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The map label for this gene is 146302514

Identifier: 146302514

GI number: 146302514

Start: 5784592

End: 5785794

Strand: Reverse

Name: 146302514

Synonym: Fjoh_4787

Alternate gene names: NA

Gene position: 5785794-5784592 (Counterclockwise)

Preceding gene: 146302516

Following gene: 146302510

Centisome position: 94.9

GC content: 34.83

Gene sequence:

>1203_bases
ATGAAGTTTGGAATTATTAAAGAAAGAAAAAATCCGCCGGATAGAAGAGTTGTTTTTTCTCCTAATGAACTGACAAAATT
AAAGCAGTCTTATCACGAAGCATCTGTTGAAGTAGAAAGCTCAGATATCAGGATATTCTCTGATGAAGCGTATAAAAATA
TGGGAATAACGGTTACTGATGACATTTCGAACTGTGACGTTTTATTTGGAGTAAAAGAAGTTCCTGTAGAAAATTTAATT
CCAAATAAAGCCTATTTTTTCTTTTCGCATACGATTAAAAAACAGCCTCATAACAGAAAATTACTTCAGGCAGTTTTAGA
GAAAAATATTGATTTATACGATCACGAAACCATAGTTGATGCACATGATCATCGTTTAATTGGTTTTGGGAAATATGCCG
GAATGGTAGGGGTTTACAACGGAATCCGTGCTTTTGGAATTAAGTTTGAATTGTTTAAACTGCCAAAAGCTGAATCTCTT
TCAGGAAAAGATGCATTAATTGAGCAGCTGAAACGTATTACAATGCCTGCTTTAAAATTTGTAGTTACCGGAACTGGAAA
AGTTGGGAGCGGAGCAAAAGAAATTCTCGATGCTATTAAAGTAAAAGAAATTACAGTTGATAATTATCTGACGAAAAAAT
ATACACAAGCTGTATATGTTCAGTTAGATGTTTTGGAATATAATAAACGTCTTGACGGACAGGTTTTAGATTTTAAAGAT
TTTGTCGAACATCCGCAAGAGTATACTTCAGATTTCGAGAAGTTTACAAAAGTGTCTGATATTTATTTTGCAGGGCATTT
CCATGCAAATAACGCTCCAATGATTTTAACGAGAGAAATGCTGAACGCGAGCGATTGTAAATTAAAAGTTGTAGCCGATA
TTTCCTGCGATGTAAACGGACCTATTGCCTGTACAATTCGTTCTTCGACAATTGAAGAACCTTTATACGGTTATTTTCCT
TTTGAAGATAAAGAAGTTGATTTTTTTCATCCTGCAGCTGTTGCTGTTATGGCGGTTGATAACCTGCCGTGTGAAATTCC
AAAAGACGCCAGCGAAGGTTTTGGTGAACAATTTATGGAACATGTTATTCCTGCTTTTTTCAACGGAGATAAAGACGGAA
TTTTAAAACGTGCCAAAATCACTGAAAACGGGAAATTGACGGAGAGATTTAGCTATCTGCAAGACTATGTTAATAATGGT
TAA

Upstream 100 bases:

>100_bases
TAAATTACATTTTTGAAACAAAATTTTAACTATATTTGTTATATTTGAAACAAATAACCTTTAAAAAGTTATATTATTAA
ACTATCAAAAACCTATTTAA

Downstream 100 bases:

>100_bases
TTGTAAATTGTTAATTATAAATTGAAAACGAGCTTTCTAAATTTTAGAAAGCTCGTTTTTTTAATGATCATATAAGATAA
TTAACAATTCACCATTAACA

Product: NAD(P) transhydrogenase subunit alpha

Products: L-lysine; 2-oxoglutarate; NADH; H+

Alternate protein names: Saccharopine Dehydrogenase; Alanine Dehydrogenase/PNT Domain Protein; NAD(P) Transhydrogenase Subunit Alpha; Alanine Dehydrogenase/Pnt Domain Protein; Monofunctional Lysine-Ketoglutarate Reductase; Alanine Dehydrogenase

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MKFGIIKERKNPPDRRVVFSPNELTKLKQSYHEASVEVESSDIRIFSDEAYKNMGITVTDDISNCDVLFGVKEVPVENLI
PNKAYFFFSHTIKKQPHNRKLLQAVLEKNIDLYDHETIVDAHDHRLIGFGKYAGMVGVYNGIRAFGIKFELFKLPKAESL
SGKDALIEQLKRITMPALKFVVTGTGKVGSGAKEILDAIKVKEITVDNYLTKKYTQAVYVQLDVLEYNKRLDGQVLDFKD
FVEHPQEYTSDFEKFTKVSDIYFAGHFHANNAPMILTREMLNASDCKLKVVADISCDVNGPIACTIRSSTIEEPLYGYFP
FEDKEVDFFHPAAVAVMAVDNLPCEIPKDASEGFGEQFMEHVIPAFFNGDKDGILKRAKITENGKLTERFSYLQDYVNNG

Sequences:

