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The map label for this gene is pdhS [H]

Identifier: 146302663

GI number: 146302663

Start: 5962498

End: 5964207

Strand: Direct

Name: pdhS [H]

Synonym: Fjoh_4936

Alternate gene names: 146302663

Gene position: 5962498-5964207 (Clockwise)

Preceding gene: 146302661

Following gene: 146302664

Centisome position: 97.8

GC content: 30.58

Gene sequence:

>1710_bases
ATGAAAAGTAAAACTCTCCAAATTACTCTTGTTTACGTTATCATATCGCTAATTATGGCAATTGTATGTCATAATTTAAT
TACTGACTACTTTTTTCAAACAAAATACTTTTATTTATTTTTCATAAAAGATGTCCTTTTCATAATAGCTACTGCATTTA
TTTTCAAATACATACTTTCAAGAAACGAAAAGAAAAATATTTCAGTTTTTAAAAAATTAAAAAAGACAAATGAAGAAATA
AAGGAGTCTAATGAAAAATATGACATAGTTGCAAAAGCAACAAGCGATACTATTTGGGACTGGAAAATACAGGAAGACCG
AATAAATTGGAATAAAGGTATCGAGGGAATTTTTGGCTATAATCCGGAAGAAGTTGGAAAAACTTCAAAATGGTGGTTTG
ATAAAATTCACCCGGAAGATAGTATCCGAATGTCAATAAAACTATATTCATTTATTGAGCAAAAAACTGAAAAATGGCAG
GATCAATATCGCTTTAGATGTGCAGACGGAACATATAAATATGTTTTGGACAGAGGTTTTTTACTTAAAGATGAAAACGG
AAGAGCCATCAGAATGATTGGAGCGATTCAGGACATCACCAAACAAAAAGAGGAAGAACAGCGATTAAAACTTTTAGAAA
CTGTAATTACACAATCTAAAGACTCTATTCTTATTACCGAAGCTAATTCTGAAGATCGAAAAATTCCAAGAATAGTTTAT
GTTAATCCAGCGTTTTCTCAAATGTCCGGATACGAATCAAACGAAATCATTGGAAAATCTACCAATATATTTAAAGGGCC
AAAATCAGATTCAGAAGAATTAAAAAAACTTTTAAGAGCTATTAAGAACGAAGAAGAATGTGTTATAGAAACCATCACCT
ATACTAAATCTAAGGAAGAATATTGGGTGCGTTTTGCCATGATTCCAATTTTCAACAACGAAGGTGTAATTACACACTGG
ATTTCTATACAACGAGACATTACTGACGAGAAAAAACTGGAAACAGAAAAAGAACATCTTATTCGTGAACTTACACAAAA
CAACAAAGATTTAAAACAGTTCTCTTACATCACCTCACACAATCTTCGCGCACCATTATCAAATTTAATTGGACTTTTAA
ATCTTATAGAAGATATTCCAATTGAAAACGAAGAACTTGAAGAAATTCTGGCAGGCTTCACAAAATCAACTCATTTATTA
AATGAAACAATAAACGACTTGGTAAAAGTTATCATAATAAAAGACAACCCATCAATGCAAAAAGAGGAGGTTTCTTTAAA
AGAGGTTTTTGAAAATGTTTTTAGCCAATTGTCTTTTCAAATCGAACTTCACAAACCCATTATAAAACTTAAATTTGACA
AAGTACCGCTTTTGAATACAAATAAAGCGTATATTGAAAGTATTTTACTGAATTTACTAACCAATTCAATTAAATACAAA
TCAGAAAACAGAAAACTAAAAATATCAATTACTGCTGAGCAAATAGATCATCAGGCGATACTTACGTTCAAAGACAATGG
AATTGGGATTGATTTAGAAAGAAACAAAGACAAAGTTTTTGGTCTTTACCAAAGATTTCATAATTATCCCGACAGCAAAG
GACTAGGTTTGTATCTTGTAAAATCTCAGGTTGAGACCATGGGAGGCACTATTTCTATAGACAGTGAAGTTAACAAAGGC
ACCACATTTACTATAACTTTTAAAAACTAA

Upstream 100 bases:

>100_bases
GTATATACAAGTAATTAGTTCATTAAAACAGTGTTAATTTACCCTCCAAAATGAACTTTACTTATTGTTTAGTTATAGTT
AATTTAACTATATTTGATTG

Downstream 100 bases:

>100_bases
ATTCATTATGTTTGAGCAAATCTTATGCATTGACGATGACCCAATTACGTTGATGCTGTGTAAAAAAGTAATTTCAAAAT
CTTCGTTTGCAAATGAAATT

Product: multi-sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 569; Mature: 569

Protein sequence:

>569_residues
MKSKTLQITLVYVIISLIMAIVCHNLITDYFFQTKYFYLFFIKDVLFIIATAFIFKYILSRNEKKNISVFKKLKKTNEEI
KESNEKYDIVAKATSDTIWDWKIQEDRINWNKGIEGIFGYNPEEVGKTSKWWFDKIHPEDSIRMSIKLYSFIEQKTEKWQ
DQYRFRCADGTYKYVLDRGFLLKDENGRAIRMIGAIQDITKQKEEEQRLKLLETVITQSKDSILITEANSEDRKIPRIVY
VNPAFSQMSGYESNEIIGKSTNIFKGPKSDSEELKKLLRAIKNEEECVIETITYTKSKEEYWVRFAMIPIFNNEGVITHW
ISIQRDITDEKKLETEKEHLIRELTQNNKDLKQFSYITSHNLRAPLSNLIGLLNLIEDIPIENEELEEILAGFTKSTHLL
NETINDLVKVIIIKDNPSMQKEEVSLKEVFENVFSQLSFQIELHKPIIKLKFDKVPLLNTNKAYIESILLNLLTNSIKYK
SENRKLKISITAEQIDHQAILTFKDNGIGIDLERNKDKVFGLYQRFHNYPDSKGLGLYLVKSQVETMGGTISIDSEVNKG
TTFTITFKN

Sequences:

>Translated_569_residues
MKSKTLQITLVYVIISLIMAIVCHNLITDYFFQTKYFYLFFIKDVLFIIATAFIFKYILSRNEKKNISVFKKLKKTNEEI
KESNEKYDIVAKATSDTIWDWKIQEDRINWNKGIEGIFGYNPEEVGKTSKWWFDKIHPEDSIRMSIKLYSFIEQKTEKWQ
DQYRFRCADGTYKYVLDRGFLLKDENGRAIRMIGAIQDITKQKEEEQRLKLLETVITQSKDSILITEANSEDRKIPRIVY
VNPAFSQMSGYESNEIIGKSTNIFKGPKSDSEELKKLLRAIKNEEECVIETITYTKSKEEYWVRFAMIPIFNNEGVITHW
ISIQRDITDEKKLETEKEHLIRELTQNNKDLKQFSYITSHNLRAPLSNLIGLLNLIEDIPIENEELEEILAGFTKSTHLL
NETINDLVKVIIIKDNPSMQKEEVSLKEVFENVFSQLSFQIELHKPIIKLKFDKVPLLNTNKAYIESILLNLLTNSIKYK
SENRKLKISITAEQIDHQAILTFKDNGIGIDLERNKDKVFGLYQRFHNYPDSKGLGLYLVKSQVETMGGTISIDSEVNKG
TTFTITFKN
>Mature_569_residues
MKSKTLQITLVYVIISLIMAIVCHNLITDYFFQTKYFYLFFIKDVLFIIATAFIFKYILSRNEKKNISVFKKLKKTNEEI
KESNEKYDIVAKATSDTIWDWKIQEDRINWNKGIEGIFGYNPEEVGKTSKWWFDKIHPEDSIRMSIKLYSFIEQKTEKWQ
DQYRFRCADGTYKYVLDRGFLLKDENGRAIRMIGAIQDITKQKEEEQRLKLLETVITQSKDSILITEANSEDRKIPRIVY
VNPAFSQMSGYESNEIIGKSTNIFKGPKSDSEELKKLLRAIKNEEECVIETITYTKSKEEYWVRFAMIPIFNNEGVITHW
ISIQRDITDEKKLETEKEHLIRELTQNNKDLKQFSYITSHNLRAPLSNLIGLLNLIEDIPIENEELEEILAGFTKSTHLL
NETINDLVKVIIIKDNPSMQKEEVSLKEVFENVFSQLSFQIELHKPIIKLKFDKVPLLNTNKAYIESILLNLLTNSIKYK
SENRKLKISITAEQIDHQAILTFKDNGIGIDLERNKDKVFGLYQRFHNYPDSKGLGLYLVKSQVETMGGTISIDSEVNKG
TTFTITFKN

Specific function: Functions as a polar differentiation marker. Essential protein that, by localizing in the old pole of dividing cells, controls cell division and maturation, probably through control of DivK phosphorylation status and cellular distribution, which in turn r

COG id: COG2202

COG function: function code T; FOG: PAS/PAC domain

Gene ontology:

Cell location: Cytoplasm. Note=Localizes at the old pole of dividing cells. Colocalizes with divK (By similarity) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI48994928, Length=273, Percent_Identity=25.6410256410256, Blast_Score=80, Evalue=5e-16,
Organism=Escherichia coli, GI1788713, Length=283, Percent_Identity=26.8551236749117, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1790436, Length=221, Percent_Identity=26.2443438914027, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1788549, Length=336, Percent_Identity=22.3214285714286, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI145693157, Length=263, Percent_Identity=24.7148288973384, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1786600, Length=252, Percent_Identity=23.8095238095238, Blast_Score=66, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 66481; Mature: 66481

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSKTLQITLVYVIISLIMAIVCHNLITDYFFQTKYFYLFFIKDVLFIIATAFIFKYILS
CCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RNEKKNISVFKKLKKTNEEIKESNEKYDIVAKATSDTIWDWKIQEDRINWNKGIEGIFGY
CCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEEECCCCCCCCCCCCCCCC
NPEEVGKTSKWWFDKIHPEDSIRMSIKLYSFIEQKTEKWQDQYRFRCADGTYKYVLDRGF
CHHHHCCCCCCHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHEEEECCCCEEEEECCCE
LLKDENGRAIRMIGAIQDITKQKEEEQRLKLLETVITQSKDSILITEANSEDRKIPRIVY
EEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEE
VNPAFSQMSGYESNEIIGKSTNIFKGPKSDSEELKKLLRAIKNEEECVIETITYTKSKEE
ECCCHHHHCCCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCC
YWVRFAMIPIFNNEGVITHWISIQRDITDEKKLETEKEHLIRELTQNNKDLKQFSYITSH
EEEEEEEEEEECCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
NLRAPLSNLIGLLNLIEDIPIENEELEEILAGFTKSTHLLNETINDLVKVIIIKDNPSMQ
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCC
KEEVSLKEVFENVFSQLSFQIELHKPIIKLKFDKVPLLNTNKAYIESILLNLLTNSIKYK
HHHHHHHHHHHHHHHHHEEEEEEECCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCC
SENRKLKISITAEQIDHQAILTFKDNGIGIDLERNKDKVFGLYQRFHNYPDSKGLGLYLV
CCCCEEEEEEEHHHCCCEEEEEEECCCEEEEEECCCHHHHHHHHHHCCCCCCCCCEEEEE
KSQVETMGGTISIDSEVNKGTTFTITFKN
EHHHHHCCCEEEECCCCCCCEEEEEEECC
>Mature Secondary Structure
MKSKTLQITLVYVIISLIMAIVCHNLITDYFFQTKYFYLFFIKDVLFIIATAFIFKYILS
CCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RNEKKNISVFKKLKKTNEEIKESNEKYDIVAKATSDTIWDWKIQEDRINWNKGIEGIFGY
CCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEEECCCCCCCCCCCCCCCC
NPEEVGKTSKWWFDKIHPEDSIRMSIKLYSFIEQKTEKWQDQYRFRCADGTYKYVLDRGF
CHHHHCCCCCCHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHEEEECCCCEEEEECCCE
LLKDENGRAIRMIGAIQDITKQKEEEQRLKLLETVITQSKDSILITEANSEDRKIPRIVY
EEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEE
VNPAFSQMSGYESNEIIGKSTNIFKGPKSDSEELKKLLRAIKNEEECVIETITYTKSKEE
ECCCHHHHCCCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCC
YWVRFAMIPIFNNEGVITHWISIQRDITDEKKLETEKEHLIRELTQNNKDLKQFSYITSH
EEEEEEEEEEECCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
NLRAPLSNLIGLLNLIEDIPIENEELEEILAGFTKSTHLLNETINDLVKVIIIKDNPSMQ
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCC
KEEVSLKEVFENVFSQLSFQIELHKPIIKLKFDKVPLLNTNKAYIESILLNLLTNSIKYK
HHHHHHHHHHHHHHHHHEEEEEEECCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCC
SENRKLKISITAEQIDHQAILTFKDNGIGIDLERNKDKVFGLYQRFHNYPDSKGLGLYLV
CCCCEEEEEEEHHHCCCEEEEEEECCCEEEEEECCCHHHHHHHHHHCCCCCCCCCEEEEE
KSQVETMGGTISIDSEVNKGTTFTITFKN
EHHHHHCCCEEEECCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA