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The map label for this gene is copA [H]

Identifier: 146300291

GI number: 146300291

Start: 3018867

End: 3021254

Strand: Direct

Name: copA [H]

Synonym: Fjoh_2536

Alternate gene names: 146300291

Gene position: 3018867-3021254 (Clockwise)

Preceding gene: 146300289

Following gene: 146300292

Centisome position: 49.52

GC content: 32.96

Gene sequence:

>2388_bases
ATGAGTGAGCAGAGTTGTTTTCATTGCGGGCTTGAAATTCCTAAAGATGAAGAGATCAATTTTGATGAAAAAACATTTTG
TTGTACAGGCTGTAAAACAGTTTACGAAATTTTTAGTCTAAATGATTTAACCTGTTATTATGATTTCGAAAAATCTCCTG
GCGCAACTCCGCAGGATATTAAAGGCAAATATGATTTTTTAGACAACGAATCTATTCTTGCAAAAGTTTTAGAGTTTCAG
GAATCAAATACTTCAATAGTTTCTTTAAATATCCCTCACATTCACTGCAGTTCATGTATCTGGATTCTGGAAAACTTAAA
CAGATTAAATTCAGGTATAAGCAGTTCTCAGGTTAATTTTCCGGAAAAAAGAGTTAGAATCACTTTTAATTCAGAAATCG
TATCACTGAAAGAAATTGCCTATTTATTGAGTTCAATTGGTTATGAACCTTATATAAGCTTAGAAAACTACGAAACAGGA
AAAACAAAAGTAGACAGAAGTTTAACTTATAAACTGGGAGTTGCCTTTTTCTGCTTTGGAAATATTATGCTGCTTTCTTT
TCCGGAATATTTCGAAATGAAAGAATTTTGGTTAGATAGCTACAAACCGTTTTTTAGACTCTTGATTTTTGTTTTGGCTC
TGCCAAGCTTCTTTTATTCAGCGAGTGGTTATTACGTTTCGGCCTATAAAAGTATCAAAAGCGGTATGCTTAACATTGAT
ATTCCAATTGCATTAGGAATCATTGTAATGTTTATACGAAGTACTTATGATATGCTAATGGACCACGGACCGGGATTTTT
TGACAGTCTTGCCAGTTTGGTTTTCTTTATGCTGCTTGGGAAAATGTTTCAAATTAAAACCTACAGTTTTTTAAGTTTTG
AAAGAGATTTTAAATCCTATTTTCCTATTGCTGTTACCCGAATTAATTCAGATGCATCTGAAGAAAGTGTGCCAATTTAC
GATGTTTTAAAAGGAAACAGACTCTTAATTAGAAATCAGGAGCTAATTCCTGTTGATGGTATTTTAATTAGTGAAAAAGC
TGAGATCGATTATAGTTTTGTAACGGGAGAAGCAGTTCCAATTACAAAAAAATCGGGAGATAAAGTTTTTGCCGGCGGAA
AACAAATTGGAAAAGTGATAGAAATGGAAGTTTTACATTCTGTTTCTCAAAGTTACTTAACACAGTTATGGAGCAATGAA
GTTTTTCAGAAAAAAGTGCAGCAAAAGCATAAAACAATTACAGATGCAATAAGCCGTTATTTTACGCCAATTTTATTATT
AATTGCATTTGCAGGATTTGGTTATTGGATATTTATTGATGCCAATACAGCTTTTAATGTTTTTACGGCAGTTTTAATTG
TTGCATGCCCTTGTGCATTGGCTTTAACAGCTCCGTTTACTTTTGGAAACATTCTCAGAATAATGGGAAAACAAAAGATG
TATCTAAAAAATGCTTTGGTTATAGAGCAATTGGATAAAGTTGATACCATCGTTTTTGATAAAACAGGAACTATTACAAC
CAATAAAAAATCGAATATCATATACGAAGGAACAAATATTTCTGACGATAATTATTTGTTGATTAAAAATGTTCTCCGAG
GATCTAATCATCCGTTAAGCAGAATGTTGTATGACTTTTTGCCTGAAAACAAACGAATTAAAATTGATGATTTCCAGGAA
ATTACCGGAAAAGGTATTCTGGCAGTCGTAGAAGGTAAAGAAATAAAAATAGGGTCTTCATCATTTGTAGAAAGTCCTGT
TGCAGAGGTATCTGAGATAGAACGAACAGCGCTTCATATCAAAATAGATAATCTTTATCTGGGAAAATTCGTTTTTCAAA
ACCAATATCGCGAAGGGTTAGAAAAATTATTTGCAACACTCAGCAAAGAGTACAACATCAAAGTCCTTTCTGGAGATAAT
GATGGAGAAAGAAATACTCTTGAAGAAATCCTGCCAAACAATACAGAATTGGTTTTTAATCAAAAACCAGAACAGAAATT
AGAATTTATCAAAGGACTTCAATCGCAAGGCAAAAACGTTATGATGGTTGGAGATGGTCTAAACGATGCTGGAGCTTTAG
CGCAAAGTAACGTTGGTATTTCAGTTTCTGAGAATGTAAATGTATTTTCTCCGGCCTGCGATGCGATCTTAGATGCAGGT
GTATTTTCAAAATTGAATTACTTTTTAAAACTGTCTCATAAGTCAATTTTAATAATTAAAATGAGCTTTACTTTATCGCT
GCTTTATAATGTAGTAGGATTGGCATTTGCAGTCACCGGAAATCTAAATCCGCTCGTTGCTGCAATCATAATGCCGCTTA
GTACAATTACCATTGTAAGCTTCGTTACTATTATGTCTAACTATTTCAGCAAGAGTAATTTAGATTAG

