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The map label for this gene is folP [H]

Identifier: 146301239

GI number: 146301239

Start: 4172767

End: 4173588

Strand: Reverse

Name: folP [H]

Synonym: Fjoh_3497

Alternate gene names: 146301239

Gene position: 4173588-4172767 (Counterclockwise)

Preceding gene: 146301247

Following gene: 146301238

Centisome position: 68.45

GC content: 34.06

Gene sequence:

>822_bases
ATGTTTATTAACTGCAAAGGCGGACTTATAGATTTATCGATTCCTAAAGTAATGGGAATTTTAAACGTTACGCCGAATTC
TTTCTTTGATGGAGGGAAATATAAAAACGAAGACGAAATTATTTCGCAAGTAGATAAAATGCTTTCTGAAGGCGCAGCAT
TTATCGATATTGGAGCCTATTCAAGCAAACCAAGCGCTGAATTTGTAACCGAACAAGAAGAAATCGACCGAATTGTTCCT
GCAATTGAATTGATTTTAAAGCATTTTCCAAAAACATTATTATCTATTGACACTTTTAGGGCTGAAGTCGCAAAAGCGAG
TATCGAAAGCGGTGCGGCGATAATAAATGATATTGCGGCGGGCGAATTAGATGATAAAATGTTTGATGTTATCGCAAAAT
ATAACGTTCCATATATCATGATGCACATGCGAGGAAATCCACAGACGATGCAGAGTTTGACGCAATACGATGATATCATT
AAAGAAATGCTTTTCTATTTTTCTGAAAAAGTAAAACAAGCAAGGTCATTAGGAATTAACGATTTAATATTAGATCCTGG
TTTTGGTTTTGCTAAAACAACGGATCAGAATTATGAAGTAATGCAGAAAATGGAGCTTTTTAATCTTTTAGAATTACCTG
TTTTAGCAGGAATTTCAAGAAAATCAATGATTTATAAAACGCTGGATATTACACCGCAAGATGCTTTAAACGGAACAACG
TTTCTAAATACCATTGCTTTGACAAAAGGTGCTAAAATTCTTCGTGTGCATGATGTAAAAGAAGCAGTGGAATGTGTTAC
TTTGTTTAATAAAATGAGTTAA

Upstream 100 bases:

>100_bases
TTAACGGCAGTAACTTGAAACTAAAAAAATGTTTCAAGTTCTCGAACTTACGCAATCTGCATCAACTTGAAACTTTGAAC
AATTAAAAACTTGAAACAAA

Downstream 100 bases:

>100_bases
AAAATATGAAATACTTCTCTATACTTATAATCTGTCTTTTGTTTTCCTGCGGAAAAAAAGAAGACGTTTTATTGCCAAAA
TCAAATATTTCAATTGTAAA

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 273; Mature: 273

Protein sequence:

>273_residues
MFINCKGGLIDLSIPKVMGILNVTPNSFFDGGKYKNEDEIISQVDKMLSEGAAFIDIGAYSSKPSAEFVTEQEEIDRIVP
AIELILKHFPKTLLSIDTFRAEVAKASIESGAAIINDIAAGELDDKMFDVIAKYNVPYIMMHMRGNPQTMQSLTQYDDII
KEMLFYFSEKVKQARSLGINDLILDPGFGFAKTTDQNYEVMQKMELFNLLELPVLAGISRKSMIYKTLDITPQDALNGTT
FLNTIALTKGAKILRVHDVKEAVECVTLFNKMS

Sequences:

>Translated_273_residues
MFINCKGGLIDLSIPKVMGILNVTPNSFFDGGKYKNEDEIISQVDKMLSEGAAFIDIGAYSSKPSAEFVTEQEEIDRIVP
AIELILKHFPKTLLSIDTFRAEVAKASIESGAAIINDIAAGELDDKMFDVIAKYNVPYIMMHMRGNPQTMQSLTQYDDII
KEMLFYFSEKVKQARSLGINDLILDPGFGFAKTTDQNYEVMQKMELFNLLELPVLAGISRKSMIYKTLDITPQDALNGTT
FLNTIALTKGAKILRVHDVKEAVECVTLFNKMS
>Mature_273_residues
MFINCKGGLIDLSIPKVMGILNVTPNSFFDGGKYKNEDEIISQVDKMLSEGAAFIDIGAYSSKPSAEFVTEQEEIDRIVP
AIELILKHFPKTLLSIDTFRAEVAKASIESGAAIINDIAAGELDDKMFDVIAKYNVPYIMMHMRGNPQTMQSLTQYDDII
KEMLFYFSEKVKQARSLGINDLILDPGFGFAKTTDQNYEVMQKMELFNLLELPVLAGISRKSMIYKTLDITPQDALNGTT
FLNTIALTKGAKILRVHDVKEAVECVTLFNKMS

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=270, Percent_Identity=40.7407407407407, Blast_Score=220, Evalue=8e-59,
Organism=Saccharomyces cerevisiae, GI6324073, Length=319, Percent_Identity=31.0344827586207, Blast_Score=132, Evalue=6e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 30459; Mature: 30459

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFINCKGGLIDLSIPKVMGILNVTPNSFFDGGKYKNEDEIISQVDKMLSEGAAFIDIGAY
CEEECCCCEEEEEHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCC
SSKPSAEFVTEQEEIDRIVPAIELILKHFPKTLLSIDTFRAEVAKASIESGAAIINDIAA
CCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHC
GELDDKMFDVIAKYNVPYIMMHMRGNPQTMQSLTQYDDIIKEMLFYFSEKVKQARSLGIN
CCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DLILDPGFGFAKTTDQNYEVMQKMELFNLLELPVLAGISRKSMIYKTLDITPQDALNGTT
CEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHEEHEECCCCHHHCCCHH
FLNTIALTKGAKILRVHDVKEAVECVTLFNKMS
HHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFINCKGGLIDLSIPKVMGILNVTPNSFFDGGKYKNEDEIISQVDKMLSEGAAFIDIGAY
CEEECCCCEEEEEHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCC
SSKPSAEFVTEQEEIDRIVPAIELILKHFPKTLLSIDTFRAEVAKASIESGAAIINDIAA
CCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHC
GELDDKMFDVIAKYNVPYIMMHMRGNPQTMQSLTQYDDIIKEMLFYFSEKVKQARSLGIN
CCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DLILDPGFGFAKTTDQNYEVMQKMELFNLLELPVLAGISRKSMIYKTLDITPQDALNGTT
CEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHEEHEECCCCHHHCCCHH
FLNTIALTKGAKILRVHDVKEAVECVTLFNKMS
HHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]