| Definition | Flavobacterium johnsoniae UW101 chromosome, complete genome. |
|---|---|
| Accession | NC_009441 |
| Length | 6,096,872 |
Click here to switch to the map view.
The map label for this gene is thrA [H]
Identifier: 146299254
GI number: 146299254
Start: 1720828
End: 1723242
Strand: Direct
Name: thrA [H]
Synonym: Fjoh_1494
Alternate gene names: 146299254
Gene position: 1720828-1723242 (Clockwise)
Preceding gene: 146299253
Following gene: 146299255
Centisome position: 28.22
GC content: 33.33
Gene sequence:
>2415_bases ATGAAAGTATTAAAATTTGGAGGTAAATCATTATCAAACGGAGAAGGACTTAACAAAGTAGTTTCAATCATTTCAGATAA AGTAAATCAAGGCGAACAAATTGCCGTAGTCGTTTCTGCCCGAGGAAATGCGACAGATGAATTAGAAGATATCTTAAGAA TTGCTGCTAAAAACGGTAATTATAAGCCTTTATTAGAAAGTTTTAAAGCATACCAGACTTCAGATTATCCGCAGGTAGAT TTATCTGAGGAATTCAATATTTTAGATAAATTATTTGAAGGAGTTAGTCTTATTGGTGATTACAGCAATAAAATTAAAGA TCAGATTTTGTCAAAAGGCGAATTGCTTTCGGCTAAATTATTGACTTCAATTTTAGTTGAAAAAGGAATTCCTGCCAATT TTGTTGATACAAGAGAATTGTTGAAAACAGATTCTAAATTTGGCGACGCCCAGCCTTTAGAACAGCTTTCAAAGAAAAAC GTTATCAATTATTTCAAACTTCATAATGGTGAAACAGTAAATATCGTTACTGGTTTTATTGGTTCAAACAACAACAACGA CACCACAACTTTAGGAAGAAACGGAAGCAATTACACCGCTTCGTTAATTGCTAATTATCTGGATGCAGAAGAACTTCAAA ACTTTACACACGTTGACGGAATCTATACAGCAAATCCAGATTTAGTTGCCGATGCTAAAAAAATCGAATTTTTATCGTTT AATGAAGCAAATGAATTAGCCAATTTTGGAGCAACAATTCTGCATGCCAAAACGATAATTCCTTTATTAGAAAAAAATAT TCCGCTTCGTATTTTAAATACATTCAATCACGAAAATCACGGAACTTTAATCACTTCAAATTCTGCTAAAGAAGGAATTA AAACCCTTTCTGTTTTAGAAAATGTATCTCTTGTAAATCTTGAAGGACGAGGATTACTTGGAAAAGCCGGAGTTGATGCC CGAATTTTTAAAGTAATGGGCGATCACAACATCAGCGTAAGCATTATTTCGCAAGGTTCTTCTGAAAGAGGAATTGGATT AGTTGTGGCTAAAGACAAAGCAACTCTTGCAATGGTTGAATTAGAAAAAGAGTTCGAAAACGACTTTTATTCTAAAGATG TAAACCAGATTACAGTGACTGATAATGTTTCGGTAATTTCTATCATCGGGCAGGATTTAAGTACATTCCATAAACCATAT ACAGCTTTAATCAAAAATAAAATAGTTCCAATTTTATTCAACAATACCGTTACTGGTAAAAACGTGAGTTTGGTTGTTAA AAAAGAAGAATTAAACAAAGCCTTAAACGTAATTCACGGAGAGATTTTTGGAGTTTCTAAAAAAATCAATATTGCGATTT TCGGTCACGGATTAGTGGGCGGAACTTTGATTAATCAAATTTTAGAATCGGCTTCTGCAATCGAAAAACGAAAAGATATT AAGCTGAATGTTTTTGCTATCGCAAACTCTAAAAAACTGCTTTTAAATAAAAATGGCGTAACTCCAAGCTGGAAAAACGA CATTGAAACAAAAGGCGAATCATATACGATTCAGGACATTATTGATTATGCAAATGAATACCATTTAGAGAACTTAATTG CAGTTGATAATACAGCGAGTGCTTCATTTGTAGAAAATTATGTTACACTGGTAGAAAGCAGTTTTGACTTAATTTCGTCA AATAAAGTCGCTAATACTTTAACGTATGGTTTCTATAAAGAATTGAGAAAAGCTTTGGCAGAAAATCAAAAGAATTATTT GTACGAAACAAATGTTGGAGCTGGATTACCGTTAATTGATACAATTAAACTGCTTCACCTTTCAGGAGAAAACATTACAA AAATTAAGGGAGTTTTCTCAGGAACATTAAGTTATTTATTCAATAATTTTTCTGCAAAAGATGCTCCATTCAGCGAAATT CTGCAGGAAGCCATTGATAACGGATATACAGAACCAGATCCGCGTGAAGATTTATGCGGAAATGATGTGGGAAGAAAATT ATTGATTCTGGCAAGAGAATTAGATTTGCAAAATGAGTTTGAAGAAATTTCAATTCAAAATTTAATTCCGGAGCACTTAC GTGAAGGAAGCGCTGCCGATTTCTTGACAAAATTAAAAGAATTTGACCCAATTTATGCGAAGATAAAAGCAGAACAACAG CCAAATCACGTATTAAGATATATTGGTGAATTGTCTGGAGATTTGCAGAATGACAAAGGAAATTTAGAAGTAAAATTAGT TTCAGTACCTTCAGATACTGCTTTAGGCGGATTAAAAGGTTCAGATTCTTTCTTCGAAATTTATACAGAATCTTACGGAG ATCGTCCAATCGTTATTCAGGGAGCCGGTGCAGGTTCTGCCGTAACAGCAAGAGGAGTTTTTGGAGATATTTTGAGATTA TCTGATAAGGGATAA
Upstream 100 bases:
>100_bases ATTGATTCGGTTCACGGACATGACGCTTTTTTAATCGAGTACAAACAATTAGATCATTTACTTGCCGATATTTTTAAGGC AGAAACAATAGCAAAATAAA
Downstream 100 bases:
>100_bases TTGATTTTAGATTGCAGATTTTAGTCCCGATAGCTATCGGGATAGATTTAAGATTTGAATTCAAACAAAACAAAAAAAAT AACAACACAATGAAAGTAAC
Product: aspartate kinase
Products: NA
Alternate protein names: AK-HD; Aspartokinase; Homoserine dehydrogenase [H]
Number of amino acids: Translated: 804; Mature: 804
Protein sequence:
>804_residues MKVLKFGGKSLSNGEGLNKVVSIISDKVNQGEQIAVVVSARGNATDELEDILRIAAKNGNYKPLLESFKAYQTSDYPQVD LSEEFNILDKLFEGVSLIGDYSNKIKDQILSKGELLSAKLLTSILVEKGIPANFVDTRELLKTDSKFGDAQPLEQLSKKN VINYFKLHNGETVNIVTGFIGSNNNNDTTTLGRNGSNYTASLIANYLDAEELQNFTHVDGIYTANPDLVADAKKIEFLSF NEANELANFGATILHAKTIIPLLEKNIPLRILNTFNHENHGTLITSNSAKEGIKTLSVLENVSLVNLEGRGLLGKAGVDA RIFKVMGDHNISVSIISQGSSERGIGLVVAKDKATLAMVELEKEFENDFYSKDVNQITVTDNVSVISIIGQDLSTFHKPY TALIKNKIVPILFNNTVTGKNVSLVVKKEELNKALNVIHGEIFGVSKKINIAIFGHGLVGGTLINQILESASAIEKRKDI KLNVFAIANSKKLLLNKNGVTPSWKNDIETKGESYTIQDIIDYANEYHLENLIAVDNTASASFVENYVTLVESSFDLISS NKVANTLTYGFYKELRKALAENQKNYLYETNVGAGLPLIDTIKLLHLSGENITKIKGVFSGTLSYLFNNFSAKDAPFSEI LQEAIDNGYTEPDPREDLCGNDVGRKLLILARELDLQNEFEEISIQNLIPEHLREGSAADFLTKLKEFDPIYAKIKAEQQ PNHVLRYIGELSGDLQNDKGNLEVKLVSVPSDTALGGLKGSDSFFEIYTESYGDRPIVIQGAGAGSAVTARGVFGDILRL SDKG
Sequences:
>Translated_804_residues MKVLKFGGKSLSNGEGLNKVVSIISDKVNQGEQIAVVVSARGNATDELEDILRIAAKNGNYKPLLESFKAYQTSDYPQVD LSEEFNILDKLFEGVSLIGDYSNKIKDQILSKGELLSAKLLTSILVEKGIPANFVDTRELLKTDSKFGDAQPLEQLSKKN VINYFKLHNGETVNIVTGFIGSNNNNDTTTLGRNGSNYTASLIANYLDAEELQNFTHVDGIYTANPDLVADAKKIEFLSF NEANELANFGATILHAKTIIPLLEKNIPLRILNTFNHENHGTLITSNSAKEGIKTLSVLENVSLVNLEGRGLLGKAGVDA RIFKVMGDHNISVSIISQGSSERGIGLVVAKDKATLAMVELEKEFENDFYSKDVNQITVTDNVSVISIIGQDLSTFHKPY TALIKNKIVPILFNNTVTGKNVSLVVKKEELNKALNVIHGEIFGVSKKINIAIFGHGLVGGTLINQILESASAIEKRKDI KLNVFAIANSKKLLLNKNGVTPSWKNDIETKGESYTIQDIIDYANEYHLENLIAVDNTASASFVENYVTLVESSFDLISS NKVANTLTYGFYKELRKALAENQKNYLYETNVGAGLPLIDTIKLLHLSGENITKIKGVFSGTLSYLFNNFSAKDAPFSEI LQEAIDNGYTEPDPREDLCGNDVGRKLLILARELDLQNEFEEISIQNLIPEHLREGSAADFLTKLKEFDPIYAKIKAEQQ PNHVLRYIGELSGDLQNDKGNLEVKLVSVPSDTALGGLKGSDSFFEIYTESYGDRPIVIQGAGAGSAVTARGVFGDILRL SDKG >Mature_804_residues MKVLKFGGKSLSNGEGLNKVVSIISDKVNQGEQIAVVVSARGNATDELEDILRIAAKNGNYKPLLESFKAYQTSDYPQVD LSEEFNILDKLFEGVSLIGDYSNKIKDQILSKGELLSAKLLTSILVEKGIPANFVDTRELLKTDSKFGDAQPLEQLSKKN VINYFKLHNGETVNIVTGFIGSNNNNDTTTLGRNGSNYTASLIANYLDAEELQNFTHVDGIYTANPDLVADAKKIEFLSF NEANELANFGATILHAKTIIPLLEKNIPLRILNTFNHENHGTLITSNSAKEGIKTLSVLENVSLVNLEGRGLLGKAGVDA RIFKVMGDHNISVSIISQGSSERGIGLVVAKDKATLAMVELEKEFENDFYSKDVNQITVTDNVSVISIIGQDLSTFHKPY TALIKNKIVPILFNNTVTGKNVSLVVKKEELNKALNVIHGEIFGVSKKINIAIFGHGLVGGTLINQILESASAIEKRKDI KLNVFAIANSKKLLLNKNGVTPSWKNDIETKGESYTIQDIIDYANEYHLENLIAVDNTASASFVENYVTLVESSFDLISS NKVANTLTYGFYKELRKALAENQKNYLYETNVGAGLPLIDTIKLLHLSGENITKIKGVFSGTLSYLFNNFSAKDAPFSEI LQEAIDNGYTEPDPREDLCGNDVGRKLLILARELDLQNEFEEISIQNLIPEHLREGSAADFLTKLKEFDPIYAKIKAEQQ PNHVLRYIGELSGDLQNDKGNLEVKLVSVPSDTALGGLKGSDSFFEIYTESYGDRPIVIQGAGAGSAVTARGVFGDILRL SDKG
Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]
COG id: COG0460
COG function: function code E; Homoserine dehydrogenase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 2 ACT domains [H]
Homologues:
Organism=Escherichia coli, GI1786183, Length=828, Percent_Identity=32.2463768115942, Blast_Score=416, Evalue=1e-117, Organism=Escherichia coli, GI1790376, Length=828, Percent_Identity=28.0193236714976, Blast_Score=312, Evalue=7e-86, Organism=Escherichia coli, GI1790455, Length=402, Percent_Identity=29.8507462686567, Blast_Score=160, Evalue=3e-40, Organism=Saccharomyces cerevisiae, GI6322599, Length=372, Percent_Identity=35.4838709677419, Blast_Score=165, Evalue=3e-41, Organism=Saccharomyces cerevisiae, GI6320893, Length=494, Percent_Identity=22.0647773279352, Blast_Score=116, Evalue=2e-26,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001048 - InterPro: IPR005106 - InterPro: IPR001341 - InterPro: IPR018042 - InterPro: IPR011147 - InterPro: IPR001342 - InterPro: IPR019811 - InterPro: IPR016040 [H]
Pfam domain/function: PF00696 AA_kinase; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]
EC number: =2.7.2.4; =1.1.1.3 [H]
Molecular weight: Translated: 88088; Mature: 88088
Theoretical pI: Translated: 5.08; Mature: 5.08
Prosite motif: PS01042 HOMOSER_DHGENASE
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.1 %Cys (Translated Protein) 0.4 %Met (Translated Protein) 0.5 %Cys+Met (Translated Protein) 0.1 %Cys (Mature Protein) 0.4 %Met (Mature Protein) 0.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKVLKFGGKSLSNGEGLNKVVSIISDKVNQGEQIAVVVSARGNATDELEDILRIAAKNGN CCEEECCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCC YKPLLESFKAYQTSDYPQVDLSEEFNILDKLFEGVSLIGDYSNKIKDQILSKGELLSAKL CHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH LTSILVEKGIPANFVDTRELLKTDSKFGDAQPLEQLSKKNVINYFKLHNGETVNIVTGFI HHHHHHHCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCEEEEEECCCCEEEEEEEEE GSNNNNDTTTLGRNGSNYTASLIANYLDAEELQNFTHVDGIYTANPDLVADAKKIEFLSF CCCCCCCCEEECCCCCCHHHHHHHHHHCHHHHCCCHHCCCEEECCCCHHCCCHHEEEEEC NEANELANFGATILHAKTIIPLLEKNIPLRILNTFNHENHGTLITSNSAKEGIKTLSVLE CCHHHHHHHCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEECCCHHHHHHHHHHHC NVSLVNLEGRGLLGKAGVDARIFKVMGDHNISVSIISQGSSERGIGLVVAKDKATLAMVE CCEEEEECCCCCEECCCCCCEEEEEECCCCEEEEEEECCCCCCCEEEEEECCCCEEEHHH LEKEFENDFYSKDVNQITVTDNVSVISIIGQDLSTFHKPYTALIKNKIVPILFNNTVTGK HHHHHCCHHHCCCCCEEEEECCCEEEEEHHHHHHHHHHHHHHHHHCCCEEEEECCEECCC NVSLVVKKEELNKALNVIHGEIFGVSKKINIAIFGHGLVGGTLINQILESASAIEKRKDI CEEEEEEHHHHHHHHHHHHHHHEECCEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCC KLNVFAIANSKKLLLNKNGVTPSWKNDIETKGESYTIQDIIDYANEYHLENLIAVDNTAS EEEEEEEECCCEEEEECCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHEEEECCCCH ASFVENYVTLVESSFDLISSNKVANTLTYGFYKELRKALAENQKNYLYETNVGAGLPLID HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHH TIKLLHLSGENITKIKGVFSGTLSYLFNNFSAKDAPFSEILQEAIDNGYTEPDPREDLCG HEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHCCC NDVGRKLLILARELDLQNEFEEISIQNLIPEHLREGSAADFLTKLKEFDPIYAKIKAEQQ CHHCCEEEEHHHHHCCHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHCCCEEEEEECCCC PNHVLRYIGELSGDLQNDKGNLEVKLVSVPSDTALGGLKGSDSFFEIYTESYGDRPIVIQ HHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCHHEEEHHCCCCCEEEEE GAGAGSAVTARGVFGDILRLSDKG ECCCCCCEEECHHHHHHHHHCCCC >Mature Secondary Structure MKVLKFGGKSLSNGEGLNKVVSIISDKVNQGEQIAVVVSARGNATDELEDILRIAAKNGN CCEEECCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCC YKPLLESFKAYQTSDYPQVDLSEEFNILDKLFEGVSLIGDYSNKIKDQILSKGELLSAKL CHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH LTSILVEKGIPANFVDTRELLKTDSKFGDAQPLEQLSKKNVINYFKLHNGETVNIVTGFI HHHHHHHCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCEEEEEECCCCEEEEEEEEE GSNNNNDTTTLGRNGSNYTASLIANYLDAEELQNFTHVDGIYTANPDLVADAKKIEFLSF CCCCCCCCEEECCCCCCHHHHHHHHHHCHHHHCCCHHCCCEEECCCCHHCCCHHEEEEEC NEANELANFGATILHAKTIIPLLEKNIPLRILNTFNHENHGTLITSNSAKEGIKTLSVLE CCHHHHHHHCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEECCCHHHHHHHHHHHC NVSLVNLEGRGLLGKAGVDARIFKVMGDHNISVSIISQGSSERGIGLVVAKDKATLAMVE CCEEEEECCCCCEECCCCCCEEEEEECCCCEEEEEEECCCCCCCEEEEEECCCCEEEHHH LEKEFENDFYSKDVNQITVTDNVSVISIIGQDLSTFHKPYTALIKNKIVPILFNNTVTGK HHHHHCCHHHCCCCCEEEEECCCEEEEEHHHHHHHHHHHHHHHHHCCCEEEEECCEECCC NVSLVVKKEELNKALNVIHGEIFGVSKKINIAIFGHGLVGGTLINQILESASAIEKRKDI CEEEEEEHHHHHHHHHHHHHHHEECCEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCC KLNVFAIANSKKLLLNKNGVTPSWKNDIETKGESYTIQDIIDYANEYHLENLIAVDNTAS EEEEEEEECCCEEEEECCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHEEEECCCCH ASFVENYVTLVESSFDLISSNKVANTLTYGFYKELRKALAENQKNYLYETNVGAGLPLID HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHH TIKLLHLSGENITKIKGVFSGTLSYLFNNFSAKDAPFSEILQEAIDNGYTEPDPREDLCG HEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHCCC NDVGRKLLILARELDLQNEFEEISIQNLIPEHLREGSAADFLTKLKEFDPIYAKIKAEQQ CHHCCEEEEHHHHHCCHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHCCCEEEEEECCCC PNHVLRYIGELSGDLQNDKGNLEVKLVSVPSDTALGGLKGSDSFFEIYTESYGDRPIVIQ HHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCHHEEEHHCCCCCEEEEE GAGAGSAVTARGVFGDILRLSDKG ECCCCCCEEECHHHHHHHHHCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 10993077 [H]