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The map label for this gene is pgl [H]

Identifier: 146302528

GI number: 146302528

Start: 5802379

End: 5803095

Strand: Direct

Name: pgl [H]

Synonym: Fjoh_4801

Alternate gene names: 146302528

Gene position: 5802379-5803095 (Clockwise)

Preceding gene: 146302527

Following gene: 146302529

Centisome position: 95.17

GC content: 37.66

Gene sequence:

>717_bases
ATGATACAGATATATAATACTACAGAAGAAATTAATACTGCAGCGGCAGACCTTTTTACAGCAGCAGCACAAGATGCAAT
TGCAAAAAGAGGAAAATTTACAGCAGTTCTTACTGGAGGTTCTTCTCCTTCAGGAATTTACAAACTGCTGGCTTCTGATG
CATACAAAAACAAAATAGACTGGAGTAAAGTCTACATATTCTGGGGCGACGAACGCTGGGTGCCGCTAAATGATGATTTG
AGCAACGCAAAAATGTCTTATGCAGCATTATTAAGCCACGTTCCTATTCCGTCTGAAAATATTTTTGAAATGTACAAAGA
CGGTGTAACACCAGAAGATTACGCAGTTACATACGAACAATCAATTCGAAAAATTTTAGGAGAAGAAGGAAAATTTGACT
TTATCTTTTTAGGAATGGGAGATGACGGACACACGGCTTCTCTTTTTCCAGGTGAAGCAGTATTAAATGAACAAAACAAG
TGGGTTGATGCCTATTTTCTGGCACCGCAGAACATGCACCGCATTACACTTACTGCTCCATTAATTAATAAAGCCGAAAA
GATTATTGTAGTCACTTTTGGAGAGAAAAAAGCACATGCTTTAAAAGAAGTAACAAAAGGAGAATACAATCCTTCACTTT
ACCCTACGCAGCTAATTAAACCTGTCTCTGGAGAATTAGTATTTCTCGTAGATAAAAGTGCTGCAGGAACCAATTAA

Upstream 100 bases:

>100_bases
TACAAAGCCGGAAGCTGGGGACCAGAAGAAGCTGATGAACTATTGGCACGCCAGGGACACAAATGGATTCCAAATACACA
AACAAAAGAAGAACTTTTAG

Downstream 100 bases:

>100_bases
AACACCAGAAAGTCCGAAAATGTTTTTCGGACTTTTTTTATGCTTTATCTTCATCCTTTATTTTCGTATTTCATCAAATC
TGGAGTTATCTGCTAATCGT

Product: 6-phosphogluconolactonase

Products: NA

Alternate protein names: 6PGL [H]

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MIQIYNTTEEINTAAADLFTAAAQDAIAKRGKFTAVLTGGSSPSGIYKLLASDAYKNKIDWSKVYIFWGDERWVPLNDDL
SNAKMSYAALLSHVPIPSENIFEMYKDGVTPEDYAVTYEQSIRKILGEEGKFDFIFLGMGDDGHTASLFPGEAVLNEQNK
WVDAYFLAPQNMHRITLTAPLINKAEKIIVVTFGEKKAHALKEVTKGEYNPSLYPTQLIKPVSGELVFLVDKSAAGTN

Sequences:

>Translated_238_residues
MIQIYNTTEEINTAAADLFTAAAQDAIAKRGKFTAVLTGGSSPSGIYKLLASDAYKNKIDWSKVYIFWGDERWVPLNDDL
SNAKMSYAALLSHVPIPSENIFEMYKDGVTPEDYAVTYEQSIRKILGEEGKFDFIFLGMGDDGHTASLFPGEAVLNEQNK
WVDAYFLAPQNMHRITLTAPLINKAEKIIVVTFGEKKAHALKEVTKGEYNPSLYPTQLIKPVSGELVFLVDKSAAGTN
>Mature_238_residues
MIQIYNTTEEINTAAADLFTAAAQDAIAKRGKFTAVLTGGSSPSGIYKLLASDAYKNKIDWSKVYIFWGDERWVPLNDDL
SNAKMSYAALLSHVPIPSENIFEMYKDGVTPEDYAVTYEQSIRKILGEEGKFDFIFLGMGDDGHTASLFPGEAVLNEQNK
WVDAYFLAPQNMHRITLTAPLINKAEKIIVVTFGEKKAHALKEVTKGEYNPSLYPTQLIKPVSGELVFLVDKSAAGTN

Specific function: Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate [H]

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily [H]

Homologues:

Organism=Homo sapiens, GI52145310, Length=232, Percent_Identity=34.4827586206897, Blast_Score=120, Evalue=7e-28,
Organism=Homo sapiens, GI6912586, Length=241, Percent_Identity=31.9502074688797, Blast_Score=111, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI115533058, Length=220, Percent_Identity=30, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI115533060, Length=220, Percent_Identity=30, Blast_Score=87, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6321957, Length=219, Percent_Identity=32.4200913242009, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6321687, Length=225, Percent_Identity=28.8888888888889, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324362, Length=216, Percent_Identity=28.7037037037037, Blast_Score=66, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6319918, Length=215, Percent_Identity=27.4418604651163, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24641119, Length=231, Percent_Identity=33.7662337662338, Blast_Score=107, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005900
- InterPro:   IPR006148 [H]

Pfam domain/function: PF01182 Glucosamine_iso [H]

EC number: =3.1.1.31 [H]

Molecular weight: Translated: 26325; Mature: 26325

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQIYNTTEEINTAAADLFTAAAQDAIAKRGKFTAVLTGGSSPSGIYKLLASDAYKNKID
CEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHCCCCC
WSKVYIFWGDERWVPLNDDLSNAKMSYAALLSHVPIPSENIFEMYKDGVTPEDYAVTYEQ
EEEEEEEECCCEEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCEEEEHHH
SIRKILGEEGKFDFIFLGMGDDGHTASLFPGEAVLNEQNKWVDAYFLAPQNMHRITLTAP
HHHHHHCCCCCEEEEEEEECCCCCEEEECCCHHHCCCCCCEEEEEEECCCCCEEEEEEEC
LINKAEKIIVVTFGEKKAHALKEVTKGEYNPSLYPTQLIKPVSGELVFLVDKSAAGTN
CCCCCCEEEEEEECCHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCEEEEEECCCCCCC
>Mature Secondary Structure
MIQIYNTTEEINTAAADLFTAAAQDAIAKRGKFTAVLTGGSSPSGIYKLLASDAYKNKID
CEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHCCCCC
WSKVYIFWGDERWVPLNDDLSNAKMSYAALLSHVPIPSENIFEMYKDGVTPEDYAVTYEQ
EEEEEEEECCCEEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCEEEEHHH
SIRKILGEEGKFDFIFLGMGDDGHTASLFPGEAVLNEQNKWVDAYFLAPQNMHRITLTAP
HHHHHHCCCCCEEEEEEEECCCCCEEEECCCHHHCCCCCCEEEEEEECCCCCEEEEEEEC
LINKAEKIIVVTFGEKKAHALKEVTKGEYNPSLYPTQLIKPVSGELVFLVDKSAAGTN
CCCCCCEEEEEEECCHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231; 9298645 [H]