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The map label for this gene is fkpA [H]

Identifier: 146302724

GI number: 146302724

Start: 6035158

End: 6035688

Strand: Direct

Name: fkpA [H]

Synonym: Fjoh_4997

Alternate gene names: 146302724

Gene position: 6035158-6035688 (Clockwise)

Preceding gene: 146302723

Following gene: 146302725

Centisome position: 98.99

GC content: 34.46

Gene sequence:

>531_bases
ATGAAACAACTTTTAACTGCTTTACTTTCATTAACACTTTTTATTTCTTGTTCTAAAGACAAAGATGAAGTCAAAGATTA
TACTGCTGAAAATGAGAAAGAGATTGTTGATTATTTAGCTCAGAATAATTTAACTGCACAAAGAACAAATTCTGGTTTAT
ACTACATTATTACCAAAGAAGGTTCAAGTGAAAGCGAAGGAGAAAATCCAGGCGAGGAAGAAAACACAGGTGAAGGGGAA
AACACAGAAGAAAATGAAAACGACGGACATCCTACATTAAATTCTAATATTACCGTTATTTACAAAGGTTATTTTACTAA
TGGGAAAGTTTTTGATGAAAGTACAGAAGGAGTTTCATATTCGCTTCGTACTCTTATTCCGGGATGGAAAGAGGGAATTC
CGCTTTTAAAATCAGGCGGCGAAATACAGCTTTTTGTACCTGCTCATTTAGGATACGGCAGCAATGGAAACAAAACTGTT
CCCGGAGGCGCCGTACTGATATTTGAAATTACTTTAGTTTCTGTTAATTAA

Upstream 100 bases:

>100_bases
AGGATAATTTAGTTTTCAGTCGCAGTTAACACACAGACTGAAAACTGCAACTGCGACTGAAAACTAATTTTATTAAATTA
GCTCTTTAAAAAGATAAAAT

Downstream 100 bases:

>100_bases
GATCATATTTTAAACCCGCATGTTGTTTCAAATCAAATCGTATTTAAATTTTCTTTGGCATTCTACAAACGAACACGGCG
TACATTCGCCTTTTGTTTTT

Product: FKBP type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 176; Mature: 176

Protein sequence:

>176_residues
MKQLLTALLSLTLFISCSKDKDEVKDYTAENEKEIVDYLAQNNLTAQRTNSGLYYIITKEGSSESEGENPGEEENTGEGE
NTEENENDGHPTLNSNITVIYKGYFTNGKVFDESTEGVSYSLRTLIPGWKEGIPLLKSGGEIQLFVPAHLGYGSNGNKTV
PGGAVLIFEITLVSVN

Sequences:

>Translated_176_residues
MKQLLTALLSLTLFISCSKDKDEVKDYTAENEKEIVDYLAQNNLTAQRTNSGLYYIITKEGSSESEGENPGEEENTGEGE
NTEENENDGHPTLNSNITVIYKGYFTNGKVFDESTEGVSYSLRTLIPGWKEGIPLLKSGGEIQLFVPAHLGYGSNGNKTV
PGGAVLIFEITLVSVN
>Mature_176_residues
MKQLLTALLSLTLFISCSKDKDEVKDYTAENEKEIVDYLAQNNLTAQRTNSGLYYIITKEGSSESEGENPGEEENTGEGE
NTEENENDGHPTLNSNITVIYKGYFTNGKVFDESTEGVSYSLRTLIPGWKEGIPLLKSGGEIQLFVPAHLGYGSNGNKTV
PGGAVLIFEITLVSVN

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

None

Paralogues:

None

Copy number: 200 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 19204; Mature: 19204

Theoretical pI: Translated: 4.17; Mature: 4.17

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQLLTALLSLTLFISCSKDKDEVKDYTAENEKEIVDYLAQNNLTAQRTNSGLYYIITKE
CHHHHHHHHHHHEEEECCCCHHHHHHHCCCCHHHHHHHHHHCCCEEEECCCCEEEEEECC
GSSESEGENPGEEENTGEGENTEENENDGHPTLNSNITVIYKGYFTNGKVFDESTEGVSY
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCEEECCCCCCCEE
SLRTLIPGWKEGIPLLKSGGEIQLFVPAHLGYGSNGNKTVPGGAVLIFEITLVSVN
EEEHHCCCCCCCCCEEECCCEEEEEEEEECCCCCCCCEECCCCEEEEEEEEEEEEC
>Mature Secondary Structure
MKQLLTALLSLTLFISCSKDKDEVKDYTAENEKEIVDYLAQNNLTAQRTNSGLYYIITKE
CHHHHHHHHHHHEEEECCCCHHHHHHHCCCCHHHHHHHHHHCCCEEEECCCCEEEEEECC
GSSESEGENPGEEENTGEGENTEENENDGHPTLNSNITVIYKGYFTNGKVFDESTEGVSY
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCEEECCCCCCCEE
SLRTLIPGWKEGIPLLKSGGEIQLFVPAHLGYGSNGNKTVPGGAVLIFEITLVSVN
EEEHHCCCCCCCCCEEECCCEEEEEEEEECCCCCCCCEECCCCEEEEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9171380 [H]