Upstream 100 bases:

>100_bases
AATTTGCTAAATTAGAATTTTGAATTCATTGTAACATGATAAATATCATAGTTATAATTACTGCTTTTTTGGAATATTTG
TCGAATTAAAAAAACAAATT

Downstream 100 bases:

>100_bases
ATTTAAATAATTCAAAGAATATTTTTTTTAATTTTAGTATTCTTCTCCGACTATGATAATTATCATATTTTAAACGCCAA
TCACCTAGTAATTTTGTTAA

Product: copper-exporting ATPase

Products: ADP; Orthophosphate. [C]

Alternate protein names: NA

Number of amino acids: Translated: 795; Mature: 794

Protein sequence:

>795_residues
MSEQSCFHCGLEIPKDEEINFDEKTFCCTGCKTVYEIFSLNDLTCYYDFEKSPGATPQDIKGKYDFLDNESILAKVLEFQ
ESNTSIVSLNIPHIHCSSCIWILENLNRLNSGISSSQVNFPEKRVRITFNSEIVSLKEIAYLLSSIGYEPYISLENYETG
KTKVDRSLTYKLGVAFFCFGNIMLLSFPEYFEMKEFWLDSYKPFFRLLIFVLALPSFFYSASGYYVSAYKSIKSGMLNID
IPIALGIIVMFIRSTYDMLMDHGPGFFDSLASLVFFMLLGKMFQIKTYSFLSFERDFKSYFPIAVTRINSDASEESVPIY
DVLKGNRLLIRNQELIPVDGILISEKAEIDYSFVTGEAVPITKKSGDKVFAGGKQIGKVIEMEVLHSVSQSYLTQLWSNE
VFQKKVQQKHKTITDAISRYFTPILLLIAFAGFGYWIFIDANTAFNVFTAVLIVACPCALALTAPFTFGNILRIMGKQKM
YLKNALVIEQLDKVDTIVFDKTGTITTNKKSNIIYEGTNISDDNYLLIKNVLRGSNHPLSRMLYDFLPENKRIKIDDFQE
ITGKGILAVVEGKEIKIGSSSFVESPVAEVSEIERTALHIKIDNLYLGKFVFQNQYREGLEKLFATLSKEYNIKVLSGDN
DGERNTLEEILPNNTELVFNQKPEQKLEFIKGLQSQGKNVMMVGDGLNDAGALAQSNVGISVSENVNVFSPACDAILDAG
VFSKLNYFLKLSHKSILIIKMSFTLSLLYNVVGLAFAVTGNLNPLVAAIIMPLSTITIVSFVTIMSNYFSKSNLD

Sequences:

>Translated_795_residues
MSEQSCFHCGLEIPKDEEINFDEKTFCCTGCKTVYEIFSLNDLTCYYDFEKSPGATPQDIKGKYDFLDNESILAKVLEFQ
ESNTSIVSLNIPHIHCSSCIWILENLNRLNSGISSSQVNFPEKRVRITFNSEIVSLKEIAYLLSSIGYEPYISLENYETG
KTKVDRSLTYKLGVAFFCFGNIMLLSFPEYFEMKEFWLDSYKPFFRLLIFVLALPSFFYSASGYYVSAYKSIKSGMLNID
IPIALGIIVMFIRSTYDMLMDHGPGFFDSLASLVFFMLLGKMFQIKTYSFLSFERDFKSYFPIAVTRINSDASEESVPIY
DVLKGNRLLIRNQELIPVDGILISEKAEIDYSFVTGEAVPITKKSGDKVFAGGKQIGKVIEMEVLHSVSQSYLTQLWSNE
VFQKKVQQKHKTITDAISRYFTPILLLIAFAGFGYWIFIDANTAFNVFTAVLIVACPCALALTAPFTFGNILRIMGKQKM
YLKNALVIEQLDKVDTIVFDKTGTITTNKKSNIIYEGTNISDDNYLLIKNVLRGSNHPLSRMLYDFLPENKRIKIDDFQE
ITGKGILAVVEGKEIKIGSSSFVESPVAEVSEIERTALHIKIDNLYLGKFVFQNQYREGLEKLFATLSKEYNIKVLSGDN
DGERNTLEEILPNNTELVFNQKPEQKLEFIKGLQSQGKNVMMVGDGLNDAGALAQSNVGISVSENVNVFSPACDAILDAG
VFSKLNYFLKLSHKSILIIKMSFTLSLLYNVVGLAFAVTGNLNPLVAAIIMPLSTITIVSFVTIMSNYFSKSNLD
>Mature_794_residues
SEQSCFHCGLEIPKDEEINFDEKTFCCTGCKTVYEIFSLNDLTCYYDFEKSPGATPQDIKGKYDFLDNESILAKVLEFQE
SNTSIVSLNIPHIHCSSCIWILENLNRLNSGISSSQVNFPEKRVRITFNSEIVSLKEIAYLLSSIGYEPYISLENYETGK
TKVDRSLTYKLGVAFFCFGNIMLLSFPEYFEMKEFWLDSYKPFFRLLIFVLALPSFFYSASGYYVSAYKSIKSGMLNIDI
PIALGIIVMFIRSTYDMLMDHGPGFFDSLASLVFFMLLGKMFQIKTYSFLSFERDFKSYFPIAVTRINSDASEESVPIYD
VLKGNRLLIRNQELIPVDGILISEKAEIDYSFVTGEAVPITKKSGDKVFAGGKQIGKVIEMEVLHSVSQSYLTQLWSNEV
FQKKVQQKHKTITDAISRYFTPILLLIAFAGFGYWIFIDANTAFNVFTAVLIVACPCALALTAPFTFGNILRIMGKQKMY
LKNALVIEQLDKVDTIVFDKTGTITTNKKSNIIYEGTNISDDNYLLIKNVLRGSNHPLSRMLYDFLPENKRIKIDDFQEI
TGKGILAVVEGKEIKIGSSSFVESPVAEVSEIERTALHIKIDNLYLGKFVFQNQYREGLEKLFATLSKEYNIKVLSGDND
GERNTLEEILPNNTELVFNQKPEQKLEFIKGLQSQGKNVMMVGDGLNDAGALAQSNVGISVSENVNVFSPACDAILDAGV
FSKLNYFLKLSHKSILIIKMSFTLSLLYNVVGLAFAVTGNLNPLVAAIIMPLSTITIVSFVTIMSNYFSKSNLD

Specific function: Involved in copper export [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 HMA domains [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=837, Percent_Identity=23.6559139784946, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI55743073, Length=530, Percent_Identity=24.7169811320755, Blast_Score=138, Evalue=2e-32,
Organism=Homo sapiens, GI115529486, Length=574, Percent_Identity=24.390243902439, Blast_Score=137, Evalue=5e-32,
Organism=Escherichia coli, GI1786691, Length=838, Percent_Identity=24.1050119331742, Blast_Score=208, Evalue=1e-54,
Organism=Escherichia coli, GI1789879, Length=692, Percent_Identity=23.121387283237, Blast_Score=146, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI17556548, Length=781, Percent_Identity=24.3277848911652, Blast_Score=145, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6319772, Length=633, Percent_Identity=24.1706161137441, Blast_Score=140, Evalue=8e-34,
Organism=Saccharomyces cerevisiae, GI6320475, Length=649, Percent_Identity=25.4237288135593, Blast_Score=133, Evalue=1e-31,
Organism=Drosophila melanogaster, GI221329854, Length=556, Percent_Identity=23.9208633093525, Blast_Score=119, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006403
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: 3.6.3.4 [C]