>Translated_400_residues
MKFGIIKERKNPPDRRVVFSPNELTKLKQSYHEASVEVESSDIRIFSDEAYKNMGITVTDDISNCDVLFGVKEVPVENLI
PNKAYFFFSHTIKKQPHNRKLLQAVLEKNIDLYDHETIVDAHDHRLIGFGKYAGMVGVYNGIRAFGIKFELFKLPKAESL
SGKDALIEQLKRITMPALKFVVTGTGKVGSGAKEILDAIKVKEITVDNYLTKKYTQAVYVQLDVLEYNKRLDGQVLDFKD
FVEHPQEYTSDFEKFTKVSDIYFAGHFHANNAPMILTREMLNASDCKLKVVADISCDVNGPIACTIRSSTIEEPLYGYFP
FEDKEVDFFHPAAVAVMAVDNLPCEIPKDASEGFGEQFMEHVIPAFFNGDKDGILKRAKITENGKLTERFSYLQDYVNNG
>Mature_400_residues
MKFGIIKERKNPPDRRVVFSPNELTKLKQSYHEASVEVESSDIRIFSDEAYKNMGITVTDDISNCDVLFGVKEVPVENLI
PNKAYFFFSHTIKKQPHNRKLLQAVLEKNIDLYDHETIVDAHDHRLIGFGKYAGMVGVYNGIRAFGIKFELFKLPKAESL
SGKDALIEQLKRITMPALKFVVTGTGKVGSGAKEILDAIKVKEITVDNYLTKKYTQAVYVQLDVLEYNKRLDGQVLDFKD
FVEHPQEYTSDFEKFTKVSDIYFAGHFHANNAPMILTREMLNASDCKLKVVADISCDVNGPIACTIRSSTIEEPLYGYFP
FEDKEVDFFHPAAVAVMAVDNLPCEIPKDASEGFGEQFMEHVIPAFFNGDKDGILKRAKITENGKLTERFSYLQDYVNNG

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI13027640, Length=444, Percent_Identity=25.9009009009009, Blast_Score=146, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17541738, Length=443, Percent_Identity=27.313769751693, Blast_Score=151, Evalue=5e-37,
Organism=Drosophila melanogaster, GI23397395, Length=443, Percent_Identity=29.3453724604966, Blast_Score=177, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 1.5.1.7; 1.5.1.8; 1.5.1.9

Molecular weight: Translated: 45288; Mature: 45288

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFGIIKERKNPPDRRVVFSPNELTKLKQSYHEASVEVESSDIRIFSDEAYKNMGITVTD
CCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHCEEEECCCEEEEECHHHCCCCCEEEC
DISNCDVLFGVKEVPVENLIPNKAYFFFSHTIKKQPHNRKLLQAVLEKNIDLYDHETIVD
CCCCCEEEECCHHCCHHHCCCCCEEEEEEHHHHCCCCHHHHHHHHHHCCCCCCCCCEEEE
AHDHRLIGFGKYAGMVGVYNGIRAFGIKFELFKLPKAESLSGKDALIEQLKRITMPALKF
CCCCEEEEEHHHHCHHHHHCCHHHHCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHEEE
VVTGTGKVGSGAKEILDAIKVKEITVDNYLTKKYTQAVYVQLDVLEYNKRLDGQVLDFKD
EEECCCCCCCCHHHHHHHHHHHEEEHHHHHHHHHCEEEEEEEEEEECCCCCCCEEECHHH
FVEHPQEYTSDFEKFTKVSDIYFAGHFHANNAPMILTREMLNASDCKLKVVADISCDVNG
HHCCHHHHHHHHHHHHHHHHEEEEEEEECCCCCEEEEHHHCCCCCCEEEEEEEEECCCCC
PIACTIRSSTIEEPLYGYFPFEDKEVDFFHPAAVAVMAVDNLPCEIPKDASEGFGEQFME
CEEEEEECCCCCCCCCCCCCCCCCCCCEECHHHEEEEEECCCCCCCCCCHHHHHHHHHHH
HVIPAFFNGDKDGILKRAKITENGKLTERFSYLQDYVNNG
HHHHHHCCCCHHHCEEEEEECCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKFGIIKERKNPPDRRVVFSPNELTKLKQSYHEASVEVESSDIRIFSDEAYKNMGITVTD
CCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHCEEEECCCEEEEECHHHCCCCCEEEC
DISNCDVLFGVKEVPVENLIPNKAYFFFSHTIKKQPHNRKLLQAVLEKNIDLYDHETIVD
CCCCCEEEECCHHCCHHHCCCCCEEEEEEHHHHCCCCHHHHHHHHHHCCCCCCCCCEEEE
AHDHRLIGFGKYAGMVGVYNGIRAFGIKFELFKLPKAESLSGKDALIEQLKRITMPALKF
CCCCEEEEEHHHHCHHHHHCCHHHHCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHEEE
VVTGTGKVGSGAKEILDAIKVKEITVDNYLTKKYTQAVYVQLDVLEYNKRLDGQVLDFKD
EEECCCCCCCCHHHHHHHHHHHEEEHHHHHHHHHCEEEEEEEEEEECCCCCCCEEECHHH
FVEHPQEYTSDFEKFTKVSDIYFAGHFHANNAPMILTREMLNASDCKLKVVADISCDVNG
HHCCHHHHHHHHHHHHHHHHEEEEEEEECCCCCEEEEHHHCCCCCCEEEEEEEEECCCCC
PIACTIRSSTIEEPLYGYFPFEDKEVDFFHPAAVAVMAVDNLPCEIPKDASEGFGEQFME
CEEEEEECCCCCCCCCCCCCCCCCCCCEECHHHEEEEEECCCCCCCCCCHHHHHHHHHHH
HVIPAFFNGDKDGILKRAKITENGKLTERFSYLQDYVNNG
HHHHHHCCCCHHHCEEEEEECCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N6-(L-1,3-dicarboxypropyl)-L-lysine; NAD+; H2O

Specific reaction: N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-lysine + 2-oxoglutarate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA