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The map label for this gene is emrA [H]

Identifier: 146299114

GI number: 146299114

Start: 1550083

End: 1551132

Strand: Direct

Name: emrA [H]

Synonym: Fjoh_1354

Alternate gene names: 146299114

Gene position: 1550083-1551132 (Clockwise)

Preceding gene: 146299113

Following gene: 146299115

Centisome position: 25.42

GC content: 38.19

Gene sequence:

>1050_bases
ATGGTTAAGATAAAAAATGAAACTAGAAGAAATAAAACGTTTCATATACTAATAACAATTATTGCGTGTGTGCTTGTTAT
AAGCGGTGTTATTTTAGGAATTTGGTTTTATGTGTTCAACAGAAATCACGAAGAAACCAACGACGCGCAAGTCGAACAAT
ATGTAACGCCAATTATGTCGCGTATTACGGGTTATGTTCAGGAAGTTCGTTTTAACGAAAATCAGTTTGTGCATAAAGGA
GATACTTTGGTTGTGATTGACAATCGTGAATATAAATCAAAATTGAATGCGGCTCTTGCCGATGTTCAAAACGCACAGCA
AAATAGTGTTGTGGCGCAGAAAAATGCTATAAATACAGCAAGTGCAACGGCGATTAACGAAGCGCAGTTAGAAGCTGCAA
AATCGAATCTTTGGAAAACCAAATTGGAATACGAAAGATATAAAGCTTTGGTAAGCGAAGAAGCGGCAACTTCTCAGCAA
TTAGAGAAAGTAAAAGCTGATTACGAGTCGGCGCAGGCGCATTTTCAGGAAATGAAAAATAGAATCCATTCATCGGCTTT
AAGTACTTCTGTTGCCGAAGCAAATGTTCCGACAACGCAAACCAATATTGCTTCAAAACAAGCTGTTGCAGATAATGCTG
CTTTATTTCTTTCGTACACCATAATAACAGCGCCTTATGACGGCTGGGTTGGAAAACGAACTTTACAGCCAGGACAATTG
GTAAAAGAAGGTCAGTCTTTATTGTCAATTGTAAGTAAAGAAAAATGGATTACGGCCAATTTTAAAGAAACGCAATTGCA
ATATTTAACCGTTGGGCAAGATGTTGAAATAAAAGCCGATGCTTTGAGTGATAAAACTTTTGTTGGCACAATTGCATCTT
TATCACCGGCGAGCGGGGCAAGATTTTCATTGCTTCCTCCGGATAATGCAACGGGTAACTTCGTAAAAATTGAACAAAGA
ATTCCCGTTAGAATTCAGTTGAAAGACAGCGACAAACAAGCCGACTTTTTAAGAGCGGGAATGAATATTACTGTGATCGC
AGCACACTAA

Upstream 100 bases:

>100_bases
GAAGTAAAAGATTAAAAAATATAGATTCAGTTCCGAAGGAACAATTCATATTGTAGCGCCGGATTTTAATCCGGGGGAAA
TAATTAAAGATATAGAGTTT

Downstream 100 bases:

>100_bases
AATGGAAGATAAAAGTATTTTTAAATCATGGGTTCCAAAATGGGCAATCATTACAATTTTGTTTGTTTGCCTTTTGCATT
CCATGATTTTATTGGGAGTT

Product: secretion protein HlyD family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MVKIKNETRRNKTFHILITIIACVLVISGVILGIWFYVFNRNHEETNDAQVEQYVTPIMSRITGYVQEVRFNENQFVHKG
DTLVVIDNREYKSKLNAALADVQNAQQNSVVAQKNAINTASATAINEAQLEAAKSNLWKTKLEYERYKALVSEEAATSQQ
LEKVKADYESAQAHFQEMKNRIHSSALSTSVAEANVPTTQTNIASKQAVADNAALFLSYTIITAPYDGWVGKRTLQPGQL
VKEGQSLLSIVSKEKWITANFKETQLQYLTVGQDVEIKADALSDKTFVGTIASLSPASGARFSLLPPDNATGNFVKIEQR
IPVRIQLKDSDKQADFLRAGMNITVIAAH

Sequences:

>Translated_349_residues
MVKIKNETRRNKTFHILITIIACVLVISGVILGIWFYVFNRNHEETNDAQVEQYVTPIMSRITGYVQEVRFNENQFVHKG
DTLVVIDNREYKSKLNAALADVQNAQQNSVVAQKNAINTASATAINEAQLEAAKSNLWKTKLEYERYKALVSEEAATSQQ
LEKVKADYESAQAHFQEMKNRIHSSALSTSVAEANVPTTQTNIASKQAVADNAALFLSYTIITAPYDGWVGKRTLQPGQL
VKEGQSLLSIVSKEKWITANFKETQLQYLTVGQDVEIKADALSDKTFVGTIASLSPASGARFSLLPPDNATGNFVKIEQR
IPVRIQLKDSDKQADFLRAGMNITVIAAH
>Mature_349_residues
MVKIKNETRRNKTFHILITIIACVLVISGVILGIWFYVFNRNHEETNDAQVEQYVTPIMSRITGYVQEVRFNENQFVHKG
DTLVVIDNREYKSKLNAALADVQNAQQNSVVAQKNAINTASATAINEAQLEAAKSNLWKTKLEYERYKALVSEEAATSQQ
LEKVKADYESAQAHFQEMKNRIHSSALSTSVAEANVPTTQTNIASKQAVADNAALFLSYTIITAPYDGWVGKRTLQPGQL
VKEGQSLLSIVSKEKWITANFKETQLQYLTVGQDVEIKADALSDKTFVGTIASLSPASGARFSLLPPDNATGNFVKIEQR
IPVRIQLKDSDKQADFLRAGMNITVIAAH

Specific function: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell [H]

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789041, Length=332, Percent_Identity=31.0240963855422, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1788711, Length=343, Percent_Identity=28.8629737609329, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1790012, Length=284, Percent_Identity=27.112676056338, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1790024, Length=283, Percent_Identity=27.9151943462898, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI1790519, Length=303, Percent_Identity=26.0726072607261, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI87081951, Length=322, Percent_Identity=25.1552795031056, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1789900, Length=292, Percent_Identity=23.6301369863014, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789637, Length=201, Percent_Identity=29.8507462686567, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 38736; Mature: 38736

Theoretical pI: Translated: 8.81; Mature: 8.81

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKIKNETRRNKTFHILITIIACVLVISGVILGIWFYVFNRNHEETNDAQVEQYVTPIMS
CEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
RITGYVQEVRFNENQFVHKGDTLVVIDNREYKSKLNAALADVQNAQQNSVVAQKNAINTA
HHHHHHHHHHCCCCCEEECCCEEEEECCHHHHHHHHHHHHHHHCCHHCCEEHHHCCCCCH
SATAINEAQLEAAKSNLWKTKLEYERYKALVSEEAATSQQLEKVKADYESAQAHFQEMKN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RIHSSALSTSVAEANVPTTQTNIASKQAVADNAALFLSYTIITAPYDGWVGKRTLQPGQL
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCCCCCCCCHHH
VKEGQSLLSIVSKEKWITANFKETQLQYLTVGQDVEIKADALSDKTFVGTIASLSPASGA
HHHHHHHHHHHHCCCEEECCCCCCEEEEEEECCCCEEEHHCCCCCHHEEEHHHCCCCCCC
RFSLLPPDNATGNFVKIEQRIPVRIQLKDSDKQADFLRAGMNITVIAAH
EEEEECCCCCCCCEEEEECCCCEEEEECCCCCHHHHHHCCCCEEEEEEC
>Mature Secondary Structure
MVKIKNETRRNKTFHILITIIACVLVISGVILGIWFYVFNRNHEETNDAQVEQYVTPIMS
CEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
RITGYVQEVRFNENQFVHKGDTLVVIDNREYKSKLNAALADVQNAQQNSVVAQKNAINTA
HHHHHHHHHHCCCCCEEECCCEEEEECCHHHHHHHHHHHHHHHCCHHCCEEHHHCCCCCH
SATAINEAQLEAAKSNLWKTKLEYERYKALVSEEAATSQQLEKVKADYESAQAHFQEMKN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RIHSSALSTSVAEANVPTTQTNIASKQAVADNAALFLSYTIITAPYDGWVGKRTLQPGQL
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCCCCCCCCHHH
VKEGQSLLSIVSKEKWITANFKETQLQYLTVGQDVEIKADALSDKTFVGTIASLSPASGA
HHHHHHHHHHHHCCCEEECCCCCCEEEEEEECCCCEEEHHCCCCCHHEEEHHHCCCCCCC
RFSLLPPDNATGNFVKIEQRIPVRIQLKDSDKQADFLRAGMNITVIAAH
EEEEECCCCCCCCEEEEECCCCEEEEECCCCCHHHHHHCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]