Molecular weight: Translated: 89465; Mature: 89334

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00154 ATPASE_E1_E2 ; PS50846 HMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQSCFHCGLEIPKDEEINFDEKTFCCTGCKTVYEIFSLNDLTCYYDFEKSPGATPQDI
CCCCCCEECCCCCCCCCCCCCCCCEEEEHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHC
KGKYDFLDNESILAKVLEFQESNTSIVSLNIPHIHCSSCIWILENLNRLNSGISSSQVNF
CCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCEEHHHHHHHHHHHHHHHCCCCCCCCCC
PEKRVRITFNSEIVSLKEIAYLLSSIGYEPYISLENYETGKTKVDRSLTYKLGVAFFCFG
CCCEEEEEECCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHCCHHHHHHHHHHHHHH
NIMLLSFPEYFEMKEFWLDSYKPFFRLLIFVLALPSFFYSASGYYVSAYKSIKSGMLNID
CCCEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHCCCEEEE
IPIALGIIVMFIRSTYDMLMDHGPGFFDSLASLVFFMLLGKMFQIKTYSFLSFERDFKSY
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
FPIAVTRINSDASEESVPIYDVLKGNRLLIRNQELIPVDGILISEKAEIDYSFVTGEAVP
CCEEEEEECCCCCCCCCCCHHECCCCEEEEECCCCCCCCCEEEECCCCCCEEEECCCEEE
ITKKSGDKVFAGGKQIGKVIEMEVLHSVSQSYLTQLWSNEVFQKKVQQKHKTITDAISRY
EECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FTPILLLIAFAGFGYWIFIDANTAFNVFTAVLIVACPCALALTAPFTFGNILRIMGKQKM
HHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHH
YLKNALVIEQLDKVDTIVFDKTGTITTNKKSNIIYEGTNISDDNYLLIKNVLRGSNHPLS
HHHHHHHHHHHHHHCEEEEECCCCEEECCCCCEEEECCCCCCCCEEEEHHHHCCCCCCHH
RMLYDFLPENKRIKIDDFQEITGKGILAVVEGKEIKIGSSSFVESPVAEVSEIERTALHI
HHHHHHCCCCCEEECCCHHHHCCCCEEEEEECCEEEECCHHHHHCHHHHHHHHHHEEEEE
KIDNLYLGKFVFQNQYREGLEKLFATLSKEYNIKVLSGDNDGERNTLEEILPNNTELVFN
EECCEEEHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCCCEEEEC
QKPEQKLEFIKGLQSQGKNVMMVGDGLNDAGALAQSNVGISVSENVNVFSPACDAILDAG
CCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHCCCCEEECCCCCEECHHHHHHHHHH
VFSKLNYFLKLSHKSILIIKMSFTLSLLYNVVGLAFAVTGNLNPLVAAIIMPLSTITIVS
HHHHHHHHEEECCCEEEEEEEHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHH
FVTIMSNYFSKSNLD
HHHHHHHHHHCCCCC
>Mature Secondary Structure 
SEQSCFHCGLEIPKDEEINFDEKTFCCTGCKTVYEIFSLNDLTCYYDFEKSPGATPQDI
CCCCCEECCCCCCCCCCCCCCCCEEEEHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHC
KGKYDFLDNESILAKVLEFQESNTSIVSLNIPHIHCSSCIWILENLNRLNSGISSSQVNF
CCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCEEHHHHHHHHHHHHHHHCCCCCCCCCC
PEKRVRITFNSEIVSLKEIAYLLSSIGYEPYISLENYETGKTKVDRSLTYKLGVAFFCFG
CCCEEEEEECCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHCCHHHHHHHHHHHHHH
NIMLLSFPEYFEMKEFWLDSYKPFFRLLIFVLALPSFFYSASGYYVSAYKSIKSGMLNID
CCCEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHCCCEEEE
IPIALGIIVMFIRSTYDMLMDHGPGFFDSLASLVFFMLLGKMFQIKTYSFLSFERDFKSY
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
FPIAVTRINSDASEESVPIYDVLKGNRLLIRNQELIPVDGILISEKAEIDYSFVTGEAVP
CCEEEEEECCCCCCCCCCCHHECCCCEEEEECCCCCCCCCEEEECCCCCCEEEECCCEEE
ITKKSGDKVFAGGKQIGKVIEMEVLHSVSQSYLTQLWSNEVFQKKVQQKHKTITDAISRY
EECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FTPILLLIAFAGFGYWIFIDANTAFNVFTAVLIVACPCALALTAPFTFGNILRIMGKQKM
HHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHH
YLKNALVIEQLDKVDTIVFDKTGTITTNKKSNIIYEGTNISDDNYLLIKNVLRGSNHPLS
HHHHHHHHHHHHHHCEEEEECCCCEEECCCCCEEEECCCCCCCCEEEEHHHHCCCCCCHH
RMLYDFLPENKRIKIDDFQEITGKGILAVVEGKEIKIGSSSFVESPVAEVSEIERTALHI
HHHHHHCCCCCEEECCCHHHHCCCCEEEEEECCEEEECCHHHHHCHHHHHHHHHHEEEEE
KIDNLYLGKFVFQNQYREGLEKLFATLSKEYNIKVLSGDNDGERNTLEEILPNNTELVFN
EECCEEEHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCCCEEEEC
QKPEQKLEFIKGLQSQGKNVMMVGDGLNDAGALAQSNVGISVSENVNVFSPACDAILDAG
CCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHCCCCEEECCCCCEECHHHHHHHHHH
VFSKLNYFLKLSHKSILIIKMSFTLSLLYNVVGLAFAVTGNLNPLVAAIIMPLSTITIVS
HHHHHHHHEEECCCEEEEEEEHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHH
FVTIMSNYFSKSNLD
HHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O [C]

Specific reaction: ATP + H2O = ADP + Orthophosphate. [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA