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The map label for this gene is luxQ [H]

Identifier: 146338538

GI number: 146338538

Start: 1562136

End: 1563485

Strand: Direct

Name: luxQ [H]

Synonym: BRADO1458

Alternate gene names: 146338538

Gene position: 1562136-1563485 (Clockwise)

Preceding gene: 146338537

Following gene: 146338543

Centisome position: 20.95

GC content: 64.22

Gene sequence:

>1350_bases
ATGAGTGCGTCCAATTCCGAGGAGCTGCAGCGCGAGGCGGCCAAGCTCAGGAAGATCAACGCCGCGCTGATGTCCCGGGT
CGAACGCTCGATGGACCAGCAATTCAACGCATTCTCGCTGTTCGAGACGGCGATCGCGCTGGATCAGCAGGTCCGAGAGC
GGACGCGGCAGCTGCGCGACGCGCTACATTCGATCGAGACGGCAAATAAGAATCTATATCACGCCAAACAGCAGGCCGAG
GCGGCCAGCTCGCTGAAGTCCTCGGTCCTGATCTCCGTGACGCATGATCTGCTGCAGCCCCTCAATGCGGCGCGGCTGAC
GCTCTCCACCTTGGCAGACGAGGTTCAATCCGAGCGCGGGGCGAGCATGCTCGGGCAGGTCGACCGCTCGCTGTCCATGC
TGGAGGACCTGCTGCGATCGCTGCTCGACATCGCCAAGCTGGATGCCGGTGCCTTGCGTCCGGAGATGCGGCCCATTCTG
CTGTCGACCTTATTCGAGCCGTTGGAACGTGAGTTCGCCCCTATCGCGGCAAAACGCGGATTGGCGTTGCGTATCAGTCC
GACATCGCTCGCCGTGGAATCCGATGCGATGATGCTGCGGCGCATCCTGCAGAACCTCCTGGCCAACGCCTTGCGTTACA
CCCGTCGCGGCGGGGTCGTAATGGGATGTCGCCGCGGCCCGGGACCTGGCCGTGTTCGCATCGAGGTTCGCGACACCGGG
CCCGGCATTCCGAAGCCGCAGCAGGAGGCGATCTTTCTTGAATTCCAGCGCGGTCAGCCGAGCACCGAGGATCAGGCCGG
GTTTGGGCTCGGCCTCTCGATCGTCCGGCGTTTCGCCAAGGCGCTGGATCATCAGGTCCGGCTGGCGTCGCGGATCGACC
ACGGCTCCACATTCACGCTCGAACTCGACCGCGTCGACGCCGCGGCCGTGCCTCCGGAGCCGCAGCCGGTGGATCAGGTC
GACCACGAGTATAGCGGGCTCGAAGGCTCCAGGATCCTGCTGATCGAAAACGACGCCGCTGGCGCGGAGGCCATGGTCAG
CCTGCTGGAAAAGTGGGGCTGCGACGTCGTGGCGACGGTCTCGCTGCATGACGCCTTGCAGCGCCTGAGCACGCTCGGCG
CAGTACCGGAAACCATCATCGCGGATCTGCATCTCGATGGCGATGAAAGCGGACTGGCCGCGATCCGCGACATCCGGCAA
TTCATCGGCAGCGATGTGCCGGCCATGATCGTCACCGCTGACTATTCGGAGGCCGCCGCGAAGGAAGCAAGCCTTTTCGG
GCTCGAGATCCTGACCAAGCCTGTCAGGCCGGCGGAGCTTCGCGCACTGTTGTCGTTCCTGTTGACGTGA

Upstream 100 bases:

>100_bases
GCATCGTCGGTTTTCATACCTATGGTGAGCAGTACGGCTCGATGCATGTCAATCAGACGCTGACGGGCGTGGCGATCGGC
AGACGCGCCGGAGCGCCGCG

Downstream 100 bases:

>100_bases
GCGGAGCGGCGCCGTCTCTCGGCGCATCGGCCGGACCGCGCGCTTCGCCGATCAGGTTCACGAAGTCGAGCTTCTCCATT
TCGATGATGGCCTGGGTCCG

Product: two-component hybrid sensor and regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 449; Mature: 448

Protein sequence:

>449_residues
MSASNSEELQREAAKLRKINAALMSRVERSMDQQFNAFSLFETAIALDQQVRERTRQLRDALHSIETANKNLYHAKQQAE
AASSLKSSVLISVTHDLLQPLNAARLTLSTLADEVQSERGASMLGQVDRSLSMLEDLLRSLLDIAKLDAGALRPEMRPIL
LSTLFEPLEREFAPIAAKRGLALRISPTSLAVESDAMMLRRILQNLLANALRYTRRGGVVMGCRRGPGPGRVRIEVRDTG
PGIPKPQQEAIFLEFQRGQPSTEDQAGFGLGLSIVRRFAKALDHQVRLASRIDHGSTFTLELDRVDAAAVPPEPQPVDQV
DHEYSGLEGSRILLIENDAAGAEAMVSLLEKWGCDVVATVSLHDALQRLSTLGAVPETIIADLHLDGDESGLAAIRDIRQ
FIGSDVPAMIVTADYSEAAAKEASLFGLEILTKPVRPAELRALLSFLLT

Sequences:

>Translated_449_residues
MSASNSEELQREAAKLRKINAALMSRVERSMDQQFNAFSLFETAIALDQQVRERTRQLRDALHSIETANKNLYHAKQQAE
AASSLKSSVLISVTHDLLQPLNAARLTLSTLADEVQSERGASMLGQVDRSLSMLEDLLRSLLDIAKLDAGALRPEMRPIL
LSTLFEPLEREFAPIAAKRGLALRISPTSLAVESDAMMLRRILQNLLANALRYTRRGGVVMGCRRGPGPGRVRIEVRDTG
PGIPKPQQEAIFLEFQRGQPSTEDQAGFGLGLSIVRRFAKALDHQVRLASRIDHGSTFTLELDRVDAAAVPPEPQPVDQV
DHEYSGLEGSRILLIENDAAGAEAMVSLLEKWGCDVVATVSLHDALQRLSTLGAVPETIIADLHLDGDESGLAAIRDIRQ
FIGSDVPAMIVTADYSEAAAKEASLFGLEILTKPVRPAELRALLSFLLT
>Mature_448_residues
SASNSEELQREAAKLRKINAALMSRVERSMDQQFNAFSLFETAIALDQQVRERTRQLRDALHSIETANKNLYHAKQQAEA
ASSLKSSVLISVTHDLLQPLNAARLTLSTLADEVQSERGASMLGQVDRSLSMLEDLLRSLLDIAKLDAGALRPEMRPILL
STLFEPLEREFAPIAAKRGLALRISPTSLAVESDAMMLRRILQNLLANALRYTRRGGVVMGCRRGPGPGRVRIEVRDTGP
GIPKPQQEAIFLEFQRGQPSTEDQAGFGLGLSIVRRFAKALDHQVRLASRIDHGSTFTLELDRVDAAAVPPEPQPVDQVD
HEYSGLEGSRILLIENDAAGAEAMVSLLEKWGCDVVATVSLHDALQRLSTLGAVPETIIADLHLDGDESGLAAIRDIRQF
IGSDVPAMIVTADYSEAAAKEASLFGLEILTKPVRPAELRALLSFLLT

Specific function: At low cell density, in absence of autoinducer has a kinase activity, and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is transferred to

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=334, Percent_Identity=28.7425149700599, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI48994928, Length=381, Percent_Identity=26.7716535433071, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI145693157, Length=339, Percent_Identity=26.8436578171091, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI87081816, Length=329, Percent_Identity=30.0911854103343, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788713, Length=264, Percent_Identity=25.3787878787879, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1788393, Length=228, Percent_Identity=29.8245614035088, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789808, Length=205, Percent_Identity=26.8292682926829, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1786912, Length=253, Percent_Identity=25.6916996047431, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1786783, Length=177, Percent_Identity=32.2033898305085, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49075; Mature: 48944

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASNSEELQREAAKLRKINAALMSRVERSMDQQFNAFSLFETAIALDQQVRERTRQLRD
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
ALHSIETANKNLYHAKQQAEAASSLKSSVLISVTHDLLQPLNAARLTLSTLADEVQSERG
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
ASMLGQVDRSLSMLEDLLRSLLDIAKLDAGALRPEMRPILLSTLFEPLEREFAPIAAKRG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
LALRISPTSLAVESDAMMLRRILQNLLANALRYTRRGGVVMGCRRGPGPGRVRIEVRDTG
CEEEECCCHHEECHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCEEEEEEEECC
PGIPKPQQEAIFLEFQRGQPSTEDQAGFGLGLSIVRRFAKALDHQVRLASRIDHGSTFTL
CCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
ELDRVDAAAVPPEPQPVDQVDHEYSGLEGSRILLIENDAAGAEAMVSLLEKWGCDVVATV
EEECCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEH
SLHDALQRLSTLGAVPETIIADLHLDGDESGLAAIRDIRQFIGSDVPAMIVTADYSEAAA
HHHHHHHHHHHHCCCHHHHHHHEECCCCCHHHHHHHHHHHHHCCCCCEEEEECCCHHHHH
KEASLFGLEILTKPVRPAELRALLSFLLT
HHHHHHHHHHHHCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SASNSEELQREAAKLRKINAALMSRVERSMDQQFNAFSLFETAIALDQQVRERTRQLRD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
ALHSIETANKNLYHAKQQAEAASSLKSSVLISVTHDLLQPLNAARLTLSTLADEVQSERG
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
ASMLGQVDRSLSMLEDLLRSLLDIAKLDAGALRPEMRPILLSTLFEPLEREFAPIAAKRG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
LALRISPTSLAVESDAMMLRRILQNLLANALRYTRRGGVVMGCRRGPGPGRVRIEVRDTG
CEEEECCCHHEECHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCEEEEEEEECC
PGIPKPQQEAIFLEFQRGQPSTEDQAGFGLGLSIVRRFAKALDHQVRLASRIDHGSTFTL
CCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
ELDRVDAAAVPPEPQPVDQVDHEYSGLEGSRILLIENDAAGAEAMVSLLEKWGCDVVATV
EEECCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEH
SLHDALQRLSTLGAVPETIIADLHLDGDESGLAAIRDIRQFIGSDVPAMIVTADYSEAAA
HHHHHHHHHHHHCCCHHHHHHHEECCCCCHHHHHHHHHHHHHCCCCCEEEEECCCHHHHH
KEASLFGLEILTKPVRPAELRALLSFLLT
HHHHHHHHHHHHCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA