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The map label for this gene is acsA [H]

Identifier: 146300608

GI number: 146300608

Start: 3390701

End: 3392611

Strand: Reverse

Name: acsA [H]

Synonym: Fjoh_2859

Alternate gene names: 146300608

Gene position: 3392611-3390701 (Counterclockwise)

Preceding gene: 146300609

Following gene: 146300606

Centisome position: 55.65

GC content: 35.53

Gene sequence:

>1911_bases
ATGAGTTATTATAAAATTGAAAATTTAGAACAATATTTTAAACATTACAATAAGTCAATACGAGAGCCGAGAAAATTTTG
GGGAAAAATTGCTGAAGAAAATTTTACTTGGTATCAACAGTGGGAAAAAGTTGTTGATTTTAATATGGCCGATGCCGAAG
TAAAATGGTTTACAGAAGCAAAGGTTAACATTACCAAAAATTGTATCGACAGACACTTAAGCAAAAGAGGAGATAAAACG
GCTATTATTTTTGAGCCGAATGAACCTTCTGAAGAAGCTTTACATATAACATACAACGAGCTTTACGAAAGAGTTTCAAA
AATGGCAAATGTTTTGCGTGAACAGGGAATTCGTAAAGGAGACCGCGTGTGCATTTACCTTCCAATGATTCCAGAACTGG
CAGTAGCTGTTTTGGCATGTGCCAGAATTGGAGCAATTCACTCAGTGGTTTTTGCAGGATTTTCTGCTTCTGCAGTTTCT
GCCAGAATTAACGACTGCGAATGTAAAATGGTTATTACATCAGACGGTGGTTACAGAGGAAATAAAACAATTGATTTAAA
AGGAATTGTTGATGAAGCCTTAGATACCTGTCCATCAGTTTCTAAAGTTTTGGTTGTAAAAAGAACTAAAACAGAAATTG
CTATGAAAGAAGGCCGTGACATTTGGTTACAGCCATTATTAGATGCAGCTCTTGATAATAGTGTTGCAGAAATTATGGAT
GCCGAAGATCCTTTGTTTATTTTATATACATCTGGATCTACAGGAAAACCAAAAGGAATGGTGCATACAACAGCTGGATA
CATGGTTTATACAGCTTATACATTCAAAAACGTATTCAGCCACGAAGAAAATGATATCTTTTGGTGTACGGCAGATATTG
GATGGATTACAGGACACTCTTATATATTATATGGACCATTGTTAAATGGAGGAACAACTGTAATTTTTGAAGGCGTTCCT
TCTTATCCTGATTTCAGCCGTTTTTGGGATATTATCGAAAAACATAAAATCACACAATTTTATACAGCACCAACAGCGAT
TCGTTCATTAGCAAAAGAAAGTTTAGATTATATTCAAAAATATCCTCTAAAATCTCTTAAAGTAATTGGATCTGTTGGAG
AACCAATCAACGAAGAAGCTTGGCACTGGTTCAACGACCACGTTGGAGACAAGAGATGTCCTGTTGTAGATACTTGGTGG
CAGACAGAAACCGGTGGAATTATGATTTCGCCAATTGCTTTTGTTACGCCTACAAAACCAACTTATGCAACTTTACCATT
ACCGGGAATTCAGCCGGTTTTAATGGATGAAAAACGCAACGAAATTGAAGGAAATCAAGTAGTTGGAAGTTTATGTATTA
AATTTCCATGGCCTGGAATCGCCAGAACAATCTGGAATAATCACGATCGTTATAAAGAAACGTATTTCTCTGCTTTCCCT
GGAAAATATTTTACAGGAGACGGTGCATTACGCGATGAAGTAGGATATTACAGAATCACAGGTAGAGTAGATGATGTTGT
AATTGTTTCTGGACATAATTTAGGAACTGCTCCAATTGAAGATGCTATCAACGAACATCAAGCGGTTGCCGAATCTGCAA
TTGTTGGATTCCCACATGATATTAAAGGAAATGCATTATATGGTTTTGTTATCCTGAAAGAAACCGGAGAAGTTAGAAAT
AAAGAAAACTTAACAAAAGAGATCAACCAGTATATTTCTGATCACATTGGACCAATTGCGAAATTAGATAAAATCCAATT
TGTTTCTGGCTTGCCAAAAACTCGTTCAGGAAAAATTATGCGTAGAATTTTACGTAAAATTGCTGAAGGTGATTTCTCTA
ACTTTGGAGATACAACTACATTATTAAATCCTGAAGTTGTAGAACAGATTATGAAAGAAAGAATTGCATAA

Upstream 100 bases:

>100_bases
TTATTTATTATATGTTTTTTTTTTGTCAAAATTTATGAATTAAATAATTTTAAGAATAGAAGCATATTTAATACATTTAT
AAAAAAAATTCCACAAAACT

Downstream 100 bases:

>100_bases
TTCTCGATAAATAAATAAAAAAGCCTCTTAAAAATTAAGAGGCTTTTTTTATGTTTACAATTTATGCCAGACTGAGCGAA
GTCGAAGTCCTGCAAATTGA

Product: acetate--CoA ligase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 636; Mature: 635

Protein sequence:

>636_residues
MSYYKIENLEQYFKHYNKSIREPRKFWGKIAEENFTWYQQWEKVVDFNMADAEVKWFTEAKVNITKNCIDRHLSKRGDKT
AIIFEPNEPSEEALHITYNELYERVSKMANVLREQGIRKGDRVCIYLPMIPELAVAVLACARIGAIHSVVFAGFSASAVS
ARINDCECKMVITSDGGYRGNKTIDLKGIVDEALDTCPSVSKVLVVKRTKTEIAMKEGRDIWLQPLLDAALDNSVAEIMD
AEDPLFILYTSGSTGKPKGMVHTTAGYMVYTAYTFKNVFSHEENDIFWCTADIGWITGHSYILYGPLLNGGTTVIFEGVP
SYPDFSRFWDIIEKHKITQFYTAPTAIRSLAKESLDYIQKYPLKSLKVIGSVGEPINEEAWHWFNDHVGDKRCPVVDTWW
QTETGGIMISPIAFVTPTKPTYATLPLPGIQPVLMDEKRNEIEGNQVVGSLCIKFPWPGIARTIWNNHDRYKETYFSAFP
GKYFTGDGALRDEVGYYRITGRVDDVVIVSGHNLGTAPIEDAINEHQAVAESAIVGFPHDIKGNALYGFVILKETGEVRN
KENLTKEINQYISDHIGPIAKLDKIQFVSGLPKTRSGKIMRRILRKIAEGDFSNFGDTTTLLNPEVVEQIMKERIA

Sequences:

>Translated_636_residues
MSYYKIENLEQYFKHYNKSIREPRKFWGKIAEENFTWYQQWEKVVDFNMADAEVKWFTEAKVNITKNCIDRHLSKRGDKT
AIIFEPNEPSEEALHITYNELYERVSKMANVLREQGIRKGDRVCIYLPMIPELAVAVLACARIGAIHSVVFAGFSASAVS
ARINDCECKMVITSDGGYRGNKTIDLKGIVDEALDTCPSVSKVLVVKRTKTEIAMKEGRDIWLQPLLDAALDNSVAEIMD
AEDPLFILYTSGSTGKPKGMVHTTAGYMVYTAYTFKNVFSHEENDIFWCTADIGWITGHSYILYGPLLNGGTTVIFEGVP
SYPDFSRFWDIIEKHKITQFYTAPTAIRSLAKESLDYIQKYPLKSLKVIGSVGEPINEEAWHWFNDHVGDKRCPVVDTWW
QTETGGIMISPIAFVTPTKPTYATLPLPGIQPVLMDEKRNEIEGNQVVGSLCIKFPWPGIARTIWNNHDRYKETYFSAFP
GKYFTGDGALRDEVGYYRITGRVDDVVIVSGHNLGTAPIEDAINEHQAVAESAIVGFPHDIKGNALYGFVILKETGEVRN
KENLTKEINQYISDHIGPIAKLDKIQFVSGLPKTRSGKIMRRILRKIAEGDFSNFGDTTTLLNPEVVEQIMKERIA
>Mature_635_residues
SYYKIENLEQYFKHYNKSIREPRKFWGKIAEENFTWYQQWEKVVDFNMADAEVKWFTEAKVNITKNCIDRHLSKRGDKTA
IIFEPNEPSEEALHITYNELYERVSKMANVLREQGIRKGDRVCIYLPMIPELAVAVLACARIGAIHSVVFAGFSASAVSA
RINDCECKMVITSDGGYRGNKTIDLKGIVDEALDTCPSVSKVLVVKRTKTEIAMKEGRDIWLQPLLDAALDNSVAEIMDA
EDPLFILYTSGSTGKPKGMVHTTAGYMVYTAYTFKNVFSHEENDIFWCTADIGWITGHSYILYGPLLNGGTTVIFEGVPS
YPDFSRFWDIIEKHKITQFYTAPTAIRSLAKESLDYIQKYPLKSLKVIGSVGEPINEEAWHWFNDHVGDKRCPVVDTWWQ
TETGGIMISPIAFVTPTKPTYATLPLPGIQPVLMDEKRNEIEGNQVVGSLCIKFPWPGIARTIWNNHDRYKETYFSAFPG
KYFTGDGALRDEVGYYRITGRVDDVVIVSGHNLGTAPIEDAINEHQAVAESAIVGFPHDIKGNALYGFVILKETGEVRNK
ENLTKEINQYISDHIGPIAKLDKIQFVSGLPKTRSGKIMRRILRKIAEGDFSNFGDTTTLLNPEVVEQIMKERIA

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI28416953, Length=620, Percent_Identity=49.5161290322581, Blast_Score=644, Evalue=0.0,
Organism=Homo sapiens, GI8923896, Length=662, Percent_Identity=50, Blast_Score=639, Evalue=0.0,
Organism=Homo sapiens, GI253970489, Length=675, Percent_Identity=49.1851851851852, Blast_Score=637, Evalue=0.0,
Organism=Homo sapiens, GI13375727, Length=637, Percent_Identity=35.9497645211931, Blast_Score=415, Evalue=1e-116,
Organism=Homo sapiens, GI42544132, Length=581, Percent_Identity=27.3666092943201, Blast_Score=188, Evalue=2e-47,
Organism=Homo sapiens, GI38505220, Length=513, Percent_Identity=28.8499025341131, Blast_Score=182, Evalue=1e-45,
Organism=Homo sapiens, GI115511026, Length=522, Percent_Identity=27.2030651340996, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI31982927, Length=638, Percent_Identity=24.9216300940439, Blast_Score=169, Evalue=1e-41,
Organism=Homo sapiens, GI122937307, Length=517, Percent_Identity=27.0793036750484, Blast_Score=168, Evalue=2e-41,
Organism=Homo sapiens, GI58082049, Length=605, Percent_Identity=25.7851239669421, Blast_Score=164, Evalue=3e-40,
Organism=Homo sapiens, GI157311624, Length=607, Percent_Identity=25.5354200988468, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI157311622, Length=607, Percent_Identity=25.5354200988468, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI42544134, Length=350, Percent_Identity=25.4285714285714, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI195947378, Length=427, Percent_Identity=23.6533957845433, Blast_Score=91, Evalue=3e-18,
Organism=Escherichia coli, GI1790505, Length=633, Percent_Identity=52.7646129541864, Blast_Score=673, Evalue=0.0,
Organism=Escherichia coli, GI1786529, Length=630, Percent_Identity=37.3015873015873, Blast_Score=411, Evalue=1e-116,
Organism=Escherichia coli, GI1788107, Length=556, Percent_Identity=26.7985611510791, Blast_Score=129, Evalue=8e-31,
Organism=Escherichia coli, GI145693145, Length=521, Percent_Identity=21.3051823416507, Blast_Score=99, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI71983001, Length=648, Percent_Identity=48.3024691358025, Blast_Score=573, Evalue=1e-163,
Organism=Caenorhabditis elegans, GI71982997, Length=648, Percent_Identity=48.3024691358025, Blast_Score=572, Evalue=1e-163,
Organism=Caenorhabditis elegans, GI17569507, Length=632, Percent_Identity=23.1012658227848, Blast_Score=142, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17557194, Length=579, Percent_Identity=22.6252158894646, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17538037, Length=543, Percent_Identity=23.572744014733, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17558820, Length=514, Percent_Identity=23.9299610894942, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI32563687, Length=519, Percent_Identity=22.7360308285164, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17560140, Length=388, Percent_Identity=24.4845360824742, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17531443, Length=548, Percent_Identity=21.8978102189781, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71985884, Length=382, Percent_Identity=21.7277486910995, Blast_Score=77, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6323182, Length=641, Percent_Identity=48.3619344773791, Blast_Score=614, Evalue=1e-176,
Organism=Saccharomyces cerevisiae, GI6319264, Length=646, Percent_Identity=46.4396284829721, Blast_Score=575, Evalue=1e-165,
Organism=Saccharomyces cerevisiae, GI6319699, Length=368, Percent_Identity=23.3695652173913, Blast_Score=87, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24667955, Length=651, Percent_Identity=48.6943164362519, Blast_Score=620, Evalue=1e-178,
Organism=Drosophila melanogaster, GI62472339, Length=565, Percent_Identity=51.858407079646, Blast_Score=584, Evalue=1e-167,
Organism=Drosophila melanogaster, GI24667959, Length=523, Percent_Identity=51.8164435946463, Blast_Score=540, Evalue=1e-153,
Organism=Drosophila melanogaster, GI21355225, Length=625, Percent_Identity=35.36, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI18859661, Length=537, Percent_Identity=23.2774674115456, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21355181, Length=543, Percent_Identity=23.572744014733, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI45550496, Length=488, Percent_Identity=21.1065573770492, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI45552801, Length=488, Percent_Identity=21.1065573770492, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 71887; Mature: 71756

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYYKIENLEQYFKHYNKSIREPRKFWGKIAEENFTWYQQWEKVVDFNMADAEVKWFTEA
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEEEEECC
KVNITKNCIDRHLSKRGDKTAIIFEPNEPSEEALHITYNELYERVSKMANVLREQGIRKG
CEEHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCC
DRVCIYLPMIPELAVAVLACARIGAIHSVVFAGFSASAVSARINDCECKMVITSDGGYRG
CCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHEECCCCEEEEEEECCCCCCC
NKTIDLKGIVDEALDTCPSVSKVLVVKRTKTEIAMKEGRDIWLQPLLDAALDNSVAEIMD
CEEEEEHHHHHHHHHCCCCCCEEEEEEECHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHC
AEDPLFILYTSGSTGKPKGMVHTTAGYMVYTAYTFKNVFSHEENDIFWCTADIGWITGHS
CCCCEEEEEECCCCCCCCCEEEECCCEEEEEHHHHHHHHCCCCCCEEEEECCCCEEECCC
YILYGPLLNGGTTVIFEGVPSYPDFSRFWDIIEKHKITQFYTAPTAIRSLAKESLDYIQK
EEEEECCCCCCCEEEECCCCCCCCHHHHHHHHHHHCHHHEEECHHHHHHHHHHHHHHHHH
YPLKSLKVIGSVGEPINEEAWHWFNDHVGDKRCPVVDTWWQTETGGIMISPIAFVTPTKP
CCHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCEEECCCCCCCCCEEEECEEEECCCCC
TYATLPLPGIQPVLMDEKRNEIEGNQVVGSLCIKFPWPGIARTIWNNHDRYKETYFSAFP
CEEECCCCCCCCHHCCCCCCCCCHHHHEEEHEEECCCCHHHHHHHCCCHHHHHHHHHHCC
GKYFTGDGALRDEVGYYRITGRVDDVVIVSGHNLGTAPIEDAINEHQAVAESAIVGFPHD
CCEEECCCCCCCCCCEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCC
IKGNALYGFVILKETGEVRNKENLTKEINQYISDHIGPIAKLDKIQFVSGLPKTRSGKIM
CCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHH
RRILRKIAEGDFSNFGDTTTLLNPEVVEQIMKERIA
HHHHHHHHCCCCCCCCCCEEECCHHHHHHHHHHHCC
>Mature Secondary Structure 
SYYKIENLEQYFKHYNKSIREPRKFWGKIAEENFTWYQQWEKVVDFNMADAEVKWFTEA
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEEEEECC
KVNITKNCIDRHLSKRGDKTAIIFEPNEPSEEALHITYNELYERVSKMANVLREQGIRKG
CEEHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCC
DRVCIYLPMIPELAVAVLACARIGAIHSVVFAGFSASAVSARINDCECKMVITSDGGYRG
CCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHEECCCCEEEEEEECCCCCCC
NKTIDLKGIVDEALDTCPSVSKVLVVKRTKTEIAMKEGRDIWLQPLLDAALDNSVAEIMD
CEEEEEHHHHHHHHHCCCCCCEEEEEEECHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHC
AEDPLFILYTSGSTGKPKGMVHTTAGYMVYTAYTFKNVFSHEENDIFWCTADIGWITGHS
CCCCEEEEEECCCCCCCCCEEEECCCEEEEEHHHHHHHHCCCCCCEEEEECCCCEEECCC
YILYGPLLNGGTTVIFEGVPSYPDFSRFWDIIEKHKITQFYTAPTAIRSLAKESLDYIQK
EEEEECCCCCCCEEEECCCCCCCCHHHHHHHHHHHCHHHEEECHHHHHHHHHHHHHHHHH
YPLKSLKVIGSVGEPINEEAWHWFNDHVGDKRCPVVDTWWQTETGGIMISPIAFVTPTKP
CCHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCEEECCCCCCCCCEEEECEEEECCCCC
TYATLPLPGIQPVLMDEKRNEIEGNQVVGSLCIKFPWPGIARTIWNNHDRYKETYFSAFP
CEEECCCCCCCCHHCCCCCCCCCHHHHEEEHEEECCCCHHHHHHHCCCHHHHHHHHHHCC
GKYFTGDGALRDEVGYYRITGRVDDVVIVSGHNLGTAPIEDAINEHQAVAESAIVGFPHD
CCEEECCCCCCCCCCEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCC
IKGNALYGFVILKETGEVRNKENLTKEINQYISDHIGPIAKLDKIQFVSGLPKTRSGKIM
CCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHH
RRILRKIAEGDFSNFGDTTTLLNPEVVEQIMKERIA
HHHHHHHHCCCCCCCCCCEEECCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA