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The map label for this gene is ddc [H]

Identifier: 146299274

GI number: 146299274

Start: 1745308

End: 1746711

Strand: Direct

Name: ddc [H]

Synonym: Fjoh_1514

Alternate gene names: 146299274

Gene position: 1745308-1746711 (Clockwise)

Preceding gene: 146299273

Following gene: 146299277

Centisome position: 28.63

GC content: 34.83

Gene sequence:

>1404_bases
ATGAATTCAAAATTACAGCATGATCTCGACAATTTTGAGAATATCTTAGAAAAGACAAAACAGCAGGGAATTGATTTTCT
GAACAATTTGGAAACTATTCCAACTTCAAATAAAAATGTAATTGATCCAAAACGTGATTTGAACGAATTAGGTTTAGGTT
CTGAAGAAGCTTTAAGTGAGTTTAAAGAAAGATTAGCTCCTCTATTAGTCTCATCGCCAGGTCCTCGTTATTGGGGATTT
GTAACCGGCGGATCAACCCCAGCTTCTATTGTTGGAGATTGGCTGGCATCAGTTTACGATCAAAATACACAATCTGTAAC
TTCACAGGGAGGTAATTCGGCTTTAATAGAGTTTGAAACTATTAATTTATTATTGCAATTATTAGAACTTCCGGATTCGT
TTTTAGGCGGATTTGTAACGGGTGCCACAATGTCTAACTTCACAAGTTTAGCAGTTGCGAGACAATGGTTTGGAAAACAG
TTTGGAAAAGATTTTGCTAAAAACGGAATTTCTGAAACCATCAATATTTTAACAGCAACACCGCATTCTTCTTCTGTAAA
ATCATTATCGATGTTAGGAATTGGAAGTCAGAATTATACTGTTGTAAAGACAATAGAAGGTAATCGTGAAGCTTTGGATA
TTGCCGATTTAGAAGAAAAGATTAAAGCTCTAAACGGAAAACCTTTTATTCTGATTTCAAGTGCTGGAACAGTAAATACA
GCCGACTTTGATGATTTTGAAGCAATAGCAGAATTGAAAGAAAAATACAATTTCTGGTGGCATATTGATGGTGCCTTTGG
CGGATTTGCGGCAGTTTCAGAAAAATACAAACATTATGTAAAAGGCTGGGAAGGAGCAGACAGTATTACGATTGACTGCC
ATAAATGGCTGAATGTTCCGTACGAAAGTGCTTTTTATTTGGTTAAAAAAGAGCATGTTAATCTGCAGATTGAAACATTC
CAAAACTCAAATGCGCCTTATTTAGGGAATCCGTTGGAGAATTTTAATTACCTAAATGTAGTTCCGGAAAATTCACGCCG
TTTAAGAGCACTGCCGGTTTGGTTTTCTTTAGTGGCTTACGGAAAAGAAGGTTTTTGTGATATTATTGAAAAAAGTATTT
TGCTGGCACTTCATTTTGCAAATGCACTTGTTGATGAGGGAAGATTTGAGCTTTTAGCTCCAATTCGATTAAATAATGTT
TGTTTTACTTTAAAAGGTGATGAAAATCAGGAAAAAGTAACAGCATTTTTAACTGAACTGAACGATACTGGTAAAGTATT
TATGACGCCGACTGTTTACCAAAATAAAAAAGGTATCCGTGCTTCATTTGTAAACTGGAGAACAAATGAAGGAGATATTA
GAATCGTTATCAAAGAAATGAAAACTATTTTGGAGAATTTATAG

Upstream 100 bases:

>100_bases
ATTTCAATACTTAAAATAAATACTAAAAACAACTTATCTCGTGTGAAATGGCTTTGACTTCGCTCAGCCTGACATTGCGT
GATGTAAATAACTATATAAT

Downstream 100 bases:

>100_bases
ACTAAAAATAAAAGAGCCTGCAAAAATCAGCAGGCTCTTTTTTCAAAAAAAAATAAAAAACAAAAAAACAAGTTCAAGGG
ATGAATTTAAATTCTGTATG

Product: pyridoxal-dependent decarboxylase

Products: NA

Alternate protein names: DABA decarboxylase; DABA-DC [H]

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MNSKLQHDLDNFENILEKTKQQGIDFLNNLETIPTSNKNVIDPKRDLNELGLGSEEALSEFKERLAPLLVSSPGPRYWGF
VTGGSTPASIVGDWLASVYDQNTQSVTSQGGNSALIEFETINLLLQLLELPDSFLGGFVTGATMSNFTSLAVARQWFGKQ
FGKDFAKNGISETINILTATPHSSSVKSLSMLGIGSQNYTVVKTIEGNREALDIADLEEKIKALNGKPFILISSAGTVNT
ADFDDFEAIAELKEKYNFWWHIDGAFGGFAAVSEKYKHYVKGWEGADSITIDCHKWLNVPYESAFYLVKKEHVNLQIETF
QNSNAPYLGNPLENFNYLNVVPENSRRLRALPVWFSLVAYGKEGFCDIIEKSILLALHFANALVDEGRFELLAPIRLNNV
CFTLKGDENQEKVTAFLTELNDTGKVFMTPTVYQNKKGIRASFVNWRTNEGDIRIVIKEMKTILENL

Sequences:

>Translated_467_residues
MNSKLQHDLDNFENILEKTKQQGIDFLNNLETIPTSNKNVIDPKRDLNELGLGSEEALSEFKERLAPLLVSSPGPRYWGF
VTGGSTPASIVGDWLASVYDQNTQSVTSQGGNSALIEFETINLLLQLLELPDSFLGGFVTGATMSNFTSLAVARQWFGKQ
FGKDFAKNGISETINILTATPHSSSVKSLSMLGIGSQNYTVVKTIEGNREALDIADLEEKIKALNGKPFILISSAGTVNT
ADFDDFEAIAELKEKYNFWWHIDGAFGGFAAVSEKYKHYVKGWEGADSITIDCHKWLNVPYESAFYLVKKEHVNLQIETF
QNSNAPYLGNPLENFNYLNVVPENSRRLRALPVWFSLVAYGKEGFCDIIEKSILLALHFANALVDEGRFELLAPIRLNNV
CFTLKGDENQEKVTAFLTELNDTGKVFMTPTVYQNKKGIRASFVNWRTNEGDIRIVIKEMKTILENL
>Mature_467_residues
MNSKLQHDLDNFENILEKTKQQGIDFLNNLETIPTSNKNVIDPKRDLNELGLGSEEALSEFKERLAPLLVSSPGPRYWGF
VTGGSTPASIVGDWLASVYDQNTQSVTSQGGNSALIEFETINLLLQLLELPDSFLGGFVTGATMSNFTSLAVARQWFGKQ
FGKDFAKNGISETINILTATPHSSSVKSLSMLGIGSQNYTVVKTIEGNREALDIADLEEKIKALNGKPFILISSAGTVNT
ADFDDFEAIAELKEKYNFWWHIDGAFGGFAAVSEKYKHYVKGWEGADSITIDCHKWLNVPYESAFYLVKKEHVNLQIETF
QNSNAPYLGNPLENFNYLNVVPENSRRLRALPVWFSLVAYGKEGFCDIIEKSILLALHFANALVDEGRFELLAPIRLNNV
CFTLKGDENQEKVTAFLTELNDTGKVFMTPTVYQNKKGIRASFVNWRTNEGDIRIVIKEMKTILENL

Specific function: Unknown

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI4503281, Length=413, Percent_Identity=23.9709443099274, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI132814448, Length=413, Percent_Identity=23.9709443099274, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI197276620, Length=493, Percent_Identity=24.7464503042596, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI4503875, Length=493, Percent_Identity=24.7464503042596, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI58331246, Length=424, Percent_Identity=25.9433962264151, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI194294551, Length=372, Percent_Identity=26.0752688172043, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI92110055, Length=407, Percent_Identity=25.5528255528256, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI197383062, Length=277, Percent_Identity=25.6317689530686, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI190341074, Length=184, Percent_Identity=28.2608695652174, Blast_Score=70, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17534819, Length=473, Percent_Identity=24.1014799154334, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17534817, Length=473, Percent_Identity=24.1014799154334, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI133931025, Length=420, Percent_Identity=23.0952380952381, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71981217, Length=288, Percent_Identity=23.9583333333333, Blast_Score=95, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI71981211, Length=288, Percent_Identity=23.9583333333333, Blast_Score=95, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI71993062, Length=361, Percent_Identity=23.8227146814404, Blast_Score=88, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17555682, Length=350, Percent_Identity=23.7142857142857, Blast_Score=88, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI71993058, Length=350, Percent_Identity=23.7142857142857, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17551992, Length=283, Percent_Identity=25.4416961130742, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24585139, Length=428, Percent_Identity=26.4018691588785, Blast_Score=122, Evalue=7e-28,
Organism=Drosophila melanogaster, GI17136190, Length=434, Percent_Identity=25.5760368663594, Blast_Score=122, Evalue=8e-28,
Organism=Drosophila melanogaster, GI221476190, Length=428, Percent_Identity=26.4018691588785, Blast_Score=121, Evalue=9e-28,
Organism=Drosophila melanogaster, GI24585143, Length=428, Percent_Identity=26.4018691588785, Blast_Score=121, Evalue=9e-28,
Organism=Drosophila melanogaster, GI17136594, Length=356, Percent_Identity=27.247191011236, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24652373, Length=415, Percent_Identity=25.7831325301205, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24585135, Length=373, Percent_Identity=26.2734584450402, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI28573972, Length=433, Percent_Identity=25.635103926097, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24586044, Length=424, Percent_Identity=25.4716981132075, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21356415, Length=300, Percent_Identity=29.6666666666667, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24657193, Length=348, Percent_Identity=26.7241379310345, Blast_Score=85, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24657185, Length=348, Percent_Identity=26.7241379310345, Blast_Score=85, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24657188, Length=348, Percent_Identity=26.7241379310345, Blast_Score=85, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.86 [H]

Molecular weight: Translated: 52155; Mature: 52155

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSKLQHDLDNFENILEKTKQQGIDFLNNLETIPTSNKNVIDPKRDLNELGLGSEEALSE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCCCHHHHHH
FKERLAPLLVSSPGPRYWGFVTGGSTPASIVGDWLASVYDQNTQSVTSQGGNSALIEFET
HHHHHHHHEECCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHCCCCEEEEEEHH
INLLLQLLELPDSFLGGFVTGATMSNFTSLAVARQWFGKQFGKDFAKNGISETINILTAT
HHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEEEEC
PHSSSVKSLSMLGIGSQNYTVVKTIEGNREALDIADLEEKIKALNGKPFILISSAGTVNT
CCCCCHHHHHEEECCCCCEEEEEEECCCCCEECHHHHHHHHHHCCCCCEEEEECCCCCCC
ADFDDFEAIAELKEKYNFWWHIDGAFGGFAAVSEKYKHYVKGWEGADSITIDCHKWLNVP
CCCHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEHHHCCCC
YESAFYLVKKEHVNLQIETFQNSNAPYLGNPLENFNYLNVVPENSRRLRALPVWFSLVAY
HHHEEEEEEECCCCEEEEEEECCCCCCCCCCHHCCCEEEEECCCCCCEEEHHHHHHHHHC
GKEGFCDIIEKSILLALHFANALVDEGRFELLAPIRLNNVCFTLKGDENQEKVTAFLTEL
CCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCEEECCEEEEEECCCCHHHHHHHHHHC
NDTGKVFMTPTVYQNKKGIRASFVNWRTNEGDIRIVIKEMKTILENL
CCCCCEEECCCCCCCCCCCEEEEEECCCCCCCEEEEHHHHHHHHHCC
>Mature Secondary Structure
MNSKLQHDLDNFENILEKTKQQGIDFLNNLETIPTSNKNVIDPKRDLNELGLGSEEALSE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCCCHHHHHH
FKERLAPLLVSSPGPRYWGFVTGGSTPASIVGDWLASVYDQNTQSVTSQGGNSALIEFET
HHHHHHHHEECCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHCCCCEEEEEEHH
INLLLQLLELPDSFLGGFVTGATMSNFTSLAVARQWFGKQFGKDFAKNGISETINILTAT
HHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEEEEC
PHSSSVKSLSMLGIGSQNYTVVKTIEGNREALDIADLEEKIKALNGKPFILISSAGTVNT
CCCCCHHHHHEEECCCCCEEEEEEECCCCCEECHHHHHHHHHHCCCCCEEEEECCCCCCC
ADFDDFEAIAELKEKYNFWWHIDGAFGGFAAVSEKYKHYVKGWEGADSITIDCHKWLNVP
CCCHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEHHHCCCC
YESAFYLVKKEHVNLQIETFQNSNAPYLGNPLENFNYLNVVPENSRRLRALPVWFSLVAY
HHHEEEEEEECCCCEEEEEEECCCCCCCCCCHHCCCEEEEECCCCCCEEEHHHHHHHHHC
GKEGFCDIIEKSILLALHFANALVDEGRFELLAPIRLNNVCFTLKGDENQEKVTAFLTEL
CCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCEEECCEEEEEECCCCHHHHHHHHHHC
NDTGKVFMTPTVYQNKKGIRASFVNWRTNEGDIRIVIKEMKTILENL
CCCCCEEECCCCCCCCCCCEEEEEECCCCCCCEEEEHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800; 9514614 [H]