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The map label for this gene is ilvC

Identifier: 146300609

GI number: 146300609

Start: 3393112

End: 3394581

Strand: Reverse

Name: ilvC

Synonym: Fjoh_2860

Alternate gene names: 146300609

Gene position: 3394581-3393112 (Counterclockwise)

Preceding gene: 146300610

Following gene: 146300608

Centisome position: 55.68

GC content: 36.05

Gene sequence:

>1470_bases
ATGGCAAATTATTTCAACACACTACCACTTAGATTACAATTAGAGCAACTAGGAGTTTGCGAATTTATGGAGCAATCAGA
ATTTGCAGACGGAATTTCAGCATTAGCTGGTAAAAAAGTTGTCATTGTAGGTTGTGGTGCACAAGGTTTGAATCAAGGTT
TAAACATGAGAGATTCAGGTTTAGATATTTCTTATGCTTTGCGTGCAGATGCAATTGCAGAAAAGAGAGCTTCATATAAA
AATGCAACTGAAAACGGGTTTAAAGTAGGTACTTATGAAGAGTTGATTCCAACAGCTGATTTAGTTTGTAACCTTACTCC
GGATAAACAGCATACTTCTGTAGTTAATGCTATTATGCCATTAATGAAACAAGGATCAACTTTAGCTTATTCTCACGGTT
TCAACATTGTTGAAGAAGGAATGCAGATTCGTAAAGATATTACAGTAATTATGTGTGCTCCTAAATGTCCTGGTTCTGAG
GTTCGTGAAGAGTACAAAAGAGGATTTGGTGTGCCAACACTTATTGCAGTTCACCCAGAAAACGATCCAAACGGATTTGG
TTTAGATCAGGCAAAAGCTTACGCTGTAGCAACTGGAGGACACAAAGCAGGAGTTTTAAGATCATCTTTCGTAGCTGAAG
TAAAATCAGATTTAATGGGTGAGCAGACAATTCTTTGCGGATTGCTTCAAACTGGATCTATTTTATGCTTTGATAAAATG
GTTGAAAAAGGAATCGATGCTGCTTATGCTTCAAAATTAATTCAATATGGATGGGAAACTATCACTGAAGCTTTGAAACA
TGGTGGTATTACAAACATGATGGATCGTTTAAATAATCCTTCTAAAATTGAAGCTTACGAATTAGCAGAAGAATTAAAAG
ACATCATGCGTCCGTTATTCCAAAAACACCAAGACGATATTATTTCTGGAGAATTCTCAAGAACTATGATGATCGACTGG
GCTAACGACGATGTTAACTTATTAAAATGGAGAGCTGCAACAGGAGAAACTAACTTCGAAAAAACAGCGCCGCAAGAAGC
TCCAATCTCTGAGCAGGAATATTTTGATAACGGAGTATTAATGATTGCTATGGTAAAAGCGGGTGTTGAATTAGCTTTTG
AAACTATGACAGAAGCTGGTATCATCGAAGAATCTGCTTACTACGAGTCATTACACGAATTACCATTAATTGCTAATACT
ATCGCTAGAAAGAAATTATTCGAAATGAACCGTGTAATTTCTGATACTGCTGAGTACGGATGTTATTTATTTGATCATGC
TTGTAAGCCATTATTGACTGAATTCATGAAAAAAGTAGAAACTAACATTATTGGTAAACCATTCTCAACTTCAAATGGAG
TAGATAATACGGTATTAATTGCTGTTAACAAAGAAATTCGTCAGCACCCTATCGAAGAAGTAGGAGCCTGGTTACGTGAG
TCTATGACAGCAATGAAAAAAATTGGATAA

Upstream 100 bases:

>100_bases
ATTACTGGAAACATTCAAATAACAATTTAAAGACGGTTTAGGCCGTAATCATAAAAATAATCAATTATTAAATTTCATTT
CATTAATATTTTAAAACAAA

Downstream 100 bases:

