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The map label for this gene is pdxH

Identifier: 146302269

GI number: 146302269

Start: 5488492

End: 5489136

Strand: Reverse

Name: pdxH

Synonym: Fjoh_4542

Alternate gene names: 146302269

Gene position: 5489136-5488492 (Counterclockwise)

Preceding gene: 146302270

Following gene: 146302268

Centisome position: 90.03

GC content: 35.19

Gene sequence:

>645_bases
ATGAACGATTTAAGCAATTATAGAAAGTCTTACGAGAAAAGCGAATTATTAGAAACTAATATTCCGGAAGATCCAATTAA
TCTTTTTAACCGCTGGTTTCATGAAGTTGAAGATTTTGGCGGAAGCGGAGAAGTAAATGCCATGACGGTTTCAACAATTG
GACTGGATGGATTTCCAAAATCGCGCGTTGTTTTACTTAAAAAATTCTCAGAAGAAGGATTTATATTCTACACCAATTAT
AATTCTGAAAAAGGAAAAGCAATTGAAGCAAATCCTAATGTTTGTTTGTCATTTTTCTGGCAGGAAGCAGAACGTCAGGT
AATTATTAAGGGAATCGCTCAGAAAACTTCTGAAATTATATCTGATAACTATTTTGATTCAAGACCTGACGGAAGTAAAT
TAGGCGCAATTGTTTCACATCAAAGTGAAGTAATTCCGTCGAGAACTTTTTTAGAAGAAAATTTAAAGAAACTTGAAGCA
GAATTTGAAGGAAAACCTATCCCAAGACCTGAAAACTGGGGAGGTTATTTAGTAACTCCATTACAAGTAGAATTCTGGCA
GGGAAGACCTAACAGACTGCACGATAGAATTCGTTATACAAGCCAATCTGATTTTTCATGGACGATTGAGCGCCTTTCTT
CTTAA

Upstream 100 bases:

>100_bases
TACTAAGTTTCTAAGTTTTTACTCATCTGTAAATTGTCATCCTGACAAACCTGAAACTTGAAACCTGAAACAAAAAATCA
ACAATCTAAAATAATAAATC

Downstream 100 bases:

>100_bases
TTTGTAAGATTTTTATTTTATATTTAAAAATAATAGTGCATTTCATCGATTATTTTTGTAGTTTACCGATAAATTGAATA
CGTTTGACGTAAGAATTTTA

Product: pyridoxamine 5'-phosphate oxidase

Products: NA

Alternate protein names: PNP/PMP oxidase; PNPOx; Pyridoxal 5'-phosphate synthase

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MNDLSNYRKSYEKSELLETNIPEDPINLFNRWFHEVEDFGGSGEVNAMTVSTIGLDGFPKSRVVLLKKFSEEGFIFYTNY
NSEKGKAIEANPNVCLSFFWQEAERQVIIKGIAQKTSEIISDNYFDSRPDGSKLGAIVSHQSEVIPSRTFLEENLKKLEA
EFEGKPIPRPENWGGYLVTPLQVEFWQGRPNRLHDRIRYTSQSDFSWTIERLSS

Sequences:

>Translated_214_residues
MNDLSNYRKSYEKSELLETNIPEDPINLFNRWFHEVEDFGGSGEVNAMTVSTIGLDGFPKSRVVLLKKFSEEGFIFYTNY
NSEKGKAIEANPNVCLSFFWQEAERQVIIKGIAQKTSEIISDNYFDSRPDGSKLGAIVSHQSEVIPSRTFLEENLKKLEA
EFEGKPIPRPENWGGYLVTPLQVEFWQGRPNRLHDRIRYTSQSDFSWTIERLSS
>Mature_214_residues
MNDLSNYRKSYEKSELLETNIPEDPINLFNRWFHEVEDFGGSGEVNAMTVSTIGLDGFPKSRVVLLKKFSEEGFIFYTNY
NSEKGKAIEANPNVCLSFFWQEAERQVIIKGIAQKTSEIISDNYFDSRPDGSKLGAIVSHQSEVIPSRTFLEENLKKLEA
EFEGKPIPRPENWGGYLVTPLQVEFWQGRPNRLHDRIRYTSQSDFSWTIERLSS

