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The map label for this gene is guaB [H]

Identifier: 146299973

GI number: 146299973

Start: 2670436

End: 2671908

Strand: Direct

Name: guaB [H]

Synonym: Fjoh_2217

Alternate gene names: 146299973

Gene position: 2670436-2671908 (Clockwise)

Preceding gene: 146299972

Following gene: 146299989

Centisome position: 43.8

GC content: 38.49

Gene sequence:

>1473_bases
ATGATAGCACACAACTCCAAGATTATCGGCGAAGGTTTAACTTACGACGATGTATTATTAGTACCTAACTACTCGAATGT
GCTTCCCCGCGAAGTGAGTATCAAATCAAAATTCTCAAGAAACATAACATTAAACGTTCCAATTGTATCTGCTGCTATGG
ATACAGTGACCGAAAGTGCAATGGCAATTGCTATGGCACAAGAAGGCGGAATTGGAGTTTTACATAAAAACATGACGATC
GAGCAGCAAGCTGCGAAAGTTAGAAAAGTGAAGCGTGCTGAGGCAGGAATGATTATCGATCCGGTAACATTACCAACAAA
TTCAACTATTGCAGATGCTAAAAACGCTATGAAAGAATTCGGAATTGGCGGTATTCCAATTGTTGACGAAAACAAAATCC
TTAAAGGAATTGTTACCAATCGTGACTTACGTTTCGAAAAAAATGGAGCAAGACCAATCGCTGAAGTAATGACAAGCTCA
AACTTAGTTACTGTTGCCGAAGGAACTTCATTAGAACAGGCTGAAGTAGTTTTACAAGGTCATAAAATCGAAAAATTACC
AGTTGTAAATGCTCAAAACGAATTAGTTGGTTTAATTACGTTTAGAGATATTACAAAACTGACTCAAAAACCAATCGCTA
ACAAAGATTCATTTGGTCGTTTAAGAGTTGCCGCTGCTATTGGCGTTACAGGAGATGCAGTTCAAAGAGCTGAAGCTTTA
GTTGCTGCCGGAGTAGATGCTATCATTATTGATACAGCTCACGGACATACTGAAGGTGTAGTTAATGTATTAAAAGAAGT
AAAATCAAAATTCCCTCAAATAGATGTAATTGTTGGAAACATTGCAACTCCGGAAGCTGCTAAATATTTAGTAGAAAGCG
GTGCTGATGGTGTAAAAGTTGGAATTGGACCTGGTTCAATCTGTACTACACGTATTGTTGCTGGTGTTGGTTTTCCTCAA
TTTTCAGCGGTTTTAGAAGTTGCTGCAGCAATTAAAGGAACTGGAGTTCCGGTTATTGCAGATGGTGGGATTCGTTATAC
AGGAGATATTCCTAAAGCAATTGCTGCTGGTGCTGACTGTGTAATGTTAGGTTCATTATTAGCAGGAACAAAAGAATCTC
CTGGAGAAACTATTATTTTTGAAGGAAGAAAATTCAAATCATACCGTGGAATGGGATCTGTTGAGGCAATGCAGACAGGT
TCTAAAGACCGTTATTTTCAAGATGTTGAAGACGATGTTAAAAAATTAGTTCCGGAAGGAATCGTTGGACGTGTTCCTTA
CAAAGGAGAATTAAACGAAAGCATGCTTCAGTTTATTGGAGGTCTTCGTGCAGGTATGGGGTACTGTGGTTCAAAAGATA
TTCCTACTTTACAGGAAACAGGACGTTTTGTTAGAATCACGTCAAGCGGAATCACTGAAAGTCACCCGCATAACGTAACT
ATTACAAAAGAAGCTCCAAATTATTCTAGATAA

Upstream 100 bases:

>100_bases
CATAAGTATTTTCCTGTAAAGTTAAATTTATGAATAAGTTAGTATTCAAGTTAGCAATTTATTCACTATATTTGCACGCA
ATTCAACTAGAAATTGCACC

Downstream 100 bases:

>100_bases
TTTTTAGTTTTTCAAATATCAAAAAAGGCATAAGATTTAGTTTCTTATGCCTTTTTTGTTTTAATTGATAATTGAAATTC
CATTATTCAATTCATCAATA

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH; Superoxide-inducible protein 12; SOI12 [H]

Number of amino acids: Translated: 490; Mature: 490

Protein sequence:

>490_residues
MIAHNSKIIGEGLTYDDVLLVPNYSNVLPREVSIKSKFSRNITLNVPIVSAAMDTVTESAMAIAMAQEGGIGVLHKNMTI
EQQAAKVRKVKRAEAGMIIDPVTLPTNSTIADAKNAMKEFGIGGIPIVDENKILKGIVTNRDLRFEKNGARPIAEVMTSS
NLVTVAEGTSLEQAEVVLQGHKIEKLPVVNAQNELVGLITFRDITKLTQKPIANKDSFGRLRVAAAIGVTGDAVQRAEAL
VAAGVDAIIIDTAHGHTEGVVNVLKEVKSKFPQIDVIVGNIATPEAAKYLVESGADGVKVGIGPGSICTTRIVAGVGFPQ
FSAVLEVAAAIKGTGVPVIADGGIRYTGDIPKAIAAGADCVMLGSLLAGTKESPGETIIFEGRKFKSYRGMGSVEAMQTG
SKDRYFQDVEDDVKKLVPEGIVGRVPYKGELNESMLQFIGGLRAGMGYCGSKDIPTLQETGRFVRITSSGITESHPHNVT
ITKEAPNYSR

Sequences:

>Translated_490_residues
MIAHNSKIIGEGLTYDDVLLVPNYSNVLPREVSIKSKFSRNITLNVPIVSAAMDTVTESAMAIAMAQEGGIGVLHKNMTI
EQQAAKVRKVKRAEAGMIIDPVTLPTNSTIADAKNAMKEFGIGGIPIVDENKILKGIVTNRDLRFEKNGARPIAEVMTSS
NLVTVAEGTSLEQAEVVLQGHKIEKLPVVNAQNELVGLITFRDITKLTQKPIANKDSFGRLRVAAAIGVTGDAVQRAEAL
VAAGVDAIIIDTAHGHTEGVVNVLKEVKSKFPQIDVIVGNIATPEAAKYLVESGADGVKVGIGPGSICTTRIVAGVGFPQ
FSAVLEVAAAIKGTGVPVIADGGIRYTGDIPKAIAAGADCVMLGSLLAGTKESPGETIIFEGRKFKSYRGMGSVEAMQTG
SKDRYFQDVEDDVKKLVPEGIVGRVPYKGELNESMLQFIGGLRAGMGYCGSKDIPTLQETGRFVRITSSGITESHPHNVT
ITKEAPNYSR
>Mature_490_residues
MIAHNSKIIGEGLTYDDVLLVPNYSNVLPREVSIKSKFSRNITLNVPIVSAAMDTVTESAMAIAMAQEGGIGVLHKNMTI
EQQAAKVRKVKRAEAGMIIDPVTLPTNSTIADAKNAMKEFGIGGIPIVDENKILKGIVTNRDLRFEKNGARPIAEVMTSS
NLVTVAEGTSLEQAEVVLQGHKIEKLPVVNAQNELVGLITFRDITKLTQKPIANKDSFGRLRVAAAIGVTGDAVQRAEAL
VAAGVDAIIIDTAHGHTEGVVNVLKEVKSKFPQIDVIVGNIATPEAAKYLVESGADGVKVGIGPGSICTTRIVAGVGFPQ
FSAVLEVAAAIKGTGVPVIADGGIRYTGDIPKAIAAGADCVMLGSLLAGTKESPGETIIFEGRKFKSYRGMGSVEAMQTG
SKDRYFQDVEDDVKKLVPEGIVGRVPYKGELNESMLQFIGGLRAGMGYCGSKDIPTLQETGRFVRITSSGITESHPHNVT
ITKEAPNYSR

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=456, Percent_Identity=42.3245614035088, Blast_Score=340, Evalue=1e-93,
Organism=Homo sapiens, GI34328930, Length=456, Percent_Identity=42.3245614035088, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI66933016, Length=483, Percent_Identity=40.7867494824017, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI34328928, Length=456, Percent_Identity=42.3245614035088, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI156616279, Length=456, Percent_Identity=42.3245614035088, Blast_Score=339, Evalue=3e-93,
Organism=Homo sapiens, GI217035152, Length=450, Percent_Identity=42, Blast_Score=330, Evalue=2e-90,
Organism=Homo sapiens, GI217035148, Length=456, Percent_Identity=41.2280701754386, Blast_Score=325, Evalue=4e-89,
Organism=Homo sapiens, GI217035150, Length=456, Percent_Identity=39.0350877192982, Blast_Score=301, Evalue=1e-81,
Organism=Homo sapiens, GI50541954, Length=341, Percent_Identity=33.7243401759531, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI50541952, Length=341, Percent_Identity=33.7243401759531, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI50541948, Length=341, Percent_Identity=33.7243401759531, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI50541956, Length=341, Percent_Identity=33.7243401759531, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI156104880, Length=225, Percent_Identity=40.8888888888889, Blast_Score=168, Evalue=9e-42,
Organism=Escherichia coli, GI1788855, Length=483, Percent_Identity=52.5879917184265, Blast_Score=471, Evalue=1e-134,
Organism=Escherichia coli, GI1786293, Length=222, Percent_Identity=38.2882882882883, Blast_Score=154, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI71994385, Length=484, Percent_Identity=36.5702479338843, Blast_Score=300, Evalue=1e-81,
Organism=Caenorhabditis elegans, GI71994389, Length=431, Percent_Identity=38.5150812064965, Blast_Score=288, Evalue=4e-78,
Organism=Caenorhabditis elegans, GI17560440, Length=259, Percent_Identity=37.8378378378378, Blast_Score=172, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6322012, Length=490, Percent_Identity=39.7959183673469, Blast_Score=328, Evalue=1e-90,
Organism=Saccharomyces cerevisiae, GI6323464, Length=483, Percent_Identity=40.3726708074534, Blast_Score=323, Evalue=4e-89,
Organism=Saccharomyces cerevisiae, GI6323585, Length=483, Percent_Identity=39.1304347826087, Blast_Score=323, Evalue=5e-89,
Organism=Saccharomyces cerevisiae, GI6319352, Length=345, Percent_Identity=39.1304347826087, Blast_Score=246, Evalue=6e-66,
Organism=Saccharomyces cerevisiae, GI6319353, Length=116, Percent_Identity=41.3793103448276, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24641071, Length=490, Percent_Identity=41.6326530612245, Blast_Score=343, Evalue=1e-94,
Organism=Drosophila melanogaster, GI24641073, Length=490, Percent_Identity=41.6326530612245, Blast_Score=343, Evalue=1e-94,
Organism=Drosophila melanogaster, GI28571163, Length=447, Percent_Identity=41.6107382550336, Blast_Score=303, Evalue=2e-82,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 51903; Mature: 51903

Theoretical pI: Translated: 7.62; Mature: 7.62

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAHNSKIIGEGLTYDDVLLVPNYSNVLPREVSIKSKFSRNITLNVPIVSAAMDTVTESA
CCCCCCEEEECCCCCCCEEEECCCCCCCCCCEEHHHHCCCCEEEECCHHHHHHHHHHHHH
MAIAMAQEGGIGVLHKNMTIEQQAAKVRKVKRAEAGMIIDPVTLPTNSTIADAKNAMKEF
HEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHCCCEEEECEECCCCCCHHHHHHHHHHC
GIGGIPIVDENKILKGIVTNRDLRFEKNGARPIAEVMTSSNLVTVAEGTSLEQAEVVLQG
CCCCCEEECCCHHHHHHHCCCCEEEECCCCCHHHHHHCCCCEEEEECCCCCHHHHHHHCC
HKIEKLPVVNAQNELVGLITFRDITKLTQKPIANKDSFGRLRVAAAIGVTGDAVQRAEAL
CCEEECCEECCCCCEEEEEEHHHHHHHHHCCCCCCCCCCEEEEEEEECCCHHHHHHHHHH
VAAGVDAIIIDTAHGHTEGVVNVLKEVKSKFPQIDVIVGNIATPEAAKYLVESGADGVKV
HHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHCCCCCEEE
GIGPGSICTTRIVAGVGFPQFSAVLEVAAAIKGTGVPVIADGGIRYTGDIPKAIAAGADC
ECCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEECCCEEECCCCCHHHHCCCCH
VMLGSLLAGTKESPGETIIFEGRKFKSYRGMGSVEAMQTGSKDRYFQDVEDDVKKLVPEG
HHHHHHHHCCCCCCCCEEEECCCEEHHHCCCCCHHHHHCCCCCHHHHHHHHHHHHHCCCC
IVGRVPYKGELNESMLQFIGGLRAGMGYCGSKDIPTLQETGRFVRITSSGITESHPHNVT
CEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCEEEEECCCCCCCCCCCEE
ITKEAPNYSR
EEECCCCCCC
>Mature Secondary Structure
MIAHNSKIIGEGLTYDDVLLVPNYSNVLPREVSIKSKFSRNITLNVPIVSAAMDTVTESA
CCCCCCEEEECCCCCCCEEEECCCCCCCCCCEEHHHHCCCCEEEECCHHHHHHHHHHHHH
MAIAMAQEGGIGVLHKNMTIEQQAAKVRKVKRAEAGMIIDPVTLPTNSTIADAKNAMKEF
HEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHCCCEEEECEECCCCCCHHHHHHHHHHC
GIGGIPIVDENKILKGIVTNRDLRFEKNGARPIAEVMTSSNLVTVAEGTSLEQAEVVLQG
CCCCCEEECCCHHHHHHHCCCCEEEECCCCCHHHHHHCCCCEEEEECCCCCHHHHHHHCC
HKIEKLPVVNAQNELVGLITFRDITKLTQKPIANKDSFGRLRVAAAIGVTGDAVQRAEAL
CCEEECCEECCCCCEEEEEEHHHHHHHHHCCCCCCCCCCEEEEEEEECCCHHHHHHHHHH
VAAGVDAIIIDTAHGHTEGVVNVLKEVKSKFPQIDVIVGNIATPEAAKYLVESGADGVKV
HHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHCCCCCEEE
GIGPGSICTTRIVAGVGFPQFSAVLEVAAAIKGTGVPVIADGGIRYTGDIPKAIAAGADC
ECCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEECCCEEECCCCCHHHHCCCCH
VMLGSLLAGTKESPGETIIFEGRKFKSYRGMGSVEAMQTGSKDRYFQDVEDDVKKLVPEG
HHHHHHHHCCCCCCCCEEEECCCEEHHHCCCCCHHHHHCCCCCHHHHHHHHHHHHHCCCC
IVGRVPYKGELNESMLQFIGGLRAGMGYCGSKDIPTLQETGRFVRITSSGITESHPHNVT
CEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCEEEEECCCCCCCCCCCEE
ITKEAPNYSR
EEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1979163; 7584024; 9384377; 9298659 [H]