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The map label for this gene is dgk [H]

Identifier: 146299479

GI number: 146299479

Start: 1990524

End: 1991657

Strand: Direct

Name: dgk [H]

Synonym: Fjoh_1719

Alternate gene names: 146299479

Gene position: 1990524-1991657 (Clockwise)

Preceding gene: 146299475

Following gene: 146299483

Centisome position: 32.65

GC content: 33.07

Gene sequence:

>1134_bases
ATGAAATCACAGCATCAAGTCGTTTTATCCATAGGCAGCAATCAGGGAAACAGGTTAGAAAACATCAAAAGTTGTATCAA
TTTGATACATCAGGAAGTGGGAACTGTTATCAGGGTTTCGAAGTTGTATGAAACGCCTGCCTGGGGTTTTGAAAGTGATG
CTTTTTACAATTGTGCCTTGCTTTTGCATACTACTTCATCAGCACAAAAAATATTAAGCCAGGTTTTAAAAGTCGAAAAA
CAGTTAGGAAGAATCAGGTTGAATCAGGAAGGATATCAATCCCGAATTATTGATGTTGATGTAATTGTTTTTGATGATGA
AATTATTGAAACCGAAAAACTTCACATTCCGCACCCTTTGATGCAGAATAGAAATTTTGTTTTACTGCCAATGCAGGATT
TAAAGTTAGACTGGAAACATCCCGTATTTCAAAAAACGATTTCAGAGTTAATCTCAGTTTCACCGGATGACAGTGTTTGC
ACTGTTGTTCAGGATTTGAAATGTCCTTTAAATGAAATTCCGCTTCAAAAGTTCAATTATATTGCTTTTGAAGGAAATAT
TGGTGCCGGAAAAACTACTTTGGTTCACAAAATTGCAGAGGATTTTAATGCAAAAACAGTTTTAGAACGTTTTGCAGATA
ATCCGTTTCTGCCCAAGTTTTACAAAGATCAGAATCGATACGCATTTCCGCTCGAAATGTCTTTTTTAGCCGATCGTTAT
CAGCAGTTATCTGATGATTTAGCTCAGTTTGATTTGTTTAAAGATTTCATTGTAGCCGATTATCATATTTTTAAATCACT
GATTTTTGCCAAAATCACTTTACAGGAAGATGAATATCGTTTGTACCGAAATCTATTCGATATTATTTACAAGGAGATGC
CTAAACCTGATTTGTATATTTACTTATATCAAAATACAGATCGATTACTTCAAAATATTAAAAAACGAGGCAGAACGTAT
GAGCAGAATATTGAAGCCCAATATCTGGATAAAATCAACAATGGTTATTTGGAATATATAAAATCTCAAAAAGATTTAAA
TGTTCTGATTATCGACGTTTCTGATCGCGATTTTGTAAAAAAACAAGAAGATTATCTTTTTGTATTAAATGAAATTCAGA
AGAAGCTCAATTAG

Upstream 100 bases:

>100_bases
ATTGTTACAAATTTTACACATAAATTTAAATTGGTTCTATGTGCCGTTTCACAAATATATTGGTTAATTCTAAAATAGTT
TTAGTTAATTTGCATTAATT

Downstream 100 bases:

>100_bases
ATAATTAGAAAATGCGTCAATGAGATATTTATTTTAATTTTCTAATTGGCAGATTATCTCATTTAAACTTATCTTTTTAA
GGAAAAATGTCCTCTCAAAA

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: DGUO kinase; dGK [H]

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MKSQHQVVLSIGSNQGNRLENIKSCINLIHQEVGTVIRVSKLYETPAWGFESDAFYNCALLLHTTSSAQKILSQVLKVEK
QLGRIRLNQEGYQSRIIDVDVIVFDDEIIETEKLHIPHPLMQNRNFVLLPMQDLKLDWKHPVFQKTISELISVSPDDSVC
TVVQDLKCPLNEIPLQKFNYIAFEGNIGAGKTTLVHKIAEDFNAKTVLERFADNPFLPKFYKDQNRYAFPLEMSFLADRY
QQLSDDLAQFDLFKDFIVADYHIFKSLIFAKITLQEDEYRLYRNLFDIIYKEMPKPDLYIYLYQNTDRLLQNIKKRGRTY
EQNIEAQYLDKINNGYLEYIKSQKDLNVLIIDVSDRDFVKKQEDYLFVLNEIQKKLN

Sequences:

>Translated_377_residues
MKSQHQVVLSIGSNQGNRLENIKSCINLIHQEVGTVIRVSKLYETPAWGFESDAFYNCALLLHTTSSAQKILSQVLKVEK
QLGRIRLNQEGYQSRIIDVDVIVFDDEIIETEKLHIPHPLMQNRNFVLLPMQDLKLDWKHPVFQKTISELISVSPDDSVC
TVVQDLKCPLNEIPLQKFNYIAFEGNIGAGKTTLVHKIAEDFNAKTVLERFADNPFLPKFYKDQNRYAFPLEMSFLADRY
QQLSDDLAQFDLFKDFIVADYHIFKSLIFAKITLQEDEYRLYRNLFDIIYKEMPKPDLYIYLYQNTDRLLQNIKKRGRTY
EQNIEAQYLDKINNGYLEYIKSQKDLNVLIIDVSDRDFVKKQEDYLFVLNEIQKKLN
>Mature_377_residues
MKSQHQVVLSIGSNQGNRLENIKSCINLIHQEVGTVIRVSKLYETPAWGFESDAFYNCALLLHTTSSAQKILSQVLKVEK
QLGRIRLNQEGYQSRIIDVDVIVFDDEIIETEKLHIPHPLMQNRNFVLLPMQDLKLDWKHPVFQKTISELISVSPDDSVC
TVVQDLKCPLNEIPLQKFNYIAFEGNIGAGKTTLVHKIAEDFNAKTVLERFADNPFLPKFYKDQNRYAFPLEMSFLADRY
QQLSDDLAQFDLFKDFIVADYHIFKSLIFAKITLQEDEYRLYRNLFDIIYKEMPKPDLYIYLYQNTDRLLQNIKKRGRTY
EQNIEAQYLDKINNGYLEYIKSQKDLNVLIIDVSDRDFVKKQEDYLFVLNEIQKKLN

Specific function: Plays an essential role in generating the deoxyribonucleotide precursors dGTP for DNA metabolism. Highly specific toward deoxyguanosine (dGuo) and deoxyinosine (dIno). Only marginal activity is observed with guanosine. UTP is slightly more efficient as ph

COG id: COG1428

COG function: function code F; Deoxynucleoside kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DCK/DGK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=125, Percent_Identity=32.8, Blast_Score=80, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002624 [H]

Pfam domain/function: PF01712 dNK [H]

EC number: =2.7.1.113 [H]

Molecular weight: Translated: 44245; Mature: 44245

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSQHQVVLSIGSNQGNRLENIKSCINLIHQEVGTVIRVSKLYETPAWGFESDAFYNCAL
CCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEE
LLHTTSSAQKILSQVLKVEKQLGRIRLNQEGYQSRIIDVDVIVFDDEIIETEKLHIPHPL
EEEECHHHHHHHHHHHHHHHHHHHEEECCCCCCCEEEEEEEEEECCCHHCCCCCCCCCHH
MQNRNFVLLPMQDLKLDWKHPVFQKTISELISVSPDDSVCTVVQDLKCPLNEIPLQKFNY
HCCCCEEEEEHHHCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHCCCCCCCE
IAFEGNIGAGKTTLVHKIAEDFNAKTVLERFADNPFLPKFYKDQNRYAFPLEMSFLADRY
EEEECCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHCCCCCEEEEEHHHHHHHHH
QQLSDDLAQFDLFKDFIVADYHIFKSLIFAKITLQEDEYRLYRNLFDIIYKEMPKPDLYI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHCCCCCEEE
YLYQNTDRLLQNIKKRGRTYEQNIEAQYLDKINNGYLEYIKSQKDLNVLIIDVSDRDFVK
EEECCHHHHHHHHHHHCCCHHHCCHHHHHHHHCCHHHHHHHCCCCCEEEEEEECCCHHHH
KQEDYLFVLNEIQKKLN
CCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MKSQHQVVLSIGSNQGNRLENIKSCINLIHQEVGTVIRVSKLYETPAWGFESDAFYNCAL
CCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEE
LLHTTSSAQKILSQVLKVEKQLGRIRLNQEGYQSRIIDVDVIVFDDEIIETEKLHIPHPL
EEEECHHHHHHHHHHHHHHHHHHHEEECCCCCCCEEEEEEEEEECCCHHCCCCCCCCCHH
MQNRNFVLLPMQDLKLDWKHPVFQKTISELISVSPDDSVCTVVQDLKCPLNEIPLQKFNY
HCCCCEEEEEHHHCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHCCCCCCCE
IAFEGNIGAGKTTLVHKIAEDFNAKTVLERFADNPFLPKFYKDQNRYAFPLEMSFLADRY
EEEECCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHCCCCCEEEEEHHHHHHHHH
QQLSDDLAQFDLFKDFIVADYHIFKSLIFAKITLQEDEYRLYRNLFDIIYKEMPKPDLYI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHCCCCCEEE
YLYQNTDRLLQNIKKRGRTYEQNIEAQYLDKINNGYLEYIKSQKDLNVLIIDVSDRDFVK
EEECCHHHHHHHHHHHCCCHHHCCHHHHHHHHCCHHHHHHHCCCCCEEEEEEECCCHHHH
KQEDYLFVLNEIQKKLN
CCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377 [H]