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The map label for this gene is crtE [H]

Identifier: 146338683

GI number: 146338683

Start: 1729716

End: 1730585

Strand: Direct

Name: crtE [H]

Synonym: BRADO1615

Alternate gene names: 146338683

Gene position: 1729716-1730585 (Clockwise)

Preceding gene: 146338680

Following gene: 146338684

Centisome position: 23.2

GC content: 71.03

Gene sequence:

>870_bases
ATGGACGTGATGGCCCGGATCGAAAAATCCCTCGTCGCTGCGGTCGCGCTGGCCGGCCGGCCCGGATGTCCGCCACGGCT
TTCGGCGGCCATGCAGGCGGCTGTCTTCCCCAAGGGCGCGCGGGTGCGGCCAAGGCTCTGTCATGCGGTGGCGGCGGCGT
GTGGCGACGACGAGCCGGCGGCGACCGATGCCGCGGGATCGGCCATCGAGCTGTTGCACTGCGCCTCGCTGGTCCATGAC
GATCTGCCGTGCTTCGACAATGCCAAGCTGCGGCGCGGCCGACCGTCGGTGCATGCCGCGTTCGGTGAGCCGCTTGCGGT
GCTCGCCGGCGATGCGCTGATCGTGCTCGCCTTCCAGACGCTCGCCAAGTCGCGCTGCTCGCCGCTGCGGCTGGCGCGAC
TGATCGAGACGATCGGCGACGCCGTCGGCGTGCCGCATGGCATTGCGGCTGGGCAAGCCTGGGAATGCGAGCCGGAGATC
GATCTGTCGCATTATCACCGCTCCAAGACCGGTGCGTTGTTCGCGGCCGCCACGATCTCTGGCGCCGCGGCAGCGGGGCA
TGCCGATCCGGAGGCCTGGCGCAGCCTGGGCGAGAAGATCGGCGAGGCCTATCAGGTCGCCGACGATATCCGCGATGCGG
CGAGTGATGAGGAGGAGGCCGGCAAGCCGGTCGGGCAGGATGCCGCCCTGGGACGTCCGAACGCCGTGCTGCGCTACGGC
CTCGCGGGCGCCGTGAGCTATCTCCACGATCTGGTCGCCGACGGCATCCGCACCATGCCGCCCTGCGCCCATGCGCACGA
GCTGCGCGCCCTGATGGAGCAGGAAGCCAAGCGCCTGGTGCCGCGCCGCCTGGCGGCGTCGGCGGCGTGA

Upstream 100 bases:

>100_bases
GGACCTGCTGCAGGAAATGTCTAGCATGATTTACAGTATGAGTGTAAGTTAGAATTTACATAGGCGAGGACCCGAATGGC
CTCGCGGCAGGGAGGCTCGC

Downstream 100 bases:

>100_bases
TTTGAAGTCATCGGGAGGCGTGTTCCGTGAGACGAGAACGTCTGCTCATCAGTTGCTCCTCATGGCCGGGCTTGACCCGG
GCATCCTTGACGCCCTTTCC

Product: geranylgeranyl pyrophosphate synthetase

Products: NA

Alternate protein names: GGPP synthase; Farnesyltranstransferase [H]

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MDVMARIEKSLVAAVALAGRPGCPPRLSAAMQAAVFPKGARVRPRLCHAVAAACGDDEPAATDAAGSAIELLHCASLVHD
DLPCFDNAKLRRGRPSVHAAFGEPLAVLAGDALIVLAFQTLAKSRCSPLRLARLIETIGDAVGVPHGIAAGQAWECEPEI
DLSHYHRSKTGALFAAATISGAAAAGHADPEAWRSLGEKIGEAYQVADDIRDAASDEEEAGKPVGQDAALGRPNAVLRYG
LAGAVSYLHDLVADGIRTMPPCAHAHELRALMEQEAKRLVPRRLAASAA

Sequences:

>Translated_289_residues
MDVMARIEKSLVAAVALAGRPGCPPRLSAAMQAAVFPKGARVRPRLCHAVAAACGDDEPAATDAAGSAIELLHCASLVHD
DLPCFDNAKLRRGRPSVHAAFGEPLAVLAGDALIVLAFQTLAKSRCSPLRLARLIETIGDAVGVPHGIAAGQAWECEPEI
DLSHYHRSKTGALFAAATISGAAAAGHADPEAWRSLGEKIGEAYQVADDIRDAASDEEEAGKPVGQDAALGRPNAVLRYG
LAGAVSYLHDLVADGIRTMPPCAHAHELRALMEQEAKRLVPRRLAASAA
>Mature_289_residues
MDVMARIEKSLVAAVALAGRPGCPPRLSAAMQAAVFPKGARVRPRLCHAVAAACGDDEPAATDAAGSAIELLHCASLVHD
DLPCFDNAKLRRGRPSVHAAFGEPLAVLAGDALIVLAFQTLAKSRCSPLRLARLIETIGDAVGVPHGIAAGQAWECEPEI
DLSHYHRSKTGALFAAATISGAAAAGHADPEAWRSLGEKIGEAYQVADDIRDAASDEEEAGKPVGQDAALGRPNAVLRYG
LAGAVSYLHDLVADGIRTMPPCAHAHELRALMEQEAKRLVPRRLAASAA

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=275, Percent_Identity=28.3636363636364, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1786623, Length=266, Percent_Identity=35.7142857142857, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI1789578, Length=205, Percent_Identity=35.1219512195122, Blast_Score=98, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17505681, Length=181, Percent_Identity=34.8066298342541, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24651612, Length=167, Percent_Identity=32.9341317365269, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.29 [H]

Molecular weight: Translated: 30098; Mature: 30098

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVMARIEKSLVAAVALAGRPGCPPRLSAAMQAAVFPKGARVRPRLCHAVAAACGDDEPA
CCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCC
ATDAAGSAIELLHCASLVHDDLPCFDNAKLRRGRPSVHAAFGEPLAVLAGDALIVLAFQT
CHHHCCHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCHHHHCCCCHHHHHCCHHHHHHHHH
LAKSRCSPLRLARLIETIGDAVGVPHGIAAGQAWECEPEIDLSHYHRSKTGALFAAATIS
HHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHCCHHCHHHHHHHHH
GAAAAGHADPEAWRSLGEKIGEAYQVADDIRDAASDEEEAGKPVGQDAALGRPNAVLRYG
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCHHHHHHH
LAGAVSYLHDLVADGIRTMPPCAHAHELRALMEQEAKRLVPRRLAASAA
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDVMARIEKSLVAAVALAGRPGCPPRLSAAMQAAVFPKGARVRPRLCHAVAAACGDDEPA
CCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCC
ATDAAGSAIELLHCASLVHDDLPCFDNAKLRRGRPSVHAAFGEPLAVLAGDALIVLAFQT
CHHHCCHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCHHHHCCCCHHHHHCCHHHHHHHHH
LAKSRCSPLRLARLIETIGDAVGVPHGIAAGQAWECEPEIDLSHYHRSKTGALFAAATIS
HHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHCCHHCHHHHHHHHH
GAAAAGHADPEAWRSLGEKIGEAYQVADDIRDAASDEEEAGKPVGQDAALGRPNAVLRYG
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCHHHHHHH
LAGAVSYLHDLVADGIRTMPPCAHAHELRALMEQEAKRLVPRRLAASAA
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721699; 10648776 [H]