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The map label for this gene is clcB [H]

Identifier: 146302647

GI number: 146302647

Start: 5940654

End: 5941934

Strand: Direct

Name: clcB [H]

Synonym: Fjoh_4920

Alternate gene names: 146302647

Gene position: 5940654-5941934 (Clockwise)

Preceding gene: 146302646

Following gene: 146302648

Centisome position: 97.44

GC content: 33.02

Gene sequence:

>1281_bases
ATGAACAAAACGGCGCAAATCAAAAAAAATCATCAATTTATCAAATTCCGAAAATTAGTTATTGTTTCTATTTTAATTGG
CTTTCTTTCAGCTTTCCTCGGAATATCACTTAAAAAAATAACCGAATATTACGAAGAAATCTTCTTTCACGAAGTATCGG
TTCATCCTGTATTTTATATCATTTTTCCGGTTTTTGGATTATCAATAATTTACTTCCTGAGACAATATCTTTTTAAGAAA
AAAGAAAATAAAGGCATCAAAGAAGTTTTTGAAAGTACAGCTTCAAAATCTAAAAATCTTCCTTCTTATAAAATTCCATC
ACACTTTATAAACGGATTATTAACGGTTATTTTTGGAGGCTCAACCGGAATTGAAGTTTCAACAGTTGTTGCAACGGCAA
CGATTGGTTCTGTTGCCCATGAAAAAGAAAATGTTTTCCGCCAGTACAAAACTGAATTAATTTGTGCGGGTGTAGCAGCT
GGAGTTACGGCACTTTTCAGCAGTCCAATTGCGGGAGTTTTGTTTGCTTTTGAAGTAATTTCACGAAAAGTGACACGAGC
TTTTGTTATCTCTAATTTAATTGCTGTTTCAATTGCTTTTGGTTTACTTACCATTTTAAAAGAAGAACCTTTATTTGCGG
TTTCAATTGTATCCTGGCAGTTAAAAGCAATTCCATATTTTATTCTTCTTGGAATTTTGGCGGGAATGAATTCGGTTTAT
TTAACTAAATGTGTTTTATTCTTCAAGTCTCAATTCGGAAAAATCGATACGCATTATTATAAAATCATTATTGGTTCAGC
TGTTTTAAGTATTTCGCTATTCTTTTTCCCTCAATTATACGGAGAAGGATATCATGCTATCAAAGGAATTTTTGGAACTT
CATCTCAGCTTCCTTTAACCATAACTTTAGCACTGACTTTTATTGCAATATTAATTTTAAAACCTATAGTTACATCCATT
ACATTGGCTTCAGGAGGCGACGGAGGTGTTTTTGCACCTAGTTTATTCATCGGAGCTTTTTTAGGATTATTACTGGCTTC
GGTTTTAAACAGCTTTTTTCATGTAAATGTAATTCCGGTCAATTTTATGATTCTCGGAATGGCTGCCGTTTTAAGCGCCA
GCATTCACGCACCTTTTACCGCAATCTTTTTGGTTTGCGGTTTAACAAACGACTATACTTTGTTTTTACCAATTCTTGCC
GTTTGTTTAATTTCAAAATATACTGCAAAAACAATTTATCCGTATACAGTATACAGTTACGCTCCAAGCTTGACTAAATA
A

Upstream 100 bases:

>100_bases
GATTTTAACACACTAAATTGAAGATTTCCTATAAAAAACCGAATTTGATGCTTAATTTTGTAATCCGCATAAAAAAAGTG
CGGATTCAAATTTACTTCTG

Downstream 100 bases:

>100_bases
TTTCAAACTAATCATAAAATCTGAAGATTAAAAACATACAGCAAAGTATATTTAAAAGCATAACGAGTAAAATATAATAC
CACAATAATGCCAACTGAAA

Product: Cl- channel, voltage-gated family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MNKTAQIKKNHQFIKFRKLVIVSILIGFLSAFLGISLKKITEYYEEIFFHEVSVHPVFYIIFPVFGLSIIYFLRQYLFKK
KENKGIKEVFESTASKSKNLPSYKIPSHFINGLLTVIFGGSTGIEVSTVVATATIGSVAHEKENVFRQYKTELICAGVAA
GVTALFSSPIAGVLFAFEVISRKVTRAFVISNLIAVSIAFGLLTILKEEPLFAVSIVSWQLKAIPYFILLGILAGMNSVY
LTKCVLFFKSQFGKIDTHYYKIIIGSAVLSISLFFFPQLYGEGYHAIKGIFGTSSQLPLTITLALTFIAILILKPIVTSI
TLASGGDGGVFAPSLFIGAFLGLLLASVLNSFFHVNVIPVNFMILGMAAVLSASIHAPFTAIFLVCGLTNDYTLFLPILA
VCLISKYTAKTIYPYTVYSYAPSLTK

Sequences:

>Translated_426_residues
MNKTAQIKKNHQFIKFRKLVIVSILIGFLSAFLGISLKKITEYYEEIFFHEVSVHPVFYIIFPVFGLSIIYFLRQYLFKK
KENKGIKEVFESTASKSKNLPSYKIPSHFINGLLTVIFGGSTGIEVSTVVATATIGSVAHEKENVFRQYKTELICAGVAA
GVTALFSSPIAGVLFAFEVISRKVTRAFVISNLIAVSIAFGLLTILKEEPLFAVSIVSWQLKAIPYFILLGILAGMNSVY
LTKCVLFFKSQFGKIDTHYYKIIIGSAVLSISLFFFPQLYGEGYHAIKGIFGTSSQLPLTITLALTFIAILILKPIVTSI
TLASGGDGGVFAPSLFIGAFLGLLLASVLNSFFHVNVIPVNFMILGMAAVLSASIHAPFTAIFLVCGLTNDYTLFLPILA
VCLISKYTAKTIYPYTVYSYAPSLTK
>Mature_426_residues
MNKTAQIKKNHQFIKFRKLVIVSILIGFLSAFLGISLKKITEYYEEIFFHEVSVHPVFYIIFPVFGLSIIYFLRQYLFKK
KENKGIKEVFESTASKSKNLPSYKIPSHFINGLLTVIFGGSTGIEVSTVVATATIGSVAHEKENVFRQYKTELICAGVAA
GVTALFSSPIAGVLFAFEVISRKVTRAFVISNLIAVSIAFGLLTILKEEPLFAVSIVSWQLKAIPYFILLGILAGMNSVY
LTKCVLFFKSQFGKIDTHYYKIIIGSAVLSISLFFFPQLYGEGYHAIKGIFGTSSQLPLTITLALTFIAILILKPIVTSI
TLASGGDGGVFAPSLFIGAFLGLLLASVLNSFFHVNVIPVNFMILGMAAVLSASIHAPFTAIFLVCGLTNDYTLFLPILA
VCLISKYTAKTIYPYTVYSYAPSLTK

Specific function: Probably acts as an electrical shunt for an outwardly- directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response [H]

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcB subfamily [H]

Homologues:

Organism=Escherichia coli, GI87081943, Length=255, Percent_Identity=25.4901960784314, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786350, Length=265, Percent_Identity=29.0566037735849, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 46753; Mature: 46753

Theoretical pI: Translated: 9.93; Mature: 9.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCC
>Mature Secondary Structure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CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA