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The map label for this gene is thrA [H]

Identifier: 146299252

GI number: 146299252

Start: 1717595

End: 1718728

Strand: Direct

Name: thrA [H]

Synonym: Fjoh_1492

Alternate gene names: 146299252

Gene position: 1717595-1718728 (Clockwise)

Preceding gene: 146299251

Following gene: 146299253

Centisome position: 28.17

GC content: 32.36

Gene sequence:

>1134_bases
ATGAAAAGAAAATCATCATACAGATATATTTTAAAAATTAAAATTATGTCAAAGCTTAAAATAAATATCATCCTATTTGG
AATAGGAAATATAGGAAGCACATTAATCAATCAGATTATCGAAAGTCAGGAGTTTTTTCTGCAAAGCAAAAATGTTGATT
TTCATTTTCCTATCATCACCAATTCTACAGTAGCCTTTTTCGAGAAAGAAGGTGTTGGATATGCCTGGGAAACCAATTTT
AGAGAATTGGCTGTTCCGTTTAGAGTCGAAGATATTATTGAATTTGCAAAAGAAAACGAATTCGAAAATCTTATTGCCGT
TGATGCCACTGCCAGCGACGAATTGATTGGTCATTATAATACTTTAATCGAAAACGGATTCAATATCGTGGCTGTAAACA
AAAAAGCCAATACGCTCCCAATTGATCTCTATAAAAAAATTAGGGAAAATCTAAAAAAATACGACAAAGAGTTCTTGTAT
GAAACCTCCGTAGATACAGGATTTCCGGTTTTGCAGACATTAAGAGATTTGTATTATTCAGGAGAAAAAATAACCAAAAT
ACGAGGTGTGTTTTCAGATAACCTGAGTTATGTATTTAATCGTTTTTCGGCCGAAGAAAACTCTTTTTCCTCTATTTTAA
AAGATGCCAGCCTTCTCGGATTAATGCGTTCTACATTTAAAGAAGATCTGTCTGGAAATGATACAGCCAGAAAATTATTG
ATCCTGACGAGGGAAATAGGAAAAGAATTCGAATTTTCAGATATCAAAATTCATCCTCTGATAAGAGAAGAACATTTAGA
AAAAAATGGAATACTGAATAAAGATGCTATTGATAAATCATTTAAAATTGCCAAAATAACCCAAAAAGACAATCACGTCT
TACGATATATAGGAGAATTTGATGTTGAAAAAAATACTCTCGAAGTAAAATTAGTCTCAGAACCTGTAACATCAGCAATT
GGCCAGTTAAAAGGTTCAGACTCTATTTTCGAAATTTACACACAATCTTATGCTAATACTCCAATTGTGCTTCAAAGCGC
ATCACCGTGCAAACAGGCAATTTCGAGAGGTTTAATAACCGATATTCTAAAAGTTGCAGAAAAAATAAAAAATAAAGAAG
CAGTCTGGCTTTAG

Upstream 100 bases:

>100_bases
TAACCCAATCGCAGTACAGCATCAATAAGAATTAGGTTTTTTTGTTTTTTGTTTGAAAAATTGCCTTTAGCAGCGTGAGT
TCTGCTAGAGGTGATTTTTT

Downstream 100 bases:

>100_bases
TGGTTTTTCAATATTAGATAGTTCTTTGACAGATTGAAACAGAAAGTTAGATATTTTTTGTAAGATTTAACCTTCTTTAA
TTCAAAATGTAATTTTGTAA

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: AK-HD; Aspartokinase; Homoserine dehydrogenase [H]

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MKRKSSYRYILKIKIMSKLKINIILFGIGNIGSTLINQIIESQEFFLQSKNVDFHFPIITNSTVAFFEKEGVGYAWETNF
RELAVPFRVEDIIEFAKENEFENLIAVDATASDELIGHYNTLIENGFNIVAVNKKANTLPIDLYKKIRENLKKYDKEFLY
ETSVDTGFPVLQTLRDLYYSGEKITKIRGVFSDNLSYVFNRFSAEENSFSSILKDASLLGLMRSTFKEDLSGNDTARKLL
ILTREIGKEFEFSDIKIHPLIREEHLEKNGILNKDAIDKSFKIAKITQKDNHVLRYIGEFDVEKNTLEVKLVSEPVTSAI
GQLKGSDSIFEIYTQSYANTPIVLQSASPCKQAISRGLITDILKVAEKIKNKEAVWL

Sequences:

