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The map label for this gene is trxA [H]

Identifier: 146299103

GI number: 146299103

Start: 1536234

End: 1536551

Strand: Direct

Name: trxA [H]

Synonym: Fjoh_1343

Alternate gene names: 146299103

Gene position: 1536234-1536551 (Clockwise)

Preceding gene: 146299101

Following gene: 146299106

Centisome position: 25.2

GC content: 39.94

Gene sequence:

>318_bases
ATGGCATTAGCAATAACAGATGCTACTTTTGACGAAGTAGTTTTAAAATCAGATAAACCAGTAATGGTGGATTTTTGGGC
AGCATGGTGCGGTCCTTGTAGAATGGTTGGTCCAATCATTGACCAATTAAGCGATGAATATGCAGGAAAAGTTGTGGTTG
GTAAAGTTGATGTAGATGCTAACCAGGAATTTGCTGCTAAATATGGTGTGCGTAACATACCAACCGTTTTGGTGTTTCAT
AACGGTGAAGTAGTAGGAAAACAAGTTGGAGTTGCTCCAAAACAAACCTACGCTGACAGCTTAGACGCTTTGTTGTAA

Upstream 100 bases:

>100_bases
ATGATTTGTTTTTAATTTTTAACTTTGTACCTCAGTTCTGAAAGTTTTTAAAAAGTCTCCCCGAGATAAGAGCTGAAGAT
AACTTTAAAGAAAAATAATT

Downstream 100 bases:

>100_bases
TCGTAAGATTATGATTTATATAAAAAAGGCCTGATATATTCAGGCCTTTTTTATTGGAGGATATATTTTAAACACATAGA
GACATAGCTTTTTGTAAATT

Product: thioredoxin

Products: NA

Alternate protein names: Trx-1; Thioredoxin-M [H]

Number of amino acids: Translated: 105; Mature: 104

Protein sequence:

>105_residues
MALAITDATFDEVVLKSDKPVMVDFWAAWCGPCRMVGPIIDQLSDEYAGKVVVGKVDVDANQEFAAKYGVRNIPTVLVFH
NGEVVGKQVGVAPKQTYADSLDALL

Sequences:

>Translated_105_residues
MALAITDATFDEVVLKSDKPVMVDFWAAWCGPCRMVGPIIDQLSDEYAGKVVVGKVDVDANQEFAAKYGVRNIPTVLVFH
NGEVVGKQVGVAPKQTYADSLDALL
>Mature_104_residues
ALAITDATFDEVVLKSDKPVMVDFWAAWCGPCRMVGPIIDQLSDEYAGKVVVGKVDVDANQEFAAKYGVRNIPTVLVFHN
GEVVGKQVGVAPKQTYADSLDALL

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=96, Percent_Identity=43.75, Blast_Score=86, Evalue=5e-18,
Organism=Homo sapiens, GI5031973, Length=85, Percent_Identity=37.6470588235294, Blast_Score=70, Evalue=3e-13,
Organism=Homo sapiens, GI50592994, Length=88, Percent_Identity=39.7727272727273, Blast_Score=68, Evalue=2e-12,
Organism=Homo sapiens, GI24308127, Length=72, Percent_Identity=41.6666666666667, Blast_Score=64, Evalue=4e-11,
Organism=Escherichia coli, GI87082331, Length=103, Percent_Identity=50.4854368932039, Blast_Score=119, Evalue=4e-29,
Organism=Escherichia coli, GI1788936, Length=100, Percent_Identity=43, Blast_Score=97, Evalue=3e-22,
Organism=Escherichia coli, GI87081747, Length=102, Percent_Identity=34.3137254901961, Blast_Score=73, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI212646193, Length=96, Percent_Identity=38.5416666666667, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17556044, Length=78, Percent_Identity=39.7435897435897, Blast_Score=75, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI71998175, Length=78, Percent_Identity=44.8717948717949, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17510299, Length=96, Percent_Identity=37.5, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71980565, Length=77, Percent_Identity=32.4675324675325, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71980562, Length=79, Percent_Identity=31.6455696202532, Blast_Score=65, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6323072, Length=88, Percent_Identity=43.1818181818182, Blast_Score=76, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6321648, Length=86, Percent_Identity=36.046511627907, Blast_Score=71, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319925, Length=89, Percent_Identity=32.5842696629214, Blast_Score=61, Evalue=3e-11,
Organism=Drosophila melanogaster, GI28573567, Length=86, Percent_Identity=39.5348837209302, Blast_Score=83, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24664269, Length=78, Percent_Identity=41.025641025641, Blast_Score=80, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24639826, Length=79, Percent_Identity=40.5063291139241, Blast_Score=79, Evalue=6e-16,
Organism=Drosophila melanogaster, GI17648013, Length=79, Percent_Identity=41.7721518987342, Blast_Score=73, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24583090, Length=79, Percent_Identity=41.7721518987342, Blast_Score=73, Evalue=4e-14,
Organism=Drosophila melanogaster, GI21358065, Length=82, Percent_Identity=41.4634146341463, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24639068, Length=96, Percent_Identity=35.4166666666667, Blast_Score=69, Evalue=6e-13,
Organism=Drosophila melanogaster, GI17530795, Length=73, Percent_Identity=35.6164383561644, Blast_Score=69, Evalue=8e-13,
Organism=Drosophila melanogaster, GI19921434, Length=80, Percent_Identity=40, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11328; Mature: 11197

Theoretical pI: Translated: 4.38; Mature: 4.38

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALAITDATFDEVVLKSDKPVMVDFWAAWCGPCRMVGPIIDQLSDEYAGKVVVGKVDVDA
CEEEECCCCCHHEEECCCCCEEEEEHHHHCCCHHHHHHHHHHHHHHHCCEEEEEEEECCC
NQEFAAKYGVRNIPTVLVFHNGEVVGKQVGVAPKQTYADSLDALL
CHHHHHHCCCCCCCEEEEEECCEEECCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
ALAITDATFDEVVLKSDKPVMVDFWAAWCGPCRMVGPIIDQLSDEYAGKVVVGKVDVDA
EEEECCCCCHHEEECCCCCEEEEEHHHHCCCHHHHHHHHHHHHHHHCCEEEEEEEECCC
NQEFAAKYGVRNIPTVLVFHNGEVVGKQVGVAPKQTYADSLDALL
CHHHHHHCCCCCCCEEEEEECCEEECCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2492995 [H]