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The map label for this gene is ygeZ [C]

Identifier: 146338571

GI number: 146338571

Start: 1597121

End: 1598524

Strand: Direct

Name: ygeZ [C]

Synonym: BRADO1492

Alternate gene names: 146338571

Gene position: 1597121-1598524 (Clockwise)

Preceding gene: 146338570

Following gene: 146338572

Centisome position: 21.42

GC content: 65.53

Gene sequence:

>1404_bases
ATGGCTGCATTCGACACCGTCATCCGCAACGGCACCGTCGCCACCGCGAGCGACACCTATCTGGCCGACGTCGCCATCAA
GAGCGGCCGCATCGCCGCCATCGGCGAGGCCATCACCGATGCCGAAGAGATCGTCGATGCGAGCGGCCTGCTGGTGCTGC
CCGGCGGCATCGACAGCCATGTCCACATCAGCCAGCCGTCCGGCCCCGGCATCGTCATGGCCGACGATTTCGAGAGCGCG
ACGCGCGCCGCCGCCTTCGGGGGCAACACTTTCGTGATGCCCTATTGCCTGCAGGAGAAGGGCCAGCCTTTGCGCGCGGC
GCTGAAGGATTATCACGCGCTGGCCGACCAGGCCTGCTATATCGATCATTCCTTCCACCTGATCATCGCCGATCCCACGG
ATGCCGTGCTCGGCCAGGAGCTGCCGGCACTGGTCGCCGACGGCTATTCGTCGCTGAAGATCTTCATGACCTATGACGGC
CTCGCGCTGAACGACTACGAGATTCTCGGCGTGCTCCAGGTCGCGCGCGAGCAGGGCGCGCTGGTGCAGATCCACGCCGA
GAACTACGACGCCATCCGCTTCCTCACCGACCGGCTCGAGCGCGAAGGCAAGATCGCGCCGTACTATCACGGCAAGTCGC
GCCCGATCCCGGTCGAGCGCGAGGCCACCCATCGCGCGATCTCGTTGGCTGAGCTCATCGACGTGCCGATCGTGATCGTC
CACGTCTCCAACCGCGAGGCGATGGAGGAGATCCGCCGCGCGCAGATGCGAGGCCTGAAGATCCATGGCGAGACCTGCCC
GCAATATCTGGTGCTCACCGAAGAGGACATGCAGGGCCTCAACATGGAGGGCGCCAAATATGTCTGTTCGCCGCCGCCCC
GTGACAAGGCGAGCCAGGAGGCTTGCTGGGAAGGCCTGCAGCAGGGCGTGTTCTCGCTGTTCTCGTCAGATCACTGCCCG
TTCCGCTACGACGACGAGGCCGGCAAGCTGACGCCGAAGGGCCGCACCAGCTTCCGCTGGGTCCCGAACGGCATCCCCGG
CGTCGAGACCCGCCTGCCGATCCTGTTCTCCGAGGGCGTCAGCAAGGGCCGCATCACCCTCAACCAGTTCGTCGCGCTCA
CCGCGACCAACCATGCCAAGACGTATGGCCTGAAAGGCAAGGGCTCGATCGCCATCGGCTACGATGCGGACATCGCGTTG
TGGGATCCGGCCAAGACCGCCAAGATCAGCCAGACCGGCCTGCACCACGGCTCTGACTACACGCCCTATGAGGGCATCGA
GATATCAGGCTGGCCGGTCGCCACCATGCTGCGCGGAAAATTCGTCGTGCGCGATGGCAAGCTCCTCGGCGCGAAAGGCG
ATGGCCGCTACGTCACGCGCGGCAAGCCGGGCGGCGTGGCGTAA

Upstream 100 bases:

>100_bases
AAATCGCTGAAGCTGGCCGGCGTCGACCCCCGTGGCGTCAGCGAATGGGGATCGCTGTTTCACAAATTCGCCTGAGCCTG
GAATTGGGAGAGCGCGTCAC

Downstream 100 bases:

>100_bases
GGCGCGCTCTCTCCAAGCGTCGTTGCGAGCGAAGCGAACCAATCCAGGGTAGTGAGCGGGACTCTGGATTGCTTCGTCGC
GGAGCCTGCCCTCGGGCTCG

Product: phenylhydantoinase

Products: 3-ureidopropanoate

Alternate protein names: NA

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MAAFDTVIRNGTVATASDTYLADVAIKSGRIAAIGEAITDAEEIVDASGLLVLPGGIDSHVHISQPSGPGIVMADDFESA
TRAAAFGGNTFVMPYCLQEKGQPLRAALKDYHALADQACYIDHSFHLIIADPTDAVLGQELPALVADGYSSLKIFMTYDG
LALNDYEILGVLQVAREQGALVQIHAENYDAIRFLTDRLEREGKIAPYYHGKSRPIPVEREATHRAISLAELIDVPIVIV
HVSNREAMEEIRRAQMRGLKIHGETCPQYLVLTEEDMQGLNMEGAKYVCSPPPRDKASQEACWEGLQQGVFSLFSSDHCP
FRYDDEAGKLTPKGRTSFRWVPNGIPGVETRLPILFSEGVSKGRITLNQFVALTATNHAKTYGLKGKGSIAIGYDADIAL
WDPAKTAKISQTGLHHGSDYTPYEGIEISGWPVATMLRGKFVVRDGKLLGAKGDGRYVTRGKPGGVA