>100_bases
ATAAATTTGGGAATTTCCGCCCATGTTAAGGTGGAATTTGCTCTGTATCAATGTTTTGAATTAATATTTTGAATTAGTAA
GCACTTATTAAGTAAATAGA

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 489; Mature: 488

Protein sequence:

>489_residues
MANYFNTLPLRLQLEQLGVCEFMEQSEFADGISALAGKKVVIVGCGAQGLNQGLNMRDSGLDISYALRADAIAEKRASYK
NATENGFKVGTYEELIPTADLVCNLTPDKQHTSVVNAIMPLMKQGSTLAYSHGFNIVEEGMQIRKDITVIMCAPKCPGSE
VREEYKRGFGVPTLIAVHPENDPNGFGLDQAKAYAVATGGHKAGVLRSSFVAEVKSDLMGEQTILCGLLQTGSILCFDKM
VEKGIDAAYASKLIQYGWETITEALKHGGITNMMDRLNNPSKIEAYELAEELKDIMRPLFQKHQDDIISGEFSRTMMIDW
ANDDVNLLKWRAATGETNFEKTAPQEAPISEQEYFDNGVLMIAMVKAGVELAFETMTEAGIIEESAYYESLHELPLIANT
IARKKLFEMNRVISDTAEYGCYLFDHACKPLLTEFMKKVETNIIGKPFSTSNGVDNTVLIAVNKEIRQHPIEEVGAWLRE
SMTAMKKIG

Sequences:

>Translated_489_residues
MANYFNTLPLRLQLEQLGVCEFMEQSEFADGISALAGKKVVIVGCGAQGLNQGLNMRDSGLDISYALRADAIAEKRASYK
NATENGFKVGTYEELIPTADLVCNLTPDKQHTSVVNAIMPLMKQGSTLAYSHGFNIVEEGMQIRKDITVIMCAPKCPGSE
VREEYKRGFGVPTLIAVHPENDPNGFGLDQAKAYAVATGGHKAGVLRSSFVAEVKSDLMGEQTILCGLLQTGSILCFDKM
VEKGIDAAYASKLIQYGWETITEALKHGGITNMMDRLNNPSKIEAYELAEELKDIMRPLFQKHQDDIISGEFSRTMMIDW
ANDDVNLLKWRAATGETNFEKTAPQEAPISEQEYFDNGVLMIAMVKAGVELAFETMTEAGIIEESAYYESLHELPLIANT
IARKKLFEMNRVISDTAEYGCYLFDHACKPLLTEFMKKVETNIIGKPFSTSNGVDNTVLIAVNKEIRQHPIEEVGAWLRE
SMTAMKKIG
>Mature_488_residues
ANYFNTLPLRLQLEQLGVCEFMEQSEFADGISALAGKKVVIVGCGAQGLNQGLNMRDSGLDISYALRADAIAEKRASYKN
ATENGFKVGTYEELIPTADLVCNLTPDKQHTSVVNAIMPLMKQGSTLAYSHGFNIVEEGMQIRKDITVIMCAPKCPGSEV
REEYKRGFGVPTLIAVHPENDPNGFGLDQAKAYAVATGGHKAGVLRSSFVAEVKSDLMGEQTILCGLLQTGSILCFDKMV
EKGIDAAYASKLIQYGWETITEALKHGGITNMMDRLNNPSKIEAYELAEELKDIMRPLFQKHQDDIISGEFSRTMMIDWA
NDDVNLLKWRAATGETNFEKTAPQEAPISEQEYFDNGVLMIAMVKAGVELAFETMTEAGIIEESAYYESLHELPLIANTI
ARKKLFEMNRVISDTAEYGCYLFDHACKPLLTEFMKKVETNIIGKPFSTSNGVDNTVLIAVNKEIRQHPIEEVGAWLRES
MTAMKKIG

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=489, Percent_Identity=75.2556237218814, Blast_Score=736, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323387, Length=256, Percent_Identity=31.640625, Blast_Score=109, Evalue=9e-25,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_FLAJ1 (A5FFY3)

Other databases:

- EMBL:   CP000685
- RefSeq:   YP_001195200.1
- ProteinModelPortal:   A5FFY3
- SMR:   A5FFY3
- STRING:   A5FFY3
- GeneID:   5090489
- GenomeReviews:   CP000685_GR
- KEGG:   fjo:Fjoh_2860
- eggNOG:   COG0059
- HOGENOM:   HBG297205
- OMA:   EKHMDDI
- ProtClustDB:   PRK05225
- BioCyc:   FJOH376686:FJOH_2860-MONOMER
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- InterPro:   IPR014359
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- PIRSF:   PIRSF000116
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 54051; Mature: 53919

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: ACT_SITE 132-132

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANYFNTLPLRLQLEQLGVCEFMEQSEFADGISALAGKKVVIVGCGAQGLNQGLNMRDSG
CCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHCCCCCCCCC
LDISYALRADAIAEKRASYKNATENGFKVGTYEELIPTADLVCNLTPDKQHTSVVNAIMP
CCEEEHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCHHHEEECCCCHHHHHHHHHHHH
LMKQGSTLAYSHGFNIVEEGMQIRKDITVIMCAPKCPGSEVREEYKRGFGVPTLIAVHPE
HHHCCCEEEECCCCHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHCCCCCEEEEECCC
NDPNGFGLDQAKAYAVATGGHKAGVLRSSFVAEVKSDLMGEQTILCGLLQTGSILCFDKM
CCCCCCCCCHHCEEEEECCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHH
VEKGIDAAYASKLIQYGWETITEALKHGGITNMMDRLNNPSKIEAYELAEELKDIMRPLF
HHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
QKHQDDIISGEFSRTMMIDWANDDVNLLKWRAATGETNFEKTAPQEAPISEQEYFDNGVL
HHHCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHCCCEE
MIAMVKAGVELAFETMTEAGIIEESAYYESLHELPLIANTIARKKLFEMNRVISDTAEYG
EEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHH
CYLFDHACKPLLTEFMKKVETNIIGKPFSTSNGVDNTVLIAVNKEIRQHPIEEVGAWLRE
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECHHHHHCCHHHHHHHHHH
SMTAMKKIG
HHHHHHHCC
>Mature Secondary Structure 
ANYFNTLPLRLQLEQLGVCEFMEQSEFADGISALAGKKVVIVGCGAQGLNQGLNMRDSG
CCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHCCCCCCCCC
LDISYALRADAIAEKRASYKNATENGFKVGTYEELIPTADLVCNLTPDKQHTSVVNAIMP
CCEEEHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCHHHEEECCCCHHHHHHHHHHHH
LMKQGSTLAYSHGFNIVEEGMQIRKDITVIMCAPKCPGSEVREEYKRGFGVPTLIAVHPE
HHHCCCEEEECCCCHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHCCCCCEEEEECCC
NDPNGFGLDQAKAYAVATGGHKAGVLRSSFVAEVKSDLMGEQTILCGLLQTGSILCFDKM
CCCCCCCCCHHCEEEEECCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHH
VEKGIDAAYASKLIQYGWETITEALKHGGITNMMDRLNNPSKIEAYELAEELKDIMRPLF
HHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
QKHQDDIISGEFSRTMMIDWANDDVNLLKWRAATGETNFEKTAPQEAPISEQEYFDNGVL
HHHCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHCCCEE
MIAMVKAGVELAFETMTEAGIIEESAYYESLHELPLIANTIARKKLFEMNRVISDTAEYG
EEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHH
CYLFDHACKPLLTEFMKKVETNIIGKPFSTSNGVDNTVLIAVNKEIRQHPIEEVGAWLRE
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECHHHHHCCHHHHHHHHHH
SMTAMKKIG
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA