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The map label for this gene is acnA [H]

Identifier: 146299712

GI number: 146299712

Start: 2262734

End: 2265031

Strand: Direct

Name: acnA [H]

Synonym: Fjoh_1952

Alternate gene names: 146299712

Gene position: 2262734-2265031 (Clockwise)

Preceding gene: 146299711

Following gene: 146299714

Centisome position: 37.11

GC content: 38.9

Gene sequence:

>2298_bases
ATGTTCAAAATAAAAAAACAAAACAATAAACTTATGGCTTTTGATATTGAAATGATAAAAAAAGTGTATGAGAACATGCC
GGAACGTGTTGATAAGGCACGCGAGCTAGTTGGTCGTCCACTTACTTTGACAGAGAAAATTTTATATAATCACCTTTGGG
ATGGAGTACCATCTCAAGTTTTTAAAAGAGGTGTAGATTATGTTGATTTTGCACCAGACCGTGTAGCGTGTCAGGATGCT
ACAGCACAAATGGCATTATTGCAGTTTATGCATGCCGGAAAATCTAAAGTAGCAGTTCCAACAACGGTGCATTGCGATCA
CCTGATTCAGGCAAAAGTAGATGCTGCAACTGATTTGGCGAGAGCTAAAACGCAGAGTAATGAAGTTTTTGACTTCCTAT
CATCTGTTTCTAATAAATACGGAATTGGTTTCTGGAAACCAGGAGCAGGAATTATTCACCAAGTAGTACTTGAAAACTAT
GCTTTCCCTGGCGGGATGATGATTGGTACCGATTCTCACACGGTAAATGCCGGAGGTTTAGGAATGGTAGCAATTGGAGT
TGGTGGAGCAGATGCCGTTGATGTTATGTCGGGTATGGCTTGGGAACTTAAATTTCCTAAACTTATTGGAGTAAAACTAA
CTGGTAAATTATCAGGTTGGACCGCTCCAAAAGATGTTATTTTGAAAGTAGCAGGTATTTTAACTGTAAAAGGAGGAACA
GGTGCTATTGTTGAATATTTTGGCGAAGGAGCAACTTCTATGTCTTGTACTGGTAAAGGGACTATTTGTAATATGGGTGC
TGAGATTGGAGCTACAACTTCTACTTTTGGTTATGATGCTTCAATGGGACGTTATCTTCGTTCTACAAACCGTGCCGATG
TTGCCGATGCTGCAGATAAAATTGCGCCATACCTAACAGGAGATCCTGAAGTTTATGCTAACCCAGAAGAATATTTCGAT
CAGGTTATCGAAATTAATTTATCTCAATTAGAGCCGCACTTAAACGGACCATTTACTCCAGATTTAGCTACTCCGATTTC
TAAAATGAAAGAAGAAGCAATCAAAAATAACTGGCCGTTGCAAATTCAGGTAGGATTAATTGGTTCTTGTACAAACTCTT
CTTACGAAGATATTTCTCGTGCAGCTTCTTTAGCAAGACAAGTTGCAGCAAAAAACTTAAAAACAAAAGCTGAGTTTACC
ATTACTCCGGGTTCTGAAGTAGTTCGTTCTACAATAGAAAGAGACGGTTTTATCGATACGTTCCATAAAATTGGAGCAAC
TGTTTTTGCTAACGCCTGCGGACCATGTATTGGTATGTGGGATAGAGATGGAGCAGAGAAAGAGGAAAGAAATACAATTG
TTCACTCTTTCAATCGTAATTTCTCAAAACGTGCAGATGGTAACCCTAATACACTTGCTTTTGTAGGTTCTCCAGAATTG
GTAACTGCAATGGCAATTGCGGGTGATTTAGGTTTTAATCCATTAACAGATAAGCTGATTAATGAAGATGGAGAAGAAGT
AATGCTGGATGCTCCAACAGGGGATGAACTTCCTGCTAAAGGTTTCTATGCTGAAGATCCAGGATTTCAGGCTCCGGCAG
CGGATGGTTCAGGTGTTCAGGTTGTGGTAAATCCAACATCAGAGCGATTACAATTACTAGCTCCTTTTGACGCTTGGGAC
GGAAAAAATATTACTGGTGCTAAATTGTTAATCAAAGCATTCGGAAAATGTACTACAGACCATATTTCTATGGCTGGACC
ATGGTTACGTTTCCGAGGACATTTAGACAATATTTCTAATAATATGCTTATTGGAGCTGTAAATGCTTATAACCAAAAAA
CAAACTCTGTTAAAAATCAATTAACAGGTCAATACGATGCTGTTCCTGCGGTTGCTCGTGCATACAAAGCAGCTGGGGTT
CCTTCTATTGTGGTTGGGGATCATAACTACGGAGAAGGTTCTTCTCGTGAACATGCGGCTATGGAGCCTCGTTTCTTAGG
TGTTAAAGCGGTATTAGTGAAATCTTTCGCTCGTATCCATGAAACTAACCTTAAAAAACAAGGTCTTTTAGGATTGACTT
TTGCTAATGAAGCAGATTACGATAAAATTCAGGAAGATGATACAATTAACTTCTTAGATTTAACTGAATTTGCTCCTGGT
AAGCCATTAACATTAGAGTTTGTGCATGCAAATGGCACAAAAGATATCATTTTGGCAAACCATACTTATAACGCTGGACA
AATTGGATGGTTTGTTGCAGGTTCTGCATTAAATTTAATTGCAGCAGGAAAAGCTTAA

Upstream 100 bases:

>100_bases
AATCGTTAGTAATGTAATCTTACGATTATTAATATTATAAAGCCCGAGTGATAAACTCGGGCTTTTTCTTTTATAGCTCT
TCTATTTTTTGTAACTTGTC

Downstream 100 bases:

>100_bases
TTTTTTAAGATTCGATTATACTTAAAAAGCGCTCTGTATATACAGAGCGCTTTTTTATTTGAAATTAATTTTGTCTGATT
TGATTTCTAATGTTTTAATT

Product: aconitate hydratase

Products: NA

Alternate protein names: Aconitase; Citrate hydro-lyase [H]

Number of amino acids: Translated: 765; Mature: 765

Protein sequence:

>765_residues
MFKIKKQNNKLMAFDIEMIKKVYENMPERVDKARELVGRPLTLTEKILYNHLWDGVPSQVFKRGVDYVDFAPDRVACQDA
TAQMALLQFMHAGKSKVAVPTTVHCDHLIQAKVDAATDLARAKTQSNEVFDFLSSVSNKYGIGFWKPGAGIIHQVVLENY
AFPGGMMIGTDSHTVNAGGLGMVAIGVGGADAVDVMSGMAWELKFPKLIGVKLTGKLSGWTAPKDVILKVAGILTVKGGT
GAIVEYFGEGATSMSCTGKGTICNMGAEIGATTSTFGYDASMGRYLRSTNRADVADAADKIAPYLTGDPEVYANPEEYFD
QVIEINLSQLEPHLNGPFTPDLATPISKMKEEAIKNNWPLQIQVGLIGSCTNSSYEDISRAASLARQVAAKNLKTKAEFT
ITPGSEVVRSTIERDGFIDTFHKIGATVFANACGPCIGMWDRDGAEKEERNTIVHSFNRNFSKRADGNPNTLAFVGSPEL
VTAMAIAGDLGFNPLTDKLINEDGEEVMLDAPTGDELPAKGFYAEDPGFQAPAADGSGVQVVVNPTSERLQLLAPFDAWD
GKNITGAKLLIKAFGKCTTDHISMAGPWLRFRGHLDNISNNMLIGAVNAYNQKTNSVKNQLTGQYDAVPAVARAYKAAGV
PSIVVGDHNYGEGSSREHAAMEPRFLGVKAVLVKSFARIHETNLKKQGLLGLTFANEADYDKIQEDDTINFLDLTEFAPG
KPLTLEFVHANGTKDIILANHTYNAGQIGWFVAGSALNLIAAGKA

Sequences:

