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The map label for this gene is galU [C]

Identifier: 146337255

GI number: 146337255

Start: 94016

End: 94738

Strand: Direct

Name: galU [C]

Synonym: BRADO0082

Alternate gene names: 146337255

Gene position: 94016-94738 (Clockwise)

Preceding gene: 146337254

Following gene: 146337256

Centisome position: 1.26

GC content: 68.05

Gene sequence:

>723_bases
ATGCCCGTCCACCCGCACAAAGCCATGGTCCTCGCCGCCGGTCTCGGATTGCGCATGCGCCCGCTGACGGAGAAGATGCC
AAAGCCGCTGGTGCGCGTCGCCGGGCGTCCGCTGCTCGACCACGTGCTCGACCGGCTCGCCGAGGCTGGCGTCACCGAGG
CCGTCGTCAACGTCCACTATCTCGCCGATCAGATCATCGAGCACACCGCGACGCGCAGCGCGCCGCGCGTGATCATCTCC
GACGAGCGCGACCAGGTGCTGGGCACCGGCGGCGGCGTGGTCAAGGCGCTGCCGCTGCTGGGTCACGAGCCGTTCTTCCA
CGTCAACTCCGACACGATGTGGATCGAGGGCGTGCGCCAGAACCTCTCGCGCCTTGCCGACGCATTCGATCCCGCGCGCA
TGGACATCATGCTGCTGATGGCCCCGACCGCGACCTCGATCGGCTATGCCGGCCAGGGCGACTACGCGATGCTCGCCGAC
GGTACCTTGCGCAAGCGCCGCGAGCACCAGGTGGTGCCGTTCGTCTACGCCGGCGCCGCGATCATCTCGCCGGCGATCTT
CGACGGCGCGCCAGAGGGCGAGTTCTCGCTGACGAAGATGTTCGACAAGGCCAATGAGCAGGACCGGCTGTATGGCCTGC
GCCTCGAAGGCGTGTGGATGCATGTCGGTACGCCGGCCGCAGTGACCGAAGCCGAAGAAGCACTGCTGGAGAGCGCGGCG
TAG

Upstream 100 bases:

>100_bases
CATATTCGTCATGGCGCCGGGCTATCGCAACCGGTCGAGACGATAGATGTTTTTGCGTGGTATGATTCGCACGTACCACC
CTTGATCGAGATGCCCTGAG

Downstream 100 bases:

>100_bases
CTTGCGCGAAGGCATCACAAGGCCGCCTGTCTCCGTCATTGCGAGCGCAGCGAAACAATCCAGAGTGGTGTGCGGGATTC
TGGATTGCTTCGCTGCGCCG

Product: putative nucleotidyl transferase family protein mannose-1-phosphate guanyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 240; Mature: 239

Protein sequence:

>240_residues
MPVHPHKAMVLAAGLGLRMRPLTEKMPKPLVRVAGRPLLDHVLDRLAEAGVTEAVVNVHYLADQIIEHTATRSAPRVIIS
DERDQVLGTGGGVVKALPLLGHEPFFHVNSDTMWIEGVRQNLSRLADAFDPARMDIMLLMAPTATSIGYAGQGDYAMLAD
GTLRKRREHQVVPFVYAGAAIISPAIFDGAPEGEFSLTKMFDKANEQDRLYGLRLEGVWMHVGTPAAVTEAEEALLESAA

Sequences:

>Translated_240_residues
MPVHPHKAMVLAAGLGLRMRPLTEKMPKPLVRVAGRPLLDHVLDRLAEAGVTEAVVNVHYLADQIIEHTATRSAPRVIIS
DERDQVLGTGGGVVKALPLLGHEPFFHVNSDTMWIEGVRQNLSRLADAFDPARMDIMLLMAPTATSIGYAGQGDYAMLAD
GTLRKRREHQVVPFVYAGAAIISPAIFDGAPEGEFSLTKMFDKANEQDRLYGLRLEGVWMHVGTPAAVTEAEEALLESAA
>Mature_239_residues
PVHPHKAMVLAAGLGLRMRPLTEKMPKPLVRVAGRPLLDHVLDRLAEAGVTEAVVNVHYLADQIIEHTATRSAPRVIISD
ERDQVLGTGGGVVKALPLLGHEPFFHVNSDTMWIEGVRQNLSRLADAFDPARMDIMLLMAPTATSIGYAGQGDYAMLADG
TLRKRREHQVVPFVYAGAAIISPAIFDGAPEGEFSLTKMFDKANEQDRLYGLRLEGVWMHVGTPAAVTEAEEALLESAA

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=237, Percent_Identity=29.1139240506329, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI11761619, Length=237, Percent_Identity=29.1139240506329, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI133931050, Length=224, Percent_Identity=32.1428571428571, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320148, Length=244, Percent_Identity=31.5573770491803, Blast_Score=79, Evalue=5e-16,
Organism=Drosophila melanogaster, GI21355443, Length=225, Percent_Identity=29.3333333333333, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24644084, Length=225, Percent_Identity=29.3333333333333, Blast_Score=88, Evalue=5e-18,

Paralogues:

None

Copy number: 120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 260 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 26079; Mature: 25948

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVHPHKAMVLAAGLGLRMRPLTEKMPKPLVRVAGRPLLDHVLDRLAEAGVTEAVVNVHY
CCCCCCHHEEEECCCCCEECCHHHHCCHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHH
LADQIIEHTATRSAPRVIISDERDQVLGTGGGVVKALPLLGHEPFFHVNSDTMWIEGVRQ
HHHHHHHHHHCCCCCEEEEECCCCCEEECCCCHHHHHHHHCCCCEEEECCCCHHHHHHHH
NLSRLADAFDPARMDIMLLMAPTATSIGYAGQGDYAMLADGTLRKRREHQVVPFVYAGAA
HHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCEEEEECCHHHHHHCCCCCCCEEHHHH
IISPAIFDGAPEGEFSLTKMFDKANEQDRLYGLRLEGVWMHVGTPAAVTEAEEALLESAA
HHHHHHHCCCCCCCHHHHHHHHHCCCCCCEEEEEEEEEEEECCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PVHPHKAMVLAAGLGLRMRPLTEKMPKPLVRVAGRPLLDHVLDRLAEAGVTEAVVNVHY
CCCCCHHEEEECCCCCEECCHHHHCCHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHH
LADQIIEHTATRSAPRVIISDERDQVLGTGGGVVKALPLLGHEPFFHVNSDTMWIEGVRQ
HHHHHHHHHHCCCCCEEEEECCCCCEEECCCCHHHHHHHHCCCCEEEECCCCHHHHHHHH
NLSRLADAFDPARMDIMLLMAPTATSIGYAGQGDYAMLADGTLRKRREHQVVPFVYAGAA
HHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCEEEEECCHHHHHHCCCCCCCEEHHHH
IISPAIFDGAPEGEFSLTKMFDKANEQDRLYGLRLEGVWMHVGTPAAVTEAEEALLESAA
HHHHHHHCCCCCCCHHHHHHHHHCCCCCCEEEEEEEEEEEECCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA