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The map label for this gene is glcR [H]

Identifier: 146302587

GI number: 146302587

Start: 5880586

End: 5881398

Strand: Direct

Name: glcR [H]

Synonym: Fjoh_4860

Alternate gene names: 146302587

Gene position: 5880586-5881398 (Clockwise)

Preceding gene: 146302585

Following gene: 146302598

Centisome position: 96.45

GC content: 32.96

Gene sequence:

>813_bases
ATGCAAAAATTGCAAATTATTGCAATTTTTAACTTATTTTTGCAATATAAAACCGCAAATAAAATGAAAAAGGAAGAACG
TCAAAAGGCAATTTTAGAATATTTATCTAAAGAACATCGTGTAACCTCCATAGAATTAAGCGAATACCTAAGTGTTTCTG
AAGATACTATCAGACGTGATTTAAAAGAACTTTCAGATCAGGGACTTTTAAAAGCTGTTCGCGGCGGTGCGGTTGCTCCT
TCCCCTATTCCATTACATTACAGAAAGAGAGAAAAGCATGATATTGAAAACAAAAAGATTATTGCGCAGAAAGCGATTTC
TTATTTAAAAGACGGACAAGTTGTTTTTATTGACGGTGGAACGACTTCTTTAGCATTAGTTGCCAGTTTTCCTTATGATT
TAAAATTAACCGTAATTACCAACAGTTTTCCGGTTGCGACATTGGCTGAAGATTTACCCAATATTGATTTAATTTTTGCA
GGCGGTAAAATGTGCAAAACTTCCTTCACAACTTCGAGTATTGAAACAGTAGACTTTTTTAGAAGTTTTAGAGCCGATGT
GTGTATTTTAGGAATCTGCAGCATTCATCATGAACGCGGTGTTACCGGAATTTTATATGATGATTCAATGCTGAAAAAAA
ACATGGTTCAGAATTCTAATTTTGTGATCGCATTAAGTTCTATCGAAAAAGTAGAAACTGCAGAATCGTATTTTGTCTGC
CCAATAAAAGATATTAATGTTTTGGTAACGAATGTTTCACCAGAAGATGAAATTTTAAAAGTGTATCAAAATACAGGTTT
GATCATTCTTTAA

Upstream 100 bases:

>100_bases
GTAATGGTCTATTATCTGCGATTCGACATCAGCGAGAACACCATCCATATCTATTGCAATTGTTTTCTTTTTCATTGTAA
TTCTATTTTGCGGTAAAATT

Downstream 100 bases:

>100_bases
ATTCATAAAACAAAAAAGCCTTTCAGAACTTCACTTCCGAAAGGCTTTTTTTCTACAAATTAATTGGCAAAATTATTTCC
ATCCGCCGCCCAGGTCTCTG

Product: DeoR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MQKLQIIAIFNLFLQYKTANKMKKEERQKAILEYLSKEHRVTSIELSEYLSVSEDTIRRDLKELSDQGLLKAVRGGAVAP
SPIPLHYRKREKHDIENKKIIAQKAISYLKDGQVVFIDGGTTSLALVASFPYDLKLTVITNSFPVATLAEDLPNIDLIFA
GGKMCKTSFTTSSIETVDFFRSFRADVCILGICSIHHERGVTGILYDDSMLKKNMVQNSNFVIALSSIEKVETAESYFVC
PIKDINVLVTNVSPEDEILKVYQNTGLIIL

Sequences:

>Translated_270_residues
MQKLQIIAIFNLFLQYKTANKMKKEERQKAILEYLSKEHRVTSIELSEYLSVSEDTIRRDLKELSDQGLLKAVRGGAVAP
SPIPLHYRKREKHDIENKKIIAQKAISYLKDGQVVFIDGGTTSLALVASFPYDLKLTVITNSFPVATLAEDLPNIDLIFA
GGKMCKTSFTTSSIETVDFFRSFRADVCILGICSIHHERGVTGILYDDSMLKKNMVQNSNFVIALSSIEKVETAESYFVC
PIKDINVLVTNVSPEDEILKVYQNTGLIIL
>Mature_270_residues
MQKLQIIAIFNLFLQYKTANKMKKEERQKAILEYLSKEHRVTSIELSEYLSVSEDTIRRDLKELSDQGLLKAVRGGAVAP
SPIPLHYRKREKHDIENKKIIAQKAISYLKDGQVVFIDGGTTSLALVASFPYDLKLTVITNSFPVATLAEDLPNIDLIFA
GGKMCKTSFTTSSIETVDFFRSFRADVCILGICSIHHERGVTGILYDDSMLKKNMVQNSNFVIALSSIEKVETAESYFVC
PIKDINVLVTNVSPEDEILKVYQNTGLIIL

Specific function: Plays a role in carbon catabolite repression (CCR). Specifically required for transcriptional repression of the levanase operon by glucose but not by other sugars [H]

COG id: COG1349

COG function: function code KG; Transcriptional regulators of sugar metabolism

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH deoR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789829, Length=243, Percent_Identity=30.4526748971193, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI226510968, Length=229, Percent_Identity=27.0742358078603, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1788069, Length=242, Percent_Identity=26.0330578512397, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1789059, Length=253, Percent_Identity=26.8774703557312, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI87082344, Length=211, Percent_Identity=26.5402843601896, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1789170, Length=209, Percent_Identity=29.6650717703349, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1789519, Length=239, Percent_Identity=23.4309623430962, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1790753, Length=248, Percent_Identity=22.1774193548387, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1787540, Length=236, Percent_Identity=27.1186440677966, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1787063, Length=247, Percent_Identity=23.8866396761134, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790635, Length=259, Percent_Identity=25.8687258687259, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014036
- InterPro:   IPR001034
- InterPro:   IPR018356
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00455 DeoR; PF08220 HTH_DeoR [H]

EC number: NA

Molecular weight: Translated: 30315; Mature: 30315

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS00894 HTH_DEOR_1 ; PS51000 HTH_DEOR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKLQIIAIFNLFLQYKTANKMKKEERQKAILEYLSKEHRVTSIELSEYLSVSEDTIRRD
CCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHCCCHHHHHHH
LKELSDQGLLKAVRGGAVAPSPIPLHYRKREKHDIENKKIIAQKAISYLKDGQVVFIDGG
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHCCCCEEEEECC
TTSLALVASFPYDLKLTVITNSFPVATLAEDLPNIDLIFAGGKMCKTSFTTSSIETVDFF
CCEEEEEEECCCEEEEEEEECCCCHHHHHHHCCCEEEEEECCCEEECCCCCCCHHHHHHH
RSFRADVCILGICSIHHERGVTGILYDDSMLKKNMVQNSNFVIALSSIEKVETAESYFVC
HHHCCCEEEEEHHHHHHHCCCEEEEECCHHHHHHHHCCCCEEEEECCCHHHHCCCCEEEE
PIKDINVLVTNVSPEDEILKVYQNTGLIIL
EECCCEEEEECCCCHHHHHHHHHCCCCEEC
>Mature Secondary Structure
MQKLQIIAIFNLFLQYKTANKMKKEERQKAILEYLSKEHRVTSIELSEYLSVSEDTIRRD
CCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHCCCHHHHHHH
LKELSDQGLLKAVRGGAVAPSPIPLHYRKREKHDIENKKIIAQKAISYLKDGQVVFIDGG
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHCCCCEEEEECC
TTSLALVASFPYDLKLTVITNSFPVATLAEDLPNIDLIFAGGKMCKTSFTTSSIETVDFF
CCEEEEEEECCCEEEEEEEECCCCHHHHHHHCCCEEEEEECCCEEECCCCCCCHHHHHHH
RSFRADVCILGICSIHHERGVTGILYDDSMLKKNMVQNSNFVIALSSIEKVETAESYFVC
HHHCCCEEEEEHHHHHHHCCCEEEEECCHHHHHHHHCCCCEEEEECCCHHHHCCCCEEEE
PIKDINVLVTNVSPEDEILKVYQNTGLIIL
EECCCEEEEECCCCHHHHHHHHHCCCCEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]