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The map label for this gene is kynA [H]

Identifier: 146338601

GI number: 146338601

Start: 1633253

End: 1634092

Strand: Direct

Name: kynA [H]

Synonym: BRADO1529

Alternate gene names: 146338601

Gene position: 1633253-1634092 (Clockwise)

Preceding gene: 146338600

Following gene: 146338602

Centisome position: 21.9

GC content: 64.52

Gene sequence:

>840_bases
GTGAGCAACGCGCCCTACGATCCCGCCACCGAAGGTGCGCGGATGAACTTCAAGGGACGTATGTCCTACGGCGATTACCT
GATGCTGGAGCGCCTGCTCGACGCGCAGGCGCCGCTGTCCTCGGCGCATGACGAACTGCTGTTCATCATTCAGCACCAGA
CCTCCGAGCTGTGGATGAAGCTCGCGATCCACGAGATCAAGGCGGCGATGGCGGCGATCGCGAGGGACGACGTGCAGCCG
GCGTTCAAGATGCTGGCGCGCGTGTCGCGCATCTTCGAGCAGCTCAACGGCGCCTGGGACGTGCTGCGCACGATGACGCC
CAGCGAATATACGCTGTTCCGCGACAAGCTCGGCGAGTCCTCCGGCTTCCAGTCGTTCCAATATCGCTCGATCGAATTCC
TGCTCGGCAACCGTAATCTCGCGATGCTGCGTCCGCATGCGCATCACCCCGAGCTGACCGCCGAGCTGGAATCGATCCTC
GCCAAGCCGAGCCTCTACGACGAGGCGCTGCGGCTGTTGGCCCGGCGCGGCTTCTTCATCGGCGCCGACGGCCAGCGCAC
CGACTGGCGGGGCACGCGCGCGGAGAGCGCGGAGGTGGCTGCGGCCTGGACCAGCGTCTATCGCGATCCGCAGCGGCATT
GGGAGCTGTACGAGCTCGCCGAGAAGCTGGTCGATTTCGAGGACTATTTCCGCCGCTGGCGCTTCAACCATGTCACCACG
GTGGAGCGCATCATCGGCTTCAAGACCGGCACCGGCGGCACCTCGGGCGTGAACTATCTCCGCAAGATGCTGGAGATCGT
GCTGTTCCCCGAATTGTGGAAATTGCGCACCGGGCTGTAG

Upstream 100 bases:

>100_bases
TCGGCGAGGCCGAGGTGCGCGGTGCCGTCGATATCCTCGAGGATGTCCTGGCCAAGAAGCTGTGGGACAGGCCCGAATAT
CGCCAGAAGGAGCTCGTGAC

Downstream 100 bases:

>100_bases
AGCCGCGCGCACTCATTCGATCTGGAGATCCTCATGCTGCATTCCGTCAAGGATTGGGACAACGCCTACGCCAACGGCCC
GAACATCCCCGGCGGCGAAC

Product: tryptophan 2,3-dioxygenase

Products: NA

Alternate protein names: TDO; Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; TO; TRPO; Tryptophan pyrrolase; Tryptophanase [H]

Number of amino acids: Translated: 279; Mature: 278

Protein sequence:

>279_residues
MSNAPYDPATEGARMNFKGRMSYGDYLMLERLLDAQAPLSSAHDELLFIIQHQTSELWMKLAIHEIKAAMAAIARDDVQP
AFKMLARVSRIFEQLNGAWDVLRTMTPSEYTLFRDKLGESSGFQSFQYRSIEFLLGNRNLAMLRPHAHHPELTAELESIL
AKPSLYDEALRLLARRGFFIGADGQRTDWRGTRAESAEVAAAWTSVYRDPQRHWELYELAEKLVDFEDYFRRWRFNHVTT
VERIIGFKTGTGGTSGVNYLRKMLEIVLFPELWKLRTGL

Sequences:

>Translated_279_residues
MSNAPYDPATEGARMNFKGRMSYGDYLMLERLLDAQAPLSSAHDELLFIIQHQTSELWMKLAIHEIKAAMAAIARDDVQP
AFKMLARVSRIFEQLNGAWDVLRTMTPSEYTLFRDKLGESSGFQSFQYRSIEFLLGNRNLAMLRPHAHHPELTAELESIL
AKPSLYDEALRLLARRGFFIGADGQRTDWRGTRAESAEVAAAWTSVYRDPQRHWELYELAEKLVDFEDYFRRWRFNHVTT
VERIIGFKTGTGGTSGVNYLRKMLEIVLFPELWKLRTGL
>Mature_278_residues
SNAPYDPATEGARMNFKGRMSYGDYLMLERLLDAQAPLSSAHDELLFIIQHQTSELWMKLAIHEIKAAMAAIARDDVQPA
FKMLARVSRIFEQLNGAWDVLRTMTPSEYTLFRDKLGESSGFQSFQYRSIEFLLGNRNLAMLRPHAHHPELTAELESILA
KPSLYDEALRLLARRGFFIGADGQRTDWRGTRAESAEVAAAWTSVYRDPQRHWELYELAEKLVDFEDYFRRWRFNHVTTV
ERIIGFKTGTGGTSGVNYLRKMLEIVLFPELWKLRTGL

Specific function: Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring [H]

COG id: COG3483

COG function: function code E; Tryptophan 2,3-dioxygenase (vermilion)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tryptophan 2,3-dioxygenase family [H]

Homologues:

Organism=Homo sapiens, GI5032165, Length=348, Percent_Identity=28.448275862069, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17552370, Length=338, Percent_Identity=26.9230769230769, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI32564651, Length=138, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17530891, Length=331, Percent_Identity=32.3262839879154, Blast_Score=108, Evalue=6e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017485
- InterPro:   IPR004981 [H]

Pfam domain/function: PF03301 Trp_dioxygenase [H]

EC number: =1.13.11.11 [H]

Molecular weight: Translated: 32198; Mature: 32067

Theoretical pI: Translated: 7.32; Mature: 7.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNAPYDPATEGARMNFKGRMSYGDYLMLERLLDAQAPLSSAHDELLFIIQHQTSELWMK
CCCCCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEHHHHHHHHH
LAIHEIKAAMAAIARDDVQPAFKMLARVSRIFEQLNGAWDVLRTMTPSEYTLFRDKLGES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCC
SGFQSFQYRSIEFLLGNRNLAMLRPHAHHPELTAELESILAKPSLYDEALRLLARRGFFI
CCCCHHHHHEEEEEECCCCEEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCEE
GADGQRTDWRGTRAESAEVAAAWTSVYRDPQRHWELYELAEKLVDFEDYFRRWRFNHVTT
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCHHHHHHHHCCCHHHH
VERIIGFKTGTGGTSGVNYLRKMLEIVLFPELWKLRTGL
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SNAPYDPATEGARMNFKGRMSYGDYLMLERLLDAQAPLSSAHDELLFIIQHQTSELWMK
CCCCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEHHHHHHHHH
LAIHEIKAAMAAIARDDVQPAFKMLARVSRIFEQLNGAWDVLRTMTPSEYTLFRDKLGES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCC
SGFQSFQYRSIEFLLGNRNLAMLRPHAHHPELTAELESILAKPSLYDEALRLLARRGFFI
CCCCHHHHHEEEEEECCCCEEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCEE
GADGQRTDWRGTRAESAEVAAAWTSVYRDPQRHWELYELAEKLVDFEDYFRRWRFNHVTT
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCHHHHHHHHCCCHHHH
VERIIGFKTGTGGTSGVNYLRKMLEIVLFPELWKLRTGL
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA