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The map label for this gene is rnz

Identifier: 146338545

GI number: 146338545

Start: 1571335

End: 1572240

Strand: Direct

Name: rnz

Synonym: BRADO1465

Alternate gene names: 146338545

Gene position: 1571335-1572240 (Clockwise)

Preceding gene: 146338543

Following gene: 146338546

Centisome position: 21.07

GC content: 65.45

Gene sequence:

>906_bases
ATGTTCGAGCTGATCTTCCTGGGAACCTCGGCGAGCGTCCCGTCGCATGACCGCAACCATCCGGGGCTTCTGGTCCAGGC
CGGCGGGCAGCGGATTCTGGTCGATTGCGGCGAGGGCATTCAGCGCCAGCTGCTGGCGAGCGGGGCGGGATTTCGCCGGC
TCGACCGCATCCTGCTGACCCACGGGCATCTCGACCATGTCCTTGGCATTCCCGGATTGTTTTCCACCCTGCGGCTGCGC
CGGAGTGCCGACGTCATGAGCGTTCATGGCAGCCCGGGTACAATCGACGTGGTCATTCGCATGCTCGCAGGGCTGTGGGG
CGACGGCCGCGCGCCCATTCCGCTTGAACTCGTGCCGCTCACACCCGGGCAGGTCCTCGACGCCGGCGCGTTCACGATCA
ACTGTTTCGCGGTCCGGCATCGCGACACCGACAGCTTCGGCTTTGAATTCGTTAGCCCGGCTCGCCGTCATCTGCTGCCG
GAGCGCCTCGCGGCTCTCGCGGTGCCGGATGGGCCGATTCGAAAGACATTGGCGGACGGATACCCGGTCACGCTCGATGA
CGGCCGAATCGTTACTCCTGAGGACGTCCTCGGGACCCCGGGTGGCGGGAAAAAACTCGTGATTGTCGGTGACACCGAAA
CCACCGATGGTCTGCAGGCGCACGTCCGCGGCGCGGATCTGCTGGTGATCGAGGCGACGTTTCTCCAACGCGATTCCGCG
ACCGCGCGCGACTATGGTCACTTGACGGCGGCAGAGGCGGCCGCGCTTGCAGCCTCCGGCAATGTCGGTCAGCTCGTGCT
GAACCACATCTCCGGCCGCTATCCCGACGAAGAGATTCTGGCGGAGGCCAGGTCGATTTTCCCGGCCACCCGGATCGCGT
CGGACTTCGACCGATTGACCGTGTAG

Upstream 100 bases:

>100_bases
AAGAAGGACGTCGAATTGATCCCGATGAGACAGCCGGCGCAGGTGCCAGGGGCAGACCCGCGGATGCTCTTTTGGCCAGA
TCCGTTGTAACGTCGCGTCG

Downstream 100 bases:

>100_bases
CTGTTCGCAGCGCCCGCCAGGTCACTCGTCGCTTCGAGAGGGGCCGCATCGGCCGACCTCGAGCACGCCGCAGGGATTGG
AACGGAGGTCTCGTCAACGG

Product: ribonuclease Z

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MFELIFLGTSASVPSHDRNHPGLLVQAGGQRILVDCGEGIQRQLLASGAGFRRLDRILLTHGHLDHVLGIPGLFSTLRLR
RSADVMSVHGSPGTIDVVIRMLAGLWGDGRAPIPLELVPLTPGQVLDAGAFTINCFAVRHRDTDSFGFEFVSPARRHLLP
ERLAALAVPDGPIRKTLADGYPVTLDDGRIVTPEDVLGTPGGGKKLVIVGDTETTDGLQAHVRGADLLVIEATFLQRDSA
TARDYGHLTAAEAAALAASGNVGQLVLNHISGRYPDEEILAEARSIFPATRIASDFDRLTV

Sequences:

>Translated_301_residues
MFELIFLGTSASVPSHDRNHPGLLVQAGGQRILVDCGEGIQRQLLASGAGFRRLDRILLTHGHLDHVLGIPGLFSTLRLR
RSADVMSVHGSPGTIDVVIRMLAGLWGDGRAPIPLELVPLTPGQVLDAGAFTINCFAVRHRDTDSFGFEFVSPARRHLLP
ERLAALAVPDGPIRKTLADGYPVTLDDGRIVTPEDVLGTPGGGKKLVIVGDTETTDGLQAHVRGADLLVIEATFLQRDSA
TARDYGHLTAAEAAALAASGNVGQLVLNHISGRYPDEEILAEARSIFPATRIASDFDRLTV
>Mature_301_residues
MFELIFLGTSASVPSHDRNHPGLLVQAGGQRILVDCGEGIQRQLLASGAGFRRLDRILLTHGHLDHVLGIPGLFSTLRLR
RSADVMSVHGSPGTIDVVIRMLAGLWGDGRAPIPLELVPLTPGQVLDAGAFTINCFAVRHRDTDSFGFEFVSPARRHLLP
ERLAALAVPDGPIRKTLADGYPVTLDDGRIVTPEDVLGTPGGGKKLVIVGDTETTDGLQAHVRGADLLVIEATFLQRDSA
TARDYGHLTAAEAAALAASGNVGQLVLNHISGRYPDEEILAEARSIFPATRIASDFDRLTV

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family

Homologues:

Organism=Homo sapiens, GI8922122, Length=317, Percent_Identity=31.2302839116719, Blast_Score=125, Evalue=3e-29,
Organism=Escherichia coli, GI87082078, Length=312, Percent_Identity=36.5384615384615, Blast_Score=175, Evalue=3e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNZ_BRASO (A4YN80)

Other databases:

- EMBL:   CU234118
- RefSeq:   YP_001203593.1
- ProteinModelPortal:   A4YN80
- SMR:   A4YN80
- STRING:   A4YN80
- GeneID:   5119969
- GenomeReviews:   CU234118_GR
- KEGG:   bra:BRADO1465
- eggNOG:   COG1234
- HOGENOM:   HBG648406
- OMA:   RICVTHF
- ProtClustDB:   CLSK819272
- BioCyc:   BSP376:BRADO1465-MONOMER
- HAMAP:   MF_01818
- InterPro:   IPR001279
- InterPro:   IPR013471
- SMART:   SM00849
- TIGRFAMs:   TIGR02651

Pfam domain/function: PF00753 Lactamase_B

EC number: =3.1.26.11

Molecular weight: Translated: 32117; Mature: 32117

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFELIFLGTSASVPSHDRNHPGLLVQAGGQRILVDCGEGIQRQLLASGAGFRRLDRILLT
CEEEEEEECCCCCCCCCCCCCCEEEECCCCEEEEECCCHHHHHHHHCCCCHHHHHHHHHH
HGHLDHVLGIPGLFSTLRLRRSADVMSVHGSPGTIDVVIRMLAGLWGDGRAPIPLELVPL
CCCHHHHHCCCHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEC
TPGQVLDAGAFTINCFAVRHRDTDSFGFEFVSPARRHLLPERLAALAVPDGPIRKTLADG
CCCCEECCCCEEEEEEEEEECCCCCCCCHHHCHHHHHHCHHHHHHEECCCCHHHHHHCCC
YPVTLDDGRIVTPEDVLGTPGGGKKLVIVGDTETTDGLQAHVRGADLLVIEATFLQRDSA
CCEEECCCEEECCHHHCCCCCCCCEEEEECCCCCCCCCEEEECCCEEEEEEEEECCCCCC
TARDYGHLTAAEAAALAASGNVGQLVLNHISGRYPDEEILAEARSIFPATRIASDFDRLT
CCHHCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHC
V
C
>Mature Secondary Structure
MFELIFLGTSASVPSHDRNHPGLLVQAGGQRILVDCGEGIQRQLLASGAGFRRLDRILLT
CEEEEEEECCCCCCCCCCCCCCEEEECCCCEEEEECCCHHHHHHHHCCCCHHHHHHHHHH
HGHLDHVLGIPGLFSTLRLRRSADVMSVHGSPGTIDVVIRMLAGLWGDGRAPIPLELVPL
CCCHHHHHCCCHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEC
TPGQVLDAGAFTINCFAVRHRDTDSFGFEFVSPARRHLLPERLAALAVPDGPIRKTLADG
CCCCEECCCCEEEEEEEEEECCCCCCCCHHHCHHHHHHCHHHHHHEECCCCHHHHHHCCC
YPVTLDDGRIVTPEDVLGTPGGGKKLVIVGDTETTDGLQAHVRGADLLVIEATFLQRDSA
CCEEECCCEEECCHHHCCCCCCCCEEEEECCCCCCCCCEEEECCCEEEEEEEEECCCCCC
TARDYGHLTAAEAAALAASGNVGQLVLNHISGRYPDEEILAEARSIFPATRIASDFDRLT
CCHHCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHC
V
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA