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The map label for this gene is dcp [H]

Identifier: 146299368

GI number: 146299368

Start: 1856220

End: 1858283

Strand: Direct

Name: dcp [H]

Synonym: Fjoh_1608

Alternate gene names: 146299368

Gene position: 1856220-1858283 (Clockwise)

Preceding gene: 146299356

Following gene: 146299375

Centisome position: 30.45

GC content: 34.59

Gene sequence:

>2064_bases
ATGGAAAAACAACCCAATTTAAATAATTCGCTGCTTCAGGAATGGTCAGGTCCGTATGGAGGAGTGCCCGATTTTACAAA
ATATAAAATTTCAGATTTTAAACCGGCAATTGAATTTGCTATTCAGGAAAAGTTGGAGGAAATTGATGCGATTGCAGATA
ATTCAGAAAAACCAACTTTTGAAAATACAGTTCAAGCTTTAGAACTTTCGGGCGAAAAGCTGGATCGTATTCATTCTGTT
TATGGAATATACAGGTCAAATTTGAGTACTCCGGAATTTAATGCGGTAGATACAGAAATGTCGCCAAAACTGGCAGAAAT
CAGTGATAAACTCTATCAAAATGAAAAATTATTTTTAAGAATAGAAGAGTTATACAAATCTGAAGAAAGTAAAAAATTAA
CTGCTGAGCAGCAGCGTCTTCTTTGGCTTTATTATACCGATTTTGTTCGTGAAGGAGCAGAGCTGAATAAGGAAGACAAA
GAGAAGGTTGCGAAAATTAACCAAGAATTAGCGGGACTTTTTACGCTTTTCAGCCAAAAATTGCTGGCAGAAGAAAATGA
TCAGTATTTAGAATTAAATTCAGAAAGTGATTTAGAAGGTCTTCCAGAAGAATTTAAAAATGCTGCAATTGCAGAGGCAA
AAGAAAGAAATCTGAATGTTTTGGCTTGTATAGGCAACACAAGATCTTCAATTGAGCCATTTTTGACTTTTTCAAATCGA
AGAAGTTTAAGAGAAAAAGCTTTTGATATTTTTGTAAAAAGAGGCGATAATCCGAACGAAAATAATACAAACGAAACGCT
GGTGTCTATTTTAAGATTACGAGCTGAAAAGGCTAAAATATTAGGGTTTAAGAATTTTGCAGAATGGAGTTTGTCTAATA
AAATGGCAAAAGACCCGCAGAAAACTTTAGATTTAATGAATTCTGTCTGGAAACCAGCTGTCGAAAAAGTAAAAAATGAT
GTTTCGGCTATGCAGAAAATGGTTGATGAAGAAGGAGGAGATTTTAAAATCCAACCTTGGGATTATCGTTTTTATGCAGA
AAAAGTGCGTAAAGCAAAATACGATTTAGATCAGAATGAAATTAAACAGTACCTGCAATTAGAAAATTTAAGAGAGGGTA
TGTTTTGGACAGCGGGAGAGTTGTTTGATTTAGGTTTTAAACAATTATTCGATGTTCCTGTTTATCATCAAGATGTTCGT
GTTTGGGAAGTAAATAATAAGAATACAGGAAAAGTAATTGGCCTATGGTATTTTGATCCTTACGCCCGTACAGGAAAACG
TTCAGGAGCTTGGATGAACTCGCATAGAGACCAGCAGAAAATAAAAGAAAACGTACTTCCAATTGTATCTAATAATTGCA
ATTTTATAAAAGGAAATGCAGATGAATCTGTTTTGATTTCGTGGGATGATGCGACGACTTTATTTCATGAATTTGGGCAT
GCTTTACACGGATTATGCTCGAATGTTACCTATCCAAGTCTTTCGGGAACTTCGGTTGCAAGAGATTATGTAGAATTTCC
TTCTCAATTATTAGAACATTGGCTGGCAACTCCGGAAGTCCTTAATAAGTTCGCACTTCATTATAAAACGAATGAACCAT
TGTCGCAGTCTTTAGTAGAAAGAATTGCAAAAGCGGCTAATTTTAATGAAGGTTTTGCCACTGTAGAAACAATTTCAAGT
TCTTTTGTGGATATGAAACTGCATTTAACTACAGAAAAAGTCGATCCTCATCAATTTGAAAAAGATATTTTAGCTGAAAT
TAATATGCCTTCAGAAATTGTAATGAGACACAGAATTCCACAGTTTGCTCATATTTTTTCGAGTGATGGATATGCTGCAG
GTTATTACAGTTATTTATGGGCTGATGTTATAAATGCAGATGCTTATGAGGCATTTTTAGAAGGCAACGGACCTTTTGAT
AAACAAGTTGCAAAACGTCTTTATGATATTGTTTTAACGGCAGGAAACACAATTGATAACGAGACGATGTATGAAAACTT
TAGGGGACACGCTCCAAAATCAGATGCTTTAATGCGTGCAAGAAATTTTCCAGTCGAAAATTAA

Upstream 100 bases:

>100_bases
ATTAGGCAGTTCGTTTGAAGTTTGCTTTCGATTGGTTAATTTTGAGACTCTATCTTTAATTCCTGAAAAGGAATAAGGAA
TTAATCTATGTACTTAAATT

Downstream 100 bases:

>100_bases
TTGATATAAAAAAGCCCGAATAAGTAAATATTCGGGCTTTTTAAATATTGAAATAATATATTAACCTAAAGTAACTCTTT
TGAAACCTGTGATTTCAACG

Product: peptidyl-dipeptidase Dcp

Products: NA

Alternate protein names: Dipeptidyl carboxypeptidase [H]

Number of amino acids: Translated: 687; Mature: 687

Protein sequence:

>687_residues
MEKQPNLNNSLLQEWSGPYGGVPDFTKYKISDFKPAIEFAIQEKLEEIDAIADNSEKPTFENTVQALELSGEKLDRIHSV
YGIYRSNLSTPEFNAVDTEMSPKLAEISDKLYQNEKLFLRIEELYKSEESKKLTAEQQRLLWLYYTDFVREGAELNKEDK
EKVAKINQELAGLFTLFSQKLLAEENDQYLELNSESDLEGLPEEFKNAAIAEAKERNLNVLACIGNTRSSIEPFLTFSNR
RSLREKAFDIFVKRGDNPNENNTNETLVSILRLRAEKAKILGFKNFAEWSLSNKMAKDPQKTLDLMNSVWKPAVEKVKND
VSAMQKMVDEEGGDFKIQPWDYRFYAEKVRKAKYDLDQNEIKQYLQLENLREGMFWTAGELFDLGFKQLFDVPVYHQDVR
VWEVNNKNTGKVIGLWYFDPYARTGKRSGAWMNSHRDQQKIKENVLPIVSNNCNFIKGNADESVLISWDDATTLFHEFGH
ALHGLCSNVTYPSLSGTSVARDYVEFPSQLLEHWLATPEVLNKFALHYKTNEPLSQSLVERIAKAANFNEGFATVETISS
SFVDMKLHLTTEKVDPHQFEKDILAEINMPSEIVMRHRIPQFAHIFSSDGYAAGYYSYLWADVINADAYEAFLEGNGPFD
KQVAKRLYDIVLTAGNTIDNETMYENFRGHAPKSDALMRARNFPVEN

Sequences:

>Translated_687_residues
MEKQPNLNNSLLQEWSGPYGGVPDFTKYKISDFKPAIEFAIQEKLEEIDAIADNSEKPTFENTVQALELSGEKLDRIHSV
YGIYRSNLSTPEFNAVDTEMSPKLAEISDKLYQNEKLFLRIEELYKSEESKKLTAEQQRLLWLYYTDFVREGAELNKEDK
EKVAKINQELAGLFTLFSQKLLAEENDQYLELNSESDLEGLPEEFKNAAIAEAKERNLNVLACIGNTRSSIEPFLTFSNR
RSLREKAFDIFVKRGDNPNENNTNETLVSILRLRAEKAKILGFKNFAEWSLSNKMAKDPQKTLDLMNSVWKPAVEKVKND
VSAMQKMVDEEGGDFKIQPWDYRFYAEKVRKAKYDLDQNEIKQYLQLENLREGMFWTAGELFDLGFKQLFDVPVYHQDVR
VWEVNNKNTGKVIGLWYFDPYARTGKRSGAWMNSHRDQQKIKENVLPIVSNNCNFIKGNADESVLISWDDATTLFHEFGH
ALHGLCSNVTYPSLSGTSVARDYVEFPSQLLEHWLATPEVLNKFALHYKTNEPLSQSLVERIAKAANFNEGFATVETISS
SFVDMKLHLTTEKVDPHQFEKDILAEINMPSEIVMRHRIPQFAHIFSSDGYAAGYYSYLWADVINADAYEAFLEGNGPFD
KQVAKRLYDIVLTAGNTIDNETMYENFRGHAPKSDALMRARNFPVEN
>Mature_687_residues
MEKQPNLNNSLLQEWSGPYGGVPDFTKYKISDFKPAIEFAIQEKLEEIDAIADNSEKPTFENTVQALELSGEKLDRIHSV
YGIYRSNLSTPEFNAVDTEMSPKLAEISDKLYQNEKLFLRIEELYKSEESKKLTAEQQRLLWLYYTDFVREGAELNKEDK
EKVAKINQELAGLFTLFSQKLLAEENDQYLELNSESDLEGLPEEFKNAAIAEAKERNLNVLACIGNTRSSIEPFLTFSNR
RSLREKAFDIFVKRGDNPNENNTNETLVSILRLRAEKAKILGFKNFAEWSLSNKMAKDPQKTLDLMNSVWKPAVEKVKND
VSAMQKMVDEEGGDFKIQPWDYRFYAEKVRKAKYDLDQNEIKQYLQLENLREGMFWTAGELFDLGFKQLFDVPVYHQDVR
VWEVNNKNTGKVIGLWYFDPYARTGKRSGAWMNSHRDQQKIKENVLPIVSNNCNFIKGNADESVLISWDDATTLFHEFGH
ALHGLCSNVTYPSLSGTSVARDYVEFPSQLLEHWLATPEVLNKFALHYKTNEPLSQSLVERIAKAANFNEGFATVETISS
SFVDMKLHLTTEKVDPHQFEKDILAEINMPSEIVMRHRIPQFAHIFSSDGYAAGYYSYLWADVINADAYEAFLEGNGPFD
KQVAKRLYDIVLTAGNTIDNETMYENFRGHAPKSDALMRARNFPVEN

Specific function: Removes dipeptides from the C-termini of N-blocked tripeptides, tetrapeptides and larger peptides [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=673, Percent_Identity=27.9346210995542, Blast_Score=248, Evalue=1e-65,
Organism=Homo sapiens, GI14149738, Length=662, Percent_Identity=26.7371601208459, Blast_Score=213, Evalue=5e-55,
Organism=Homo sapiens, GI156105687, Length=689, Percent_Identity=22.2060957910015, Blast_Score=142, Evalue=1e-33,
Organism=Escherichia coli, GI1787819, Length=683, Percent_Identity=36.3103953147877, Blast_Score=443, Evalue=1e-125,
Organism=Escherichia coli, GI1789913, Length=669, Percent_Identity=30.3437967115097, Blast_Score=306, Evalue=3e-84,
Organism=Caenorhabditis elegans, GI32565901, Length=633, Percent_Identity=22.1169036334913, Blast_Score=96, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI71999758, Length=580, Percent_Identity=23.2758620689655, Blast_Score=93, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6319793, Length=649, Percent_Identity=26.502311248074, Blast_Score=200, Evalue=6e-52,
Organism=Saccharomyces cerevisiae, GI6322715, Length=487, Percent_Identity=22.5872689938398, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI20129717, Length=536, Percent_Identity=22.7611940298507, Blast_Score=140, Evalue=3e-33,
Organism=Drosophila melanogaster, GI21356111, Length=466, Percent_Identity=22.1030042918455, Blast_Score=128, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.15.5 [H]

Molecular weight: Translated: 78953; Mature: 78953

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKQPNLNNSLLQEWSGPYGGVPDFTKYKISDFKPAIEFAIQEKLEEIDAIADNSEKPTF
CCCCCCCCHHHHHHHCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCH
ENTVQALELSGEKLDRIHSVYGIYRSNLSTPEFNAVDTEMSPKLAEISDKLYQNEKLFLR
HHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHEEE
IEELYKSEESKKLTAEQQRLLWLYYTDFVREGAELNKEDKEKVAKINQELAGLFTLFSQK
HHHHHCCHHHHHHHHHHHHEEHHHHHHHHHCCHHCCHHHHHHHHHHHHHHHHHHHHHHHH
LLAEENDQYLELNSESDLEGLPEEFKNAAIAEAKERNLNVLACIGNTRSSIEPFLTFSNR
HHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHEEHHH
RSLREKAFDIFVKRGDNPNENNTNETLVSILRLRAEKAKILGFKNFAEWSLSNKMAKDPQ
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHH
KTLDLMNSVWKPAVEKVKNDVSAMQKMVDEEGGDFKIQPWDYRFYAEKVRKAKYDLDQNE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHCCCCHHH
IKQYLQLENLREGMFWTAGELFDLGFKQLFDVPVYHQDVRVWEVNNKNTGKVIGLWYFDP
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEECCEEEEEECCCCCCCEEEEEEECC
YARTGKRSGAWMNSHRDQQKIKENVLPIVSNNCNFIKGNADESVLISWDDATTLFHEFGH
HHHCCCCCCCCHHCCHHHHHHHHCCCCEECCCCCEEECCCCCEEEEEECHHHHHHHHHHH
ALHGLCSNVTYPSLSGTSVARDYVEFPSQLLEHWLATPEVLNKFALHYKTNEPLSQSLVE
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHH
RIAKAANFNEGFATVETISSSFVDMKLHLTTEKVDPHQFEKDILAEINMPSEIVMRHRIP
HHHHHCCCCCCHHHHHHHHHHHEEEEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHCCH
QFAHIFSSDGYAAGYYSYLWADVINADAYEAFLEGNGPFDKQVAKRLYDIVLTAGNTIDN
HHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCC
ETMYENFRGHAPKSDALMRARNFPVEN
HHHHHHHCCCCCCHHHHHHHCCCCCCC
>Mature Secondary Structure
MEKQPNLNNSLLQEWSGPYGGVPDFTKYKISDFKPAIEFAIQEKLEEIDAIADNSEKPTF
CCCCCCCCHHHHHHHCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCH
ENTVQALELSGEKLDRIHSVYGIYRSNLSTPEFNAVDTEMSPKLAEISDKLYQNEKLFLR
HHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHEEE
IEELYKSEESKKLTAEQQRLLWLYYTDFVREGAELNKEDKEKVAKINQELAGLFTLFSQK
HHHHHCCHHHHHHHHHHHHEEHHHHHHHHHCCHHCCHHHHHHHHHHHHHHHHHHHHHHHH
LLAEENDQYLELNSESDLEGLPEEFKNAAIAEAKERNLNVLACIGNTRSSIEPFLTFSNR
HHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHEEHHH
RSLREKAFDIFVKRGDNPNENNTNETLVSILRLRAEKAKILGFKNFAEWSLSNKMAKDPQ
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHH
KTLDLMNSVWKPAVEKVKNDVSAMQKMVDEEGGDFKIQPWDYRFYAEKVRKAKYDLDQNE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHCCCCHHH
IKQYLQLENLREGMFWTAGELFDLGFKQLFDVPVYHQDVRVWEVNNKNTGKVIGLWYFDP
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEECCEEEEEECCCCCCCEEEEEEECC
YARTGKRSGAWMNSHRDQQKIKENVLPIVSNNCNFIKGNADESVLISWDDATTLFHEFGH
HHHCCCCCCCCHHCCHHHHHHHHCCCCEECCCCCEEECCCCCEEEEEECHHHHHHHHHHH
ALHGLCSNVTYPSLSGTSVARDYVEFPSQLLEHWLATPEVLNKFALHYKTNEPLSQSLVE
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHH
RIAKAANFNEGFATVETISSSFVDMKLHLTTEKVDPHQFEKDILAEINMPSEIVMRHRIP
HHHHHCCCCCCHHHHHHHHHHHEEEEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHCCH
QFAHIFSSDGYAAGYYSYLWADVINADAYEAFLEGNGPFDKQVAKRLYDIVLTAGNTIDN
HHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCC
ETMYENFRGHAPKSDALMRARNFPVEN
HHHHHHHCCCCCCHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1537804; 11677609 [H]