

Downstream 100 bases:

>100_bases
AACTCGTTGTCTTGAACCGCGTAGATTGAGTCATGACGGCCGCCCTGCCCCGCGCCATGCTGATCGACATGGATGACACC
ATCCTGTCGGCCTACGGCCG

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 295; Mature: 294

Protein sequence:

>295_residues
MTTAAIEDRKARARAWFESLRDQICAAFERLEEEAPADLYPRASAHFVRTPWERTDHGGGHGGGGVMSMMHGRLFEKVGV
HCSTVHGEFAPEFRSQIPGASEDPRFWASGISLIAHLWSPHVPAVHMNTRFVVTTKSWFGGGADLTPVLDRRRNQEDPDT
VAFHAAMKGACDAHAAVASYDKYKRWCDEYFYLPHRKEPRGIGGIFYDHHDSGNWDADLAFTQDVGRAFLKVYPDLVRRN
FSAPWTEADREEQLIRRGRYVEFNLLYDRGTTFGLKTGGNVDSILSSMPPEVKWP

Sequences:

>Translated_295_residues
MTTAAIEDRKARARAWFESLRDQICAAFERLEEEAPADLYPRASAHFVRTPWERTDHGGGHGGGGVMSMMHGRLFEKVGV
HCSTVHGEFAPEFRSQIPGASEDPRFWASGISLIAHLWSPHVPAVHMNTRFVVTTKSWFGGGADLTPVLDRRRNQEDPDT
VAFHAAMKGACDAHAAVASYDKYKRWCDEYFYLPHRKEPRGIGGIFYDHHDSGNWDADLAFTQDVGRAFLKVYPDLVRRN
FSAPWTEADREEQLIRRGRYVEFNLLYDRGTTFGLKTGGNVDSILSSMPPEVKWP
>Mature_294_residues
TTAAIEDRKARARAWFESLRDQICAAFERLEEEAPADLYPRASAHFVRTPWERTDHGGGHGGGGVMSMMHGRLFEKVGVH
CSTVHGEFAPEFRSQIPGASEDPRFWASGISLIAHLWSPHVPAVHMNTRFVVTTKSWFGGGADLTPVLDRRRNQEDPDTV
AFHAAMKGACDAHAAVASYDKYKRWCDEYFYLPHRKEPRGIGGIFYDHHDSGNWDADLAFTQDVGRAFLKVYPDLVRRNF
SAPWTEADREEQLIRRGRYVEFNLLYDRGTTFGLKTGGNVDSILSSMPPEVKWP

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=302, Percent_Identity=38.4105960264901, Blast_Score=189, Evalue=2e-48,
Organism=Escherichia coli, GI1788777, Length=293, Percent_Identity=39.2491467576792, Blast_Score=196, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6320249, Length=299, Percent_Identity=39.7993311036789, Blast_Score=198, Evalue=1e-51,
Organism=Drosophila melanogaster, GI17864388, Length=302, Percent_Identity=38.4105960264901, Blast_Score=193, Evalue=1e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 33357; Mature: 33225

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTAAIEDRKARARAWFESLRDQICAAFERLEEEAPADLYPRASAHFVRTPWERTDHGGG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCCC
HGGGGVMSMMHGRLFEKVGVHCSTVHGEFAPEFRSQIPGASEDPRFWASGISLIAHLWSP
CCCHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHCC
HVPAVHMNTRFVVTTKSWFGGGADLTPVLDRRRNQEDPDTVAFHAAMKGACDAHAAVASY
CCCEEEECCEEEEEEHHHCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHH
DKYKRWCDEYFYLPHRKEPRGIGGIFYDHHDSGNWDADLAFTQDVGRAFLKVYPDLVRRN
HHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
FSAPWTEADREEQLIRRGRYVEFNLLYDRGTTFGLKTGGNVDSILSSMPPEVKWP
CCCCCCCCHHHHHHHHCCCCEEEEEEEECCCEEEECCCCCHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TTAAIEDRKARARAWFESLRDQICAAFERLEEEAPADLYPRASAHFVRTPWERTDHGGG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCCC
HGGGGVMSMMHGRLFEKVGVHCSTVHGEFAPEFRSQIPGASEDPRFWASGISLIAHLWSP
CCCHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHCC
HVPAVHMNTRFVVTTKSWFGGGADLTPVLDRRRNQEDPDTVAFHAAMKGACDAHAAVASY
CCCEEEECCEEEEEEHHHCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHH
DKYKRWCDEYFYLPHRKEPRGIGGIFYDHHDSGNWDADLAFTQDVGRAFLKVYPDLVRRN
HHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
FSAPWTEADREEQLIRRGRYVEFNLLYDRGTTFGLKTGGNVDSILSSMPPEVKWP
CCCCCCCCHHHHHHHHCCCCEEEEEEEECCCEEEECCCCCHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]