>Translated_765_residues
MFKIKKQNNKLMAFDIEMIKKVYENMPERVDKARELVGRPLTLTEKILYNHLWDGVPSQVFKRGVDYVDFAPDRVACQDA
TAQMALLQFMHAGKSKVAVPTTVHCDHLIQAKVDAATDLARAKTQSNEVFDFLSSVSNKYGIGFWKPGAGIIHQVVLENY
AFPGGMMIGTDSHTVNAGGLGMVAIGVGGADAVDVMSGMAWELKFPKLIGVKLTGKLSGWTAPKDVILKVAGILTVKGGT
GAIVEYFGEGATSMSCTGKGTICNMGAEIGATTSTFGYDASMGRYLRSTNRADVADAADKIAPYLTGDPEVYANPEEYFD
QVIEINLSQLEPHLNGPFTPDLATPISKMKEEAIKNNWPLQIQVGLIGSCTNSSYEDISRAASLARQVAAKNLKTKAEFT
ITPGSEVVRSTIERDGFIDTFHKIGATVFANACGPCIGMWDRDGAEKEERNTIVHSFNRNFSKRADGNPNTLAFVGSPEL
VTAMAIAGDLGFNPLTDKLINEDGEEVMLDAPTGDELPAKGFYAEDPGFQAPAADGSGVQVVVNPTSERLQLLAPFDAWD
GKNITGAKLLIKAFGKCTTDHISMAGPWLRFRGHLDNISNNMLIGAVNAYNQKTNSVKNQLTGQYDAVPAVARAYKAAGV
PSIVVGDHNYGEGSSREHAAMEPRFLGVKAVLVKSFARIHETNLKKQGLLGLTFANEADYDKIQEDDTINFLDLTEFAPG
KPLTLEFVHANGTKDIILANHTYNAGQIGWFVAGSALNLIAAGKA
>Mature_765_residues
MFKIKKQNNKLMAFDIEMIKKVYENMPERVDKARELVGRPLTLTEKILYNHLWDGVPSQVFKRGVDYVDFAPDRVACQDA
TAQMALLQFMHAGKSKVAVPTTVHCDHLIQAKVDAATDLARAKTQSNEVFDFLSSVSNKYGIGFWKPGAGIIHQVVLENY
AFPGGMMIGTDSHTVNAGGLGMVAIGVGGADAVDVMSGMAWELKFPKLIGVKLTGKLSGWTAPKDVILKVAGILTVKGGT
GAIVEYFGEGATSMSCTGKGTICNMGAEIGATTSTFGYDASMGRYLRSTNRADVADAADKIAPYLTGDPEVYANPEEYFD
QVIEINLSQLEPHLNGPFTPDLATPISKMKEEAIKNNWPLQIQVGLIGSCTNSSYEDISRAASLARQVAAKNLKTKAEFT
ITPGSEVVRSTIERDGFIDTFHKIGATVFANACGPCIGMWDRDGAEKEERNTIVHSFNRNFSKRADGNPNTLAFVGSPEL
VTAMAIAGDLGFNPLTDKLINEDGEEVMLDAPTGDELPAKGFYAEDPGFQAPAADGSGVQVVVNPTSERLQLLAPFDAWD
GKNITGAKLLIKAFGKCTTDHISMAGPWLRFRGHLDNISNNMLIGAVNAYNQKTNSVKNQLTGQYDAVPAVARAYKAAGV
PSIVVGDHNYGEGSSREHAAMEPRFLGVKAVLVKSFARIHETNLKKQGLLGLTFANEADYDKIQEDDTINFLDLTEFAPG
KPLTLEFVHANGTKDIILANHTYNAGQIGWFVAGSALNLIAAGKA

Specific function: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate [H]

COG id: COG1048

COG function: function code C; Aconitase A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aconitase/IPM isomerase family [H]

Homologues:

Organism=Homo sapiens, GI4501867, Length=739, Percent_Identity=61.2990527740189, Blast_Score=913, Evalue=0.0,
Organism=Homo sapiens, GI8659555, Length=748, Percent_Identity=28.6096256684492, Blast_Score=208, Evalue=2e-53,
Organism=Homo sapiens, GI41352693, Length=774, Percent_Identity=24.6770025839793, Blast_Score=162, Evalue=9e-40,
Organism=Escherichia coli, GI1787531, Length=697, Percent_Identity=28.2639885222382, Blast_Score=175, Evalue=1e-44,
Organism=Escherichia coli, GI87081781, Length=614, Percent_Identity=24.2671009771987, Blast_Score=122, Evalue=6e-29,
Organism=Escherichia coli, GI1786259, Length=390, Percent_Identity=25.6410256410256, Blast_Score=114, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI25149337, Length=736, Percent_Identity=62.6358695652174, Blast_Score=917, Evalue=0.0,
Organism=Caenorhabditis elegans, GI32564738, Length=681, Percent_Identity=63.8766519823789, Blast_Score=867, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25149342, Length=572, Percent_Identity=62.9370629370629, Blast_Score=726, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17568399, Length=789, Percent_Identity=27.8833967046895, Blast_Score=192, Evalue=6e-49,
Organism=Saccharomyces cerevisiae, GI6323335, Length=740, Percent_Identity=62.4324324324324, Blast_Score=946, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322261, Length=754, Percent_Identity=53.9787798408488, Blast_Score=793, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6320440, Length=447, Percent_Identity=25.9507829977629, Blast_Score=130, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6321429, Length=424, Percent_Identity=27.122641509434, Blast_Score=116, Evalue=1e-26,
Organism=Drosophila melanogaster, GI281365315, Length=740, Percent_Identity=61.8918918918919, Blast_Score=903, Evalue=0.0,
Organism=Drosophila melanogaster, GI17864292, Length=740, Percent_Identity=61.8918918918919, Blast_Score=903, Evalue=0.0,
Organism=Drosophila melanogaster, GI28571643, Length=738, Percent_Identity=60.5691056910569, Blast_Score=880, Evalue=0.0,
Organism=Drosophila melanogaster, GI161076999, Length=685, Percent_Identity=63.2116788321168, Blast_Score=854, Evalue=0.0,
Organism=Drosophila melanogaster, GI24645686, Length=817, Percent_Identity=29.1309669522644, Blast_Score=186, Evalue=6e-47,
Organism=Drosophila melanogaster, GI17137564, Length=862, Percent_Identity=27.8422273781903, Blast_Score=183, Evalue=3e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015931
- InterPro:   IPR015937
- InterPro:   IPR001030
- InterPro:   IPR015928
- InterPro:   IPR006249
- InterPro:   IPR015934
- InterPro:   IPR015932
- InterPro:   IPR018136
- InterPro:   IPR000573 [H]

Pfam domain/function: PF00330 Aconitase; PF00694 Aconitase_C [H]

EC number: =4.2.1.3 [H]

Molecular weight: Translated: 82421; Mature: 82421

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00450 ACONITASE_1 ; PS01244 ACONITASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKIKKQNNKLMAFDIEMIKKVYENMPERVDKARELVGRPLTLTEKILYNHLWDGVPSQV
CCEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHH
FKRGVDYVDFAPDRVACQDATAQMALLQFMHAGKSKVAVPTTVHCDHLIQAKVDAATDLA
HHCCCCCEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEECHHHHHHHHHHHHHHHH
RAKTQSNEVFDFLSSVSNKYGIGFWKPGAGIIHQVVLENYAFPGGMMIGTDSHTVNAGGL
HHHCCCHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHCCCCCCEEEECCCCEECCCCC
GMVAIGVGGADAVDVMSGMAWELKFPKLIGVKLTGKLSGWTAPKDVILKVAGILTVKGGT
EEEEEECCCCHHHHHHCCCEEEEECCEEEEEEEEECCCCCCCCHHHHHEEEEEEEECCCC
GAIVEYFGEGATSMSCTGKGTICNMGAEIGATTSTFGYDASMGRYLRSTNRADVADAADK
CHHHHHHCCCCCEEEECCCCCEEECCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHH
IAPYLTGDPEVYANPEEYFDQVIEINLSQLEPHLNGPFTPDLATPISKMKEEAIKNNWPL
HCCCCCCCCCEECCHHHHHHHHHHCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCE
QIQVGLIGSCTNSSYEDISRAASLARQVAAKNLKTKAEFTITPGSEVVRSTIERDGFIDT
EEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHCCHHHH
FHKIGATVFANACGPCIGMWDRDGAEKEERNTIVHSFNRNFSKRADGNPNTLAFVGSPEL
HHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCHH
VTAMAIAGDLGFNPLTDKLINEDGEEVMLDAPTGDELPAKGFYAEDPGFQAPAADGSGVQ
HHHHHHHCCCCCCHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCE
VVVNPTSERLQLLAPFDAWDGKNITGAKLLIKAFGKCTTDHISMAGPWLRFRGHLDNISN
EEECCCHHHEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCHHHCCCCHHEEECCCCCCCC
NMLIGAVNAYNQKTNSVKNQLTGQYDAVPAVARAYKAAGVPSIVVGDHNYGEGSSREHAA
CEEEEEEHHHCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCC
MEPRFLGVKAVLVKSFARIHETNLKKQGLLGLTFANEADYDKIQEDDTINFLDLTEFAPG
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHCCCCCCEEEEECCCCCCC
KPLTLEFVHANGTKDIILANHTYNAGQIGWFVAGSALNLIAAGKA
CCEEEEEEECCCCCEEEEEECCCCCCCEEEEEECCCEEEEECCCC
>Mature Secondary Structure
MFKIKKQNNKLMAFDIEMIKKVYENMPERVDKARELVGRPLTLTEKILYNHLWDGVPSQV
CCEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHH
FKRGVDYVDFAPDRVACQDATAQMALLQFMHAGKSKVAVPTTVHCDHLIQAKVDAATDLA
HHCCCCCEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEECHHHHHHHHHHHHHHHH
RAKTQSNEVFDFLSSVSNKYGIGFWKPGAGIIHQVVLENYAFPGGMMIGTDSHTVNAGGL
HHHCCCHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHCCCCCCEEEECCCCEECCCCC
GMVAIGVGGADAVDVMSGMAWELKFPKLIGVKLTGKLSGWTAPKDVILKVAGILTVKGGT
EEEEEECCCCHHHHHHCCCEEEEECCEEEEEEEEECCCCCCCCHHHHHEEEEEEEECCCC
GAIVEYFGEGATSMSCTGKGTICNMGAEIGATTSTFGYDASMGRYLRSTNRADVADAADK
CHHHHHHCCCCCEEEECCCCCEEECCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHH
IAPYLTGDPEVYANPEEYFDQVIEINLSQLEPHLNGPFTPDLATPISKMKEEAIKNNWPL
HCCCCCCCCCEECCHHHHHHHHHHCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCE
QIQVGLIGSCTNSSYEDISRAASLARQVAAKNLKTKAEFTITPGSEVVRSTIERDGFIDT
EEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHCCHHHH
FHKIGATVFANACGPCIGMWDRDGAEKEERNTIVHSFNRNFSKRADGNPNTLAFVGSPEL
HHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCHH
VTAMAIAGDLGFNPLTDKLINEDGEEVMLDAPTGDELPAKGFYAEDPGFQAPAADGSGVQ
HHHHHHHCCCCCCHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCE
VVVNPTSERLQLLAPFDAWDGKNITGAKLLIKAFGKCTTDHISMAGPWLRFRGHLDNISN
EEECCCHHHEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCHHHCCCCHHEEECCCCCCCC
NMLIGAVNAYNQKTNSVKNQLTGQYDAVPAVARAYKAAGVPSIVVGDHNYGEGSSREHAA
CEEEEEEHHHCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCC
MEPRFLGVKAVLVKSFARIHETNLKKQGLLGLTFANEADYDKIQEDDTINFLDLTEFAPG
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHCCCCCCEEEEECCCCCCC
KPLTLEFVHANGTKDIILANHTYNAGQIGWFVAGSALNLIAAGKA
CCEEEEEEECCCCCEEEEEECCCCCCCEEEEEECCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA