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The map label for this gene is macA [H]

Identifier: 146299432

GI number: 146299432

Start: 1941463

End: 1942752

Strand: Direct

Name: macA [H]

Synonym: Fjoh_1672

Alternate gene names: 146299432

Gene position: 1941463-1942752 (Clockwise)

Preceding gene: 146299431

Following gene: 146299433

Centisome position: 31.84

GC content: 33.49

Gene sequence:

>1290_bases
ATGTCAAAAAAAATAGTTTACTTCTCAGTTGGCGGGGCATTAGTTCTAATTGCATTATTAGTAAGTCTTTCTAAGGCAGG
AGTAATAGGAAATAAAGATGAAGGAAAAGAAGTTGAAACTTCAAAAGTAACAGCTTCTACAATCGTTGAAACTGTATCGG
CGACTGGAAAAATCCAGCCGGAAATAGAAGTAAAACTTTCATCAATGGTTTCCGGTGAAATTATTGCGTTAAATGTAAAA
GAAGGGCAGGTTGTAAAAAAAGGAGATTTATTAGTAAAAATAAATCCTGATTTATATACTTCAGGACTAGAAAGATCTGT
AGCAAATTTATCTGGAACAAAAGCCGGATTAGTACAATCTGAAGCCAGTTTTAAAGAAGCTAAAGCCAATTACGAACGTA
ATAAAACATTATACGACAAAGGAGTAATTTCAAAGTCAGACTGGGATAAAGCTATTTCGACATACGAAGTTGCCAAAGCA
ACAAAACAAAATGCGTACTATAATGTTCAAAGTGCTTCGGCATCTGTAACAGAAGCCAGAGATAATTTAGGACGTACCAC
AATTTATGCTCCTGCCGATGGTACTATTTCTGTATTGAATGTAGAATTAGGAGAGCGTGTTTTAGGAACACAGCAAATGG
CCGGAACAGAACTTTTAAGGGTTGCCAATCTTAACAACATGGAAGTTGAAGTTGATGTTAATGAAAATGATATCGTAAAA
ATTAAAATTGGAGACGAAGCAAATGTTGAAGTCGATGCTTACCTAAAAAAGAAATTTAAAGGTGTAGTAACCAGTATTTC
TAATTCTGCCAGCACAACATTAACATCAGATCAGGTTACAAACTTTAAAGTTAAAGTTCGTATTTTAAAAGAATCATATC
AGGATTTATTAGAAGGAAAACCAGATGCTTATTCGCCTTTTAGACCTGGAATGACAGCAACAGTAGATATTATTACCACA
ACTAAAAACAATGTTTTGGCAGTACCAATTAGTTCTGTAGTTGTAAAATCTGATACAACGGCTGTTAAAGATTTTAAAGT
TGACGATCCAAACGAGAAAAAAACAACTCCAAAAAGCGATAAGAAATTTGAGTGTGTTTTTGTAAAAGTAGGTGATAAAG
CTAAAATCAGAATTATTAAAACCGGAATTCAGGATGATACGAATATCGAAGTAATGTCTGGATTAAAATCTGGAGATGTA
GTAATTACAGGGCCTTATACAACCGTTTCTAAAGAACTAAATTCTGGAGATAAAGTTAAACTTAAAAAAGCTGACGCTCC
TAAAAAATAA

Upstream 100 bases:

>100_bases
AGACGTTATTAGAACGAAATACGATTACATGTTTAAAATTAAAATACTTGAATTCTATTTCGGAATTCCAATTGTTCCAG
TTATTACAAAATAATTTATT

Downstream 100 bases:

>100_bases
ATAAGATATATTTGTCAGGCTGAGCAGAATTAAGTTTTCTCTCAGCCTGAAATAATTAATTTTAAAATCATACACATTGT
CTTTTATTCTCAATATCGAA

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MSKKIVYFSVGGALVLIALLVSLSKAGVIGNKDEGKEVETSKVTASTIVETVSATGKIQPEIEVKLSSMVSGEIIALNVK
EGQVVKKGDLLVKINPDLYTSGLERSVANLSGTKAGLVQSEASFKEAKANYERNKTLYDKGVISKSDWDKAISTYEVAKA
TKQNAYYNVQSASASVTEARDNLGRTTIYAPADGTISVLNVELGERVLGTQQMAGTELLRVANLNNMEVEVDVNENDIVK
IKIGDEANVEVDAYLKKKFKGVVTSISNSASTTLTSDQVTNFKVKVRILKESYQDLLEGKPDAYSPFRPGMTATVDIITT
TKNNVLAVPISSVVVKSDTTAVKDFKVDDPNEKKTTPKSDKKFECVFVKVGDKAKIRIIKTGIQDDTNIEVMSGLKSGDV
VITGPYTTVSKELNSGDKVKLKKADAPKK

Sequences:

>Translated_429_residues
MSKKIVYFSVGGALVLIALLVSLSKAGVIGNKDEGKEVETSKVTASTIVETVSATGKIQPEIEVKLSSMVSGEIIALNVK
EGQVVKKGDLLVKINPDLYTSGLERSVANLSGTKAGLVQSEASFKEAKANYERNKTLYDKGVISKSDWDKAISTYEVAKA
TKQNAYYNVQSASASVTEARDNLGRTTIYAPADGTISVLNVELGERVLGTQQMAGTELLRVANLNNMEVEVDVNENDIVK
IKIGDEANVEVDAYLKKKFKGVVTSISNSASTTLTSDQVTNFKVKVRILKESYQDLLEGKPDAYSPFRPGMTATVDIITT
TKNNVLAVPISSVVVKSDTTAVKDFKVDDPNEKKTTPKSDKKFECVFVKVGDKAKIRIIKTGIQDDTNIEVMSGLKSGDV
VITGPYTTVSKELNSGDKVKLKKADAPKK
>Mature_428_residues
SKKIVYFSVGGALVLIALLVSLSKAGVIGNKDEGKEVETSKVTASTIVETVSATGKIQPEIEVKLSSMVSGEIIALNVKE
GQVVKKGDLLVKINPDLYTSGLERSVANLSGTKAGLVQSEASFKEAKANYERNKTLYDKGVISKSDWDKAISTYEVAKAT
KQNAYYNVQSASASVTEARDNLGRTTIYAPADGTISVLNVELGERVLGTQQMAGTELLRVANLNNMEVEVDVNENDIVKI
KIGDEANVEVDAYLKKKFKGVVTSISNSASTTLTSDQVTNFKVKVRILKESYQDLLEGKPDAYSPFRPGMTATVDIITTT
KNNVLAVPISSVVVKSDTTAVKDFKVDDPNEKKTTPKSDKKFECVFVKVGDKAKIRIIKTGIQDDTNIEVMSGLKSGDVV
ITGPYTTVSKELNSGDKVKLKKADAPKK

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=366, Percent_Identity=25.4098360655738, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1788711, Length=311, Percent_Identity=26.6881028938907, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87082036, Length=377, Percent_Identity=23.0769230769231, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790519, Length=235, Percent_Identity=25.1063829787234, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 46235; Mature: 46104

Theoretical pI: Translated: 9.43; Mature: 9.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKIVYFSVGGALVLIALLVSLSKAGVIGNKDEGKEVETSKVTASTIVETVSATGKIQP
CCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
EIEVKLSSMVSGEIIALNVKEGQVVKKGDLLVKINPDLYTSGLERSVANLSGTKAGLVQS
EEEEEEECCCCCEEEEEEECCCCEEECCCEEEEECCCHHHHHHHHHHHHCCCCCCCEEEC
EASFKEAKANYERNKTLYDKGVISKSDWDKAISTYEVAKATKQNAYYNVQSASASVTEAR
HHHHHHHHCCCCCCCEEHHCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHH
DNLGRTTIYAPADGTISVLNVELGERVLGTQQMAGTELLRVANLNNMEVEVDVNENDIVK
HCCCCEEEEECCCCEEEEEEEECCCHHHCHHHHCCHHEEEEECCCCEEEEEEECCCCEEE
IKIGDEANVEVDAYLKKKFKGVVTSISNSASTTLTSDQVTNFKVKVRILKESYQDLLEGK
EEECCCCCEEHHHHHHHHHHHHHHHCCCCCCEEEECCCCEEEEEEEEEHHHHHHHHHCCC
PDAYSPFRPGMTATVDIITTTKNNVLAVPISSVVVKSDTTAVKDFKVDDPNEKKTTPKSD
CCCCCCCCCCCEEEEEEEEECCCCEEEEECCEEEEECCCCEEEEEECCCCCCCCCCCCCC
KKFECVFVKVGDKAKIRIIKTGIQDDTNIEVMSGLKSGDVVITGPYTTVSKELNSGDKVK
CCEEEEEEEECCCEEEEEEEECCCCCCCCCEEECCCCCCEEEECCCHHHHHHCCCCCEEE
LKKADAPKK
EECCCCCCC
>Mature Secondary Structure 
SKKIVYFSVGGALVLIALLVSLSKAGVIGNKDEGKEVETSKVTASTIVETVSATGKIQP
CCEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
EIEVKLSSMVSGEIIALNVKEGQVVKKGDLLVKINPDLYTSGLERSVANLSGTKAGLVQS
EEEEEEECCCCCEEEEEEECCCCEEECCCEEEEECCCHHHHHHHHHHHHCCCCCCCEEEC
EASFKEAKANYERNKTLYDKGVISKSDWDKAISTYEVAKATKQNAYYNVQSASASVTEAR
HHHHHHHHCCCCCCCEEHHCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHH
DNLGRTTIYAPADGTISVLNVELGERVLGTQQMAGTELLRVANLNNMEVEVDVNENDIVK
HCCCCEEEEECCCCEEEEEEEECCCHHHCHHHHCCHHEEEEECCCCEEEEEEECCCCEEE
IKIGDEANVEVDAYLKKKFKGVVTSISNSASTTLTSDQVTNFKVKVRILKESYQDLLEGK
EEECCCCCEEHHHHHHHHHHHHHHHCCCCCCEEEECCCCEEEEEEEEEHHHHHHHHHCCC
PDAYSPFRPGMTATVDIITTTKNNVLAVPISSVVVKSDTTAVKDFKVDDPNEKKTTPKSD
CCCCCCCCCCCEEEEEEEEECCCCEEEEECCEEEEECCCCEEEEEECCCCCCCCCCCCCC
KKFECVFVKVGDKAKIRIIKTGIQDDTNIEVMSGLKSGDVVITGPYTTVSKELNSGDKVK
CCEEEEEEEECCCEEEEEEEECCCCCCCCCEEECCCCCCEEEECCCHHHHHHCCCCCEEE
LKKADAPKK
EECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]