>Translated_377_residues
MKRKSSYRYILKIKIMSKLKINIILFGIGNIGSTLINQIIESQEFFLQSKNVDFHFPIITNSTVAFFEKEGVGYAWETNF
RELAVPFRVEDIIEFAKENEFENLIAVDATASDELIGHYNTLIENGFNIVAVNKKANTLPIDLYKKIRENLKKYDKEFLY
ETSVDTGFPVLQTLRDLYYSGEKITKIRGVFSDNLSYVFNRFSAEENSFSSILKDASLLGLMRSTFKEDLSGNDTARKLL
ILTREIGKEFEFSDIKIHPLIREEHLEKNGILNKDAIDKSFKIAKITQKDNHVLRYIGEFDVEKNTLEVKLVSEPVTSAI
GQLKGSDSIFEIYTQSYANTPIVLQSASPCKQAISRGLITDILKVAEKIKNKEAVWL
>Mature_377_residues
MKRKSSYRYILKIKIMSKLKINIILFGIGNIGSTLINQIIESQEFFLQSKNVDFHFPIITNSTVAFFEKEGVGYAWETNF
RELAVPFRVEDIIEFAKENEFENLIAVDATASDELIGHYNTLIENGFNIVAVNKKANTLPIDLYKKIRENLKKYDKEFLY
ETSVDTGFPVLQTLRDLYYSGEKITKIRGVFSDNLSYVFNRFSAEENSFSSILKDASLLGLMRSTFKEDLSGNDTARKLL
ILTREIGKEFEFSDIKIHPLIREEHLEKNGILNKDAIDKSFKIAKITQKDNHVLRYIGEFDVEKNTLEVKLVSEPVTSAI
GQLKGSDSIFEIYTQSYANTPIVLQSASPCKQAISRGLITDILKVAEKIKNKEAVWL

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=332, Percent_Identity=30.421686746988, Blast_Score=170, Evalue=2e-43,
Organism=Escherichia coli, GI1790376, Length=357, Percent_Identity=27.4509803921569, Blast_Score=145, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6322599, Length=373, Percent_Identity=28.9544235924933, Blast_Score=140, Evalue=5e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001048
- InterPro:   IPR005106
- InterPro:   IPR001341
- InterPro:   IPR018042
- InterPro:   IPR011147
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00696 AA_kinase; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =2.7.2.4; =1.1.1.3 [H]

Molecular weight: Translated: 43077; Mature: 43077

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRKSSYRYILKIKIMSKLKINIILFGIGNIGSTLINQIIESQEFFLQSKNVDFHFPIIT
CCCCCCCEEEEEEEEECEEEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEE
NSTVAFFEKEGVGYAWETNFRELAVPFRVEDIIEFAKENEFENLIAVDATASDELIGHYN
CCEEEEEECCCCCEEEECCHHHEECCCCHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHH
TLIENGFNIVAVNKKANTLPIDLYKKIRENLKKYDKEFLYETSVDTGFPVLQTLRDLYYS
HHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHC
GEKITKIRGVFSDNLSYVFNRFSAEENSFSSILKDASLLGLMRSTFKEDLSGNDTARKLL
CCHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
ILTREIGKEFEFSDIKIHPLIREEHLEKNGILNKDAIDKSFKIAKITQKDNHVLRYIGEF
HHHHHHCCCCCCCCEEEEECHHHHHHHHCCCCCCHHCCCCEEEEEECCCCCHHHHHHHHC
DVEKNTLEVKLVSEPVTSAIGQLKGSDSIFEIYTQSYANTPIVLQSASPCKQAISRGLIT
CCCCCEEEEEEECCHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHH
DILKVAEKIKNKEAVWL
HHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKRKSSYRYILKIKIMSKLKINIILFGIGNIGSTLINQIIESQEFFLQSKNVDFHFPIIT
CCCCCCCEEEEEEEEECEEEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEE
NSTVAFFEKEGVGYAWETNFRELAVPFRVEDIIEFAKENEFENLIAVDATASDELIGHYN
CCEEEEEECCCCCEEEECCHHHEECCCCHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHH
TLIENGFNIVAVNKKANTLPIDLYKKIRENLKKYDKEFLYETSVDTGFPVLQTLRDLYYS
HHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHC
GEKITKIRGVFSDNLSYVFNRFSAEENSFSSILKDASLLGLMRSTFKEDLSGNDTARKLL
CCHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
ILTREIGKEFEFSDIKIHPLIREEHLEKNGILNKDAIDKSFKIAKITQKDNHVLRYIGEF
HHHHHHCCCCCCCCEEEEECHHHHHHHHCCCCCCHHCCCCEEEEEECCCCCHHHHHHHHC
DVEKNTLEVKLVSEPVTSAIGQLKGSDSIFEIYTQSYANTPIVLQSASPCKQAISRGLIT
CCCCCEEEEEEECCHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHH
DILKVAEKIKNKEAVWL
HHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10993077 [H]