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The map label for this gene is capA [H]

Identifier: 146338466

GI number: 146338466

Start: 1473917

End: 1475398

Strand: Direct

Name: capA [H]

Synonym: BRADO1383

Alternate gene names: 146338466

Gene position: 1473917-1475398 (Clockwise)

Preceding gene: 146338465

Following gene: 146338469

Centisome position: 19.77

GC content: 69.37

Gene sequence:

>1482_bases
TTGGGTGGCGCGGCACCTGTCGGCGAACGTGCTGTCGTGTCCGGCGCGTCAGCCGTGATGCGGGCCGCGCTGGCGCTGCT
GCTCGTCGTCTCCGGCTTGGCAGCCGCGGAGGCGGCGGAGGTTGATGCCGCGCGGCTGCTGTTCACCGGCGACATCATGC
TATCGCGACAGGTGGCGCGCGAGATCGCCGCGCGCGGTGGCCTGTCGCCGTGGCACGGCATGAGCGACATGTTCCGGCGC
GCCGATCTCGTTGTCGGAAATTTCGAGGGTACGGTGGGCACGGCCGAGGCGTGCGACGCGCCGAGGGAGCTGTGCTTCGC
GGTCGATCCGCGCCTCGTGGGGCTGCTCAAGCACGCCGGCTTCACGGCGCTCGGTATCGCCAACAATCATTCGGGCGATC
TCGGCGCGACCGGACGGAAGGCGACGCGCGAGGCGTTGCATGCCGCCGGCCTCGGTGCGATCGGCTCGGCGGAGTCTCCG
GCGTTCCTCAAGGTCCGCGGGCGCACGCTGGCGCTGATCAGCCTCAATCTCGTGCCGGGCCGCGACGGCCAGATCGATCA
GGTCCCGTCCTGGCCTGTGGCCCAGAAGCTGCGGCTGGCGCGGGCGCTGGCGGATTGGGTGCTCGTGTCCGTGCATTGGG
GCAAGGAACTCGCCGACTGGGTGGTGCCCGAGCAGGAGTCCGCGGCGCGGTGGCTGGTAGCACAAGGCGCTGACCTCATC
ATCGGCGCGCATCCGCATGTCGTGCAGCCGCCGGCCTGCGTCGACGGCAAGCCAGTGTTCTATTCGCTCGGCAATCACGT
GTTCGACCAGAAATATCCACTCACCAAGCGCGGCCTGATCGCCGATTGCGAGATCGAGGACGACCGACTGGTCTGCAGCG
GCCTGCCGACCGGCACGCCGGATGGCTCGGCGTATCCCGTGCTGTCAGCAACGCCAGAGCAGTCGGCTTCCAGTCTCGCG
CAATGTCCCGTCCAGGCCGGCCCGCCGCTGCGCGTCGCGGGGCTGACCATCGGTCCGTGGCTTCGCGATGGCGAGATCGT
CTCGGATCGGCTCGTTCTCGAAGGCCGCGCCAAGGCAAGCCGTTGGCGGACGCCGCCGCGCGCGCTGCTGTCAGCTGAAG
CGGGACGGCTCGTCGCCGACCAGCCGCCGCTGCTGTTCACGCTGGAGCGCCATGCCTCGCCGATCGACGGCGAGGACGGT
CCGCGTCCCTATGTCTACGAAGTCACGATGCATGGCCTGGTCGCCAGATGGCGCGGCTCCGCGCTGGCCTGGCCGCTGCT
CGACGCCGTGCTGATCGCCGATGATGCCGGGCAGTCGTATCTGTGCGCGCTGCATCGTGGCGATTCCTTCATCATGCTGG
ACACGGCCACGCCGTCGGCGACGCGAACGCAGGCCTATGCCTGGAACGGCTTCGGCTTCACCGGCGTGAATGACGGCGAG
CTTGCCGCGCGCTGTGCGCAGCGTTTCGCGCCGGTCAATTGA

Upstream 100 bases:

>100_bases
TCGTCAAGGGCGGTGTCTATTCCTACTACGAGTTCGCCTCGCCGCAGCCGATCGATGACGCCGCCTGGCGCAAGGTGGTC
GATGCGCAGGTGCGGCCGGA

Downstream 100 bases:

