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The map label for this gene is dapA2 [H]

Identifier: 146338404

GI number: 146338404

Start: 1407634

End: 1408554

Strand: Reverse

Name: dapA2 [H]

Synonym: BRADO1318

Alternate gene names: 146338404

Gene position: 1408554-1407634 (Counterclockwise)

Preceding gene: 146338405

Following gene: 146338403

Centisome position: 18.89

GC content: 67.54

Gene sequence:

>921_bases
ATGACGACCGCTCGAACACCCCTGCAAGGACTCTGGCTGCCGCTGATCACGCCGTTCCGCCACGGCGCCCTGGACGAAGC
GTCGTTGCGCAACCTCGTTCGGCACTACGCTGGCAAGGCCGTCGATGGCCTGGTGCTCGGCGCGACCTCCGGCGAAGGAT
TGGCGCTGTCGTGGGACGAACGCGCACGGCTCGTCAGTGTGGTCCACGATGAGCTCACGTCCATCGGCCGGCAGCTGCCG
ATCTGTCTTGGCCTCGGCGGCGTCGCGACATCCGATCTGATCGAGGCGCTCGATCGGACCGCAGCATGGCCGATCGATTT
CTATCTCATCTCGAGCCCGCCTTACGTCCGCCCGTCGCAGCGCGGGCTGCTGGCGCATTTTTCCGCGTTGGCTGAGCGCG
CCGCGCATCCGATCGTGCTCTATAACATCCCCTACCGTTCCGCCGTCGGTCTCGACAACGACACGCTGCTGCAACTCGCC
GCGCATCCGGCCATTGCGGGACTGAAGGATTGCTGCGCCAGTCGCACGCAGACCCGGGAGTTGATCGTGCGCCGGCCCGC
AGGCTTCCAGATCCTGACCGGCGAGGACGCCCAGAGCTTCGACGCGCTGCAGGCCGGCGCCGACGGCGCCATCCTGCTGT
CGGCGCATATCGAGACCGAAACCTTTGCTGCCCTCCTGCAGCATGTGCAGGCAGGCCGTCACGACGCCGCTGCGGCGTGC
TGGATCCAGGTCGAGCCTCTCACGCGGCTGCTGTTTGCTGAGCCGAGCCCGGCTCCGGCGAAGTACTGGCTCGCCCGGAC
CGGTGTGATCTCGAGCGCGGAGGTGCGGCTGCCAATGGTCGAGGTCGGTGCCGACCTCGCCGCACGGCTCGATGACGAGA
TCGCGCATCGCACAGCCACGGCAAAGAGCCGCGTCGCCTGA

Upstream 100 bases:

>100_bases
TAGACTCTCTTCCGAGTTCACGCCGCACTACCAAGCCCCGCCGCCAGGACGGGGCTTTTTATATGTCCCGTCTCCGGCTC
AACACTTGAGGAGATGGACC

Downstream 100 bases:

>100_bases
GCCGTCGCCGCACGCAATCGTCGGCTCTGTCGCAACCTTTGGGGGTCGAGGACGGCAGAGCCGGCCCCGCGCGGTTCTTG
GTTAATCGGGACTAACGGGG

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS 2 [H]

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MTTARTPLQGLWLPLITPFRHGALDEASLRNLVRHYAGKAVDGLVLGATSGEGLALSWDERARLVSVVHDELTSIGRQLP
ICLGLGGVATSDLIEALDRTAAWPIDFYLISSPPYVRPSQRGLLAHFSALAERAAHPIVLYNIPYRSAVGLDNDTLLQLA
AHPAIAGLKDCCASRTQTRELIVRRPAGFQILTGEDAQSFDALQAGADGAILLSAHIETETFAALLQHVQAGRHDAAAAC
WIQVEPLTRLLFAEPSPAPAKYWLARTGVISSAEVRLPMVEVGADLAARLDDEIAHRTATAKSRVA

Sequences:

>Translated_306_residues
MTTARTPLQGLWLPLITPFRHGALDEASLRNLVRHYAGKAVDGLVLGATSGEGLALSWDERARLVSVVHDELTSIGRQLP
ICLGLGGVATSDLIEALDRTAAWPIDFYLISSPPYVRPSQRGLLAHFSALAERAAHPIVLYNIPYRSAVGLDNDTLLQLA
AHPAIAGLKDCCASRTQTRELIVRRPAGFQILTGEDAQSFDALQAGADGAILLSAHIETETFAALLQHVQAGRHDAAAAC
WIQVEPLTRLLFAEPSPAPAKYWLARTGVISSAEVRLPMVEVGADLAARLDDEIAHRTATAKSRVA
>Mature_305_residues
TTARTPLQGLWLPLITPFRHGALDEASLRNLVRHYAGKAVDGLVLGATSGEGLALSWDERARLVSVVHDELTSIGRQLPI
CLGLGGVATSDLIEALDRTAAWPIDFYLISSPPYVRPSQRGLLAHFSALAERAAHPIVLYNIPYRSAVGLDNDTLLQLAA
HPAIAGLKDCCASRTQTRELIVRRPAGFQILTGEDAQSFDALQAGADGAILLSAHIETETFAALLQHVQAGRHDAAAACW
IQVEPLTRLLFAEPSPAPAKYWLARTGVISSAEVRLPMVEVGADLAARLDDEIAHRTATAKSRVA

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=217, Percent_Identity=25.3456221198157, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1788823, Length=276, Percent_Identity=30.4347826086957, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1789620, Length=276, Percent_Identity=27.1739130434783, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87082415, Length=219, Percent_Identity=26.9406392694064, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1786463, Length=225, Percent_Identity=27.1111111111111, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 32822; Mature: 32691

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTARTPLQGLWLPLITPFRHGALDEASLRNLVRHYAGKAVDGLVLGATSGEGLALSWDE
CCCCCCCHHHHHHHHHCHHHCCCCCHHHHHHHHHHHCCCCCCCEEEECCCCCCEEEEHHH
RARLVSVVHDELTSIGRQLPICLGLGGVATSDLIEALDRTAAWPIDFYLISSPPYVRPSQ
HHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCC
RGLLAHFSALAERAAHPIVLYNIPYRSAVGLDNDTLLQLAAHPAIAGLKDCCASRTQTRE
CHHHHHHHHHHHHCCCCEEEEECCCHHCCCCCCHHHHHHHHCCHHHHHHHHHCCHHHHHH
LIVRRPAGFQILTGEDAQSFDALQAGADGAILLSAHIETETFAALLQHVQAGRHDAAAAC
HHEECCCCEEEEECCCCHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHCCCCCCCEEE
WIQVEPLTRLLFAEPSPAPAKYWLARTGVISSAEVRLPMVEVGADLAARLDDEIAHRTAT
EEEECHHHHHHCCCCCCCCHHHHHHHCCCCCCCCEECCHHHHCHHHHHHHHHHHHHHHHH
AKSRVA
HHHCCC
>Mature Secondary Structure 
TTARTPLQGLWLPLITPFRHGALDEASLRNLVRHYAGKAVDGLVLGATSGEGLALSWDE
CCCCCCHHHHHHHHHCHHHCCCCCHHHHHHHHHHHCCCCCCCEEEECCCCCCEEEEHHH
RARLVSVVHDELTSIGRQLPICLGLGGVATSDLIEALDRTAAWPIDFYLISSPPYVRPSQ
HHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCC
RGLLAHFSALAERAAHPIVLYNIPYRSAVGLDNDTLLQLAAHPAIAGLKDCCASRTQTRE
CHHHHHHHHHHHHCCCCEEEEECCCHHCCCCCCHHHHHHHHCCHHHHHHHHHCCHHHHHH
LIVRRPAGFQILTGEDAQSFDALQAGADGAILLSAHIETETFAALLQHVQAGRHDAAAAC
HHEECCCCEEEEECCCCHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHCCCCCCCEEE
WIQVEPLTRLLFAEPSPAPAKYWLARTGVISSAEVRLPMVEVGADLAARLDDEIAHRTAT
EEEECHHHHHHCCCCCCCCHHHHHHHCCCCCCCCEECCHHHHCHHHHHHHHHHHHHHHHH
AKSRVA
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]