Sequences:

>Translated_467_residues
MAAFDTVIRNGTVATASDTYLADVAIKSGRIAAIGEAITDAEEIVDASGLLVLPGGIDSHVHISQPSGPGIVMADDFESA
TRAAAFGGNTFVMPYCLQEKGQPLRAALKDYHALADQACYIDHSFHLIIADPTDAVLGQELPALVADGYSSLKIFMTYDG
LALNDYEILGVLQVAREQGALVQIHAENYDAIRFLTDRLEREGKIAPYYHGKSRPIPVEREATHRAISLAELIDVPIVIV
HVSNREAMEEIRRAQMRGLKIHGETCPQYLVLTEEDMQGLNMEGAKYVCSPPPRDKASQEACWEGLQQGVFSLFSSDHCP
FRYDDEAGKLTPKGRTSFRWVPNGIPGVETRLPILFSEGVSKGRITLNQFVALTATNHAKTYGLKGKGSIAIGYDADIAL
WDPAKTAKISQTGLHHGSDYTPYEGIEISGWPVATMLRGKFVVRDGKLLGAKGDGRYVTRGKPGGVA
>Mature_466_residues
AAFDTVIRNGTVATASDTYLADVAIKSGRIAAIGEAITDAEEIVDASGLLVLPGGIDSHVHISQPSGPGIVMADDFESAT
RAAAFGGNTFVMPYCLQEKGQPLRAALKDYHALADQACYIDHSFHLIIADPTDAVLGQELPALVADGYSSLKIFMTYDGL
ALNDYEILGVLQVAREQGALVQIHAENYDAIRFLTDRLEREGKIAPYYHGKSRPIPVEREATHRAISLAELIDVPIVIVH
VSNREAMEEIRRAQMRGLKIHGETCPQYLVLTEEDMQGLNMEGAKYVCSPPPRDKASQEACWEGLQQGVFSLFSSDHCPF
RYDDEAGKLTPKGRTSFRWVPNGIPGVETRLPILFSEGVSKGRITLNQFVALTATNHAKTYGLKGKGSIAIGYDADIALW
DPAKTAKISQTGLHHGSDYTPYEGIEISGWPVATMLRGKFVVRDGKLLGAKGDGRYVTRGKPGGVA

Specific function: Catalyzes the stereospecific hydrolysis of the cyclic amide bond of D-hydantoin. Has no activity on dihydropyrimidines [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503375, Length=470, Percent_Identity=34.468085106383, Blast_Score=243, Evalue=4e-64,
Organism=Homo sapiens, GI4503377, Length=464, Percent_Identity=33.6206896551724, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI190194363, Length=461, Percent_Identity=32.5379609544469, Blast_Score=238, Evalue=1e-62,
Organism=Homo sapiens, GI4503051, Length=461, Percent_Identity=32.7548806941432, Blast_Score=237, Evalue=1e-62,
Organism=Homo sapiens, GI62422571, Length=461, Percent_Identity=32.7548806941432, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI4503379, Length=459, Percent_Identity=30.9368191721133, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI19923821, Length=467, Percent_Identity=32.5481798715203, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI18105007, Length=433, Percent_Identity=24.4803695150115, Blast_Score=102, Evalue=8e-22,
Organism=Escherichia coli, GI87082175, Length=463, Percent_Identity=37.5809935205184, Blast_Score=283, Evalue=2e-77,
Organism=Escherichia coli, GI1786722, Length=450, Percent_Identity=32.4444444444444, Blast_Score=213, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17539558, Length=468, Percent_Identity=33.5470085470085, Blast_Score=228, Evalue=4e-60,
Organism=Caenorhabditis elegans, GI71989490, Length=465, Percent_Identity=33.3333333333333, Blast_Score=221, Evalue=7e-58,
Organism=Caenorhabditis elegans, GI86575075, Length=446, Percent_Identity=23.542600896861, Blast_Score=132, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI193204318, Length=456, Percent_Identity=21.9298245614035, Blast_Score=102, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6322218, Length=469, Percent_Identity=28.3582089552239, Blast_Score=131, Evalue=2e-31,
Organism=Drosophila melanogaster, GI221377917, Length=462, Percent_Identity=36.1471861471861, Blast_Score=255, Evalue=5e-68,
Organism=Drosophila melanogaster, GI17137462, Length=460, Percent_Identity=33.9130434782609, Blast_Score=240, Evalue=1e-63,
Organism=Drosophila melanogaster, GI24644287, Length=303, Percent_Identity=37.2937293729373, Blast_Score=159, Evalue=4e-39,
Organism=Drosophila melanogaster, GI24644289, Length=232, Percent_Identity=37.0689655172414, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24642586, Length=455, Percent_Identity=25.2747252747253, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI18859883, Length=430, Percent_Identity=26.046511627907, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011778
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: 3.5.2.2

Molecular weight: Translated: 50628; Mature: 50497

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAFDTVIRNGTVATASDTYLADVAIKSGRIAAIGEAITDAEEIVDASGLLVLPGGIDSH
CCCHHHHHCCCEEEECCCCEEEEEEECCCCEEEHHHHHHCHHHHHCCCCEEEECCCCCCC
VHISQPSGPGIVMADDFESATRAAAFGGNTFVMPYCLQEKGQPLRAALKDYHALADQACY
EEEECCCCCEEEEECCCCHHHHHHHCCCCEEEEEEHHHHCCCHHHHHHHHHHHHHCCEEE
IDHSFHLIIADPTDAVLGQELPALVADGYSSLKIFMTYDGLALNDYEILGVLQVAREQGA
EECCEEEEEECCCHHHHHCCCCHHHHCCCCCEEEEEEECCEEECCHHHHHHHHHHHCCCC
LVQIHAENYDAIRFLTDRLEREGKIAPYYHGKSRPIPVEREATHRAISLAELIDVPIVIV
EEEEECCCCCHHHHHHHHHHHCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHCCCEEEE
HVSNREAMEEIRRAQMRGLKIHGETCPQYLVLTEEDMQGLNMEGAKYVCSPPPRDKASQE
EECCHHHHHHHHHHHHCCEEEECCCCCCEEEEEHHHCCCCCCCCCEEECCCCCCCCCHHH
ACWEGLQQGVFSLFSSDHCPFRYDDEAGKLTPKGRTSFRWVPNGIPGVETRLPILFSEGV
HHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCEEECCCCCCCCCCCCCEEEECCC
SKGRITLNQFVALTATNHAKTYGLKGKGSIAIGYDADIALWDPAKTAKISQTGLHHGSDY
CCCCEEEEEEEEEEECCCCEEECCCCCCCEEEECCCCEEEECCCCCCEEHHCCCCCCCCC
TPYEGIEISGWPVATMLRGKFVVRDGKLLGAKGDGRYVTRGKPGGVA
CCCCCEEECCCCEEHHHCCEEEEECCEEEECCCCCEEEECCCCCCCC
>Mature Secondary Structure 
AAFDTVIRNGTVATASDTYLADVAIKSGRIAAIGEAITDAEEIVDASGLLVLPGGIDSH
CCHHHHHCCCEEEECCCCEEEEEEECCCCEEEHHHHHHCHHHHHCCCCEEEECCCCCCC
VHISQPSGPGIVMADDFESATRAAAFGGNTFVMPYCLQEKGQPLRAALKDYHALADQACY
EEEECCCCCEEEEECCCCHHHHHHHCCCCEEEEEEHHHHCCCHHHHHHHHHHHHHCCEEE
IDHSFHLIIADPTDAVLGQELPALVADGYSSLKIFMTYDGLALNDYEILGVLQVAREQGA
EECCEEEEEECCCHHHHHCCCCHHHHCCCCCEEEEEEECCEEECCHHHHHHHHHHHCCCC
LVQIHAENYDAIRFLTDRLEREGKIAPYYHGKSRPIPVEREATHRAISLAELIDVPIVIV
EEEEECCCCCHHHHHHHHHHHCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHCCCEEEE
HVSNREAMEEIRRAQMRGLKIHGETCPQYLVLTEEDMQGLNMEGAKYVCSPPPRDKASQE
EECCHHHHHHHHHHHHCCEEEECCCCCCEEEEEHHHCCCCCCCCCEEECCCCCCCCCHHH
ACWEGLQQGVFSLFSSDHCPFRYDDEAGKLTPKGRTSFRWVPNGIPGVETRLPILFSEGV
HHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCEEECCCCCCCCCCCCCEEEECCC
SKGRITLNQFVALTATNHAKTYGLKGKGSIAIGYDADIALWDPAKTAKISQTGLHHGSDY
CCCCEEEEEEEEEEECCCCEEECCCCCCCEEEECCCCEEEECCCCCCEEHHCCCCCCCCC
TPYEGIEISGWPVATMLRGKFVVRDGKLLGAKGDGRYVTRGKPGGVA
CCCCCEEECCCCEEHHHCCEEEEECCEEEECCCCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 5,6-dihydrouracil; H2O

Specific reaction: 5,6-dihydrouracil + H2O = 3-ureidopropanoate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7765480 [H]