Click here to switch to the map view.

The map label for this gene is maeB [H]

Identifier: 146299411

GI number: 146299411

Start: 1914721

End: 1917012

Strand: Direct

Name: maeB [H]

Synonym: Fjoh_1651

Alternate gene names: 146299411

Gene position: 1914721-1917012 (Clockwise)

Preceding gene: 146299410

Following gene: 146299412

Centisome position: 31.4

GC content: 36.47

Gene sequence:

>2292_bases
ATGAACAAAGAGAGTAAAAAAAGAGAGGCATTACAGTACCACGCTGAGCCAACTCCAGGAAAAATTCAGGTAGTTCCAAC
AAAAAAATATGCAACCCAGAGAGACTTATCGCTTGCGTATTCGCCGGGAGTTGCTGAACCTTGTTTAGCAATTGCAGAAA
ACATTGAAGATGTTTATAAATATACAGCAAAAGGAAATTTAGTTGCCGTAATTTCAAACGGTACAGCTGTTTTAGGACTT
GGAGATATAGGCCCGGAAGCAGGAAAACCAGTAATGGAAGGTAAAGGTTTATTGTTTAAAATATTCTCTGATATTGATGT
TTTTGATATCGAAGTTGATACAAAAAATGTTGAAGAATTTATTCAGACTGTAAAAAATATTGCTCCAACTTTTGGAGGTA
TTAATCTTGAAGATATTAAAGCACCAGAATCTTTTGAAATCGAAAGAAGATTAATCGAAGAATTAGACATTCCGGTAATG
CACGACGATCAGCACGGAACTGCAATTATTTCTTCTGCAGCTTTAATCAATGCACTTGAATTAGCAGGAAAAAAAGCAGA
AGATGTAAAAGTAGTAGTTTCTGGAGCAGGATCTGCAGCAATCGCTTGTACTGACTTATATGTTTTATTAGGAGTAAAAG
TTGAAAATGTTTTAATGTTTAATAGTAAAGGACTTTTAACAAAAGACAATCCTGCACTTTCAGATTTACAATTAAAATAT
GCTGTTAATGGTCCTAAAATTGAGTTAGCAGAAGCGGTAAAAGGAGCAGATGTTTTCATCGGCTTATCATCTGGAGATAT
TTTATCGCCGGAAATGCTGTTAACAATGAAAGAAAATCCGATTGTTTTTGCAATGGCAAATCCAAATCCGGAAATCGATT
ATAATTTAGCTGTACAAACACGTAAAGACGTGATTATGGCTACAGGCCGTTCAGATTTTCCTAATCAGGTAAATAACGTT
CTTGGTTTCCCTTATATTTTTAGAGGAGCTTTAGACGTGCGTGCTACAAAAATTAACGAAGCTATGAAAATGGCTGCTGT
AAAAGCATTGGCTATTTTAGCAAAAGAACCAGTTCCAGAACAGGTTAACGTAGCTTACGGAGCAATGAAATTAGGTTTTG
GGCAAGAATATATCATTCCTAAACCATTCGATCCTAGATTGATTACTGTTGTGGCACCAGCAGTTGCAAAAGCAGCAATG
GAATCTGGAGTTGCAAAAAATCCTATTACAGACTGGGCAGCTTATGAAGATAAGCTTCGCGAGCGTATGGGTAACGATAA
TAAAATGGTGCGTTTAATTACAAACCGAGCGAAATTAGATCCTAAAAAAGTAGTTTTTGCTGAGGCAGACCAATTAAATG
TGTTAAAAGCGGCACAAATTGTACACGAAGACGGAATTGGTATTCCGGTTTTATTAGGAAACAGAGAAACTATTTTAGAA
TTAAAAGAGGAATTAGGTTTTGACGCCGAATTAGAAATCATCGATCCTAAAACAAACGAAGAAGAAGAAAGACGTAACAA
ATTTGCAAATTCATACTGGGAATCAAGAGAACGCAGAGGAGTTTCATTGCTTGATGCTCAAAAATTCATGCGCGAAAGAA
ACTATTTCGCTGCCATGATGGTAAACGAAGGAGAAGCAGATGCACTTGTTACAGGATATTCAAGAAGTTACCCAAGTGTT
GTAAAACCAATGCTGCAATTAATTGAAAAAGCACACGGCGCTTCACTTGTTGCAACAGCAAACATGATGCTTACATCACG
CGGACCAATGTTCTTGTCAGATACAGCAATCAATATCAATCCATCATCAGAAGATTTAGTAAATATTGCATTGATGACTG
CTAAAACAGCAAAAATGTTCGGAATTGAACCCGTAATTGCAATGGTTTCTTATTCAAACTTTGGTTCATCAACGCATCAA
AATGCTTCAAAAGTAAGAGATGCAGTGGCGTATTTACATAAAAATCACCCTGAGATGGTCGTAGATGGTGAGATTCAGGC
AGACTTTGCTTTAAATTCTGAAATGCTTCAGGAAAAGTTCCCATTCTCTAAACTGGCAGGTAAAAAAGTAAACACGCTTG
TGTTCCCTAACTTAGAGTCGGCTAATATCACTTATAAATTGATGAAAGAACTGAATAAATCAGCTTCTATCGGGCCTATT
ATGATGGGAATGGATAAACCAGTTCACATTTTCCAATTAGGGGCAAGCGTTGAAGAAATGGTTAATATGGCAGCAATTGC
GGTTATTGACGCTCAGGAAAAAGAAAACAAAAAGAACAAATTAGCAAAATAA

Upstream 100 bases:

>100_bases
TGATTTTACCATTTTGATATTTTAACAAAAGAAAGCAGTAAAAGCGTCCCATTTTAAACTAAGACTTATATCTTTGTAAG
CTAGAATAAAAGCTAAAATA

Downstream 100 bases:

>100_bases
TTCACTAAAAAATAGGACAAAATAATATTGTCCTATTTTTATTGCATTTTTACTATATTTGGATTCTTACTAAATTATAT
TATGATAGCACATTTGCAGG

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 763; Mature: 763

Protein sequence:

>763_residues
MNKESKKREALQYHAEPTPGKIQVVPTKKYATQRDLSLAYSPGVAEPCLAIAENIEDVYKYTAKGNLVAVISNGTAVLGL
GDIGPEAGKPVMEGKGLLFKIFSDIDVFDIEVDTKNVEEFIQTVKNIAPTFGGINLEDIKAPESFEIERRLIEELDIPVM
HDDQHGTAIISSAALINALELAGKKAEDVKVVVSGAGSAAIACTDLYVLLGVKVENVLMFNSKGLLTKDNPALSDLQLKY
AVNGPKIELAEAVKGADVFIGLSSGDILSPEMLLTMKENPIVFAMANPNPEIDYNLAVQTRKDVIMATGRSDFPNQVNNV
LGFPYIFRGALDVRATKINEAMKMAAVKALAILAKEPVPEQVNVAYGAMKLGFGQEYIIPKPFDPRLITVVAPAVAKAAM
ESGVAKNPITDWAAYEDKLRERMGNDNKMVRLITNRAKLDPKKVVFAEADQLNVLKAAQIVHEDGIGIPVLLGNRETILE
LKEELGFDAELEIIDPKTNEEEERRNKFANSYWESRERRGVSLLDAQKFMRERNYFAAMMVNEGEADALVTGYSRSYPSV
VKPMLQLIEKAHGASLVATANMMLTSRGPMFLSDTAININPSSEDLVNIALMTAKTAKMFGIEPVIAMVSYSNFGSSTHQ
NASKVRDAVAYLHKNHPEMVVDGEIQADFALNSEMLQEKFPFSKLAGKKVNTLVFPNLESANITYKLMKELNKSASIGPI
MMGMDKPVHIFQLGASVEEMVNMAAIAVIDAQEKENKKNKLAK

Sequences:

>Translated_763_residues
MNKESKKREALQYHAEPTPGKIQVVPTKKYATQRDLSLAYSPGVAEPCLAIAENIEDVYKYTAKGNLVAVISNGTAVLGL
GDIGPEAGKPVMEGKGLLFKIFSDIDVFDIEVDTKNVEEFIQTVKNIAPTFGGINLEDIKAPESFEIERRLIEELDIPVM
HDDQHGTAIISSAALINALELAGKKAEDVKVVVSGAGSAAIACTDLYVLLGVKVENVLMFNSKGLLTKDNPALSDLQLKY
AVNGPKIELAEAVKGADVFIGLSSGDILSPEMLLTMKENPIVFAMANPNPEIDYNLAVQTRKDVIMATGRSDFPNQVNNV
LGFPYIFRGALDVRATKINEAMKMAAVKALAILAKEPVPEQVNVAYGAMKLGFGQEYIIPKPFDPRLITVVAPAVAKAAM
ESGVAKNPITDWAAYEDKLRERMGNDNKMVRLITNRAKLDPKKVVFAEADQLNVLKAAQIVHEDGIGIPVLLGNRETILE
LKEELGFDAELEIIDPKTNEEEERRNKFANSYWESRERRGVSLLDAQKFMRERNYFAAMMVNEGEADALVTGYSRSYPSV
VKPMLQLIEKAHGASLVATANMMLTSRGPMFLSDTAININPSSEDLVNIALMTAKTAKMFGIEPVIAMVSYSNFGSSTHQ
NASKVRDAVAYLHKNHPEMVVDGEIQADFALNSEMLQEKFPFSKLAGKKVNTLVFPNLESANITYKLMKELNKSASIGPI
MMGMDKPVHIFQLGASVEEMVNMAAIAVIDAQEKENKKNKLAK
>Mature_763_residues
MNKESKKREALQYHAEPTPGKIQVVPTKKYATQRDLSLAYSPGVAEPCLAIAENIEDVYKYTAKGNLVAVISNGTAVLGL
GDIGPEAGKPVMEGKGLLFKIFSDIDVFDIEVDTKNVEEFIQTVKNIAPTFGGINLEDIKAPESFEIERRLIEELDIPVM
HDDQHGTAIISSAALINALELAGKKAEDVKVVVSGAGSAAIACTDLYVLLGVKVENVLMFNSKGLLTKDNPALSDLQLKY
AVNGPKIELAEAVKGADVFIGLSSGDILSPEMLLTMKENPIVFAMANPNPEIDYNLAVQTRKDVIMATGRSDFPNQVNNV
LGFPYIFRGALDVRATKINEAMKMAAVKALAILAKEPVPEQVNVAYGAMKLGFGQEYIIPKPFDPRLITVVAPAVAKAAM
ESGVAKNPITDWAAYEDKLRERMGNDNKMVRLITNRAKLDPKKVVFAEADQLNVLKAAQIVHEDGIGIPVLLGNRETILE
LKEELGFDAELEIIDPKTNEEEERRNKFANSYWESRERRGVSLLDAQKFMRERNYFAAMMVNEGEADALVTGYSRSYPSV
VKPMLQLIEKAHGASLVATANMMLTSRGPMFLSDTAININPSSEDLVNIALMTAKTAKMFGIEPVIAMVSYSNFGSSTHQ
NASKVRDAVAYLHKNHPEMVVDGEIQADFALNSEMLQEKFPFSKLAGKKVNTLVFPNLESANITYKLMKELNKSASIGPI
MMGMDKPVHIFQLGASVEEMVNMAAIAVIDAQEKENKKNKLAK

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=343, Percent_Identity=23.3236151603499, Blast_Score=68, Evalue=3e-11,
Organism=Escherichia coli, GI1788806, Length=760, Percent_Identity=48.9473684210526, Blast_Score=691, Evalue=0.0,
Organism=Escherichia coli, GI1788635, Length=325, Percent_Identity=33.2307692307692, Blast_Score=182, Evalue=7e-47,
Organism=Escherichia coli, GI1788800, Length=325, Percent_Identity=33.2307692307692, Blast_Score=173, Evalue=4e-44,
Organism=Escherichia coli, GI87081919, Length=455, Percent_Identity=23.956043956044, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6322823, Length=273, Percent_Identity=29.3040293040293, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24646388, Length=363, Percent_Identity=26.7217630853994, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24646386, Length=363, Percent_Identity=26.7217630853994, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI281362672, Length=412, Percent_Identity=26.4563106796117, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI281362674, Length=412, Percent_Identity=26.4563106796117, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21356279, Length=412, Percent_Identity=26.4563106796117, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI78707242, Length=340, Percent_Identity=22.9411764705882, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI78707238, Length=340, Percent_Identity=22.9411764705882, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 83486; Mature: 83486

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKESKKREALQYHAEPTPGKIQVVPTKKYATQRDLSLAYSPGVAEPCLAIAENIEDVYK
CCCHHHHHHHHHCCCCCCCCEEEEEECHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHH
YTAKGNLVAVISNGTAVLGLGDIGPEAGKPVMEGKGLLFKIFSDIDVFDIEVDTKNVEEF
HHCCCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCEEEEEECCCEEEEEEECHHHHHHH
IQTVKNIAPTFGGINLEDIKAPESFEIERRLIEELDIPVMHDDQHGTAIISSAALINALE
HHHHHHHCCCCCCCCHHHCCCCCCHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHH
LAGKKAEDVKVVVSGAGSAAIACTDLYVLLGVKVENVLMFNSKGLLTKDNPALSDLQLKY
HCCCCCCCEEEEEECCCCCEEHHHHHHHHCCCEEEEEEEECCCCCEECCCCCCCCEEEEE
AVNGPKIELAEAVKGADVFIGLSSGDILSPEMLLTMKENPIVFAMANPNPEIDYNLAVQT
EECCCCEEHHHHCCCCEEEEEECCCCCCCCCEEEEEECCCEEEEECCCCCCCEEEEEEEE
RKDVIMATGRSDFPNQVNNVLGFPYIFRGALDVRATKINEAMKMAAVKALAILAKEPVPE
CCCEEEECCCCCCCHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
QVNVAYGAMKLGFGQEYIIPKPFDPRLITVVAPAVAKAAMESGVAKNPITDWAAYEDKLR
CHHHHHHEEEECCCCCCCCCCCCCCEEEEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
ERMGNDNKMVRLITNRAKLDPKKVVFAEADQLNVLKAAQIVHEDGIGIPVLLGNRETILE
HHHCCCCCEEEEEECCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHH
LKEELGFDAELEIIDPKTNEEEERRNKFANSYWESRERRGVSLLDAQKFMRERNYFAAMM
HHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEE
VNEGEADALVTGYSRSYPSVVKPMLQLIEKAHGASLVATANMMLTSRGPMFLSDTAININ
ECCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEEEEEEECCCCEEEECEEEEEC
PSSEDLVNIALMTAKTAKMFGIEPVIAMVSYSNFGSSTHQNASKVRDAVAYLHKNHPEMV
CCCCHHEEEEEEEEHHHHHCCCCHHHHHEEECCCCCCCCCHHHHHHHHHHHHHCCCCCEE
VDGEIQADFALNSEMLQEKFPFSKLAGKKVNTLVFPNLESANITYKLMKELNKSASIGPI
ECCCEEECEECCHHHHHHHCCHHHHCCCCCCEEECCCCCCCCHHHHHHHHHCCCCCCCCE
MMGMDKPVHIFQLGASVEEMVNMAAIAVIDAQEKENKKNKLAK
EECCCCCEEEEEECCCHHHHHHHHHEEEEECHHHHCHHHCCCC
>Mature Secondary Structure
MNKESKKREALQYHAEPTPGKIQVVPTKKYATQRDLSLAYSPGVAEPCLAIAENIEDVYK
CCCHHHHHHHHHCCCCCCCCEEEEEECHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHH
YTAKGNLVAVISNGTAVLGLGDIGPEAGKPVMEGKGLLFKIFSDIDVFDIEVDTKNVEEF
HHCCCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCEEEEEECCCEEEEEEECHHHHHHH
IQTVKNIAPTFGGINLEDIKAPESFEIERRLIEELDIPVMHDDQHGTAIISSAALINALE
HHHHHHHCCCCCCCCHHHCCCCCCHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHH
LAGKKAEDVKVVVSGAGSAAIACTDLYVLLGVKVENVLMFNSKGLLTKDNPALSDLQLKY
HCCCCCCCEEEEEECCCCCEEHHHHHHHHCCCEEEEEEEECCCCCEECCCCCCCCEEEEE
AVNGPKIELAEAVKGADVFIGLSSGDILSPEMLLTMKENPIVFAMANPNPEIDYNLAVQT
EECCCCEEHHHHCCCCEEEEEECCCCCCCCCEEEEEECCCEEEEECCCCCCCEEEEEEEE
RKDVIMATGRSDFPNQVNNVLGFPYIFRGALDVRATKINEAMKMAAVKALAILAKEPVPE
CCCEEEECCCCCCCHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
QVNVAYGAMKLGFGQEYIIPKPFDPRLITVVAPAVAKAAMESGVAKNPITDWAAYEDKLR
CHHHHHHEEEECCCCCCCCCCCCCCEEEEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
ERMGNDNKMVRLITNRAKLDPKKVVFAEADQLNVLKAAQIVHEDGIGIPVLLGNRETILE
HHHCCCCCEEEEEECCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHH
LKEELGFDAELEIIDPKTNEEEERRNKFANSYWESRERRGVSLLDAQKFMRERNYFAAMM
HHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEE
VNEGEADALVTGYSRSYPSVVKPMLQLIEKAHGASLVATANMMLTSRGPMFLSDTAININ
ECCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEEEEEEECCCCEEEECEEEEEC
PSSEDLVNIALMTAKTAKMFGIEPVIAMVSYSNFGSSTHQNASKVRDAVAYLHKNHPEMV
CCCCHHEEEEEEEEHHHHHCCCCHHHHHEEECCCCCCCCCHHHHHHHHHHHHHCCCCCEE
VDGEIQADFALNSEMLQEKFPFSKLAGKKVNTLVFPNLESANITYKLMKELNKSASIGPI
ECCCEEECEECCHHHHHHHCCHHHHCCCCCCEEECCCCCCCCHHHHHHHHHCCCCCCCCE
MMGMDKPVHIFQLGASVEEMVNMAAIAVIDAQEKENKKNKLAK
EECCCCCEEEEEECCCHHHHHHHHHEEEEECHHHHCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 36376 [H]