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The map label for this gene is fadE [H]

Identifier: 146302483

GI number: 146302483

Start: 5752844

End: 5754649

Strand: Direct

Name: fadE [H]

Synonym: Fjoh_4756

Alternate gene names: 146302483

Gene position: 5752844-5754649 (Clockwise)

Preceding gene: 146302482

Following gene: 146302484

Centisome position: 94.36

GC content: 38.04

Gene sequence:

>1806_bases
ATGGCAGATACAATTCAAAAAAACGTGACTCGTGGTGGTCAGTTTTTAGTTAAAGAAACAAAATGCGAAGATATCTTCAC
ACCAGAAGATTTCTCAGAAGAGCAGTTAATGATGCGTGACTCAGTAAAGGAGTTCGTAGACAAAGAATTATGGGCGCACA
AAGATCGTTTTGAGAAAAAAGATTATGCGTATACAGAATCATCTATGCGTAAAGCTGGTGAACTAGGACTTCTGGGAGTT
GCAGTTCCAGAAGAATACGGCGGATTAGGAATGGGATTTGTTTCTACAATGTTAGTTTGTGACTACATTTCTGGAGCAAC
AGGTTCTTTCTCTACTGCTTTTGGTGCACATACAGGAATTGGAACTATGCCAATTACACTTTACGGTACTGAAGAACAAA
AGAAAAAATACGTTCCGAAATTGGCTTCTGGAGAATGGTTTGGAGCTTATTGCTTAACTGAGCCAGGCGCAGGATCTGAT
GCTAACTCAGGAAAAACTAAAGCAGTTTTATCTGATGATGGAAAGTACTACTCTATTACAGGACAAAAAATGTGGATTTC
GAATGCAGGTTTCTGCAGCGTTTTCATCGTTTTTGCTCGTATTGGAGATGATAAAAATATTACAGGTTTCATCGTAGAAA
ACGATCCTTCAAACGGAATTTCTATGAATGAAGAAGAACATAAATTAGGAATCCGTGCTTCATCTACTCGTCAGGTTTTC
TTCAACGAAACAAAAGTTCCGGTTGAAAATATGTTATCTGAAAGAGGAAACGGTTTCAAAATTGCAATGAATGCTTTAAA
TGTTGGTCGTATTAAATTAGCAGCAGCTTGTTTAGATGCTCAAAGAAGAGTTACTTCTGGAGCTGTAAAATATGCTAACG
AAAGAATTCAGTTCAATACATCTATTTCATCTTTTGGAGCTATTCGTTCTAAATTAGCTGAAATGGCAACTAATGCTTAT
GCAGGAGAAAGTGCTTCTTACCGTGCTGCAAAAGATATCGAAGACAGAATCGCTGCTCGTGAGGCGGAAGGAACAAGTCA
CCAGGAAGCAGAATTGAAAGGTGTTGAAGAATACGCTATCGAGTGTTCTATCTTGAAAGTAGCGGTTTCTGAGGACGTTC
AAAACTGTTCTGACGAAGGTATCCAGGTTTTTGGTGGAATGGGATTCTCTGAAGATACTCCAATGGAGAGTGCCTGGAGA
GATGCTCGTATCGCTCGTATCTACGAAGGAACAAACGAAATCAACAGAATGCTTTCTGTAGGTATGCTGATCAAAAAAGC
AATGAAAGGACACGTTGATTTACTTGGACCAGCAATGAAAGTTCAGGAAGAATTAATGGGAATTCCATCTTTTGATACGC
CTGATTTCTCTGAATTATTCTCTGAAGAAAAAGTAATCGTGGCTAACTTGAAAAAAGTTTTCTTAATGGTTGCCGGAAGC
GCTGTTCAAAAATACGGTCCGGAATTAGATTCTCACCAACAATTATTGATGGCTGCAGCTGATATCTTAATCGAAATCTA
CATGGCTGAAAGTACTATTCTTAGAACTGAGAAATTAGCTAAAAAAGAAGGTGAAGATAAAGTACAAGAGCAAATCGCTA
TGGCAAAATTATACTTGTACAAAGCAGTAGATATCGTAAACTTAAGAGGAAAAGAAGGAATCGCTTCTTTCTCTGAAGGT
GACGAACAGCGTATGATGTTAATGGGACTTAAACGTTTCACTAAATACACTAACCTGCCAAACGTAGTAGCATTAAGAGA
AAAAATCGCAGAAAAATTAGTTGCAGAAAATTCATACTGCTTCTAA

Upstream 100 bases:

>100_bases
AACGAAGCAACCTCGCTAACAATTGCGCAAAGCAAGTGTGGTTGCTTCGTTCCTCGCAATGACAAGATTGAGCAAAAACA
AAATATAAAAAAACATAATC

Downstream 100 bases:

>100_bases
TATCAAAATAGTTTTTAGCTTTTAATTTGTTTAAACCCGTACAAGTCCGAAACTGTGCGGGTTTATTTTTTTTATCAATT
TTGAAAAGCCGTAAAAGCAT

Product: acyl-CoA dehydrogenase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 601; Mature: 600

Protein sequence:

>601_residues
MADTIQKNVTRGGQFLVKETKCEDIFTPEDFSEEQLMMRDSVKEFVDKELWAHKDRFEKKDYAYTESSMRKAGELGLLGV
AVPEEYGGLGMGFVSTMLVCDYISGATGSFSTAFGAHTGIGTMPITLYGTEEQKKKYVPKLASGEWFGAYCLTEPGAGSD
ANSGKTKAVLSDDGKYYSITGQKMWISNAGFCSVFIVFARIGDDKNITGFIVENDPSNGISMNEEEHKLGIRASSTRQVF
FNETKVPVENMLSERGNGFKIAMNALNVGRIKLAAACLDAQRRVTSGAVKYANERIQFNTSISSFGAIRSKLAEMATNAY
AGESASYRAAKDIEDRIAAREAEGTSHQEAELKGVEEYAIECSILKVAVSEDVQNCSDEGIQVFGGMGFSEDTPMESAWR
DARIARIYEGTNEINRMLSVGMLIKKAMKGHVDLLGPAMKVQEELMGIPSFDTPDFSELFSEEKVIVANLKKVFLMVAGS
AVQKYGPELDSHQQLLMAAADILIEIYMAESTILRTEKLAKKEGEDKVQEQIAMAKLYLYKAVDIVNLRGKEGIASFSEG
DEQRMMLMGLKRFTKYTNLPNVVALREKIAEKLVAENSYCF

Sequences:

>Translated_601_residues
MADTIQKNVTRGGQFLVKETKCEDIFTPEDFSEEQLMMRDSVKEFVDKELWAHKDRFEKKDYAYTESSMRKAGELGLLGV
AVPEEYGGLGMGFVSTMLVCDYISGATGSFSTAFGAHTGIGTMPITLYGTEEQKKKYVPKLASGEWFGAYCLTEPGAGSD
ANSGKTKAVLSDDGKYYSITGQKMWISNAGFCSVFIVFARIGDDKNITGFIVENDPSNGISMNEEEHKLGIRASSTRQVF
FNETKVPVENMLSERGNGFKIAMNALNVGRIKLAAACLDAQRRVTSGAVKYANERIQFNTSISSFGAIRSKLAEMATNAY
AGESASYRAAKDIEDRIAAREAEGTSHQEAELKGVEEYAIECSILKVAVSEDVQNCSDEGIQVFGGMGFSEDTPMESAWR
DARIARIYEGTNEINRMLSVGMLIKKAMKGHVDLLGPAMKVQEELMGIPSFDTPDFSELFSEEKVIVANLKKVFLMVAGS
AVQKYGPELDSHQQLLMAAADILIEIYMAESTILRTEKLAKKEGEDKVQEQIAMAKLYLYKAVDIVNLRGKEGIASFSEG
DEQRMMLMGLKRFTKYTNLPNVVALREKIAEKLVAENSYCF
>Mature_600_residues
ADTIQKNVTRGGQFLVKETKCEDIFTPEDFSEEQLMMRDSVKEFVDKELWAHKDRFEKKDYAYTESSMRKAGELGLLGVA
VPEEYGGLGMGFVSTMLVCDYISGATGSFSTAFGAHTGIGTMPITLYGTEEQKKKYVPKLASGEWFGAYCLTEPGAGSDA
NSGKTKAVLSDDGKYYSITGQKMWISNAGFCSVFIVFARIGDDKNITGFIVENDPSNGISMNEEEHKLGIRASSTRQVFF
NETKVPVENMLSERGNGFKIAMNALNVGRIKLAAACLDAQRRVTSGAVKYANERIQFNTSISSFGAIRSKLAEMATNAYA
GESASYRAAKDIEDRIAAREAEGTSHQEAELKGVEEYAIECSILKVAVSEDVQNCSDEGIQVFGGMGFSEDTPMESAWRD
ARIARIYEGTNEINRMLSVGMLIKKAMKGHVDLLGPAMKVQEELMGIPSFDTPDFSELFSEEKVIVANLKKVFLMVAGSA
VQKYGPELDSHQQLLMAAADILIEIYMAESTILRTEKLAKKEGEDKVQEQIAMAKLYLYKAVDIVNLRGKEGIASFSEGD
EQRMMLMGLKRFTKYTNLPNVVALREKIAEKLVAENSYCF

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI21361497, Length=416, Percent_Identity=40.1442307692308, Blast_Score=280, Evalue=3e-75,
Organism=Homo sapiens, GI4557235, Length=361, Percent_Identity=40.4432132963989, Blast_Score=259, Evalue=6e-69,
Organism=Homo sapiens, GI76496475, Length=535, Percent_Identity=33.8317757009346, Blast_Score=259, Evalue=7e-69,
Organism=Homo sapiens, GI4557233, Length=408, Percent_Identity=32.3529411764706, Blast_Score=229, Evalue=6e-60,
Organism=Homo sapiens, GI4501859, Length=393, Percent_Identity=33.3333333333333, Blast_Score=209, Evalue=7e-54,
Organism=Homo sapiens, GI226958412, Length=394, Percent_Identity=33.248730964467, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI187960098, Length=395, Percent_Identity=34.6835443037975, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI4557231, Length=395, Percent_Identity=34.6835443037975, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI226958414, Length=354, Percent_Identity=35.0282485875706, Blast_Score=198, Evalue=1e-50,
Organism=Homo sapiens, GI7656849, Length=390, Percent_Identity=30.5128205128205, Blast_Score=177, Evalue=4e-44,
Organism=Homo sapiens, GI4501857, Length=408, Percent_Identity=29.9019607843137, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI4503943, Length=394, Percent_Identity=27.6649746192893, Blast_Score=149, Evalue=1e-35,
Organism=Homo sapiens, GI7669494, Length=316, Percent_Identity=30.0632911392405, Blast_Score=146, Evalue=6e-35,
Organism=Homo sapiens, GI38505218, Length=306, Percent_Identity=27.4509803921569, Blast_Score=96, Evalue=7e-20,
Organism=Escherichia coli, GI87081958, Length=392, Percent_Identity=28.5714285714286, Blast_Score=125, Evalue=7e-30,
Organism=Escherichia coli, GI1786223, Length=404, Percent_Identity=26.7326732673267, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI87081702, Length=495, Percent_Identity=23.2323232323232, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI87082384, Length=291, Percent_Identity=23.3676975945017, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71985184, Length=352, Percent_Identity=40.625, Blast_Score=259, Evalue=3e-69,
Organism=Caenorhabditis elegans, GI17569725, Length=402, Percent_Identity=34.3283582089552, Blast_Score=219, Evalue=5e-57,
Organism=Caenorhabditis elegans, GI17534899, Length=389, Percent_Identity=35.73264781491, Blast_Score=218, Evalue=6e-57,
Organism=Caenorhabditis elegans, GI17506239, Length=421, Percent_Identity=34.916864608076, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI71985192, Length=303, Percent_Identity=39.2739273927393, Blast_Score=212, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI17538396, Length=393, Percent_Identity=32.0610687022901, Blast_Score=201, Evalue=7e-52,
Organism=Caenorhabditis elegans, GI17570075, Length=423, Percent_Identity=31.2056737588652, Blast_Score=192, Evalue=6e-49,
Organism=Caenorhabditis elegans, GI17508101, Length=390, Percent_Identity=30.7692307692308, Blast_Score=183, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17533517, Length=383, Percent_Identity=31.331592689295, Blast_Score=177, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI32563615, Length=237, Percent_Identity=41.3502109704641, Blast_Score=166, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI71990804, Length=261, Percent_Identity=37.1647509578544, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17534353, Length=420, Percent_Identity=27.8571428571429, Blast_Score=135, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI17551932, Length=388, Percent_Identity=24.2268041237113, Blast_Score=125, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI71982178, Length=287, Percent_Identity=29.616724738676, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17505929, Length=388, Percent_Identity=22.4226804123711, Blast_Score=112, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI86563381, Length=377, Percent_Identity=26.790450928382, Blast_Score=100, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI86563383, Length=377, Percent_Identity=26.790450928382, Blast_Score=100, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17562446, Length=343, Percent_Identity=25.3644314868805, Blast_Score=89, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17531909, Length=251, Percent_Identity=25.4980079681275, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI281363737, Length=424, Percent_Identity=34.9056603773585, Blast_Score=257, Evalue=2e-68,
Organism=Drosophila melanogaster, GI21356377, Length=425, Percent_Identity=33.8823529411765, Blast_Score=243, Evalue=3e-64,
Organism=Drosophila melanogaster, GI24660351, Length=394, Percent_Identity=34.7715736040609, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24646207, Length=399, Percent_Identity=32.5814536340852, Blast_Score=212, Evalue=7e-55,
Organism=Drosophila melanogaster, GI24666513, Length=401, Percent_Identity=33.4164588528678, Blast_Score=206, Evalue=3e-53,
Organism=Drosophila melanogaster, GI21355753, Length=394, Percent_Identity=32.741116751269, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI19920834, Length=302, Percent_Identity=28.8079470198675, Blast_Score=131, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: NA

Molecular weight: Translated: 66295; Mature: 66164

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00072 ACYL_COA_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADTIQKNVTRGGQFLVKETKCEDIFTPEDFSEEQLMMRDSVKEFVDKELWAHKDRFEKK
CCCHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCH
DYAYTESSMRKAGELGLLGVAVPEEYGGLGMGFVSTMLVCDYISGATGSFSTAFGAHTGI
HHHHCHHHHHHCCCCCEEEEECCHHHCCCCHHHHHHHHHHHHHCCCCCCCCHHCCCCCCC
GTMPITLYGTEEQKKKYVPKLASGEWFGAYCLTEPGAGSDANSGKTKAVLSDDGKYYSIT
CCCEEEEECCHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCEEEEEECCCCEEEEE
GQKMWISNAGFCSVFIVFARIGDDKNITGFIVENDPSNGISMNEEEHKLGIRASSTRQVF
CCEEEECCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCHHHHCCCEECCCCEEE
FNETKVPVENMLSERGNGFKIAMNALNVGRIKLAAACLDAQRRVTSGAVKYANERIQFNT
ECCCCCCHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEC
SISSFGAIRSKLAEMATNAYAGESASYRAAKDIEDRIAAREAEGTSHQEAELKGVEEYAI
CHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHCHHHHHH
ECSILKVAVSEDVQNCSDEGIQVFGGMGFSEDTPMESAWRDARIARIYEGTNEINRMLSV
HHHHEEEHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHH
GMLIKKAMKGHVDLLGPAMKVQEELMGIPSFDTPDFSELFSEEKVIVANLKKVFLMVAGS
HHHHHHHHHCCHHHHCHHHHHHHHHCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHH
AVQKYGPELDSHQQLLMAAADILIEIYMAESTILRTEKLAKKEGEDKVQEQIAMAKLYLY
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
KAVDIVNLRGKEGIASFSEGDEQRMMLMGLKRFTKYTNLPNVVALREKIAEKLVAENSYC
HHHHEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCC
F
C
>Mature Secondary Structure 
ADTIQKNVTRGGQFLVKETKCEDIFTPEDFSEEQLMMRDSVKEFVDKELWAHKDRFEKK
CCHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCH
DYAYTESSMRKAGELGLLGVAVPEEYGGLGMGFVSTMLVCDYISGATGSFSTAFGAHTGI
HHHHCHHHHHHCCCCCEEEEECCHHHCCCCHHHHHHHHHHHHHCCCCCCCCHHCCCCCCC
GTMPITLYGTEEQKKKYVPKLASGEWFGAYCLTEPGAGSDANSGKTKAVLSDDGKYYSIT
CCCEEEEECCHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCEEEEEECCCCEEEEE
GQKMWISNAGFCSVFIVFARIGDDKNITGFIVENDPSNGISMNEEEHKLGIRASSTRQVF
CCEEEECCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCHHHHCCCEECCCCEEE
FNETKVPVENMLSERGNGFKIAMNALNVGRIKLAAACLDAQRRVTSGAVKYANERIQFNT
ECCCCCCHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEC
SISSFGAIRSKLAEMATNAYAGESASYRAAKDIEDRIAAREAEGTSHQEAELKGVEEYAI
CHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHCHHHHHH
ECSILKVAVSEDVQNCSDEGIQVFGGMGFSEDTPMESAWRDARIARIYEGTNEINRMLSV
HHHHEEEHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHH
GMLIKKAMKGHVDLLGPAMKVQEELMGIPSFDTPDFSELFSEEKVIVANLKKVFLMVAGS
HHHHHHHHHCCHHHHCHHHHHHHHHCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHH
AVQKYGPELDSHQQLLMAAADILIEIYMAESTILRTEKLAKKEGEDKVQEQIAMAKLYLY
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
KAVDIVNLRGKEGIASFSEGDEQRMMLMGLKRFTKYTNLPNVVALREKIAEKLVAENSYC
HHHHEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCC
F
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]