>100_bases
GCGCAAGTCCAGTGAGTGCAAGTCCACTCAGTGCAAGCCTACTCAGTGCACGCCCAACATAGCGCCGGGCGGCTGCAACT
CTCAGACGGTCTCACGAGCT

Product: metallo-dependent phosphatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 493; Mature: 492

Protein sequence:

>493_residues
MGGAAPVGERAVVSGASAVMRAALALLLVVSGLAAAEAAEVDAARLLFTGDIMLSRQVAREIAARGGLSPWHGMSDMFRR
ADLVVGNFEGTVGTAEACDAPRELCFAVDPRLVGLLKHAGFTALGIANNHSGDLGATGRKATREALHAAGLGAIGSAESP
AFLKVRGRTLALISLNLVPGRDGQIDQVPSWPVAQKLRLARALADWVLVSVHWGKELADWVVPEQESAARWLVAQGADLI
IGAHPHVVQPPACVDGKPVFYSLGNHVFDQKYPLTKRGLIADCEIEDDRLVCSGLPTGTPDGSAYPVLSATPEQSASSLA
QCPVQAGPPLRVAGLTIGPWLRDGEIVSDRLVLEGRAKASRWRTPPRALLSAEAGRLVADQPPLLFTLERHASPIDGEDG
PRPYVYEVTMHGLVARWRGSALAWPLLDAVLIADDAGQSYLCALHRGDSFIMLDTATPSATRTQAYAWNGFGFTGVNDGE
LAARCAQRFAPVN

Sequences:

>Translated_493_residues
MGGAAPVGERAVVSGASAVMRAALALLLVVSGLAAAEAAEVDAARLLFTGDIMLSRQVAREIAARGGLSPWHGMSDMFRR
ADLVVGNFEGTVGTAEACDAPRELCFAVDPRLVGLLKHAGFTALGIANNHSGDLGATGRKATREALHAAGLGAIGSAESP
AFLKVRGRTLALISLNLVPGRDGQIDQVPSWPVAQKLRLARALADWVLVSVHWGKELADWVVPEQESAARWLVAQGADLI
IGAHPHVVQPPACVDGKPVFYSLGNHVFDQKYPLTKRGLIADCEIEDDRLVCSGLPTGTPDGSAYPVLSATPEQSASSLA
QCPVQAGPPLRVAGLTIGPWLRDGEIVSDRLVLEGRAKASRWRTPPRALLSAEAGRLVADQPPLLFTLERHASPIDGEDG
PRPYVYEVTMHGLVARWRGSALAWPLLDAVLIADDAGQSYLCALHRGDSFIMLDTATPSATRTQAYAWNGFGFTGVNDGE
LAARCAQRFAPVN
>Mature_492_residues
GGAAPVGERAVVSGASAVMRAALALLLVVSGLAAAEAAEVDAARLLFTGDIMLSRQVAREIAARGGLSPWHGMSDMFRRA
DLVVGNFEGTVGTAEACDAPRELCFAVDPRLVGLLKHAGFTALGIANNHSGDLGATGRKATREALHAAGLGAIGSAESPA
FLKVRGRTLALISLNLVPGRDGQIDQVPSWPVAQKLRLARALADWVLVSVHWGKELADWVVPEQESAARWLVAQGADLII
GAHPHVVQPPACVDGKPVFYSLGNHVFDQKYPLTKRGLIADCEIEDDRLVCSGLPTGTPDGSAYPVLSATPEQSASSLAQ
CPVQAGPPLRVAGLTIGPWLRDGEIVSDRLVLEGRAKASRWRTPPRALLSAEAGRLVADQPPLLFTLERHASPIDGEDGP
RPYVYEVTMHGLVARWRGSALAWPLLDAVLIADDAGQSYLCALHRGDSFIMLDTATPSATRTQAYAWNGFGFTGVNDGEL
AARCAQRFAPVN

Specific function: Essential for the synthesis of the polyglutamate capsule of B.anthracis which is one of the principal virulence factors during anthrax infection. May form a polyglutamyl synthetase complex together with proteins CapB and CapC [H]

COG id: COG2843

COG function: function code M; Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation)

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CapA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019079 [H]

Pfam domain/function: PF09587 PGA_cap [H]

EC number: NA

Molecular weight: Translated: 52070; Mature: 51939

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGAAPVGERAVVSGASAVMRAALALLLVVSGLAAAEAAEVDAARLLFTGDIMLSRQVAR
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHH
EIAARGGLSPWHGMSDMFRRADLVVGNFEGTVGTAEACDAPRELCFAVDPRLVGLLKHAG
HHHHHCCCCCCCCHHHHHHHHCEEEECCCCCCCCHHHCCCHHHHHHHCCHHHHHHHHHCC
FTALGIANNHSGDLGATGRKATREALHAAGLGAIGSAESPAFLKVRGRTLALISLNLVPG
EEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEECCCEEEEEEEEECCC
RDGQIDQVPSWPVAQKLRLARALADWVLVSVHWGKELADWVVPEQESAARWLVAQGADLI
CCCCCCCCCCCCHHHHHHHHHHHHHHEEEEEECCHHHHHHCCCCCHHHHHHHEECCCCEE
IGAHPHVVQPPACVDGKPVFYSLGNHVFDQKYPLTKRGLIADCEIEDDRLVCSGLPTGTP
EECCCCCCCCCCCCCCCCCEEHHCCHHCCCCCCCCCCCEEEECEECCCEEEECCCCCCCC
DGSAYPVLSATPEQSASSLAQCPVQAGPPLRVAGLTIGPWLRDGEIVSDRLVLEGRAKAS
CCCCCEEEECCCCHHHHHHHHCCCCCCCCEEEEEEEECCCCCCCCEECCEEEECCCCHHH
RWRTPPRALLSAEAGRLVADQPPLLFTLERHASPIDGEDGPRPYVYEVTMHGLVARWRGS
HCCCCHHHHHHHCCCCEEECCCCEEEEECCCCCCCCCCCCCCCEEEEEEHHHHHHHHCCC
ALAWPLLDAVLIADDAGQSYLCALHRGDSFIMLDTATPSATRTQAYAWNGFGFTGVNDGE
EEHHHHHHEEEEECCCCCCEEEEEECCCEEEEEECCCCCCCCCEEEEECCCCCCCCCCHH
LAARCAQRFAPVN
HHHHHHHHCCCCC
>Mature Secondary Structure 
GGAAPVGERAVVSGASAVMRAALALLLVVSGLAAAEAAEVDAARLLFTGDIMLSRQVAR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHH
EIAARGGLSPWHGMSDMFRRADLVVGNFEGTVGTAEACDAPRELCFAVDPRLVGLLKHAG
HHHHHCCCCCCCCHHHHHHHHCEEEECCCCCCCCHHHCCCHHHHHHHCCHHHHHHHHHCC
FTALGIANNHSGDLGATGRKATREALHAAGLGAIGSAESPAFLKVRGRTLALISLNLVPG
EEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEECCCEEEEEEEEECCC
RDGQIDQVPSWPVAQKLRLARALADWVLVSVHWGKELADWVVPEQESAARWLVAQGADLI
CCCCCCCCCCCCHHHHHHHHHHHHHHEEEEEECCHHHHHHCCCCCHHHHHHHEECCCCEE
IGAHPHVVQPPACVDGKPVFYSLGNHVFDQKYPLTKRGLIADCEIEDDRLVCSGLPTGTP
EECCCCCCCCCCCCCCCCCEEHHCCHHCCCCCCCCCCCEEEECEECCCEEEECCCCCCCC
DGSAYPVLSATPEQSASSLAQCPVQAGPPLRVAGLTIGPWLRDGEIVSDRLVLEGRAKAS
CCCCCEEEECCCCHHHHHHHHCCCCCCCCEEEEEEEECCCCCCCCEECCEEEECCCCHHH
RWRTPPRALLSAEAGRLVADQPPLLFTLERHASPIDGEDGPRPYVYEVTMHGLVARWRGS
HCCCCHHHHHHHCCCCEEECCCCEEEEECCCCCCCCCCCCCCCEEEEEEHHHHHHHHCCC
ALAWPLLDAVLIADDAGQSYLCALHRGDSFIMLDTATPSATRTQAYAWNGFGFTGVNDGE
EEHHHHHHEEEEECCCCCCEEEEEECCCEEEEEECCCCCCCCCEEEEECCCCCCCCCCHH
LAARCAQRFAPVN
HHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2536679; 10475962; 12004073 [H]