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The map label for this gene is fadA [H]

Identifier: 146302482

GI number: 146302482

Start: 5751516

End: 5752697

Strand: Direct

Name: fadA [H]

Synonym: Fjoh_4755

Alternate gene names: 146302482

Gene position: 5751516-5752697 (Clockwise)

Preceding gene: 146302481

Following gene: 146302483

Centisome position: 94.34

GC content: 39.76

Gene sequence:

>1182_bases
ATGAAAACAGCATATATAGTAAAAGCATATAGAACAGCAGTTGGAAAAGCTCCAAAAGGTGTTTTTAGATTTAAAAGACC
TGATGAATTAGCTGCAGAAACCATTCAGTTTATGATGGACGAACTGCCTAATTTCGATAAAAAACGTATCGATGATGTTA
TGGTAGGAAATGCCATGCCGGAGGCGGAACAAGGTCTTAACGTTGGACGTTTAATCTCTTTAATGGGATTAAAAGTAGAA
GACGTTCCTGGAGTTACAGTAAACCGCTATTGCGCATCTGGATTAGAAACTATCGGAATGGCAACTGCTAAAATCCAATC
AGGAATGGCAGATTGTATCATCGCTGGTGGTGCAGAAAGTATGAGTTATATTCCGATGGGAGGTTACAAACCAACTCCGG
ATTATAAAGTTGCTGCAGCGGGTCACGAAGATTACTATTGGGGAATGGGTTTAACTGCTGAGGCGGTGGCTAACCAATAC
AAAATCTCTAGAGAAGATCAGGATGAGTTTGCTTACAACTCTCACATGAAAGCATTAAAAGCGCAGGCAGAAGGGAAATT
CGATAAACAAATCGTTCCAATTACTGTTGAGCAGACTTTCATCAATGAAAATGGTAAAAAAGAAACAAAATCATACGTTG
TAAACAAAGACGAAGGACCAAGAGCAGGAACTTCTAAAGAAGCTTTAGCAGGTTTAAAACCAGTTTTTGCTGCTGACGGA
AGTGTAACAGCTGGTAACTCTTCTCAAATGAGCGACGGTGCTGCATTCGTTTTAATCATGAGCGAAGAAATGGTAAAAGA
ATTAAACCTTGAACCAATTGCACGTTTGGTAAACTTTGCTTCTTCTGGTGTTGAGCCAAGAATTATGGGTATCGGTCCTG
TAAAAGCAATTCCGAAAGCGTTGAAACAAGCAGGATTAACATTGAACGATATTGAGTTAATTGAATTAAATGAGGCTTTT
GCTTCACAAGCTTTAGCAGTAACTCGCGAATTAAACATAAACCCAGAAATCGTAAACGTAAATGGTGGAGCAATTGCTTT
AGGTCACCCTCTGGGATGTACTGGAGCTAAACTTTCTGTTCAGTTGTTTGATGAAATGAAACGTAGAGGCAATAAGTACG
GAATCGTTTCTATGTGTGTAGGAACTGGGCAAGGAAGCGCGGGGATTTACGAAGTGTTGTAA

Upstream 100 bases:

>100_bases
AGCAACATGAATTTTGCGCTTCAAAGATCTCTAAAAAAATAATAACTATATCGATTGGCAGTCTTAATACTTAATACACC
AATCTTAATACATTTTATAA

Downstream 100 bases:

>100_bases
TAAGTAGTATTAAGTAAAGTATACGTCCAGTTTGGTCATTGCGAGGAACGAAGCAACCTCGCTAACAATTGCGCAAAGCA
AGTGTGGTTGCTTCGTTCCT

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MKTAYIVKAYRTAVGKAPKGVFRFKRPDELAAETIQFMMDELPNFDKKRIDDVMVGNAMPEAEQGLNVGRLISLMGLKVE
DVPGVTVNRYCASGLETIGMATAKIQSGMADCIIAGGAESMSYIPMGGYKPTPDYKVAAAGHEDYYWGMGLTAEAVANQY
KISREDQDEFAYNSHMKALKAQAEGKFDKQIVPITVEQTFINENGKKETKSYVVNKDEGPRAGTSKEALAGLKPVFAADG
SVTAGNSSQMSDGAAFVLIMSEEMVKELNLEPIARLVNFASSGVEPRIMGIGPVKAIPKALKQAGLTLNDIELIELNEAF
ASQALAVTRELNINPEIVNVNGGAIALGHPLGCTGAKLSVQLFDEMKRRGNKYGIVSMCVGTGQGSAGIYEVL

Sequences:

>Translated_393_residues
MKTAYIVKAYRTAVGKAPKGVFRFKRPDELAAETIQFMMDELPNFDKKRIDDVMVGNAMPEAEQGLNVGRLISLMGLKVE
DVPGVTVNRYCASGLETIGMATAKIQSGMADCIIAGGAESMSYIPMGGYKPTPDYKVAAAGHEDYYWGMGLTAEAVANQY
KISREDQDEFAYNSHMKALKAQAEGKFDKQIVPITVEQTFINENGKKETKSYVVNKDEGPRAGTSKEALAGLKPVFAADG
SVTAGNSSQMSDGAAFVLIMSEEMVKELNLEPIARLVNFASSGVEPRIMGIGPVKAIPKALKQAGLTLNDIELIELNEAF
ASQALAVTRELNINPEIVNVNGGAIALGHPLGCTGAKLSVQLFDEMKRRGNKYGIVSMCVGTGQGSAGIYEVL
>Mature_393_residues
MKTAYIVKAYRTAVGKAPKGVFRFKRPDELAAETIQFMMDELPNFDKKRIDDVMVGNAMPEAEQGLNVGRLISLMGLKVE
DVPGVTVNRYCASGLETIGMATAKIQSGMADCIIAGGAESMSYIPMGGYKPTPDYKVAAAGHEDYYWGMGLTAEAVANQY
KISREDQDEFAYNSHMKALKAQAEGKFDKQIVPITVEQTFINENGKKETKSYVVNKDEGPRAGTSKEALAGLKPVFAADG
SVTAGNSSQMSDGAAFVLIMSEEMVKELNLEPIARLVNFASSGVEPRIMGIGPVKAIPKALKQAGLTLNDIELIELNEAF
ASQALAVTRELNINPEIVNVNGGAIALGHPLGCTGAKLSVQLFDEMKRRGNKYGIVSMCVGTGQGSAGIYEVL

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=387, Percent_Identity=43.4108527131783, Blast_Score=299, Evalue=3e-81,
Organism=Homo sapiens, GI167614485, Length=410, Percent_Identity=38.0487804878049, Blast_Score=255, Evalue=5e-68,
Organism=Homo sapiens, GI148539872, Length=320, Percent_Identity=40.625, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI4557237, Length=404, Percent_Identity=34.9009900990099, Blast_Score=198, Evalue=8e-51,
Organism=Homo sapiens, GI194353979, Length=387, Percent_Identity=33.8501291989664, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI4504327, Length=411, Percent_Identity=30.9002433090024, Blast_Score=162, Evalue=3e-40,
Organism=Escherichia coli, GI1787663, Length=410, Percent_Identity=41.4634146341463, Blast_Score=286, Evalue=2e-78,
Organism=Escherichia coli, GI48994986, Length=399, Percent_Identity=40.6015037593985, Blast_Score=277, Evalue=8e-76,
Organism=Escherichia coli, GI1788554, Length=405, Percent_Identity=41.4814814814815, Blast_Score=264, Evalue=8e-72,
Organism=Escherichia coli, GI87082165, Length=400, Percent_Identity=39.25, Blast_Score=254, Evalue=7e-69,
Organism=Escherichia coli, GI1788683, Length=366, Percent_Identity=31.6939890710383, Blast_Score=158, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI133906874, Length=405, Percent_Identity=40.9876543209877, Blast_Score=273, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI25147385, Length=398, Percent_Identity=33.9195979899498, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17535921, Length=400, Percent_Identity=34.75, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17551802, Length=418, Percent_Identity=28.2296650717703, Blast_Score=148, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17535917, Length=400, Percent_Identity=28, Blast_Score=129, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6322031, Length=400, Percent_Identity=40, Blast_Score=252, Evalue=6e-68,
Organism=Saccharomyces cerevisiae, GI6325229, Length=406, Percent_Identity=36.6995073891626, Blast_Score=228, Evalue=9e-61,
Organism=Drosophila melanogaster, GI24655093, Length=404, Percent_Identity=39.6039603960396, Blast_Score=261, Evalue=5e-70,
Organism=Drosophila melanogaster, GI17648125, Length=405, Percent_Identity=40.2469135802469, Blast_Score=247, Evalue=8e-66,
Organism=Drosophila melanogaster, GI24640423, Length=400, Percent_Identity=32, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI17137578, Length=411, Percent_Identity=30.9002433090024, Blast_Score=169, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 42139; Mature: 42139

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTAYIVKAYRTAVGKAPKGVFRFKRPDELAAETIQFMMDELPNFDKKRIDDVMVGNAMP
CCCEEEHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCC
EAEQGLNVGRLISLMGLKVEDVPGVTVNRYCASGLETIGMATAKIQSGMADCIIAGGAES
CHHHCCCHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCC
MSYIPMGGYKPTPDYKVAAAGHEDYYWGMGLTAEAVANQYKISREDQDEFAYNSHMKALK
CEEEECCCCCCCCCCEEEECCCCCEEECCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHH
AQAEGKFDKQIVPITVEQTFINENGKKETKSYVVNKDEGPRAGTSKEALAGLKPVFAADG
HHHCCCCCCEEEEEEEEEEECCCCCCCHHHHEEEECCCCCCCCCCHHHHHCCCCEEECCC
SVTAGNSSQMSDGAAFVLIMSEEMVKELNLEPIARLVNFASSGVEPRIMGIGPVKAIPKA
CEECCCCCCCCCCCEEEEEECHHHHHHCCHHHHHHHHHHHHCCCCCEEEECCCHHHHHHH
LKQAGLTLNDIELIELNEAFASQALAVTRELNINPEIVNVNGGAIALGHPLGCTGAKLSV
HHHHCCEECCEEEEEECHHHHHHHHHHHEECCCCCEEEEECCCEEEECCCCCCCCCEEHH
QLFDEMKRRGNKYGIVSMCVGTGQGSAGIYEVL
HHHHHHHHCCCCCCEEEEEEECCCCCCCCEECC
>Mature Secondary Structure
MKTAYIVKAYRTAVGKAPKGVFRFKRPDELAAETIQFMMDELPNFDKKRIDDVMVGNAMP
CCCEEEHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCC
EAEQGLNVGRLISLMGLKVEDVPGVTVNRYCASGLETIGMATAKIQSGMADCIIAGGAES
CHHHCCCHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCC
MSYIPMGGYKPTPDYKVAAAGHEDYYWGMGLTAEAVANQYKISREDQDEFAYNSHMKALK
CEEEECCCCCCCCCCEEEECCCCCEEECCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHH
AQAEGKFDKQIVPITVEQTFINENGKKETKSYVVNKDEGPRAGTSKEALAGLKPVFAADG
HHHCCCCCCEEEEEEEEEEECCCCCCCHHHHEEEECCCCCCCCCCHHHHHCCCCEEECCC
SVTAGNSSQMSDGAAFVLIMSEEMVKELNLEPIARLVNFASSGVEPRIMGIGPVKAIPKA
CEECCCCCCCCCCCEEEEEECHHHHHHCCHHHHHHHHHHHHCCCCCEEEECCCHHHHHHH
LKQAGLTLNDIELIELNEAFASQALAVTRELNINPEIVNVNGGAIALGHPLGCTGAKLSV
HHHHCCEECCEEEEEECHHHHHHHHHHHEECCCCCEEEEECCCEEEECCCCCCCCCEEHH
QLFDEMKRRGNKYGIVSMCVGTGQGSAGIYEVL
HHHHHHHHCCCCCCEEEEEEECCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]