Specific function: Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)

COG id: COG0259

COG function: function code H; Pyridoxamine-phosphate oxidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxamine 5'-phosphate oxidase family

Homologues:

Organism=Homo sapiens, GI8922498, Length=228, Percent_Identity=40.3508771929825, Blast_Score=180, Evalue=8e-46,
Organism=Escherichia coli, GI1787926, Length=213, Percent_Identity=40.3755868544601, Blast_Score=171, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI17553712, Length=220, Percent_Identity=40.9090909090909, Blast_Score=169, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6319509, Length=207, Percent_Identity=40.0966183574879, Blast_Score=157, Evalue=2e-39,
Organism=Drosophila melanogaster, GI45551845, Length=201, Percent_Identity=43.7810945273632, Blast_Score=151, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24644901, Length=201, Percent_Identity=43.7810945273632, Blast_Score=151, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24644903, Length=175, Percent_Identity=26.2857142857143, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXH_FLAJ1 (A5FB76)

Other databases:

- EMBL:   CP000685
- RefSeq:   YP_001196860.1
- ProteinModelPortal:   A5FB76
- SMR:   A5FB76
- STRING:   A5FB76
- GeneID:   5092615
- GenomeReviews:   CP000685_GR
- KEGG:   fjo:Fjoh_4542
- eggNOG:   COG0259
- HOGENOM:   HBG327559
- OMA:   LLETNIP
- ProtClustDB:   CLSK851562
- BioCyc:   FJOH376686:FJOH_4542-MONOMER
- HAMAP:   MF_01629
- InterPro:   IPR000659
- InterPro:   IPR019740
- InterPro:   IPR019576
- InterPro:   IPR011576
- InterPro:   IPR012349
- InterPro:   IPR009002
- Gene3D:   G3DSA:2.30.110.10
- PANTHER:   PTHR10851
- PIRSF:   PIRSF000190
- TIGRFAMs:   TIGR00558

Pfam domain/function: PF10590 PNPOx_C; PF01243 Pyridox_oxidase; SSF50475 FMN_binding

EC number: =1.4.3.5

Molecular weight: Translated: 24671; Mature: 24671

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS01064 PYRIDOX_OXIDASE

Important sites: BINDING 62-62 BINDING 65-65 BINDING 67-67 BINDING 84-84 BINDING 124-124 BINDING 128-128 BINDING 132-132

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDLSNYRKSYEKSELLETNIPEDPINLFNRWFHEVEDFGGSGEVNAMTVSTIGLDGFPK
CCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCC
SRVVLLKKFSEEGFIFYTNYNSEKGKAIEANPNVCLSFFWQEAERQVIIKGIAQKTSEII
HHHHEEEECCCCCEEEEECCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SDNYFDSRPDGSKLGAIVSHQSEVIPSRTFLEENLKKLEAEFEGKPIPRPENWGGYLVTP
HCCCCCCCCCCHHHHHHHHCHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEE
LQVEFWQGRPNRLHDRIRYTSQSDFSWTIERLSS
EEEEEECCCCHHHHHHHHCCCCCCHHHHHHHHCC
>Mature Secondary Structure
MNDLSNYRKSYEKSELLETNIPEDPINLFNRWFHEVEDFGGSGEVNAMTVSTIGLDGFPK
CCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCC
SRVVLLKKFSEEGFIFYTNYNSEKGKAIEANPNVCLSFFWQEAERQVIIKGIAQKTSEII
HHHHEEEECCCCCEEEEECCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SDNYFDSRPDGSKLGAIVSHQSEVIPSRTFLEENLKKLEAEFEGKPIPRPENWGGYLVTP
HCCCCCCCCCCHHHHHHHHCHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEE
LQVEFWQGRPNRLHDRIRYTSQSDFSWTIERLSS
EEEEEECCCCHHHHHHHHCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA