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The map label for this gene is cytR [H]

Identifier: 146299750

GI number: 146299750

Start: 2322598

End: 2323629

Strand: Direct

Name: cytR [H]

Synonym: Fjoh_1990

Alternate gene names: 146299750

Gene position: 2322598-2323629 (Clockwise)

Preceding gene: 146299749

Following gene: 146299751

Centisome position: 38.09

GC content: 36.34

Gene sequence:

>1032_bases
ATGGAAGAAAATAAACATGTAACGATTTATGATATTGCCGAACGTCTTAATTTGGCAACATCAACTATTTCACGCGCTTT
AAAAGACCATCACACGATAAGTGACAAGACAATTAAGAAGGTGAAAAAAACTGCCGAAGAAATGGGGTTTGTTCCCAATA
CTTTAGCGGCAGGTTTGCGTGGAAACAAAACCAGAACTATTGGTGTTTTGATTCCCACCGTTACACAGCCCTTTTTATCA
TCTTTAATCAGCGGAATTGAAATCACGGCCCAAAAATCCGATTATACCGTAATCATTATGCAGTCGCATGACTCGTATGA
AGAAGAAGTAAATATGGCGAAATCTTTGTATTCCAATCGTGTAAGCGGTGTAATTTGCTCATTAGCAATGGAAACCAGAG
ATACGGCACACTTTCATCAGTTTTCAAACAATAATATTCCACTGGTTTTTGTCGATAGGGTGCCAAAAGACTACAACACT
TTTAGAGTAGTTATCGATAACTATACAGCAGGTTATAAAGCAACAAAGCATCTTATTGAACAGGGCTGTATTCGTATTGC
GCATTTAACAGCAGGATCAGAATTAGGAAATCTGTACAACGAAAGAAAAAGAGGGTATATAGAAGCCTTAAAAGATCATA
ATATCGAAGTGGAAGAAGAATTGATTATCAATTTAAATTCAGTTACTTACGAAGATGGTGTAAAAGCCAGCAATGCTTTA
TTCGATTTAAAACCAATTCCGGACGGATTGTTTGCACCTGGAGATATTCTGGCTGTAAGTGCCGTTCAGACTGCTAAAAA
AAGAGGTACTAAAGTACCCGAAGAATTTAAAGTAATTGGCTTTAACAACGACCCTATTTCGCAGATTATAGACCCTAATT
TATCTACAATTACGCATCCTGCAGAAAAAATGGGAAAAGCAGCAGCTGAAATTATTATCAAAAATCTAAAGTCATCTAAA
AATGATGATGCCAAAGAAATTACCTTTTTAAATACAGAAGTCCTTGCCAGAGAGTCATCTAGTAAAGAGTAA

Upstream 100 bases:

>100_bases
CTAACACTTTTTCTTCTAACTTCTTTTATTTAATGCCAATTTTTACGAAAGAACATCTTGAACGAAAATAGTTTATATTT
ACATCTTTATTTTTTATTTC

Downstream 100 bases:

>100_bases
ATGAGAAAGAATTAAATTGTCATTTATGCATACCATTACACTTCCCGATGAAATGAATTTAGAAAAAACACAGCAAATAC
ATGTTGTGGATTACAGAAGT

Product: alanine racemase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MEENKHVTIYDIAERLNLATSTISRALKDHHTISDKTIKKVKKTAEEMGFVPNTLAAGLRGNKTRTIGVLIPTVTQPFLS
SLISGIEITAQKSDYTVIIMQSHDSYEEEVNMAKSLYSNRVSGVICSLAMETRDTAHFHQFSNNNIPLVFVDRVPKDYNT
FRVVIDNYTAGYKATKHLIEQGCIRIAHLTAGSELGNLYNERKRGYIEALKDHNIEVEEELIINLNSVTYEDGVKASNAL
FDLKPIPDGLFAPGDILAVSAVQTAKKRGTKVPEEFKVIGFNNDPISQIIDPNLSTITHPAEKMGKAAAEIIIKNLKSSK
NDDAKEITFLNTEVLARESSSKE

Sequences:

>Translated_343_residues
MEENKHVTIYDIAERLNLATSTISRALKDHHTISDKTIKKVKKTAEEMGFVPNTLAAGLRGNKTRTIGVLIPTVTQPFLS
SLISGIEITAQKSDYTVIIMQSHDSYEEEVNMAKSLYSNRVSGVICSLAMETRDTAHFHQFSNNNIPLVFVDRVPKDYNT
FRVVIDNYTAGYKATKHLIEQGCIRIAHLTAGSELGNLYNERKRGYIEALKDHNIEVEEELIINLNSVTYEDGVKASNAL
FDLKPIPDGLFAPGDILAVSAVQTAKKRGTKVPEEFKVIGFNNDPISQIIDPNLSTITHPAEKMGKAAAEIIIKNLKSSK
NDDAKEITFLNTEVLARESSSKE
>Mature_343_residues
MEENKHVTIYDIAERLNLATSTISRALKDHHTISDKTIKKVKKTAEEMGFVPNTLAAGLRGNKTRTIGVLIPTVTQPFLS
SLISGIEITAQKSDYTVIIMQSHDSYEEEVNMAKSLYSNRVSGVICSLAMETRDTAHFHQFSNNNIPLVFVDRVPKDYNT
FRVVIDNYTAGYKATKHLIEQGCIRIAHLTAGSELGNLYNERKRGYIEALKDHNIEVEEELIINLNSVTYEDGVKASNAL
FDLKPIPDGLFAPGDILAVSAVQTAKKRGTKVPEEFKVIGFNNDPISQIIDPNLSTITHPAEKMGKAAAEIIIKNLKSSK
NDDAKEITFLNTEVLARESSSKE

Specific function: This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins. Binds cytidine and adenosine as effectors [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=333, Percent_Identity=30.9309309309309, Blast_Score=177, Evalue=6e-46,
Organism=Escherichia coli, GI1787580, Length=313, Percent_Identity=28.4345047923323, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1788474, Length=310, Percent_Identity=28.7096774193548, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1787948, Length=318, Percent_Identity=26.1006289308176, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1790194, Length=309, Percent_Identity=25.8899676375405, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI48994940, Length=318, Percent_Identity=26.4150943396226, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1790715, Length=326, Percent_Identity=24.8466257668712, Blast_Score=111, Evalue=8e-26,
Organism=Escherichia coli, GI1789202, Length=335, Percent_Identity=23.2835820895522, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1789068, Length=302, Percent_Identity=26.8211920529801, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786268, Length=292, Percent_Identity=23.2876712328767, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1787906, Length=328, Percent_Identity=24.390243902439, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1786540, Length=312, Percent_Identity=23.3974358974359, Blast_Score=86, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 38050; Mature: 38050

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEENKHVTIYDIAERLNLATSTISRALKDHHTISDKTIKKVKKTAEEMGFVPNTLAAGLR
CCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHCCC
GNKTRTIGVLIPTVTQPFLSSLISGIEITAQKSDYTVIIMQSHDSYEEEVNMAKSLYSNR
CCCCEEEEEEECHHHHHHHHHHHCCCEEEEECCCEEEEEEECCCCHHHHHHHHHHHHHHH
VSGVICSLAMETRDTAHFHQFSNNNIPLVFVDRVPKDYNTFRVVIDNYTAGYKATKHLIE
HHHHHHHHHHHCCCHHHHHHCCCCCCCEEEEECCCCCCCEEEEEEECCCCCHHHHHHHHH
QGCIRIAHLTAGSELGNLYNERKRGYIEALKDHNIEVEEELIINLNSVTYEDGVKASNAL
HHHEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCEEECCCCCCCCCE
FDLKPIPDGLFAPGDILAVSAVQTAKKRGTKVPEEFKVIGFNNDPISQIIDPNLSTITHP
EEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHCCCHHHHCCC
AEKMGKAAAEIIIKNLKSSKNDDAKEITFLNTEVLARESSSKE
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEECHHHHHCCCCCCC
>Mature Secondary Structure
MEENKHVTIYDIAERLNLATSTISRALKDHHTISDKTIKKVKKTAEEMGFVPNTLAAGLR
CCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHCCC
GNKTRTIGVLIPTVTQPFLSSLISGIEITAQKSDYTVIIMQSHDSYEEEVNMAKSLYSNR
CCCCEEEEEEECHHHHHHHHHHHCCCEEEEECCCEEEEEEECCCCHHHHHHHHHHHHHHH
VSGVICSLAMETRDTAHFHQFSNNNIPLVFVDRVPKDYNTFRVVIDNYTAGYKATKHLIE
HHHHHHHHHHHCCCHHHHHHCCCCCCCEEEEECCCCCCCEEEEEEECCCCCHHHHHHHHH
QGCIRIAHLTAGSELGNLYNERKRGYIEALKDHNIEVEEELIINLNSVTYEDGVKASNAL
HHHEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCEEECCCCCCCCCE
FDLKPIPDGLFAPGDILAVSAVQTAKKRGTKVPEEFKVIGFNNDPISQIIDPNLSTITHP
EEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHCCCHHHHCCC
AEKMGKAAAEIIIKNLKSSKNDDAKEITFLNTEVLARESSSKE
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEECHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]